Drug Week
Susan Hasty, Publisher
Table of Contents . . . November 5th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Adverse Drug Events - Study documents adverse events of pneumococcal vaccine in children
Benign Prostatic Hyperplasia - Statistically significant positive phase II data reported on Cetrorelix
Crohn Disease - Positive phase II data reported for Alequel
HIV/AIDS Treatment - Study: Fuzeon plus active boosted PI doubles long-term response
Osteoporosis - SERM+ teriparatide offers improved bone therapy for postmenopausal patients
AIDS/HIV Diagnosis - HIV-1 superinfections assessed by autologous heteroduplex mobility
AIDS/HIV Epidemiology - Current state of HIV and AIDS in Sub-Saharan Africa reviewed
AIDS/HIV Vaccine - HIV-1 immunogen vaccine plus antiretrovirals promotes virologic control
Abdominal Aortic Aneurysm - Estrogen protects male rats from aneurysm
Acinetobacter Baumannii - Multiresistant Acinetobacter baumannii outbreak occurred in surgical room
Acne - Phase II study of zileuton for moderate-to-severe acne begins
Acute Myeloid Leukemia - Loss of clone with FLT3 gene mutation at relapse does not improve AML prognosis
Addiction Medicine - Genetic profiling links key genes to alcohol-related expectancies
Adenovirus - Membrane Cofactor Protein identified as adenovirus receptor
Adipogenesis - Growth hormone treatment stimulates adiponectin gene expression in adipocytes
Adipose Tissue - Carbohydrate response element-binding protein gene expression studied
Adrenoceptor - Increased insulin not needed for increases in mouse brain tryptophan
Adverse Drug Effects - Combination therapy for liver cancer is linked to interstitial pneumonia
Adverse Drug Effects - Genes involved in valproic acid teratogenicity identified
Adverse Drug Effects - Slightly increased risk of ischemic stroke found with tamoxifen
Adverse Drug Events - Study suggests caution against using certain drugs to unclog heart arteries
Alcohol Use - Ethanol effects on uncoupling protein-1 mRNA alter thermogenesis set point
Allergies - Study: Anti-dust mite covers effective in reducing allergens
Allergy Medicine - Allergen immunotherapy reviewed
Allergy Medicine - NFAT1 protein assists mast cells with interleukin-13 gene transcription
Allergy Medicine - Patient knowledge of allergy immunotherapy better than expected
Alzheimer Disease - Biotechcompany scientist presented with award from Alzheimer Association
Alzheimer Disease - Blood pressure drugs may slow deterioration of Alzheimer
Alzheimer Disease - Forecast: Considerable research to be devoted to pathomechanism of Alzheimer
Alzheimer Disease - NSAID prodrugs show promise for CNS delivery
Alzheimer Disease - Partnership between government, industry will streamline clinical trials
Alzheimer Disease - Pharma company announces progress with Alzheimer strategy
Alzheimer Disease - Pharma company's long-term study of Celebrex expected to continue
Amyotrophic Lateral Sclerosis - CytRx adds three drug candidates with acquisition of Biorex assets
Anemia - Phase I trial of Hematide initiated
Anesthesia Awareness - JCAHO Sentinel Event Alert issued targeted at preventing anesthesia awareness
Angiology - Microvascular dysfunction encourages the progression of steatohepatitis in mice
Angiology - Vitamin E can increase carotid artery compliance and baroreflex gain
Anthrax - Prescriptions for antibiotics to prevent anthrax now uncommon
Antibiotic Resistance - Biotech company working to address problem of antibiotic resistance
Antifungal Therapy - Oral fluconazole safe/effective empiric treatment for neutropenic fever
Antisense Technology - Antisense inhibitors of TRADD could modulate TNF-related pathologies
Antisense Technology - The antisense mRNA sONE offers endothelial-cell specific gene expression
Antitumor Drugs - Antiestrogenic drug combinations may be used for glioblastoma malignancies
Antiviral Therapy - RANTES haplotypes influence the response to chronic hepatitis C therapy
Apoptosis - CD45 plays significant role in nuclear apoptosis by chloride channel regulation
Apoptosis - Humic acid induces apoptosis in premyelocytic leukemia HL-60 cells
Arthritis - Pharmaceutical company offers its alternative to recalled arthritis medication
Arthritis - Topical medication effective in relieving symptoms of knee osteoarthritis
Arthritis Therapy - Glucuronoxylomannan exhibits anti-inflammatory effects in arthritis
Arthritis Vaccine - Bioassay detects soluble MAdCAM-1 in body fluids
Asthma - Data collection complete for phase III Aridol study
Asthma - Suite of asthma control and asthma impact surveys launched
Atherosclerosis - Drug for rheumatism possible boon to heart patients
Atherosclerosis - Results presented on antibody-based treatment of atherosclerosis
Atherosclerosis Vaccine - Cholesteryl ester transfer protein induces long-lasting antibodies
Atrial Flutter - Beta-radiation can create linear lesions that are contiguous and nonthrombogenic
Autoimmune Disease - Antinuclear antibody absorption by hepatitis B vaccine warrants evaluation
Autoimmune Disease - T cell genes expressed in human and murine autoimmune disease compared
Autoimmune Disease - Thyroid peroxidase DNA immunization replicates thyroid autoimmunity
Avian Influenza Vaccine - Reassortant influenza vaccines control avian influenza
Awards - Biotech firm lauds Nobel winner, announces olfactory-based government contract
Bacterial Pathogen - Oligonucleotide array technology rapidly detects foodborne pathogenic bacteria
Bacteriology - Biosynthesis study results of 55 bacterial strains reported
Bacteriology - Pharma company completes phase 1 clinical trial for complicated skin infections
Bacteriology - Significance of microbial interactions in biooxidation of pyrite
Bacteriology - Swedish company presents mass screening tests at investment conference
Bacteriology - Triclosan's insertion in cell membrane may account for its antibacterial effect
Basal Cell Carcinoma - Gli proteins up-regulate expression of basonuclin in basal cell carcinoma
Benign Prostatic Hyperplasia - Avodart offers improvements in quality of life for men with prostate problems
Biochip Technology - Peptidomics offers sensitive search for biomarkers
Biofilms - Lactobacillus spp. biofilm growth promoted by Actinomyces spp., S. mutans
Bioprocessing - BioProcess International Conference & Exhibition unites 1,000 attendees
Bioreactors - Polycation-mediated precipitation captures plasmid DNA from alkaline lysate
Biosynthesis - Tetrahydropapaverine seen to inhibit serotonin biosynthesis in murine model
Biotechnology - More than 1 million Bioanalyzer chips sold
Bioterrorism - NIH grants awards for the development of human antibody against anthrax
Bipolar Disorder - FDA approves ABILIFY for acute bipolar mania, including manic and mixed episodes
Bladder Cancer - Anticancer effects of DADS characterized
Bladder Cancer - Molecular assessments can facilitate the management of bladder carcinoma
Botulinum Toxin - Interaction of two botulinum subdomains needed to elicit antibodies
Bovine Mastitis - Clinical bovine mastitis diagnosed in a Prototheca zopfii outbreak
Brain Cancer - Brain metastases patients' radiographic response at 3 months predicts survival
Brain Cancer - Data on GliaSite Radiation Therapy System presented at ASTRO
Brain Cancer - N-ethyl-N-nitrosourea increases brain mutations in neonatal mice
Brain Cancer - New findings from EFAPROXYN brain metastases trial releases
Brain Cancer - Positive cancer data on ECO-4601 presented at symposium
Brain Cancer - Protein protecting brain from toxins also blocks some chemotherapy
Breast Cancer - In vitro, arachidonic acid release may mediate tamoxifen, raloxifene actions
Breast Cancer - Komen Foundation names husband-wife team honorary co-chairs for San Diego race
Breast Cancer - Medical device company announces kit for accelerated partial breast irradiation
Breast Cancer - NYU Medical Center begins validation study on early detection breast cancer test
Breast Cancer - PC cell-derived growth factor inflames breast tumor aggression
Breast Cancer - Study links low HDL levels with increased risk of postmenopausal breast cancer
Breast Cancer - The adenoviral type 5 E1A gene sensitizes breast tumors to paclitaxel
Breast Cancer - Well-differentiated breast tumors have more 16q loss than poorly differentiated
Business & Finance - Biomedical foods company receives large order for Asorbine Flex+
Business & Finance - Biotechnology company delists from TSX Venture Exchange
Business & Finance - Biotechnology company files registration statement with SEC
Business & Finance - Pharmaceutical company files universal shelf registration statement
Business & Finance - U.S. biotech invests in Australian cancer-focused company to widen collaboration
Business Update - Agilent Technologies to partner in bioinformatics work on $11.7M ATP grant
Business Update - Amgen awards 3-year outsourced clinical study support project
Business Update - Biotech company undertakes value-enhancement plan
Business Update - Biotech firm strengthens drug pipeline by acquiring a phase II compound
Business Update - Cancer research foundation announces new partnership
Business Update - Clinical development organization forms centralized document and data centers
Business Update - Company changes name and prepares for HIV vaccine trial
Business Update - Contract research organization opens office in top German biotech region
Business Update - DNAPrint genomics to acquire majority ownership in German pharmaceutical company
Business Update - Information solutions company signs multiyear agreement with Boots the Chemist
Business Update - Orthopedic products company presented technology overview at conference
Business Update - Partnership formed to market phase 3 chemoprotective agent in North America
Business Update - Pharma company and IVAX conclude license agreement for anticancer agent
Business Update - Pharma company announced grant to Health Partners International of Canada
Business Update - Pharma marketing organization expands operations
Business Update - Pharmaceutical company announces plan to sell Clontech
Business Update - Report finds integrated operations important priority for pharma industry
Business Update - Update provided on Latin American operations for diabetes drug
Cancer Imaging Technology - Changes made to computed radiography system
Cancer Research - Biopharma company announces update on trial of compound for advanced cancers
Cancer Research - Companies announce filing of MAA in Europe to inject anticancer drug for MDS
Cancer Research - Icelandic technology fund to support collaborative cancer diagnostics project
Cancer Research - Leukemia society awards two $5 million grants to develop anticancer therapies
Cancer Research - New therapy may counteract Paclitaxel resistance in cancer cells
Cancer Risk Factor - Hepatitis B virus core promoter mutations prevail in liver cancer
Cancer Screening - DOD awards sole-source contract for the ThinPrep Pap Test
Cancer Therapeutics - Pharmaceutical company enters licensing agreement to develop oral cancer drug
Cancer Therapies - Pharma company presented six studies at cancer therapy conference
Cancer Therapy - Anticancer activity of Scutellaria barbata characterized
Cancer Therapy - Biliary excretion of imatinib mesylate and metabolite characterized
Cancer Therapy - Compounds with MDR1-enhanced anticancer activity identified
Cancer Therapy - Data analysis confirms BrachySilTM is safe and effective at tumor regression
Cancer Therapy - Data released on two spectrum selective kinase inhibitors: XL647, XL999
Cancer Therapy - Data supports value of prostate brachytherapy
Cancer Therapy - Energy blocker kills big tumors in rats
Cancer Therapy - Flow cytometric assay provides measure of transient tumor hypoxia
Cancer Therapy - Fruit and veg extract enhances cancer drug
Cancer Therapy - Minute doses of JNJ-17029259 enhance the utility of standard chemotherapy
Cancer Therapy - Normal cells in tumors may aid cancer growth
Cancer Therapy - Pharmaceutical company offers phase I trial update for DAVANAT
Cancer Therapy - Protein biomarkers and drug design for cancer treatments reviewed
Cancer Therapy - Tamoxifen alters cytokines and nitric oxide levels in breast cancer patients
Cancer Therapy - The nuclear factor-kappa B inhibitor sulfasalazine overwhelms glioblastoma
Cancer Therapy - Tumor regression reported with AP23573 in relapsed, refractory cancer
Cancer Treatment - Scientists develop new drugs that improve survival after bone marrow transplant
Cancer Vaccine - Biotech company receives $3 million NCI award for anticancer vaccine protein
Cancer Vaccine - Chemotherapy after vaccination benefits glioblastoma patients
Cancer Vaccine - Raf kinase expression increases mortality of influenza-infected mice
Cardiac Arrest - Ephedrine linked to sudden cardiac death
Cardiology - Electroporation of hepatocyte growth factor DNA treats cardiomyopathy
Cardiology - New catheter available for crossing chronic total occlusions
Cardiology - New treatment may help prevent blood clots
Cardiopulmonary Resuscitation - Flemish T.V. watchers overestimate succcess of CPR
Cardiovascular Disease - Biopharmaceutical company announces CARE 2 study
Cardiovascular Disease - Biosciences company enters collaboration to study genetics of heart disease
Cardiovascular Disease - Data on Thelin presented at American College of Rheumatology Meeting
Carpal Tunnel Syndrome - High body mass index increases risk of carpal tunnel syndrome
Cervical Cancer - Infection site and patient ethnicity affect HPV-induced cancer pathways
Childhood Obesity - Adiponectin regulation altered in obese children
Childhood Obesity - Prevalence of overweight and obesity among Kuwaiti adolescents reported
Childhood Obesity - Zinc nutritional status linked to hyperinsulinemia in obese children
Cholesterol - Cholesterol guidelines become a morality play about conflict of interest
Cholesterol - New drug designed to reduce cholesterol levels launched
Chronic Hepatitis B - Estrogen receptor alpha genotypes associate with susceptibility to hepatitis B
Chronic Hepatitis B - Lamivudine does not improve the response of hepatitis B to peginterferon
Chronic Hepatitis B - Real-time PCR and melting curve analysis offer rapid assessments of hepatitis B
Chronic Liver Disease - Serum hepatitis B virus strains parallel hepatic strains in acute exacerbations
Chronic Liver Disease - Site-specific keratin hyperphosphorylation marks liver disease progression
Chronic Myeloid Leukemia - Absolute guidelines needed for monitoring minimal residual disease in CML
Chronic Obstructive Pulmonary Disease - Replacement testosterone assists COPD patients
Circovirus Type 2 - Porcine circovirus type 2 from pigs was in Croatia detected and characterized
Cirrhosis - Epivir-HBV delays liver complications from chronic hepatitis B
Clinical Trial - Trial results on COLD-fx show natural compound cuts recurrent colds in half
Clinical Trials - Clinical investigators review, endorse phase 2 trials for deep vein therapy
Clinical Trials - Company expands consulting services to full service clinical trials
Clinical Trials - David Allen Galbraith, MD, joins board of Hana Biosciences
Clinical Trials - Drug improves Huntington disease movement disorder in clinical trial
Clinical Trials - Strategic alliance to provide turnkey solution for clinical trials
Collaborations - Agreement signed to market docosanol 10% cream in Scandanavia
Collaborations - Agreement signed with Tegent Technology to establish distribution in China
Collaborations - Alliance to develop novel anticancer compound
Collaborations - Altana Pharma selects partner for a kinase lead identification program
Collaborations - Antibody alliance with Centocor expanded
Collaborations - Biogen enters pharmacodiagnostic research collaboration
Collaborations - Chemical compound catalogs added to cheminformatics database
Collaborations - Cooperation, license agreements signed related to mouse genetics
Collaborations - Device companies announce distribution agreement for nebulizer system
Collaborations - Pharma company, Pennsylvania reach economic stimulus agreement
Collaborations - Pharmaceutical firm secures an investment of EUR 20 million by DNAPrint
Collaborations - eTag technology evaluated for patient selection for targeted cancer therapies
Colon Cancer - Antitumor effects of thymidylate synthase inhibitors mediated by p21Cip1
Colon Cancer - CoFactor results reported showing antitumor activity, lower systemic toxicity
Colon Cancer - Glutathione-S-transferase P1-1 may have role in early colon cancer
Colorectal Cancer - ZD9331 has minimal antitumor activity as 2nd/3rd line colorectal cancer therapy
Complementary & Alternative Medicine - Chiropractors cite alternatives to antidepressants for pain-related depression
Complementary & Alternative Medicine - Community-based research shows mixed therapy regimens in an Australian suburb
Complementary & Alternative Medicine - New studies confirm safety of chromium picolinate as nutrient in bars, beverages
Complementary and Alternative Medicine - Molecular data show berberine is a potent inhibitor of HIF-1 alpha expression
Complementary and Alternative Medicine - Sweet broomweed possesses antidiabetic activity
Conjunctivitis Outbreak - E-mail surveys assist investigation and response in conjunctivitis outbreak
Coronary Artery Bypass Grafting - Fasudil attenuates post-CABG coronary artery spasm
Coronary Artery Disease - Pharma company releases phase 1 results for coronary atherosclerosis treatment
Crohn Disease - SEEK1 polymorphisms not associated with Crohn disease in Newfoundland
Cystic Fibrosis - Company announces final research report on cystic fibrosis treatment
Cystic Fibrosis Therapy - Ionic interaction of amiloride and UTP in nebulizer solution characterized
Cytomegalovirus Vaccine - Microneutralization assay using cytomegalovirus strains developed
DNA Damage - p53-dependent transcription exhibits on and off responses after genotoxic stress
Dental Caries - HIV infection increases risk of dental caries in children
Depression - Are depressed patients exploited by the drug industry?
Dermatology - Biopharmaceutical company announces resutls of dermatological disorder trial
Dermatology - Gene silencing, posttranscriptional regulation studied in ocular melanoma
Dermatology - Pharma company acquires PURELL from GOJO industries
Diabetes - Pharma development company discovers potential treatment for type 2 diabetes
Diabetes Genomics and Genetics - Lactase persistence C(-13910)T variant not linked to diabetes risk
Diabetes Pathogenesis - AMPK activation does not increase insulin-stimulated glucose uptake
Diabetes Pathogenesis - Analysis of CAP, Cbl, and CrkII role in insulin-regulation of GLUT4 performed
Diabetes Pathogenesis - Insulin signaling impaired in people with family history of diabetes
Diabetes Pathogenesis - Phosphatase expression downregulated before diabetes onset
Diabetes Pathogenesis - Regulatory T cells and type 1 diabetes reviewed
Diabetes Prevention - Statins do not prevent development of type 2 diabetes
Diabetes Therapy - FDA approval granted for Metformin Hydrochloride 500 mg
Diabetes Therapy - Insulin pump doses in children with type 1 diabetes compared
Diabetes Therapy - Macrocyclic oxovanadium complex protects diabetic pancreatic cells
Diabetes Therapy - Second-generation thiazolidinediones and hepatotoxicity reviewed
Diabetic Gastroparesis - Regional gastric contractility altered in diabetic gastroparesis model
Diabetic Ketoacidosis - Cardiac troponin I concentration increases in diabetic ketoacidosis
Diabetic Nephropathy - ACE inhibitors increase survival in Chinese type 2 diabetic patients
Diabetic Nephropathy - Nephrotic syndrome disappears after pancreas-kidney transplantation
Diabetic Nephropathy - Osteoprotegerin levels increased in diabetic hemodialysis patients
Diabetic Nephropathy - Therapies for ventricular hypertrophy compared in diabetic patients
Diabetic Nephropathy - Treating albuminuria may prevent heart disease in diabetic patients
Diabetic Nephropathy - Treatment strategies in patients with chronic renal disease outlined
Diabetic Nephropathy - glomerulopathy progresses in normoalbuminuric patients with diabetes
Diabetic Neuropathy - C-peptide corrects endoneurial blood flow but not oxidative stress
Diagnostic Imaging - Dual-color fluorescence imaging dissects elements of tumor vascularity
Diagnostics - CGE-LIF cycling probe technology analyzes small samples for genomic DNA
Diagnostics - Japanese supplier launches new subsidiary in the United States
Diagnostics - Life sciences company announces Nanobacteria blood test manufacturing agreement
Diagnostics - Polymerase chain reaction quickly identifies Salmonella enterotoxin genes
Diagnostics - Total HCV core antigen assay detects early infection but not viral elimination
Diet and Nutrition - Diet can minimize atherogenic risk in children with renal transplants
Diet and Nutrition - Emerging food technology and world health reviewed
Diet and Nutrition - Gluten-free diet improves growth in diabetics with celiac disease
Discovery Laboratories - MAA submitted to market Surfaxin in Europe
Disease Associations - Immune restoration disease arises in association with antiretroviral therapy
Disease Transmission - Study identifies target for preventing sexual transmission of HIV
Drug Addiction - Women make up growing percentage of meth treatment patients
Drug Delivery - Chemoenzymatic technique generates self-assembled polymeric nanomicelles
Drug Delivery - First cough/cold treatment in film form that melts on the tongue to be marketed
Drug Delivery - Low molecular weight chitosan fractions exhibit marked solubility
Drug Delivery - Melamine dendrimer delivery vehicle has favorable toxicity profile
Drug Delivery - Microencapsulation improves safety and efficacy of amphotericin B
Drug Delivery - Release kinetics of Egalet constant-release system determined via scintigraphy
Drug Delivery - Thrombin peptide-loaded microspheres improve bone healing in rabbits
Drug Delivery - U.S. FDA approves new and easy way to take ENBREL
Drug Development - Agreement entered to develop structure-based drug design process
Drug Development - Agreement signed to develop Geomatrix drug delivery technology
Drug Development - Anticancer compound inhibits growth in drug resistant cell lines, company says
Drug Development - Biotechnology company files a request of re-examination of Benitec
Drug Development - Company opens new research and development laboratory
Drug Development - Drug developer launches immediate-release oral proton pump for gastro diseases
Drug Development - Inhalation drug company secures new funding
Drug Development - Nitrosated serum albumin characterized
Drug Development - Novel antiapoptotic protein X-linked IAP antagonists potential cancer therapy
Drug Development - Novel compounds exhibit antiviral and antitumor effects
Drug Development - Novel erectile dysfunction drug DA-8159 doesn't cause retinal damage in rabbits
Drug Development - Novel mass spectrometry assay suitable for flavone analysis
Drug Development - Novel virtual screening method improves identification of GPCR ligands
Drug Development - Pharmaceutical receives U.S. FDA approval of GI disease and hepatitis drugs
Drug Development - Phase 1 clinical trial for intranasal delivery of antibiotic initiated
Drug Development - Sense oligonucleotides targeting VEGF may help patients with ischemic tissues
Drug Development - Site-directed protein assay used to identify caspase allosteric site
Drug Development - Sphingomyelinase inhibitors reduce ischemic neuron death
Drug Development - Study results of treatment for leukemia with arsenic trioxide presented
Drug Development - Thelin for vascular constriction promising in patients failing bosentan therapy
Drug Development - U.S. FDA grants orphan status to drug for treatment of soft tissue sarcoma
Drug Discovery - Biotechnology company signs license agreement for Transfluor technology
Drug Resistance - PCR-RFLP detects ethambutol-resistant Mycobacterium tuberculosis strains
Drug Testing - Roadside drug testing study to include American company
Drug Therapy - A number of agents can modulate the expression of CD40 ligand
Drug Therapy - Large study will evaluate n-3 polyunsaturated fatty acids and rosuvastatin
Drug Therapy - Levosimendan activates potassium flux to the mitochondrial matrix
Drug Therapy - Tezosentan at 1-25 mg/h improves hemodynamics and reduces B natriuretic peptide
Drug Therapy - Ventricular function and NYHA class, rather than age, predict low tolerability
Embryonic Development - Connexin expression maintains lens quality and heart function in embryogenesis
Encephalitis Vaccine - Ascorbate-Cu(II) protects CF-1 mice against HSV-2 encephalitis
Encephalomyelitis - Polymerase inhibitor in encephalomyelitis linked to immunomodulation
Endocrinology - Concomitant use of Luveris, Gonal ok'd for hypogonadotropic hypogonadal women
Endocrinology - Ghrelin pulsatility linked to growth hormone pulsatility in healthy men
Endocrinology - The Notch signaling pathway is a conduit between estrogen and angiogenesis
Endocrinology - The acute response to islet PPAR gamma overexpression is insulin resistance
Endocrinology - Triiodothyronine increases lipogenic enzyme expression and triglyceride deposits
Environmental Health - A new high-capacity biofilm reactor system studied for treating domestic sewage
Environmental Health - Diesel exhaust enhances expression of IL-13 in bronchial epithelium
Enzymology - Ashkenazi Jewish patients with glycogen storage disease Ia bear R83C mutations
Enzymology - Structure of cytochrome P450 3A4 determined
Enzymology - Superoxide dismutase gene transfer may treat complex I deficiency disorders
Enzymology - dUTPase suppression sensitizes cancer cell lines to TS inhibition
Epidemiology - DJ-1 gene mutations are population-specific in Parkinson disease patients
Epstein Barr Virus - EBV is integrated between REL and BCL-11A in American Burkitt lymphoma cell line
Esophageal Cancer - Company announces clinical hold on TNFerade trials
Esophageal Cancer - High serum SCC Ag predicts poor survival in esophageal cancer with esophagectomy
Esophageal Cancer - Interim results from TNFerade study presented at international cancer meeting
Exercise - Aerobic fitness associated with repeated-sprint ability in women
Exercise - Dietary n-3 fatty acids do not improve exercise performance
Exercise - Exercise and lipoic acid improve insulin signaling in skeletal muscle
Facilities - DaVita acquires three dialysis centers
Factor XIII - Functional human coagulation factor XIII A-domain expressed in plants
Fertility - Architect Systems' fertility menu enhanced with test for Estradiol
Finance - American Stock Exchange lists common stock oncology company
Finance - Antidepressant maker expects better-than-anticipated Q2
Finance - Biopharma announces new debt financing for research and development operations
Finance - Biopharmaceutical company announces closing of private placement
Finance - Biopharmaceutical company calls for redemption of convertible subordinated notes
Finance - Biotech company files Canadian preliminary prospectus for common share offering
Finance - Biotech company raises new cancer financing; appoints new vice president
Finance - Biotech firm to establish Level 1 American Depository Receipt program
Finance - Biotherapeutics announces third-quarter 2004 results
Finance - Canadian science company announces agreement with healthcare technology company
Finance - Cancer-focused bioscience company reports Q3 financials, operating highlights
Finance - Cangene reports earnings of 52 cents per share for fiscal 2004
Finance - Company extends share repurchase program
Finance - Company focused on antibiotic-resistant bacteria closes $1.1M investment round
Finance - Company raises $12 million to fund gene therapy
Finance - Diagnostics firm secured new funding to develop new sensor technology
Finance - Drug delivery systems provider raises funds via issue of convertible bonds
Finance - Drug discovery company announces filing of $175 million shelf registration
Finance - Forward Ventures invests in monoclonal antibody startup
Finance - Medical device firm reports first quarter sales up 23%
Finance - Neuroscience company raises $12.75M in private placement
Finance - Nutraceuticals company reports release of escrow funds
Finance - Pharmaceutical company announces effectiveness of registration statement
Finance - Pharmaceutical company announces third quarter 2004 trading update
Finance - Pharmaceutical company leapfrogs from seed funding to major milestones
Finance - Pharmaceutical company raises GBP 16M, seeks admission to AIM
Finance - Pharmaceutical services company projects earnings per share
Fitness & Wellness - Online survey shows restaurants struggling to keep dieting customers
Food Allergies - Food allergy group calls for standardized guidelines and training in schools
Food-Borne Illness - Biogenic amines and bacteria analyzed in recalled canned anchovies
Foot and Mouth Disease - ELISA to detect foot-and-mouth disease virus antibodies developed
Fungal Infections - Aminocandin phase I trial initiated for systemic fungal infections
GU/GI Disorders - Pharmaceutical company licenses compounds for GU and GI disorders
Gastric Cancer - Expression of 7 ARP2/3 complex genes are decreased in gastric cancer
Gastric Cancer - KiSS-1 downregulation causes tumor invasion/worse prognosis in gastric cancer
Gastroenterology - Monoclonal antibody identifies interstitial cells of Cajal in GI tract
Gastroenterology - Pharmaceutical companies announce copromotion alliance for ZEGRID
Gastroenterology - Pharmaceutical company announces enrolment in post-operative Ileus trial
Gender Studies - Gender differences in insulin action exist after single bout of exercise
Gene Expression - Genomics company announces gene study in human embryonic stem cells
Gene Expression - The embryo offers a safe haven for genomic imprinting
Gene Profiling - Biological materials provider signs distribution agreement with GE Healthcare
Gene Promotion - Chimeric constructs target heterologous genes in cancer-derived cells
Gene Regulation - Globin gene activation driven by protein complexes nucleated by GATA-1/GATA-2
Gene Therapy - New grant awarded for anemia treatment
Gene Transfer - Selective electroporation leaves adipocytes receptive to plasmid DNA
Generic Drugs - Pharma company makes recommendation for usage of generic Vioxx
Generic Drugs - Pharma company recieves FDA approval for nicotine gum and ibuprofen suspension
Genetic Disorders - Novel sialidase confers normal phenotype to sialidosis cells
Genetic Modification - Transgenesis could make chicks viable models for genetic research
Genomics - Comparative study of Legionnaire's disease published
Genomics - Deoxyribozymes exhibit the ability to silence disease-associated genes
Genomics - Research company collaborates with scientists on BAC clone from tomato genome
Genomics & Genetics - TNF-TNFR super-family gene SNPs associated with immune-mediated disease
Geobacillus Stearothermophilus V - Thermostable cysteine synthase from G. stearothermophilus V characterized
Geriatrics - Seniors want medical professions, not government, to pick Medicare-covered drugs
Geriatrics - Vascular dysfunction may be responsible for age-related hearing loss
Glaucoma - FDA gives final approval for Brimonidine Tartrate Ophthalmic Solution, 0.2% ANDA
Glycemic Control - Morisky score detects diabetic patients with poor drug-taking behavior
Glycopeptide-Resistant Enterococci - Debate-guidelines for glycopeptide-resistant enterococci control have not worked
Group B Rotaviruses - Group B rotaviruses have been circulating in Western India since 1993
Gynecology - Gene profiles illuminate the polycystic ovary syndrome theca cell phenotype
HIV/AIDS - Biopharma company intends to continue development of treatment for Cachexia
HIV/AIDS Epidemiology - HIV-1 non-B subtypes from heterosexual transmission predominate in Scotland
HIV/AIDS Prevention - Primary hotline questions in Netherlands regard HIV transmission/risk/testing
HIV/AIDS Research - APOBEC3G incorporated into HIV-1 virions through viral/nonviral RNA interactions
HIV/AIDS Research - Antisense U7 snRNAs and siRNAs targeting cyclophilin A inhibit HIV-1 replication
HIV/AIDS Research - Dying cells drive the capacity of HIV-1 to kill noncycling primary CD4+ cells
HIV/AIDS Research - HIV-1 infectivity enhanced by forming particle-mediated syncytia in CD4+ cells
HIV/AIDS Research - Host cell gene expression varies during HIV-1 latency or reactivation
HIV/AIDS Research - Memantine protects hippocampal neuronal function in HIV-1 encephalitis
HIV/AIDS Research - R5 HIV-1 replicates more efficiently in primary CD4+ cells than X4 HIV-1
HIV/AIDS Research - Structure of initiation complex of HIV-1 reverse transcription is not conserved
HIV/AIDS Research - TSG101 mutations that inhibit PTAP or VPS28 binding block HIV-1 budding
HIV/AIDS Research - Tumorigenesis by HHV-8 chemokine receptor vGPCR is accelerated by HIV-1 Tat
HIV/AIDS Therapy - CD4+ cell non-production during HAART due to inefficiencies at multiple steps
HIV/AIDS Therapy - Critical reporting elements for quality of study methods reported
HIV/AIDS Therapy - Jury is still out regarding benefits of switching to protease-sparing regimen
HIV/AIDS Therapy - Nevirapine is better than efavirenz at raising "good" cholesterol
HIV/AIDS Treatment - Private clinics in South Africa urge drug companies to lower prices
HIV/AIDS Vaccine - CCR5-targeted SIV vaccination strategy prevents or inhibits SIV
HIV/AIDS-Related Pain Medicine - HIV-1 gp120-induced nitric oxide increases proinflammatory cytokines
Head & Neck Cancer - Positive phase I/II HuMax-EGFr safety data announced
Head and Neck Cancer - HIF-1 and VEGF are survival prediction markers for esophageal cancer
Healthcare Access - New PAHO fact sheets on HIV reflect differences in cost, care, coverage
Healthcare Access - Nurse system available for U.S. patients with multiple sclerosis
Healthcare Access - State of Tennessee extends healthcare services contract for behavior management
Healthcare Coverage - Health workers confirm Wisconsin's first flu case of the season
Heart Disease - Canadian biotech company begins two studies on cholesterol combination therapy
Heart Disease - Clinical trials slated for choelsterol drug
Heat Shock Protein - Heat shock protein is cytoprotective in gastric mucosa of cirrhosis
Hematology - Analyses reveal siblings with rare double clotting deficiencies
Hematology - Neutrophil CD177 mRNA production shadows chronic myeloproliferative disorders
Hematopoiesis - Leukemia-associated Rho GEF factor helps regulate early hematopoiesis stages
Hemorrhagic Stroke - Mice depict the contribution of amyloid-beta to vascular amyloid pathology
Hepatitis - Drug development company announces hepatitis C study presented at conference
Hepatitis - Study reports results of PegIntron and Rebetol combination therapy for hepatitis
Hepatitis C Virus Infection - Persistence of hepatitis C virus associated with human leukocyte antigen class 1
Hepatitis/HIV Coinfection - FDA grants priority review to Pegasys with Copegus for HCV in HIV patients
Hepatology - Novel peptide-based vaccines generate immunity to hepatotropic pathogens
Hepatology - Patients with liver disease have lower levels of circulating dendritic cells
Hepatology - Prognosis and treatment of hepatorenal syndrome reviewed
Hereditary Disease - Huntington disease gene mutations in Russia and Europe share similarities
Herpesvirus Vaccine - Viral subunit protein plus CpG ODN protects against HSV-2
Hodgkin's Disease - Drug receives orphan designation
Hormone Replacement Therapy - New guidelines confirm clinical value HRT for menopausal symptoms
Hormone Replacement Therapy - Short-term HRT effects vary among vascular sites
Hormone Replacement Therapy - Study finds no association between HRT use and risk of lymphomas, myelomas
Human Papillomavirus Vaccine - HPV type 18 L1 VLP vaccine safe and immunogenic in women
Hypercholesterolemia - MRI can measure early benefits of cholesterol-lowering drugs, plaque reduction
Hyperparathyroidism - Positive trial results reported for ABX10241 antibody product candidate
Hypertension - Captopril and L-arginine affect ventilation through different mechanisms
Hypertension - Stanford to test effects of drug widely used for pediatric hypertension
Hypertension Risk Factor - Obstructive sleep apnea syndrome increases hypertension risk in obese children
Imaging Devices - Cancer center utilizes new CT technology
Immunizations - Medical, maternal, and child health care in Chinese women studied
Immunology - CTL epitopes predicted using QM, SVM, and ANN techniques
Immunology - Dendritic cells in chronic hepatitis C patients alter immunological response
Immunology - Energetic and nutritional regulation of immune response reviewed
Immunology - New ranking names America's cough and cold capitals
Immunology - Peptide-HSP70 complexes generate cytolytic T-lymphocyte responses
Immunology - Polysaccharides from Salvia officinalis are immuno-modulators
Immunology - Sphingolipids influence on physiologic pathways in eukaryotic cells explored
Infection Control - Disinfection, and sterilization adherence reduce hospital-related infections
Infectious Disease - Company awarded SIBR grant for infectious disease detection
Inflammatory Reaction - VEGF is a key mediator of angiotensin II-induced vascular inflammation
Influenza - Disease management company to offer viral antidote to U.S. during flu season
Influenza - Drug-DNA combination could offer longer-lasting, more efficient flu vaccine
Influenza - Pediatricians: Flu vaccine needed to protect children under age 2
Influenza - Study to test flu shot and nasal spray flu vaccine side by side
Influenza - Survey of hospitals quantifies flu vaccine price gouging
Influenza - Thirty million doses of influenza vaccine shipped to healthcare providers
Influenza - U.S. funding granted for new influenza drug
Influenza Vaccine - Cost of flu vaccine rising as supply dwindles
Influenza Vaccine - Effect of influenza vaccination on primary care contact rates studied
Influenza Vaccine - Hospital visit prevention by influenza vaccine during pregnancy studied
Influenza Vaccine - Influenza Shot-Gouging: With scarce supplies of flu shots, prices go up, way up
Influenza Vaccine - Remaining flu shots directed to high-risk patients
Influenza Vaccine - Study of influenza virus A M2 peptide conjugate vaccines conducted
Influenza Virus - Antigenically and genetically similar influenza C viruses in Japan characterized
Influenza Virus - Influenza B virus lacks sequence homology to influenza A virus antigenic sites
Information Technology - Canadian drug mart corporation signs service contract with business IT group
Information Technology - Healthcare technology announces availability of NDC PharmacyRx
Information Technology - Medical services company launches new Web site
Information Technology - Monitoring service keeps executives appraised of adverse drug reactions
Information Technology - New Web site provides research reports to healthcare marketers
Information Technology - PACS launched in U.K. with first sale to Benenden Hospital
Information Technology - Software designer receives NIH grant to develop nutrition education software
Information Technology - Software systems company to provide pharmacy benefit services
Information Technology - U. of Pennsylvania medical school gives students hand-held information devices
Information Technology - Web portal launched helps clinicians track progress in drug therapies
Insomnia - Enrollment complete for phase 2 study of drug treatment for adult insomnia
Insulin - Insulin induces alpha(1B)-adrenergic receptor desensitization
Insulin Delivery - Nasal insulin delivery in chitosan solution examined
Insulin Resistance - Growth hormone receptor gene disruption increases insulin sensitivity
Insulin Resistance - Insulin resistance reduces carbohydrate utilization during exercise
Insulin Resistance - Insulinotropic agent activates insulin signaling in rats
Ischemia/Reperfusion - SOD2/3 shows promise for treatment of mesenteric I/R injury
Ischemic Heart Disease - COX-2 inhibition in patients with ischemic heart disease merits investigation
Islet Transplantation - Murine model of human islet allograft rejection developed
Islet Transplantation - Role of MHC in diabetes after islet transplantation characterized
Legal Issues - Accused nurse admits addiction, denies depriving patients
Legal Issues - Government marijuana? No thanks, say Dutch, "coffee" shop pot will do fine
Legal Issues - Skin products maker proceeds with patent infringement lawsuit against Syneron
Legal Issues - St. Albans, Vermont, school confronts drug problem
Lentivirus - LEDGF/p75 is a component of functional lentiviral preintegration complexes
Leptin Studies - Leptin increases adiponectin but barely decreases resistin
Leptospirosis - Unique Leptospira strain isolated from patient with pulmonary hemorrhage
Leukemia Therapy - Molecular mechanisms of ATRA in APL determined
Listeria - Listeria monocytogenes tracked in cheese processing plants
Liver Cancer - CD44v3 predicts the risk of hepatocellular carcinoma distant metastasis
Liver Cancer - Estrogen plays a critical role in female hepatocarcinogenesis
Liver Cancer - Patients with hepatic fibrosis and hepatitis C need broader cancer screenings
Liver Necrosis - Plasma osteopontin levels rise in patients diagnosed with fulminant hepatitis
Loiasis - Short-course of albendazole before ivermectin studied in microfilaremia
Lung Cancer - BNIP3 levels correlate with the prognosis of non-small cell lung cancer
Lung Cancer - Erbitux non-small cell lung cancer clinical development program advances
Lung Cancer - Laser-induced thermotherapy effective in lung metastases and primary lung tumors
Lung Cancer - Photodynamic and brachytherapy show good results for endobronchial tumor control
Lung Cancer - Utility of gefitinib in NSCLC treatment reviewed
Lymphoma - T cells needed early in ASCT to induce a graft-versus-lymphoma effect
Lymphoma Therapy - Cytostatic drugs enhance antitumor activity of anti-CD30 antibody
Lymphoma Therapy - Ki-67 expression determines rituximab efficacy in follicular lymphoma
MMR Vaccine - MMR vaccination not associated with developmental disorders
Macular Degeneration - Drug firm closes $15M financing, initiates trial of RNAi therapeutic
Macular Degeneration - Pharma company announces data for ocular disorders trial
Macular Degeneration - U.S. FDA gives fast-track status for antiangiogenic
Malaria Prevention - New malaria vaccine has promising test results
Malaria Vaccine - Antibodies to P. vivax protein studied in malaria-exposed subjects
Malaria Vaccine - Incidence of severe malaria useful as endpoint for vaccine trials
Malaria Vaccine - Molecular analysis of antibody response to malaria sporozoite reported
Malaria Vaccine - Quantitative PCR used to test vaccines in human experimental malaria
Market Analysis - Biotech's third quarter fundraising brings year-to-date total to more than $20B
Medical Devices - Electronics company announces partnership, 500th installation of CardioMD
Medical Devices - Intrinsic adhesion force of lubricants to steel surfaces determined
Medicare - Group organizes 2005 pharmaceutical meeting on new Medicare laws
Melanoma - B-RAF is therapeutic target in melanoma
Melanoma Vaccine - Dendritic cell vaccine boosts T cell-mediated immunity to tyrosinase
Meningitis Outbreak - Nosocomial meningitis outbreak caused by Acinetobacter baumannii
Meningitis Vaccine - PorA-specific differences found in antibody avidity after Men B vaccine
Meningococcal Disease - Domestic clones of N. meningitidis circulated in meningococcal disease outbreak
Meningococcal Vaccine - People often infected have poor immune response to Neisseria vaccine
Menopause - New campaign promotes benefits of hormone therapy
Menopause - Tentative approval granted for generic version of Femhrt tablets
Menopause - Update provided on Bio-E-Gel phase III trial
Menopause Therapy - Phase III trial update provided on Bio-E-Gel
Mental Health - Company outlines warning signs for depression
Mental Health - Pharma company launches Mirtazapine orally disintegrating tablets
Mergers & Acquisitions - Assets, certain business of Aventis Pharmaceuticals Puerto Rico to be acquired
Mergers & Acquisitions - Biopharma outsourcing organization acquires Integrated Marketing Corporation
Mergers & Acquisitions - CombiMatrix to acquire 33% of oncology drug developer
Mergers & Acquisitions - Merger creates discovery services, respiratory drug development firm
Mergers & Acquisitions - Orthopedic device company completes acquisition of gel-based product developer
Mergers & Acquisitions - Pharmaceutical company divests its Resins business
Mergers & Acquisitions - Therapeutics company sells subsidiary to Neurogenesis Biotech
Metabolic Syndrome - Aspects of metabolic syndrome associated with retinal microvascular signs
Metabolic Syndrome - Incidence of metabolic syndrome among Moroccan Sahraoui women reported
Multiple Myeloma - U.S. FDA grants Aplidin orphan drug status for the treatment of multiple myeloma
Multiple Sclerosis - Immune therapy appears to reduce risk of second attack of MS
Muscle Regeneration - BM-derived SP/Mac-1low cells play an important role in muscle regeneration
Muscular Dystrophy - Companies enter option, license agreement to discover muscle disease therapies
Mutagenesis - CPD-photolyase adenovirus-mediated gene transfer tracks photorepair in situ
Mutagenesis - DNA microarray is a high-throughput tool for exposing methylation status
Mutagenesis - Mutations in the collagen type II gene cause spondyloperipheral dysplasia
Mutagenesis - Novel method assesses DNA damage after exposure to benzo(a)pyrene
Mutagenesis - PCR-RFLP is quick and reliable for detecting hepatitis B virus core mutants
Myasthenia Gravis - HLA haplotypes associated with myasthenia gravis
Mycobacterium Haemocanis - M. haemocanis infection prevalence higher in kennel-raised than pet dogs
Myelodysplastic Syndrome - Telomere dynamics is prognostic factor for assessment of AML risk in MDS patient
Myocardial Infarction - Spanish trial suggests angioplasty after anticlotting therapy safe, beneficial
Myocardial Ischemia-Reperfusion - CAPE reduces size of I/R-induced myocardial infarction in rats
Myocardial Protein - The effects of broad band electromagnetic fields on HSP70 appear to be biphasic
Neonatology - Use of substance honed to improve lung function in premature infants
Neurodegeneration - Cerebrospinal VEGF may protect amyotrophic lateral sclerosis patients' neurons
Neurodegeneration - Genetic variants of monocyte chemoattractant protein support Alzheimer disease
Neurology - Anti-glucocorticoid gene delivery restructures neuronal stress response
Neuroscience - 5-HT treatment may attenuate glutamate efflux during brain ischemia
Neuroscience - Dietary restriction has antiangiogenic and proapoptotic effects in brain tumors
Nosocomial Infection - Catheter-related infections in European hospitals characterized
Nutrition - Expecta LIPIL DHA supplement now available for pregnant and nursing women
Nutrition - New prenatal and nursing supplement contains DHA
Obesity - Company wins phase I SBIR grant for obesity program
Obesity Epidemiology - Prevalence of obesity in Germany increasing
Obesity Pathogenesis - Uncoupling protein 1 not required for resistance to obesity in RII-beta-/- mice
Obesity Therapy - MCH-1 receptor antagonism decreases feeding by reducing meal size
Obesity Therapy - Moxonidine treatment lowers weight and blood pressure in overweight patients
Obstetrics - DNA sequencing identifies bacteria that place women at risk for premature labor
Obstetrics - LMW heparin is preferred treatment for venous thromboembolism in pregnancy
Obstetrics - Leukemia-inhibitory factor regulates endometrial genes during implantation
Obstetrics - Tocolysis with beta-mimetic agent normalizes CTG pattern in early labor
Oncogenesis - A new model of ductal carcinoma in situ mimics human breast cancer progression
Oncogenesis - Tumor and host-derived nitric oxide differentially regulate cancer metastasis
Oncogenesis - Viruses, chemicals, and co-carcinogenesis reviewed
Oncology - Anticancer agent may help induce cancer cell death
Oncology - Cancer research company receives grant to study cell-based cancer vaccine
Oncology - FDA grants fast-track designation for metastatic melanoma treatment
Oncology - Pharma companies announced research milestone in oncology therapeutic area
Oncology - Pharma company acquires rites for Campto chemotherapy agent
Oncology - Phase II trial slated for renal cancer treatment
Oncology - Pre-clinical results show promise for cancer treatment
Oncology - Restoration of metastasis suppressor genes could abate cancer dissemination
Oncolysis - Viral properties can be incorporated into adenovirus-based cancer therapies
Ophthalmology - Proliferative diabetic vitrectomy fellow eye study completed
Opthalmology - Treatment for wet age-related macular degeneration receives new brand name
Oral Health - Patients with periodontal disease show no evidence of more 3020insC mutations
Oral Mucositis - Company announces clinical progress with CG53135 for oral mucositis
Oral Squamous Cell Carcinoma - TNF-alpha/soluble receptors ratios prognostic in oral squamous cell carcinoma
Orthopedics - Sequestosome polymorphisms are rare in Paget disease of the bone in Belgium
Osteoarthritis - Investigational therapy for bone loss increased bone mineral density
Osteopenia - Actonel reduces vertebral, nonvertebral fracture risk
Osteoporosis - Analysis showed teriparatide reduced fracture risk independent of bone turnover
Osteoporosis - In vivo results presented on AC-100
Osteoporosis - Less than 50% of osteoporosis patients adhere to bisphosphonate therapy regimens
Osteoporosis - Novel semiannual therapy may prove effective in bone resorption
Osteoporosis - Pharmaceutical company presents positive results on osteoporosis study
Osteoporosis - Phase 1 trial of injected peptide for osteoporosis presented at meeting
Osteoporosis - Presentation discussed phase II intranasal therapy trials for osteoporosis
Osteoporosis - Prior fractures are predictors of future fractures in women with osteoporosis
Osteoporosis - Ribavirin impairs osteoblast proliferation and differentiation in lab cultures
Osteoporosis - Strontium ranelate may reduce fractures in older women
Osteoporosis - Study shows once-monthly Boniva increases bone density and reduces breakdown
Osteoporosis - Study shows vitamin D inadequacy prevalent among osteoporosis sufferers
Osteoporosis - Women with osteoporosis treated with Actonel have good bone mineralization
Osteosarcoma - Trichostatin A offers novel therapeutic strategy for osteosarcoma
Otitis Media - Nasopharyngeal pathogens in Danish children with otitis media studied
Ovarian Cancer - Positive results from phase 2 trial of ovarian cancer drug with Doxil reported
Oxygen Therapy - Update provided on revised Oxygent development plan
Pain Control - Chronic opiate use may raise vulnerability to stress
Pain Medicine - Circumcised newborns respond best to anesthetic relief
Pain Medicine - Company reports positive phase IIa trial results in postsurgical pain
Pancreatic Cancer - Suppressed synthesis of HMGA1 protein treats pancreatic carcinomas in mice
Papillomatosis - Omomyc expression in the skin prevents Myc-induced papillomatosis
Parainfluenza Virus - Sendai virus vaccine is safe and immunogenic in healthy adults
Parasitic Infections - Anthelmintic improves maternal anemia, infant birthweight and survival in Nepal
Parkinson Disease - Agilect provides significant symptom benefit as monotherapy
Parkinson Disease - Drug development company reports positive Parkinson disease study results
Patents - European patent office grants patent for oral administration of GCS-100
Patents - Patent issued for method of improving drug delivery to tumors
Patents - Periostat maker files patent infringement claim against IVAX, CorePharma
Pediatric Oncology - Chromosome 11q loss characterizes a unique subset of neuroblastoma
Pediatric Tumor - Infantile hemangioma endothelial cells arrest at an early developmental stage
Personnel - Abbott-Takeda pharmaceuticals joint venture names Glenn Warner executive VP
Personnel - Biopharma company appoints vice president clinical research and development
Personnel - Biopharma names executive VP of corporate development and general counsel
Personnel - Biopharmaceutical company announces appointment of new director
Personnel - Biopharmaceutical company announces appointment to board of directors
Personnel - Biotech board names Raj Parekh chairman, Wilson Totten as member
Personnel - Biotech company appoints senior director of drug metabolism
Personnel - Biotech company appoints senior sales, marketing executive
Personnel - Biotech firm appoints David Welch to the board of directors
Personnel - Biotechnology holding company announces board changes and loan settlement
Personnel - Cancer diagnostic company announces new research and development executive
Personnel - Cardiovascular-focused biopharma appoints new CFO
Personnel - Chinese biotech firm appoints independent director of company
Personnel - Dr. Eric von Hofe named VP for product development and scientific affairs
Personnel - Dr. Udo Klein named SVP of chemical genetics-based drug development company
Personnel - Drug delivery company appoints nonexecutive directors to the board
Personnel - Drug development company appoints executive vice president
Personnel - Former Biogen executive vice president Sylvie Gregoire named CEO of GlycoFi
Personnel - Health-focused company appoints Richard H. Anderson executive vice president
Personnel - Healthcare company names Geri Brouwers GM of Belgium/Luxembourg operations
Personnel - Healthcare venture capital investment firm appoints general partner
Personnel - Icogenex adds scientific advisor to Alzheimer disease program
Personnel - Jeremy Hayward-Surry named board chair by drug developer, manufacturer
Personnel - Pharma company elects member to board of directors
Personnel - Pharma company focusing on bone loss appoints CEO
Personnel - Pharmaceutical company adds new business development executive
Personnel - Pharmaceutical company announces addition of three executives
Personnel - Pharmaceutical company appoints new board member
Personnel - Pharmaceutical company reports retirement of president Aaron Levitt
Personnel - Pharmaceuticals firm announces executive promotions in R&D
Personnel - Pharmaceuticals focused on metabolic disease announces directors, advisors
Personnel - Pharmacy benefit manager appoints chief information officer
Personnel - Research institute appoints researcher specializing in nervous disorders
Personnel - Therapeutics developer names vice president, corporate and business development
Personnel - Timothy R.G. Sear named to board of directors of men's health company
Personnel - Ulf Jonsson named CEO by Swedish developer of life science tools
Pertussis Vaccine - Computer simulations of strategies for pertussis vaccination developed
Pharmacogenomics - Advancements in genomics, proteomics broaden role of biomarkers
Pharmacokinetics - CYP19/aromatase is the major enzyme in methadone metabolism in placenta
Pharmacology - CYP2C19 mutations regulate interactions between lansoprazole and tacrolimus
Pharmacology - Myosin ATPase inhibitor activates ion channels and Ca2+-handling proteins
Pharmacology - P-glycoprotein rapidly regulated at the blood-brain barrier by endothelin-1
Physical Activity - Exercise does not affect circulating angiotensin-converting enzyme
Pneumococcal Vaccine - Murine model of immunity induced by pneumococcal vaccine developed
Polio Vaccine - Polio vaccines containing simian virus 40 may cause human cancer
Poxvirus Vaccine - Structural proteomics of the poxvirus family reviewed
Premature Ejaculation - Recruitment begins for phase III trial for premature ejaculation compound LI301
Prescription Drugs - VIOXX prescription refunds offered by Minneapolis-based retail store
Product Licensing - Life sciences company, Rubicon Genomics sign genome amplification agreement
Prostate Cancer - Micelle delivery of doxorubicin increases cytotoxicity to prostate cancer cells
Prostate Cancer - Novel antitumor agents block intracellular protein kinase B/Akt activation
Prostate Cancer - Oncology group's prostate cancer chemotherapy study shows benefit in treatment
Protein Precursor - Transferrin receptor 2 protein not expressed in normal erythroid cells
Protein Signal - Dok/SHIP/Grb2 key intermediates in regulating antigen-induced mediator release
Protein Signal - Novel repressor of NF-kappa B-inducing kinase suppresses NF-kappa B activation
Proteomics - Helical forms of peptides determined by NMR and molecular dynamics
Proteomics - Novel assay devised for localization of protein-ligand binding sites
Proteomics - Protein binding sites attractive drug target for TCL1 protein-caused leukemia
Proteomics - SP100 interacts with ETS1 transcription factor to control its activity
Psoriasis - NK cell activating gene associated with susceptibility to psoriasis vulgaris
Pulmonary Medicine - Midkine causes pulmonary vascular remodeling in response to hypoxia
Pulmonary Medicine - VEGF promotes lung cancer pleural invasion and lymph node metastasis
RNA Research - Intron arrays shed light on antisense intronic RNA in malignancies
RNA Research - KIN17 may be involved in RNA processing
Radiation Therapy - Largest-ever study of prostate brachytherapy reveals long-term success
Radiation Therapy - Lithium may protect neurons from radiation therapy
Receptor Studies - Hepatocyte growth factor controls pyramidal dendrite formation in the cortex
Receptor Studies - Roles of insulin and insulin-like growth factor-I receptors studied
Receptor Studies - Saccharide-directed delivery to biological receptors optimized
Receptor Studies - The angiopoietins 3 and 4 show strong receptor and species-specific affinity
Respiratory Syncytial Virus - HLA-DP4 presents immunodominant peptide from RSV G protein to T cells
Restenosis - Thirty-day safety data reported from Taxus V drug-eluting stent clinical trial
Retinopathy - Elusive signals trigger endothelial cell growth in the ischemic retina
Rheumatology - Osteopontin levels denote the angiogenesis of juvenile idiopathic arthritis
Rubella Vaccine - Rubella immunization and postpartum care reviewed
SARS - U.S. NIH grant awarded for development of nasally delivered SARS vaccine
SARS Coronavirus - Highly infectious SARS-CoV reveals cell tropism/receptor expression correlation
SARS Infection Control - Providing SARS infection control information to outpatients increases compliance
SARS Vaccine - Antibody responses against SARS-coronavirus studied in SARS patients
Salmonella Outbreak - Salmonella outbreak traced to unshelled peanuts originating from one country
Scrapie Epidemic - Mathematical model analyzes early stages of scrapie epidemic in Cyprus
Secretory Diarrhea - Pharmaceutical firm receives grant from NIH for diarrhea drug development
Sinusitis Vaccine - Haemophilus membrane protein and cholera toxin induce mucosal immunity
Smallpox - FDA fast track status granted for modified vaccinia ankara program
Smallpox - U.S. HHS awards $232 million in biodefense contracts for vaccine development
Smallpox Research - California scientists help bring study of smallpox virus into 'molecular age'
Smallpox Vaccine - Positive side effects of smallpox vaccination described
Sphingolipidoses - Sphingolipidoses are relatively common and important health problem in Turkey
Squamous Cell Carcinoma - hCAP18(109-135) may be useful antitumor therapeutic agent for oral SCC
Staffing - Maine healthcare association awards staffing contract
Stem Cell Research - Company gets patent for feeder-free growth of hESCs
Stem Cell Research - G-CSF augments 1,25-dihydroxyvitamin D-3-induced monocytic differentiation
Stem Cell Research - IFN-gamma promotes neuronal differentiation and neurite outgrowth of neural SCs
Stem Cell Research - IV neural SCs migrate to injured spinal cord and differentiate into neural cells
Stem Cell Research - New report evaluates importance of cell therapy
Stem Cell Research - Science magazine hosts discussion of debate on embryonic stem cell research
Stem Cell Research - Stem cell research company provides update on programs
Stem Cell Research - c-Kit receptor identified as regulator of adult neural stem cells in the eye
Stem Cell Transplantation - De novo testosterone produced following transplantation of Leydig stem cells
Stem Cell Transplantation - Donor lymphocyte infusions induce graft-versus-myeloma effect after ASCT rescue
Stem Cell Transplantation - Methotrexate associated with improved overall survival following ASCT
Stem Cell Transplantation - Pre-allogeneic SCT is not associated with increased hypercoagulability
Stem Cell Transplantation - Telomere length predicts neutrophil recovery in G-CSF absence after ASCT
Stem Cell Transplantation - Topical and systemic dermal stem cell transplant accelerates skin wound healing
Stem Cells Research - Companies ink agreement for ACE system in adult-derived stem-cell research
Stem-Cell Transplantation - Daclizumab increases GVHD mortality when combined with steroids
Stereoselective Oxidation - Active microorganism strains sought in secondary alcohols
Stroke - Pharma company enters into license agreement for Enecadin
Stroke - Plasticity-enhancing effect of D-amphetamine is not related to its CV arousal
Stroke - Selecting patients by prognostic features can improve trial's statistical power
Surgical Devices - Results of new heart surgery system discussed at conference
Swine Dysentery - Brachyspira hyodysenteriae lipoprotein protects pigs from dysentery
Swine Fever Virus - Optimized protocol developed for detection of classical swine fever virus
Systemic Lupus Erythematosus - Mycophenolate mofetil is effective for managing non-renal lupus
Systemic Lupus Erythematosus - Oral contraceptive use doesn't cause disease flare in patients with SLE
Systemic Lupus Erythematosus - Preliminary results of Prestara trial on BMD in women with lupus not positive
Systemic Lupus Erythematosus - Therapeutic target discovered for potential rheumatic disease treatment
T Cell Lymphoma - U.S. FDA grants Fast Track designation for FK228 in cutaneous T cell lymphoma
Tamoxifen - MPT-independent pathway suggested for tamoxifen-induced apoptosis
Teratogenesis - Antisense evidence shows nuclear factor-kappa B contributes to embryopathy
Tissue Engineering - Scaffold topography alters cardiomyocyte network intracellular calcium dynamics
Tobacco Use - Smoking but not areca quid chewing increase micronuclei formation
Toxoplasmosis - Toxoplasmosis reported during pregnancy in immunocompetent woman
Transplant Medicine - Iron levels in donor livers associate with fibrosis in female graft recipients
Transplant Medicine - Placental blood cell transplant feasible in children with sickle cell disease
Transplantation Medicine - Newer drugs target recurrent hepatitis B after liver transplantation
Tuberculosis - M. tuberculosis antigen structures confirm binding orientation
Tuberculosis - U.S. government agency awards global TB drug development group $8 million grant
Tuberculosis Prevention - Cooperative agreement aims to create a new tuberculosis vaccine
Tuberculosis Vaccine - "M. tuberculosis-induced IFN-gamma expression lower in TB patients
Tuberculosis Vaccine - BCG heat-shock proteins protect against tuberculosis challenge
Tularemia - Genetic relations among Francisella tularensis isolates analyzed
Tumor Suppression - Low-voltage electroporation augments antiangiogenic cancer gene therapy
Tumor Therapy - Results from phase I trial of AP5346 presented at meeting in Switzerland
Tumorigenesis - IKK beta links inflammation and tumorigenesis in colitis-associated cancer
Type 1 Diabetes - CTLA4 may be a susceptibility gene for type 1 diabetes
Type 1 Diabetes - Rare HLA-DQA 1*03-DQB1*02 haplotype confers susceptibility to type 1 diabetes
Type 2 Diabetes - Forecast: Diabetes may no longer be a bitter pill to swallow
Urology - Tenascin-C expression patterns delineate malignant bladder tumor invasion
Usutu Virus - Pathology/viral distribution characterized in fatal usutu virus infection
Vaccine Adjuvant - Aluminum hydroxide adjuvant induces macrophage differentiation
Vaccine Adjuvant - CPG 7909 allows lower dose of Fluarix influenza vaccine
Vaccine Adjuvant - Cholera toxin subunit enhances efficacy of DPT vaccine
Vaccine Adjuvant - Very small size proteoliposomes are effective vaccine adjuvants
Vaccine Development - Vibrio cholerae proteinases characterized
Vaccine Development - Active immunization against cytokines demonstrated
Vaccine Development - Cyclooxygenase-2 is target for disorders of skin and oral cavity
Vaccine Development - HSP70 domains stimulate cytokines and chemokines
Vaccine Development - Memory T cells boost the DNA vaccine adjuvant interleukin-2/immunoglobulin
Vaccine Development - Novel vaccine containing hepatitis C E1 protein shows promise in volunteers
Vaccine Safety - Pneumococcal and influenza vaccines can be administered simultaneously
Vaccine Safety - Use of vaccines in pregnancy reviewed
Vaccine Vector - Adenoviral vector carrying type 35 fiber is promising vaccine vehicle
Vector Detection - Microarray screening can supply a vast selection of transgene candidates
Vector Development - Herpesvirus-based vector guides fusion protein to cancer cells
Vector Development - Influenza A virus hemagglutinin constructs tend to lose fusion activity
Venous Thromboembolism - Fondaparinux highly effective as VT prophylaxis in orthopedic surgery
Ventricular Fibrillation - Radiofrequency ablation in children with Wolff-Parkinson-White syndrome studied
Virology - Estimates of hepatitis E virus mutagenesis produce alluring data
Virology - Host immunology and genomics govern hepatitis C virus progression
Virology - Poxvirus protein N1L inhibits NF-kappa B and IRF3 signaling
Virology Vaccine - Interfering vaccine converts virulent infection into immunizing one
Virology Vaccine - PRRSV vaccine did not affect virus shedding in PRRSV-infected pigs
Vitamin Therapy - Vitamin treatment may reduce cardiovascular morbidity and mortality
Vulvovaginal Candidiasis - Lactobacillus treatment ineffective for preventing post-antibiotic infection
West Nile Fever - Clinicopathologic study of West Nile Virus encephalomyelitis reported
Wilms Tumor - Evidence that therapy with doxorubicin improves survival remains elusive
Wound Care - Negative pressure wound therapy promotes diabetic foot ulcer healing
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