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Ulcerative Colitis

Alicaforsen significantly improves symptoms of ulcerative colitis

Published in Drug Week, December 31st, 2004

Isis Pharmaceuticals, Inc., (ISIS) announced the results of three phase II studies of alicaforsen enema to treat patients with ulcerative colitis (UC).

In these phase II clinical trials, alicaforsen enema produced significant and long-lasting disease improvement, as measured by changes in Disease Activity Index (DAI) scores and other indicators of disease.

In particular, a substantial number of patients treated with alicaforsen enema experienced mucosal healing, as well as decreases in rectal bleeding and in stool frequency; manifestations of the disease that cause considerable discomfort, inconvenience and pain to patients. In all three trials,...

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