Published in Drug Week, November 5th, 2004
"The metastatic cascade is a complicated process that involves many steps from gain of the metastatic phenotype in the primary tumor cells through establishment of macroscopic tumor at the distant target organ. A group of genes, termed metastasis suppressor genes (MSG), encode for proteins that inhibit various steps of the metastatic cascade. Accordingly, loss of MSG promotes the metastatic phenotype," scientists in the United States report.
"Although several MSG have been identified, the mechanisms through which they enhance metastasis are not clearly defined. Gene array...
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