Protein Signal
Novel repressor of NF-kappa B-inducing kinase suppresses NF-kappa B activation
Published in Drug Week, November 5th, 2004
"NF-kappaB- inducing kinase (NIK) has been implicated as an essential component of NF-kappaB activation. However, the regulatory mechanism of NIK signaling remains elusive. We have identified a novel NIK interacting protein, TNAP (for TRAFs and NIK-associated protein)," scientists in the United States report.
"In mammalian cells," wrote W.H. Hu and coauthors, "TNAP physically interacts with NIK, TRAF2, and TRAF3 but not IKK1 or IKK2. TNAP specifically inhibits NF-kappaB activation induced by tumor necrosis factor (TNF)-alpha, TNF receptor 1, TRADD, RIP, TRAF2, and NIK...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Drug Week
Source: Drug Week (2004-11-05)
More Articles from Drug Week
- Adverse Drug Events
Study documents adverse events of pneumococcal vaccine in children - Benign Prostatic Hyperplasia
Statistically significant positive phase II data reported on Cetrorelix - Crohn Disease
Positive phase II data reported for Alequel - HIV/AIDS Treatment
Study: Fuzeon plus active boosted PI doubles long-term response - Osteoporosis
SERM+ teriparatide offers improved bone therapy for postmenopausal patients - AIDS/HIV Diagnosis
HIV-1 superinfections assessed by autologous heteroduplex mobility - More from this issue of Drug Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
