Liposomal Delivery
Novel RGD lipopeptides target liposomes to integrin-expressing melanoma cells
Published in Drug Week, December 3rd, 2004
"RGD peptides targeting alpha(v)-integrins are promising ligands for the generation of vascular targeting agents. We isolated from phage display RGD motif libraries novel high-affinity cyclic RGD peptides by selection on either endothelial or melanoma cells.
"Although the starting sequences contained only two cysteine residues flanking the RGD motif, several of the isolated peptides possessed four cysteine residues," researchers in Germany report.
"A high-affinity peptide (RGD10) constrained by only one disulfide bond was used to generate novel...
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Source: Drug Week (2004-12-03)
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