Published in Drug Week, November 26th, 2004
"Phenotypes produced by expression of human amyloid precursor protein (APP) transgenes vary depending on the genetic background of the mouse. FVB/N mice overexpressing human APP695 develop a central nervous system disorder and die prematurely, precluding development of A-beta peptide amyloid plaques. 129S6 mice are resistant to the lethal effects of APP overexpression, allowing sufficient levels of A-beta expression for the development of amyloid plaques and age-dependent memory deficits," investigators in the United States...
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