Drug Week

HIV/AIDS Research - SI viruses may hasten disease progression by perturbing T cell homeostasis

HIV/AIDS Research - Temporal HIV-1 structures detected in samples separated by 22 months or more

HIV/AIDS Therapy - Spending bill includes $8 million increase for microbicide development

HIV/AIDS Treatment - European CHMP gives positive opinion on Truvada as part of combo HIV therapy

HIV/AIDS Treatment - HPLC method monitors atazanavir therapy in HIV-infected patients

HIV/AIDS Treatment - Mobius subfamily member kalata B1 exhibits anti-HIV activity

HIV/AIDS Treatment - Study finds high use of antacids, other heartburn medications among HIV patients

HIV/AIDS Treatment - Study: LEXIVA + RTV may replace AGENERASE + RTV

HIV/AIDS Treatment - U.S. HHS secretary Thompson applauds efforts to fight HIV/AIDS in Tanzania

HIV/AIDS Treatment - Updated federal guidelines recommend additional first-line therapy for HIV

HIV/AIDS Treatment - Zidovudine forms DNA adducts in treated HIV-infected patients

HIV/AIDS Viral Load - Abbott LCx concordant with Roche Amplicor and Bayer bDNA HIV viral load assays

HIV/AIDS-Associated Infection - Higher CD4 counts/HAART predicts pulmonary M. kansasii/HIV infection survival

HIV/AIDS-Associated Nephropathy - HAART helps prevent progression of pediatric HIV-associated nephropathy

HIV/AIDS-Mental Health - HIV/AIDS patients beliefs vary on causal attributions of fatigue

HLA Typing - High-resolution class I HLA typing may optimize donor selection/improve outcome

Haemophilus Vaccine -  Haemophilus influenzae type b vaccination provides indirect protection

Haemophilus Vaccine - Stochastic model of vaccine trials for endemic infections developed

Haemophilus Vaccine - Transmission of Haemophilus influenzae type b modeled

Hair Studies - Beta-catenin/lef-1 signaling required for DP-induced hair differentiation

Head and Neck Cancer - Gene assays back up sentinel node navigation surgery in oral cancer patients

Healthcare & Politics - Bill to suspend sale of RU-486 drug to be reintroduced by Republican lawmakers

Heart Disease - Genetics company announces publication of gene-therapy approach to heart disease

Heart Disease - Heart group works to improve quality of patient care

Heart Disease Risk Factor - Link between body composition and left ventricular geometry examined

Heart Disease Therapy - Cypher stent trial yields positive results for diabetics with heart disease

Heart Failure - Acute heart failure study stopped for futility

Heart Failure - First African-American heart failure trial shows 43% increase in survival

Heart Transplantation - Scale helps to predict which patients are candidates for VAD or heart transplant

Helicobacter Therapy - Evolving therapy for Helicobacter pylori infection reviewed

Hematology - Extended beta-globin locus control region elements prolong transgene expression

Hematology - Pharmacogenetics enhances the management of patients on warfarin therapy

Hematology - Several variants mark the genomics of congenital dyserythropoietic anemia

Hematology - Techniques to evaluate erythrocyte deformability in diabetes outlined

Hematopoiesis - Activated H-Ras regulates hematopoietic cell survived by modulating Survivin

Hemophilia - OBI-1, recombinant procine Factor VIII, to enter phase II clinical studies

Hepatitis - The HBV large envelope protein can be controlled in a new human cell line

Hepatitis B Virus - Eisai in-licenses antihepatitis B agent clevudine

Herpesvirus - Herpes simplex virus infections reviewed

Herpesvirus Outbreak - Owner likely spreads deadly herpesvirus to colony of captive common marmosets

Histoplasmosis - Functional T cells in primary immune response to histoplasmosis

Hormone Therapy - Researchers continue to weigh in on estrogen monotherapy arm of WHI study

Human Papillomavirus Vaccine - HPV-like particles encapsidating IL-2 adjuvant enhanced immunogenicity

Hyperlipidemia Therapy - Ezetimibe/simvastatin effective for treatment of hyperlipidemia

Hypertension - Obesity affects sodium and water excretion in hypertensive patients

Hyperthyroidism - Iodine contaminants responsible for neonatal chemical hyperthyroidism in Nigeria

Immune Response - DC-T cell interactions in BM play important role in immune responses to antigens

Immunology - Chimera of lutropin receptor and chorionic gonadotropin subunit developed

Immunology - Dendritic cells retain stimulatory ability after becoming hepatitis B-infected

Immunology - Hepatitis delta virus reveals new HLA-A*0201-restricted CD8+ T-cell epitopes

Immunology - Local blockade of negative stimulatory molecules augments antitumor cytokines

Immunology - Mucosal and systemic immunity to intestinal infection in aged mice studied

Immunology - Scientists identify mechanism governing immune system suppression

Immunosuppression - Calcineurin inhibitors slow fibrosis progression after HCV-related liver grafts

Immunotherapy - Company receives FDA approval to begin sublingual-oral immunotherapy trial

Infection - Drug company announces results from clinical trial of onychomycosis treatment

Infection - Manufacturing agreement for staph infection treatment announced

Infection - Peptidoglycan not associated with sensing of bacteria by toll-like receptor 2

Infection - Protective role nuclear factor-kappa B in pneumococcal meningitis

Infectious Bursal Disease Virus - Particles formed by infectious bursal disease virus protein characterized

Infectious Disease - Immunology experts move forward on worldwide research database

Infertility - Five advanced tests provide answers to couples with unexplained infertility

Inflammatory Bowel Disease - Nutrition plays an important role in the treatment of inflammatory bowel disease

Inflammatory Disorders - Pharma company, technology group announce deal on inflammatory disorder research

Influenza Vaccine - Federal officials investigate flu vaccine smuggling

Influenza Vaccine - Flu vaccine nearly as abundant as in 2003 in New Mexico

Influenza Vaccine - Hawaii gets more flu vaccine for at-risk patients

Influenza Vaccine - Health director now plans to order more doses of flu vaccine

Influenza Vaccine - Method to measure T cell immunity to influenza vaccination developed

Influenza Vaccine - Nevadans to be offered 93,000 flu vaccine doses

Influenza Vaccine - Structured model of influenza virus replication in MDCK cells created

Influenza Vaccine - TCR V beta repertoire directed against influenza CTL epitope reported

Influenza Vaccine - Tennessee's flu shot plan inoculates elderly in facilities first

Influenza Vaccine - U.S., Russian pharmaceuticals sign contract to produce flu vaccines in Russia

Influenza Vaccine - Vermont to hold more flu clinics

Influenza Virus - H2N2 and early H3N2 influenza viruses exhibit genetic divergence

Information Technology - BioRyx 200 optical trapping system launched

Information Technology - Company launches diagnostics data sharing technology

Information Technology - Compliance with U.S. FDA, Florida, California drug reporting timelines enabled

Information Technology - Genomics company releases pathway visualization and analysis software

Information Technology - Information systems provider launches research tool for drug, biotech industries

Information Technology - Pharmaceutical IT company signs contract with health maintenance organization

Information Technology - Web conferencing developer introduces MedConferenceLive

Information Technology - Webware for analysis and reporting chromosomal data from array CGH launched

Insulin Therapy - Study results presented for transmucosal insulin administration

Intraductal Carcinoma - Microvessel phenotypes are altered in pre-invasive breast lesions

Irritable Bowel Syndrome - Clinical trial for irritable bowel drug initiated at New York medical facilities

Ischemic Stroke - Aggrenox may have benefits over aspirin in preventing recurrent stroke

Ischemic Stroke - Report presents guidelines for therapeutic management of ischemic stroke

Kidney Disease - Beneficial effects of Seliciclib reported in models of kidney disease

Kidney Transplant - IL-2 receptor antagonists, steroid minimization reviewed for transplant patients

Lab Technology - Evolute ABN introduced for bioanalytical sample preparation

Legal Issues - Company sues former CEO and president

Legal Issues - Coroner reviewing deaths after recall of arthritis drug

Leishmaniasis - Cutaneous leishmaniasis treated with lipid formulations of amphotericin B

Leptin Studies - Leptin leads hypothalamic feeding circuits in a new direction

Leptin Studies - Leptin resistance is region-specific in hypothalamus of obese mice

Leukemia - Mast cell neoplasms may respond to target-specific approaches

Leukemia - Study: StemEx for the treatment of leukemia safe and efficacious

Lipid Studies - Conjugated linoleic acid isomer reduces hepatic triacylglycerol content

Lipid Studies - Determinants of dyslipidemia in type 2 diabetes patients reported

Lipid Studies - Hydrocarbon chain ether diols and ether diacids improve lipid disorders

Lipid Studies - Niacin noncompetitively inhibits DGAT2 but not DGAT1

Lipoproteins - JTT-705 was shown as safe, effective in decreasing CETP activity

Liver Disease - Histological criteria guide the diagnosis of non-alcoholic steatohepatitis

Liver Transplantation - Short-term weight loss would expand the pool of living liver transplant donors

Liver X Receptors - Synthetic oxysterol does not alter circulating plasma triglycerides

Lung Cancer - Long-term smokers avoid lung cancer risk if they quit smoking

Lyme Disease Vaccine - OspA protein of Borrelia burgdorferi vaccination results in neuropathy

Lymphoma - Arthritis treatment may reactivate virus responsible for some lymphomas

Lymphoma - NK cells induce resistance to cytotoxic chemotherapy in B lymphoma cells

Malaria -  Plasmodium falciparum polymorphisms analyzed from Brazilian Amazon region

Malaria - Double dose of sulphadoxine-pyrimethamine effectively reduces pregnancy malaria

Malaria - Homology modeling, mutagenesis analyses of Plasmodium falciparum reported

Malaria - Individual malaria disease susceptibility/outbreak severity varies in Sudan

Malaria Vaccine - Membrane antigen and merozoite protein protect against P. chabaudi malaria

Mantle Cell Lymphoma - Rituximab plus thalidomide effective for relapsed/refractory MCL

Market Analysis - Big changes ahead for technology-based pharmaceutical detailing

Measles Transmission - Airplane measles exposure offers lessons on disease contact response

Measles Vaccine - Impact of declining vaccination on subclinical measles infections reported

Medical Devices - The current status of material used for depot delivery of drugs

Medical Errors - Study examines nature and prevalence of errors in patient care

Menstruation - Study reveals women like idea of skipping periods but want more information

Mental Health - Oppenheim, pharmaceutial companies announce top 10 toys for children with ADHD

Mergers & Acquisitions - Companies merge to provide image analysis, informatics solutions

Mergers & Acquisitions - Fun City Popcorn enters into merger agreement with pharmaceutical company

Mergers & Acquisitions - Henry Schein acquires Barton-Cyker Dental Supply

Metabolism - Regulation, temperature dependence of oxygen binding in globin proteins reported

Metastasis - Reovirus foils the growth of metastatic breast cancer brain lesions

Minamata Disease - Effects of methylmercury in neonatal brains determined

Molecular Biology - Dual fluorophores assess intramolecular dynamics in large biomolecules

Monoclonal Antibodies - EMBL inks agreement for high-throughput monoclonal antibody production

Mucosal Immunization - Delivery to gut addressin by parenteral targeting elicits local IgA responses

Multiple Sclerosis - U.S. FDA approves new drug to treat multiple sclerosis

Mutagenesis - A GHRHR gene mutation causes growth hormone deficiency in Western India

Mutagenesis - Glycophorin A is potential biomarker for mutagenic effects of pesticides

Mutagenesis - Presenilin 1 gene mutations associate with early onset subcortical dementia

Myoblast Transplantation - Follow-up data on myoblast cell therapy for congestive heart failure presented

Myocardial Infarction - Acetaminophen shows positive in vivo cardioprotective effects

Myocardial Infarction - Reducing enlarged heart muscle cuts risk, independent of lowered blood pressure

Natural Products - beta-HIVS suppresses TNF receptor-associated protein 1 gene expression

Neural Stem Cell Research - GluR2 predominantly expressed among AMPA receptor subunits in neural SCs

Neural Stem Cell Research - Pleiotrophin signaling systems involved in modulation of fate of neural SCs

Neurodegeneration - DRD3 gene variations are not linked to the psychosis of Alzheimer disease

Neuroimmunology - Minocycline prevents neuronal apoptosis by blocking glial NO release

Neurological Disease - Commercial solutions provider announces nurse educators agreement

Neurology - Combined gene therapy and cancer immunotherapy attack glioma in murine models

Neurology - VEGF supports nervous system activity as well as angiogenesis

Neuroscience - Hallucinogens enhance glutamate release in rat prefrontal cortex

Neuroscience - P311 hastens facial nerve regeneration following injury

Neuroscience - Rare human sequence variants do not impact vesicular monoamine transporter 2

Neuroscience - Scrapie-infected brain tissue shows changes in gene expression patterns

Norovirus - Detergent followed by bleach/detergent reduces Norovirus contamination

Nutrition - Group questions conclusions in recent vitamin E meta-analysis

Obesity - Cardiovascular treatment drug used for smoking cessation also keeps weight off

Obesity - Pediatric hospital announces first bariatric surgical procedure

Obesity - Study shows that lack of sleep may lead to obesity

Obesity Genomics and Genetics - HapMap helps identify sequence variants increasing obesity risk

Obesity Pathogenesis - 11-Beta-hydroxysteroid dehydrogenase regulates glucocorticoid response

Obesity Pathogenesis - Central administration of ghrelin preferentially enhances fat ingestion

Obesity Pathogenesis - Endocrinological effects of agouti-related protein examined

Obesity Pathogenesis - Fenofibrate differentially affects body weight via PPAR-alpha

Obesity Pathogenesis - Hepatic gene expression profiles in obesity mouse model reported

Obesity Risk Factor - Non-food-related environmental stimuli increase meal intake in women

Obesity Surgery - Physical activity promotes weight loss in gastric bypass patients

Obesity Survival and Mortality - Higher obesity prevalence in U.S. may contribute to mortality

Obesity Therapy - LE³AN program provides effective weight loss for females

Obesity Therapy - Recent advances in cannabinoids reviewed

Obesity and Diabetes - Low carbohydrate diet benefits obese type 2 diabetic patients

Obstetrics - Guidelines address use of antithrombotics by pregnant women

Oncology - Biotech company announces commercial supply agreement for cancer treatment

Oncology - Biotech company announces initiation of Phase II trial for cancer treatment

Oncology - EXACT Sciences broadens relationship to include PIK3CA colorectal cancer marker

Oncology - Estrogen receptor beta makes breast cancer cells susceptible to retinoic acid

Oncology - Interleukin-6 may favor tumor-host interactions in uveal melanoma

Oncology - Matrix enzyme inhibitor predicts poor outcomes for esophageal cancer patients

Oncology - New census shows growth in PET/CT installations

Oncology - Perillyl alcohol inhibits angiogenesis

Oncology - Platelet activation shifts the angiogenic balance in cancer patients

Ophthalmology - Insulin-like growth factor-1 plays a role in age-related macular degeneration

Ophthalmology - Somatostatin arrests excess vessel growth in the eyes

Orthopedic Infection - Alternative materials for depot antibiotic delivery reviewed

Orthopedic Surgery - Surfactant irrigation effective in rat model of S. aureus infection

Orthopedics - Genes can transduce tendon-bone insertion sites after transplantation

Orthopedics - Implants containing fibroblast growth factor stimulate vessel and bone growth

Osteoporosis - Antagonizing PPARgamma activity in fat effectively combats osteoporosis

Osteoporosis - Imaging devices producer, software developer sign distribution agreement

Osteoporosis - Soybean isoflavone metabolite inhibits bone loss in ovariectomized mice

Otolaryngology - Fibrin matrix and angiogenic growth factor revitalize tracheal transplants

Ovarian Cancer - CPT-11 plus mitomycin C may work against platinum-refractory disease

Overactive Bladder - U.S. FDA approves new medication

Pain Management - Patient-controlled pain control system compares to IV PCA morphine, study shows

Pain Medicine - ENT-103 reported effective in preclinical model for pain

Pain Medicine - Humibide and Humibidcs to be offered over-the-counter to consumers

Pain Medicine - Pain relief could be easy with a simple injection

Pain Medicine - Study identifies factors associated with long-term opioid treatment of veterans

Pain Therapy - FDA issues approvable letter for Ralivia ER

Paraneoplastic Neurologic Disorders - Pyridoxal phosphatase is a novel cancer autoantigen in the central nervous system

Parkinson Disease - Rifampicin shows promise for fighting PD in laboratory tests

Patents - Cellular health supplement company files lawsuit for patent infringement

Patents - Company announces issuance of new patent for kidney-disease therapy

Patents - U.S. Patent Office grants new patent for cholesterol-lowering niacin formulation

Patents - U.S. Patent issued for peptide used to diagnose, treat neuroectodermal tumors

Patient Safety - Nearly half of all consumers worry about the safety of their healthcare

Pediatric HIV/AIDS - African children with HIV would benefit from daily doses of cheap antibiotic

Personnel - Australian biotech firm appoints two new directors

Personnel - Biomedical company announces new chairman

Personnel - Biotech greenhouse in Pennsylvania names first entrepreneur-in-residence

Personnel - Bruce F. Mackler, PhD, JD, named to biopharm's HIV Scientific Advisory Board

Personnel - Cancer-focused biotech company names Rick Hamm general counsel

Personnel - Contract research organization appoints medical director of oncology, Europe

Personnel - Dean J. Mitchell appointed president and CEO of AGGRASTAT maker

Personnel - Diagnostics company announces new chief information officer

Personnel - Drug company announces new board member

Personnel - Health care company announces senior staff appointments

Personnel - J.S. Thompson named nonexecutive chairman of drug-development-services company

Personnel - Microsphere technology company appoints Richard J. Faleschini as CEO

Personnel - Molecular pathology firm promotes CFO to senior VP/general manager

Personnel - Oncology company announces change in senior management

Personnel - Oncology company appoints European marketing manager

Personnel - Pharmaceutical company announces chairman's retirement

Personnel - Pharmaceutical company appoints John H. Dillon II to board of directors

Personnel - Pharmaceutical company appoints director of commercial development

Personnel - Pharmaceutical company will eliminate total of 2,000 jobs

Personnel - Sam Gibbons joins pharmaceutical as new vice president of sales

Personnel - Sandra Calman, MD, named clinical research director for Solano unit

Personnel - Stephen Kasnet named Columbia Labs board chair, Edward Blechschmidt vice chair

Personnel - Strategic business assistance firm names president and chief executive officer

Personnel - Victor P. Micati joins biopharmaceutical's board of directors

Pharmaceutical Marketing - Pfizer halts Celebrex sales in Turkey in dispute over warning

Pharmaceuticals - Ohio company touts pills for middle-aged middle class

Pharmacology - Feeding schedule influences rhythm of acetaminophen-induced hepatotoxicity

Pharmacology - Omeprazole has similar effects in patients with different CYP2C19 genotypes

Pharmacology - Pharmacokinetics of novel dipeptide ester prodrugs of acyclovir reported

Pneumocystis Carinii - SP-A is local effector molecule in lung host defense against P. carinii

Pneumocystis Carinii Pneumonia - Suspected pediatric PCP in resource-poor settings should be treated as emergency

Polio Epidemiology - Areas at increased risk for poliovirus circulation in Ecuador assessed

Poxvirus - Poxvirus protein forms a complex with left-handed Z-DNA

Poxvirus - Vaccinia virus kinase induces p53 downregulation by Mdm2-dependent mechanism

Preeclampsia - Cytotrophoblasts generate signals that disturb placental vascular remodeling

Premenstrual Dysphoric Disorder - Approvable letter granted for oral contraceptive containing drospirenone

Prescription Drug Cost - Discount plan for prescription drugs delayed until January

Prescription Drugs - Doctors say statin drug should have been pulled sooner

Prion Disease - Humoral immune response to prion protein correlates with protection

Prions - Oligomerization of proteolytic products in prions shown

Prostate Cancer - Coding sequence determined for orthologs of prostate cancer susceptibility gene

Prostate Cancer - First-ever Cs-131 brachytherapy seeds to treat prostate cancer implanted

Prostate Cancer - Ovine atadenovirus guides gene-directed enzyme prodrug therapy to cancer cells

Prostate Cancer - Primary tumor-derived human prostate cancer cells retain neoplastic phenotypes

Prostatic Hyperplasia - An alpha₁ -AR antagonistis a first choice treatment in patients with LUTS/BPH

Protein Mimicry - Synthetic heparin disaccharides show little competition with heparin albumin

Proteomics - Pseudolarix acid B opposes the anti-apoptotic effects of VEGF

Psoriasis - Clinical development of BCX-4208 for psoriasis initiated

Pulmonary Hypertension - Exacerbation of underlying pulmonary disease in pregnancy investigated

Pulmonary Hypertension - Exercise desaturation and pulmonary hemodynamics link unclear

Pulmonary Medicine - Lentivirus-mediated gene transfer has the potential to treat cystic fibrosis

Pure Red Cell Aplasia - Successful resumption of epoetin alfa after rituximab treatment reported

Pyomyositis - Bacterial pyomyositis increasing in HIV and non-HIV infected patients in the US

Quality Assurance - Company's sera, media division registers as class I medical device manufacturer

RNA Research - Electroporation improves the success of embryonic stem cell transfection

Rabies - Company discovers, validates human monoclonal antibody protection against rabies

Rabies Therapy - Patient who received experimental treatment for rabies is unusual success story

Recurrent Spontaneous Abortion - Th1 cytokine levels higher in women with RSA

Regulatory Issues - FDA called "defenseless" against bad drugs

Regulatory Issues - FDA tried to discredit whistleblower over drug safety claims

Renal Cancer - CD8+ cytotoxic T lymphocytes recognize renal carcinoma antigens

Renal Cell Carcinoma - HIF1A gene polymorphisms associated with renal cell carcinoma phenotype

Renal Disease - Fatty acid-binding protein in urine denotes proximal tubule stress overload

Reproductive Medicine - Androgen receptor gene CAG repeat length may not be related to male infertility

Reproductive Medicine - Basic fibroblast growth factor may be involved in ovarian follicle development

Reproductive Medicine - Factors affecting release rate of levonorgestrel implants identified

Reproductive Medicine - Novel mouse model used to clarify effects of long-term progestin use

Respiratory Disease - Asbestos precipitates tissue factor production in lung epithelial cells

Respiratory Syncytial Virus - Bovine respiratory syncytial virus detected/quantitated by real-time RT-PCR

Respiratory Syncytial Virus - Palivizumab used to control RSV outbreak in neonatal intensive care unit

Restenosis - AGGRASTAT trial data presented at American Heart Association meeting

Rhabdomyolysis - Risk of muscle-damaging disorder low for most commonly prescribed statin drugs

Rheumatoid Arthritis - Rheumatoid arthritis inhibited by agonistic anti-4-1BB monoclonal antibody

Rheumatoid Arthritis Therapy - Compliance is viral for the success of TNF antagonist therapy

Rheumatology - Nitric oxide may be a drug target for patients with rheumatoid arthritis

Rubella Vaccine - Immunization law revisions affect incidence of congenital rubella in Japan

SARS - Methods to inactivate SARS virus described

SARS Diagnosis - Laboratory diagnosis of SARS in Guangdong Province, China, described

Salmonella Pathogenesis -  Salmonella-induced actin assembly role during infection of host cells elucidated

Schizophrenia - Differential expression of PK, immediate early genes studied in schizophrenia

Schizophrenia Therapy - Clozapine raises acetylcholine and dopamine levels in rat ventral hippocampus

Selenium - Bioavailable selenium not preferentially toxic to transformed hepatocytes

Sexual & Reproductive Health - Company announces preliminary results from FLD500 study

Sexual Health - Article: Controversial testosterone patch for women puts FDA on the hot seat

Sexual Health - Testosterone improves women's sex lives

Sinus Conditions - Sinus health discussed on Ed McMahon's syndicated radio program

Skin Care - GNC to carry new wrinkle-reducing serum and skin care line

Sleep Disorders - Sleep and its disorders in children reviewed

Smallpox - Computer modeling helps identify new smallpox drug candidate

Smallpox Diagnosis - Rapid detection method for vaccinia virus developed

Solar Lentigines - Mequinol 2%/tretinoin 0.01% solution safe and effective

Spinal Cord Injury - Proneuron, Shriners Hospital enrolling phase 2 stem cell, spinal cord study

Spondylitis - T cell epitopes in HLA-B27 mice linked to spondyloarthropathy identified

Staphylococcus Aureus - Data presented on ceftobiprole and BAL8557 at conference

Stem Cell Research - Bryostatin-1 enhances maturation/antigen-presenting ability of dendritic cells

Stem Cell Research - DNA demethylation necessary for epigenetic reprogramming of somatic cell nuclei

Stem Cell Research - Gfi-1 restricts proliferation and preserves functional integrity of HSCs

Stem Cell Research - Hematopoietic stem cells are highly receptive to adenovirus type 11p

Stem Cell Research - ID/OLIG protein interactions mediate BMP4 inhibition on OL differentiation

Stem Cell Research - Informed consent recommendations offered for tissue/cell research donors

Stem Cell Research - Research: Cells derived from hESCs can be immortalized by telomerase

Stem Cell Transplantation - Alpha-erythropoietin + filgrastim improves outcome/cost balance of ASCT

Stem Cell Transplantation - Majority of SCT patients accept poor QOL for small chance of cure

Stem Cell Transplantation - Megakaryocyte engraftment follows reduced-intensity conditioning

Stem Cell Transplantation - Stem cells from donors with abnormal findings can be used for HCT

Stent Restenosis - Vascular brachytherapy should be available for patients with stent restenosis

Substance Abuse - Proposed addiction treatment successful, safe in second small trial

Thrombocytosis - HIV/AIDS-associated thrombocytosis is associated with severe disease

Thrombosis - Novel peptide antagonists to thrombin and factor VIIa characterized

Tissue Engineering - Acellular liver matrix improves survival and function of cultured hepatocytes

Tissue Engineering - Bioreactor validated for engineering vocal fold tissues

Tissue Engineering - Heparin conjugated polylactide may be applied as blood compatible material

Tissue Engineering - Tissue engineered stomach regenerates into complex tissue resembling stomach

Toxicology - Time to develop new antidotes for chemical attacks

Toxoplasmosis Vaccine - Vaccination protects B cell-deficient mice against Toxoplasma gondii

Transfection - Lipids containing acylhydrazone linkers conduct acid-sensitive gene delivery

Traumatic Brain Injury - Therapeutic options studied for pharmacological intervention after brain injury

Tuberculosis - Mathematical model predicts emergence of multidrug-resistant TB 'hot zones'

Tuberculosis - Small populations of fit MDRTB strains can out-compete low fitness strains

Tumor Pathology - Stromal VEGF is a diagnostic biomarker in mammary phyllodes tumors

Vaccine Adjuvant - Gut dendritic cells mobilize and mature after oral cholera toxin vaccine

Vaccine Delivery - Topical permeation enhancers deliver microparticles to Langerhans' cells

Vaccine Development - Bacterial heat shock proteins enhance class II MHC antigen processing

Vaccine Development - IFN-gamma enables cross-presentation of protein antigen in Langerhans cells

Vaccine Safety - Safety concerns regarding combination vaccines described

Vaccinia Virus Vaccine - Neutralizing antibody activities to vaccinia virus proteins are synergistic

Vancomycin Resistance - Two vancomycin-resistant E. faecium outbreaks in NICU caused by different clones

Varicella - Wyoming health officials concerned with chickenpox cases

Varicella-Zoster Virus - Varicella-zoster virus genome cloned as artificial chromosome in E. coli

Viral Epidemiology - Age, season, and occupation are hepatitis A virus risk factors in Amman, Jordan

Viral Proteomics - RB/E2F activation modulates hepatitis C core protein-induced cell growth

Virology - Prototypic foamy virus vectors exhibit transduction advantages

Virology - Self-inactivating vectors outpace those that feature long terminal repeats

Virology Vaccine - Rapid response of marginal zone B cells to viral particles reported

Vision Loss - Oligonucleotide control of VEGF expression stops choroidal neovascularization

Weight Loss - Peptide YY[3-36] effects on food intake are not affected by ghrelin

West Nile Virus - Economic impact of West Nile virus in Louisiana estimated

Wound Healing - Pharmaceutical company markets wound gel in China

X-ray Imaging - Theory of X-ray imaging based on Wigner distributions developed

Yellow Fever Vaccine - Risk of fatal adverse events linked to 17DD yellow fever vaccine determined

Yersinia Pestis - Study shows evolution of virulent Yersinia pestis epidemic clone