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Leukemia

Mature B-cell acute lymphoblastic leukemia with t(9;11) translocation studied

Published in Drug Week, October 8th, 2004

Mature B-cell acute lymphoblastic leukemia with t(9;11) translocation can express a "mature" B-cell phenotype and may represent a distinct subset.

According to a study from the United States, "Mature B-cell acute lymphoblastic leukemia (ALL) is typically associated with the FAB-L3 morphology and rearrangement of the MYC gene, features characteristic of the leukemic phase of Burkitt's lymphoma.

"However, the term 'mature' has also been used to describe other rare cases of B-ALL with light-chain surface immunoglobulin expression. In contrast, infantile B-cell ALL is generally characterized by rearrangement of the MLL gene, an immature pro-B-cell...

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