Published in Drug Week, October 1st, 2004
"We investigated apoptosis during early stages of in vitro differentiation of neuronal precursors generated by embryonic day 14 (E14) mouse striata stem cells. Differentiation was in conditions of suboptimal growth factor supply. Apoptosis reached 10-15% of cells and affected proliferating as well as postmitotic cells, including TUJ1-positive cells," researchers in Switzerland wrote.
"Inhibition of apoptosis led to an increased proportion of TUJ1-positive cells generated by stem cells. K+ current was reported to be related to apoptosis. Outward K+ currents...
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