Drug Week
Susan Hasty, Publisher
Table of Contents . . . January 28th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Anal Fissures - U.S. FDA issues not approvable letter for Cellegesic
Antimicrobials - Antimicrobial and antioxidant activities of medicinal plants reviewed
Breast Cancer - New findings in breast cancer described
Clinical Trials - Company provides update on cancer and HIV clinical-development programs
Depression - European drug review group meets on paroxetine and other SSRIs
Drug Development - FDA grants approval for Enjuvia for vasomotor symptoms
AIDS/HIV Vaccines - New findings in the area of AIDS/HIV vaccines described
Acute Lymphocytic Leukemia - Unrelated cord blood transplantation is an option for children with ALL
Acute Myelogenous Leukemia - Clinical outcome not affected in pediatric AML patients with PTPN11 mutations
Acute Radiation Syndrome - Biotechnology company responds to U.S. HHS Request for Information
Addiction Medicine - Ghrelin and glucagon-like peptide studied, role of cannabinoids revealed
Adenovirus - Antihexon antibody model neutralizes adenovirus
Adenovirus - Cidofovir effectively treats adenoviral hemorrhagic cystitis in HSCT patients
Adult T-Cell Leukemia - Adult T-cell leukemia cells down-regulate CD26 antigens via epigenetic machinery
Adverse Drug Effect - Statins induce apoptosis in rat and human myotube cultures
Adverse Drug Events - Consumer Group: Drug industry volunteer reporting plan falls short
Adverse Drug Events - Doctors must consider potentially inappropriate meds when treating elderly
Adverse Drug Events - Long-term use of NSAIDs causes severe intestinal damage
Adverse Drug Events - U.S. FDA gives scientist permission to publish Vioxx safety data
Adverse Drug Reaction - Collaborative to study unanticipated serious adverse drug events using enTRUST
Adverse Drug Reaction - Markers implicated in fatal side effects of schizophrenia drug identified
Advocacy - AIDS group to call for ban on consumer drug advertising
Aging - Activation of AMPK by in vivo hypoxia is slower than in vitro
Air Pollution - Several hazardous air pollutants exceed cancer risk level in Portland
Alcohol Use - Bipolar alcoholics helped by seizure drug
Alcohol Use - College attendance influences alcohol drinking patterns in young females
Alcohol Use - Taurine not involved in pharmacological effects of ethanol in rats
Allergy & Immunology - Hay fever treatment shown to reduce symptoms by 37%
Allergy and Immunology - Thymalfasin augments the immune system's response to disease
Alzheimer Disease - Healthy cleavage: How statins protect against AD
Alzheimer Disease - Method for screening beta-amyloid secretion inhibitors developed
Alzheimer Disease - Results of clinical trial of GABA(B) receptor antagonist SGS742 reported
Angiology - Correlates of carotid artery stiffness in young adults reported
Angiology - Mef2c mediates vascular gene expression during endothelial cell development
Angiology - Physiological roles of angiotensin-converting enzyme 2 reviewed
Angiology - Structure of angiotensin I-converting enzyme revealed
Angiology - VEGF isoforms reveal a time-related response to hypoxia in the knee joint
Angiology - Vascular smooth muscle viability is pertinent to tumor biology
Ankylosing Spondylitis - U.S. FDA approves REMICADE for patients with ankylosing spondylitis
Anthrax - Breakthrough could lead to anthrax antidote
Antibiotics - Binding of an aminoacridine derivative to a GAAA RNA tetraloop revealed
Antifungal Activity - Chitinase from E. coli carrying Streptomyces gene is antifungal
Antimicrobials - Treatment of dialysis catheter-related bacteremia reviewed
Antioxidants - Oral antioxidants have mixed effects on UV-induced skin damage
Apoptosis - Apoptosis analyzed, resistance in regenerating hepatocytes demonstrated
Apoptosis - Fibroblast cell lines derived from LEC rats are highly susceptible to heat
Apoptosis - Tumor necrosis factor-alpha induces apoptosis in adrenocortical cells
Argemone Oil - Argemone oil is genotoxic
Arthritis - Laser therapy is an alternative to VIOXX for arthritis sufferers
Arthritis - Renal amyloidosis complicating rheumatoid arthritis treated with etanercept
Assisted Reproduction - Genes expressed during ovarian hyperstimulation may not affect implantation
Assisted Reproduction - Growth differentiation factor gene fragments treat porcine ovarian dysfunction
Asthma - S. mansoni-infected asthma patients produce lower levels of Th2 cytokines
Astrocytoma - Chromosomal aberrations identified in diffuse astrocytomas
Atheroscerlosis Risk Factors - Caloric restriction significantly improves insulin sensitivity
Atherosclerosis - COX-2-derived prostacyclin confers atheroprotection on female mice
Atherosclerosis - Reduced progression of plaques tied to statin drugs
Atherosclerosis - Stent-based gene therapies offer a strategic way to treat arterial disease
Atopic Dermatitis - EWGAD issues clinical guidance on use of topical calcineurin inhibitors
Atrial Fibrillation - Clinical trial enrollment announced for radiofrequency ablation technology
Atrial Fibrillation - Ximelagatran is as effective as warfarin for stroke prevention
Autoimmune Diseases - Positive results reported in phase I/II trial with HuMax-Inflam/MDX-018
Awards - Shanghai chemistry R&D services company recognized for excellence by government
Awards - Winners of 2004 Life Science Industry Awards announced
Bacteriology - Effect of oxalic acid on bacterial regrowth in drinking water studied
Bacteriology - Modeling of therapies targeted at bacterial quorum sensing described
Benzene - Xenobiotic metabolism and mechanism of benzene toxicity reviewed
Biological Therapy - DNA decontamination protocols will enhance the value of cell and gene therapies
Biomarkers - Biomarkers valuable for risk assessment in molecular epidemiology of cancer
Biomedical Engineering - Companies sign process development and manufacturing agreement for blood enzyme
Biomedical Engineering - Matrix-bound ligand boosts local neovascularization
Biomedical Engineering - Stem cell-focused company targets cardio patients for adult stem cell therapy
Biotechnology - Simultaneous tether extraction stabilizes neutrophil rolling under high stress
Bladder Cancer - No association between inorganic arsenic concentration and bladder cancer risk
Body Composition - Body fat values from anthropometric methods and impedance compared
Bone Repair - Hydrolysis treatment improves anionic collagen scaffolds for bone repair
Breast Cancer - Adenosine is a breast carcinoma cell mitogen
Breast Cancer - Angiogenic profiles of breast carcinomas expose leukocyte penetration
Breast Cancer - Anti-aromatase coumarin derivative characterized
Breast Cancer - Breast cancer may be uniquely sensitive to inhibitors of PI3K pathway
Breast Cancer - Drugs induce superinvasive phenotype in breast cancer cells
Breast Cancer - Insulin receptor substrate is involved in mammary tumor metastasis
Breast Cancer - Pharma company updates breast cancer research results from 2004 symposium
Breast Cancer - RT-PCR detects disseminated epithelial cells in BM of breast cancer patients
Breast Cancer - Reports describe recent advances in breast cancer research
Breast Cancer - Researchers call for new approach to clinical trials in postgenomic era
Breast Cancer - Statins may have anticarcinogenic effects in older women
Breast Cancer - Studies describe new findings in breast cancer research
Burkholderia - Patterns of genomic variation in Burkholderia species identified
Business & Finance - Concurrent Pharmaceuticals changes name, secures $34 million in financing
Business & Finance - Genelabs gets $1.25M for amendment to DNA amplification technology license
Business & Finance - Guilford completes sale and leaseback; receives $19.4M in net proceeds
Business & Finance - HIPAA alters pharmaceutical company rep strategy
Business & Finance - Institutional pharmacy provider commented on proxy statement
Business & Finance - Pain management company provides financial guidance for 2005
Business & Finance - Pharma company provides support to relief effort in Asia
Business Update - Autologous platelet rich plasma preparation system launched
Business Update - Biopharmaceutical firm announces relocation
Business Update - Biopharmaceutical firm announces result of meeting
Business Update - Biotech company completes European Mutual Recognition Procedure
Business Update - Biotechnology company announces sale and leaseback transactions
Business Update - Company expands mite rearing, processing facility
Business Update - Generic pharmaceutical company announces filing of ANDA with U.S. FDA
Business Update - GeoPharma shares launch strategy for Mucotrol
Business Update - Government services provider awarded pharmacy services contract
Business Update - Light-based devices manufacturer announced 150th shipment of Lumenis
Business Update - Natural skin care products company begins manufacturing core offerings in Canada
Business Update - Norak Biosciences changes name
Business Update - Pharma firm to divest its plasma products business to U.S. investors
Business Update - Pharmaceutical firm adopts renewed shareholder rights plan
Business Update - Reports indicate Bristol-Myers may sell its consumer drug line
Business Update - Subsidiary granted marketing rights for Neovastat
Business Update - U.S. EPA to use chemogenomics platform to predict potential chemical toxicity
Cadmium Exposure - Increased cadmium exposure may influence occurrence of disease
Cancer Survival - Reduced health care access and ability to pay decrease cancer survival
Cancer Therapy - Additional information provided to U.S. FTC for melanoma treatment
Cancer Therapy - Angiogenesis inhibitors antagonize lymphoma proliferation
Cancer Therapy - Breast cancer patients boost quality of life with vaginal moisturizer
Cancer Therapy - Brochures help cancer patients make informed treatment decisions
Cancer Therapy - Clolar wins FDA approval for common pediatric leukemia
Cancer Therapy - Data on successful treatments for lymphoma with few side effects presented
Cancer Therapy - IND filed with U.S. FDA for AP5346
Cancer Therapy - Protein arginine methyltransferase complexes regulate tumor suppressor genes
Cancer Therapy - Quinolones enhance antitumor activity of ultrasonic irradiation
Cancer Therapy - Research in cancer therapy provides new insights
Cancer Therapy - Researchers detail new studies and findings in the area of cancer therapy
Cancer Therapy - Researchers publish new studies and findings in the area of cancer therapy
Cancer Therapy - Residual tumor cells are a barrier to targeted cancer therapeutics
Cancer Therapy - Trial: IRESSA failed to significantly prolong survival in comparison to placebo
Cancer Therapy - Tumor cells resistant to hemiasterlin analogue characterized
Cancer Vaccines - Biopharmaceutical company announces survival data of trial with cancer vaccine
Cancer Vaccines - Findings advance knowledge in cancer vaccines research
Cancer Vaccines - Reports add new data to cancer vaccines research
Cancer Vaccines - Researchers' findings advance cancer vaccines research
Cancer Vaccines - Studies add new findings to cancer vaccines body of knowledge
Cancer Vaccines - Studies advance knowledge in cancer vaccines research
Candidemia - Antifungal medicine VFEND receives U.S. FDA approval for blood infection
Candidiasis - CaMIT1 inactivation reduces Candida albicans virulence
Cardiology - "Annexin A5 resistance" is a mechanism for thrombosis in aPL syndrome
Cardiology - TrxR2 plays a pivotal role in both hematopoiesis and heart function
Cardiology - Early aortic remodeling in hypertensive rats may have genetic origins
Cardiology - Findings describe new data in cardiology research
Cardiology - Model reproduces experimental results for Ca2+ handling in myocytes
Cardiology - Oxidative stress plays a role in clomipramine-induced cardiotoxicity
Cardiology - Report describes perioperative diagnosis of cardiac risk patients
Cardiology - Researchers detail new studies and findings in the area of cardiology
Cardiology - Researchers provide details of new studies and findings in the area of cardiology
Cardiology - Tirofiban reduced the risk for death, MI, and refractory ischemia
Cardiology - Transplanted bone marrow cells generate angiogenic factors in the heart
Cardioprotection - Cardioprotection of erythropoietin is linked with apoptosis inhibition
Cardiovascular Disease - Complication risk with coronary catheterization low in moderate obesity
Cardiovascular Research - Increased BP suggests increased vascular resistance during feeding
Cardiovascular Research - Midodrine improves the recovery of beat-to-beat BP after exercise
Cardiovascular Research - Pioglitazone attenuates collagen type I synthesis in fibroblasts
Cardiovascular Research - Study supports evidence of gating-induced changes in Phe656 side chains
Cartilage Repair - Biphasic scaffold developed for cartilage tissue engineering
Cell Biology - Binding site for antimitotic peptides identified on beta-tubulin
Cell Biology - Interferon-gamma and interferon-alpha have opposing effects on stellate cells
Cell Biology - Proteomic gate-keepers regulate the outcomes of senescent cells
Cell Biology - VEGF increases the availability of channels used for paracellular transport
Cell Differentiation - Claudin localization is regulated in developing by fetal alveolar epithelia
Cerebrovascular Disease - Genes delivered following cerebral infarction improve neurological outcomes
Cerebrovascular Disease - Homeobox D3 gene delivery initiates cerebral angiogenesis in mice
Chagas Disease - Trypanosoma cruzi gene structure does not sway drug susceptibility
Chlamydia - Candidate NAD+ transporter in bacterial symbiont identified
Cholesterol - Cholesterol drug co-administered with fenofibrate study results reported
Chronic Liver Disease - Angiotensin II receptor antagonist treats nonalcoholic steatohepatitis
Chronic Pain - U.S. FDA approves ziconotide intrathecal infusion for severe chronic pain
Clinical Trails - Phase II trial of HyCAMPTM initiated for colorectal cancer
Clinical Trials - DATATRAK to provide technology solutions for clinical trials
Clinical Trials - Race may influence the response to recombinant HIV-1 gp120 vaccines
Clinical Trials - Results of autoimmune therapy in healthy volunteers study released
Clinical Trials - Synthetic antibodies manufacturer announces phase 1 trial
Collaborations - Agreement signed for transdermal treatment for major depressive disorder
Collaborations - Alliance formed for Canvaxin for melanoma
Collaborations - Companies to commercialize INTERCEPT system for plasma in Asian region
Collaborations - Deal signed for development of osteoporosis and bone loss therapy
Collaborations - Discovery program launched to combine antibody technologies
Collaborations - Drug discovery company announces collaborations
Collaborations - GPC Biotech announces achievement of milestones totaling $1.2M
Collaborations - Joint venture formed to develop fixed-dose combination of three HIV medicines
Collaborations - Library deal signed with Sanofi-Synthelabo Recherche
Collaborations - Neugene antisense deal signed with Walter Reed Army Institute of Research
Collaborations - New anti-angiogenesis program added to collaborative agreement
Collaborations - Pharmaceutical firm acquires exclusive rights to Nordette
Collaborations - Pharmaceutical firm signs supply agreement with Ceph International
Collaborations - Pharmaceutical firms team up to develop diabetes treatments
Collaborations - Research alliance formed to develop compounds for metabolic disease
Collaborations - Supplier agreement signed with Bausch & Lomb for viscoelastic products
Collaborations - Trisenox financing agreement signed
Colon Cancer - Breakthrough cancer treatment Avastin approved in Switzerland
Colon Cancer - CHOP regulates ER stress-induced apoptosis by enhancing DR5 expression
Colon Cancer - Integrated therapies show promise for treating colorectal cancer
Colorectal Cancer - APAF-1 gene dysfunction from allelic imbalance increases with tumor progression
Colorectal Cancer - Colorectal cancer detected by quantitative fluorescence of stool DNA
Complementary & Alternative Medicine - Tinospora cordifolia restores antioxidant function in diabetic organs
Complementary & Alternative Medicine - Green tea flavonoid may lower the invasive potential of prostate cancer
Congestive Heart Failure - Collaboration to develop AAV-based gene therapies for congestive heart failure
Contraception - Getting pregnant while on the pill: another health hazard of being overweight
Crosslinking - Carbodiimide-crosslinked HA/collagen membrane safe and effective antiadhesive
Cryptosporidium - Cyclospora oocysts are not ingested by the nematode Caenorhabditis elegans
Cystic Fibrosis - Biopharma company announces phase 1 study for PTC124
Cytomegalovirus - Initiation of HCMV lytic replication involves transcriptional activation
DNA Research - Novel bleomycin conjugates cleave double-stranded DNA
Dairy Science - Skeletal tissue growth rates increased in prepubertal dairy heifers
Dermatology - Genetic characterization of epidermolysis bullosa should improve diagnoses
Dermatology - Genomic response to asiaticoside in fibroblasts clarified
Dermatology - Keratinocyte growth and differentiation factors guide drug investigation
Dermatology - Non-healing ulcers signal the possibility of factor V Leiden mutation
Dermatology - Non-viral gene therapy may help patients with skin disorders
Dermatology - Phase II trial of AVAC fails to meet the primary efficacy endpoint
Dermatology - Researchers' work adds to dermatology body of knowledge
Dermatology - Semaphorin 3F prohibits melanoma metastasis
Diabetes Complications - Lipid lowering agents may reduce the risk for diabetes-related vision loss
Diabetes Complications - Pancreatic islets from type 2 diabetic patients have functional defects
Diabetes Complications - TNF-alpha release negatively associated with apolipoprotein B
Diabetes Genomics and Genetics - Biethnic comparisons of autosomal genomic scan for loci linked to adiponectin
Diabetes Genomics and Genetics - Insulin-like growth factor-II receptor gene linked to type 1 diabetes
Diabetes Genomics and Genetics - Lymphoid tyrosine phosphatase locus associated with type 1 diabetes
Diabetes Genomics and Genetics - Protein tyrosine phosphatase polymorphisms linked to glucose homeostasis
Diabetes Genomics and Genetics - Variation in NCB50R does not contribute to nonautoimmune diabetes
Diabetes Pathogenesis - Biological importance of peptides of calcitonin family examined
Diabetes Pathogenesis - Findings describe new data in diabetes pathogenesis research
Diabetes Pathogenesis - Hyperglycemia induces vagally mediated increase in C-peptide secretion
Diabetes Pathogenesis - PPAR-gamma overexpression suppresses insulin secretory capacity in islets
Diabetes Pathogenesis - Phosphatidylinositol 3-kinase inhibitors reveal enhanced insulin secretion
Diabetes Pathogenesis - Platelet-derived growth factor stimulates glucose transport in muscles
Diabetes Pathogenesis - Research in diabetes pathogenesis provides new insights
Diabetes Pathogenesis - Researchers publish new studies and findings in the area of diabetes pathogenesis
Diabetes Pathogenesis - Serine phosphorylation promotes insulin resistance
Diabetes Pathogenesis - Studies advance knowledge in diabetes pathogenesis research
Diabetes Research - Agreement signed to secure embryonic stem cell technology for diabetes research
Diabetes Risk Factors - Gamma-glutamyltransferase predicts risk of type 2 diabetes
Diabetes Therapy - Activated protein C preserves islet mass after intraportal transplantation
Diabetes Therapy - Affinity chromatography of insulin with heptapeptide ligand reported
Diabetes Therapy - Amylase inhibitor from kidney beans has hypoglycemic activity
Diabetes Therapy - Dual-wave bolus feature in insulin pumps better at controlling hyperglycemia
Diabetes Therapy - Free radical scavenger protects against glucose-induced cell dysfunction
Diabetes Therapy - Glibenclamide treatment effective in permanent neonatal diabetes
Diabetes Therapy - Glycoinsulins possess prolonged blood-sugar-lowering activity
Diabetes Therapy - New findings in diabetes therapy described
Diabetes Therapy - Phloridzin improves hyperglycemia but not hepatic insulin resistance
Diabetes Therapy - Pioglitazone restores impaired glucose-stimulated insulin secretion
Diabetes Therapy - Proteins released by islets affect islet engraftment in type 1 diabetes
Diabetes Therapy - Reports describe recent advances in diabetes therapy research
Diabetes Therapy - Severe hypo-alpha-lipoproteinemia reported during rosiglitazone therapy
Diabetes Therapy - Simvastatin restores vasoconstriction via effects on oxidizing metabolism
Diabetes Therapy - Synthetic polymer stimulates insulin release from RINm5F insulinoma cells
Diabetes Type 2 Complications - Obesity and metabolic syndrome powerful predictors of diabetes type 2
Diabetic Ketoacidosis - Transcriptome and proteome expression in activated T lymphocytes described
Diabetic Nephropathy - Kidneys from nonobese diabetic mice analyzed in non-diabetic stage
Diabetic Nephropathy - New findings in the area of diabetic nephropathy detailed
Diabetic Neuropathy - Alpha-lipoic acid provides neuroprotection in diabetic rats
Diabetic Neuropathy - Hyperglycemia attenuates nerve conduction velocity in male rats
Diabetic Neuropathy - Venlafaxine provides complete pain relief in acute diabetic neuropathy
Diabetic Retinopathy - Combined risk factors accelerate vision complications in diabetics
Diagnostics - Fluorescent ligation detection assay identifies leukemia translocations
Diagnostics - Hair analysis divulges the ingestion of toxic weight loss products
Diagnostics - Homogeneous competitive-type immunoassay for insulin developed
Diagnostics - Microarray system cleared by U.S. FDA
Diagnostics - Neural networks used as statistical tools in epidemiological studies
Diagnostics - Photoswitchable cyan fluorescent protein developed for protein tracking
Diagnostics - Radiation sensitivity of Aspergillus flavus in beef jerky reported
Diagnostics - Tandem-repeated DNA probe based amplification simplifies gene detection
Diagnostics - Universal procedure exposes DNA and RNA targets in whole blood
Diet & Nutrition - Clinical trials planned for new dietary supplement candidates
Diet & Nutrition - New ebook discusses alternative therapy to reverse chronic disease
Diet & Nutrition - Research forecasts low-carbohydrate market surge in first quarter of 2005
Diphtheria - Proteins required for biosynthesis of diphthamide identified
Drug Delivery - 6-Ketocholestanol improves skin permeation of 5-aminolevulinic acid
Drug Delivery - Characteristics of water-soluble phospholipid polymer hydrogels described
Drug Delivery - Glucose-targeted niosomes may deliver VIP to brain
Drug Delivery - Needle-free injection device made for use with insulin in India
Drug Delivery - Sweet basil essential oils enhance transdermal drug delivery
Drug Development - Emblica officinalis extract reduces DMBA genotoxicity in mice
Drug Development - Animal study results point to ATL1102's potential as an inhaled asthma drug
Drug Development - AstraZeneca withdraws application to market lung cancer drug
Drug Development - Biophosphonates for bone metastases pain is potentially lucrative market
Drug Development - Cardiome's pivotal AF study achieves primary endpoint
Drug Development - Chemical microarray identifies FVIIa-binding compounds
Drug Development - Companies enter partnership to commercialize functional human protein arrays
Drug Development - Company launches the HCS Reader 2004 Upgrade
Drug Development - Company provides EVOscreen to Institut Pasteur Korea
Drug Development - EU expands approval of Advate for use in children with hemophilia A
Drug Development - Effects of novel anxiolytic AF-5 on monoamine neurotransmitters determined
Drug Development - First patient enrolled into phase II trial of Phenoptin for PKU
Drug Development - Genetic modifications increase antibiotic yields from microbes
Drug Development - Genetically engineered animals in drug development reviewed
Drug Development - Innovative R&D strategies are key to developing new drugs, according to study
Drug Development - Investigational new drug application submitted for cancer candidate
Drug Development - Ion exchange membranes capture vector-borne virus
Drug Development - Medicinal and pharmaceutical uses of seaweed natural products reviewed
Drug Development - Meeting with U.S. FDA completed for amoxicillin Pulsys phase III trial
Drug Development - Molecular diversity management schemes for compound screening outlined
Drug Development - NDA for Retaane submitted to U.S., European regulatory authorities
Drug Development - Novel centrally acting thyrotropin-releasing hormone analogues designed
Drug Development - Novel docetaxel analogues with high tubulin activity synthesized
Drug Development - Optimized freeze-drying keeps nonviral vectors stable during storage
Drug Development - Pharma company licenses Ingenuity Pathways Analysis application
Drug Development - Pharmaceutical company announces collaboration plans on NRP104
Drug Development - Pharmaceuticals company presents data on potency of antifungal, antibiotic drugs
Drug Development - Pharmacokinetics, safety, and tolerability of Oritavancin analyzed
Drug Development - Reactivation of beta-galactosidase by glutathione is tunable
Drug Development - Results reported from phase III study of alvimopan for postoperative ileus
Drug Development - Third performance milestone in Genentech Alliance announced
Drug Fatalities - Prescription drug deaths skyrocket in Virginia's coal region
Drug Importation - Canada considering ban of Internet pharmacy prescription drug trade
Drug Importation - Savings from purchasing drugs from Canada fell last year
Drug Importation - Trade group speaks out on drug supply chain safety
Drug Importation - Two governors complain to President Bush about Canadian drugs
Drug Resistance - ABC transporters have multiple functions in drug resistance
Drug Resistance - CDC issues public reminder about proper antibiotic use
Drug Resistance - Curcumin I most effective multidrug resistance modulator among curcuminoids
Drug Resistance - Genetic resistance to nevirapine emerging in pregnant HIV+ women
Electronic Medical Records - Companies compete in Medical Record Institute's ePrescribing challenge
Electronic Medical Records - Medical database provider upgrades to meet JCAHO patient safety compliance goals
Embryonic Stem Cell Research - Cryopreservation technique increases ESC viability and reduces differentiation
Embryonic Stem Cell Research - ESC gene profiles show more highly expressed genes than adult cells
Emergency Contraception - Study: Readily available EC doesn't increase unprotected intercourse, STI risk
Emergency Contraception - U.S. ob/gyn group: Study findings put spotlight on controversial FDA OTC ruling
Emergency Medicine - Insulin treatment in critically ill trauma patients normalizes glucose
Endocrinology - Activation of nuclear factor by hyperglycemia regulated by aldose reductase
Endocrinology - Affect of exogenous progestagens on the human breast remains controversial
Endocrinology - Cofilin suppresses glucocorticoid receptor activity in hormone-resistant cells
Endocrinology - Expression of mini-proinsulin in Pichia pastoris improved
Endocrinology - Growth hormone prompts endocrine or paracrine activity during spermatogenesis
Endocrinology - Insulin acts via protein kinase phosphorylation in blastocysts
Endocrinology - Link found between mitochondrial efficiency and insulin resistance
Endocrinology - Microenvironmental factors guide glucocorticoid influence in the thymus
Environmental Health - Waste minimization plans affect U.S. medical waste management
Enzymology - Matrix metalloproteinases govern capillary tube formation differentially
Enzymology - Metal ions direct prostasin activity
Enzymology - Researchers' work adds to enzymology body of knowledge
Enzymology - Sp1 mediates lysozyme activation in epithelial cells
Enzymology - Two-step activation manages gene expression in skeletal muscles
Epilepsy - Clonazepam may use alternate control routes in genetic absence epilepsy rats
Erythropoiesis - CPEC induces erythroid differentiation through CTP depletion and p38 MAP kinase
Escherichia Coli - E. coli metabolism studied, role of transcription factor revealed
Escherichia Coli - Ozone treatment alternative to pasteurization
Escherichia coli - High incidence of ESBLs among outpatient clinical E. coli isolates
Esophageal Variceal Bleeding - FDA issues approvable letter for Sanvar for esophageal variceal bleeding
Estrogen - Estradiol-induced induction does not require direct MAPK/ERK activation
Ethics - NIH whistleblower says government bungled AIDS study in Uganda
Finance - ASP closes private placement
Finance - Biotech firm increases financing to $12,570,000
Finance - Biotherapeutic company announces financial results
Finance - Cancer-focused biopharmaceutical company files registration for proposed IPO
Finance - Cancer/inflammation-focused biopharma announces $14M private placement
Finance - Cell-based company executive adopts Rule 10b5-1 prearranged stock sales plan
Finance - China-focused company revises guidance, issues preliminary Q3 results
Finance - Clinical research organization reports second quarter financial results
Finance - Company announces closing of $60M private placement of common stock
Finance - Company's stock delisted, per its demand, from Berlin-Bremen stock exchange
Finance - Cryosurgical technology company closes second-round investment
Finance - DNA-focused company announces third quarter 2004 financial results
Finance - Device maker to restate some historical financial statements
Finance - Drug development company raised third round of financing
Finance - Drug discovery company announced private placement
Finance - Emisphere agrees to new terms for note repayment
Finance - Food safety company announces financial results
Finance - Genetics-focused biopharmaceutical company reports Q3 2004 financial results
Finance - Health care venture capital investments increase 23% in 2004, publisher reports
Finance - Medical device company closes $26 million in financing
Finance - Nanotech company named to Merrill Lynch index
Finance - Pharma announces pricing of $65M of 2.50% convertible subordinated debentures
Finance - Pharma company provides financial update
Finance - Pharmaceutical company announces results for fiscal 2005 first quarter
Finance - Pharmaceutical firm announces $12.5M private placement financing
Finance - Pharmaceutical firm closes $11.6M financing
Finance - Pharmaceutical firm reports loss of $0.09 per share
Finance - Pharmaceutical firm reports loss of $2.06 per share
Finance - Pharmaceutical firm sells $283M of senior convertible notes
Finance - Protein-focused biopharmaceutical company reports Q3 2004 financial results
Finance - Protein-misfolding-focused company closes on $16M round of funding
Finance - Science-based growth company completes private bridge loan
Finance - Science-based pharmaceutical company reports third quarter 2004 financials
Finance - Theranostics company closes private offering
Food Contamination - F-specific coliphages detected by PCR in fresh market-ready produce
Food Safety - Emerging trends of foodborne illness surveillance and prevention analyzed
Food-Borne Disease - Lysozyme augments antimicrobial activity of chitosan films
Gastric Cancer Diagnostics - LOH genotyping may be independent prognostic indicator in gastric carcinoma
Gastroenterology - Findings describe new data in gastroenterology research
Gastroenterology - Interferon-alpha and antisense K-ras RNA suppress pancreatic cancer cell growth
Gastroenterology - Synergy between acid and pepsin affects posterior laryngeal tissues
Gene Transfer - Jet injection and electroporation deliver plasmids to large muscles
Gene Transfer - Nucleotides targeting anti-apoptosis protein bind to erythroleukemia cells
Generic Drugs - Company announces the first approval of Ciclopirox Cream
Generic Drugs - Company launches Halobetasol Cream 0.05% (Rx), and Ointment 0.05% (Rx)
Generic Drugs - Pharma company receives approval for generic Accupril
Generic Drugs - Research: Generics provide consumers more savings than price controls
Generic Drugs - Spain to suspend reference-price system, support generics
Genetic Disorders - Dendritic cells made to express intereukin-12 prevent atopic disorders
Genomics - Varied recombination rates may bias gene mapping studies
Geriatrics - Aging-focused pharmaceutical company opens new research labs in North Carolina
Geriatrics - Psychosocial intervention aids patients with age-related macular degeneration
Glioma - Diffusion-weighted imaging values highlight brain tumor invasion
Glioma - IFNgamma's inhibitory effect on COX-2 expression relevant to glioma therapy?
Graft-Versus-Tumor Effect - Graft-versus-tumor effect following ASCT generated against solid tumors
Group B Streptococcal Infection - Effects of intrapartum penicillin prophylaxis studied in infants
Gynecology - SU5416 controls enzyme signals to block ovarian cancer angiogenesis
Gynecology - Transcriptional switches initiate estrogen-regulated endometrial growth
HIV/AIDS Healthcare - Education positively associated with awareness of HIV/AIDS-related services
HIV/AIDS Healthcare - Point-of-care rapid HIV testing may improve entry into healthcare
HIV/AIDS Prevention - Acceptability of HIV prevention strategies in central Tanzania explored
HIV/AIDS Prevention - German pharmaceutical company continues commitment to HIV/AIDS community
HIV/AIDS Prevention - Multifaceted intervention strategy associated with lower HIV rates
HIV/AIDS Research - Anti-termination by SIV Tat requires flexibility of nascent TAR structure
HIV/AIDS Research - HIV-1 Vpr-mediated G(2) arrest requires Rad17 and Hus1
HIV/AIDS Research - Reports add new data to HIV/AIDS research
HIV/AIDS Research - Researchers publish new studies and findings in the area of HIV/AIDS
HIV/AIDS Therapy - AIDS Drug Assistance Program of Utah selects prescription benefit service
HIV/AIDS Therapy - Acute interstitial nephritis associated with protease inhibitor atazanavir
HIV/AIDS Therapy - Clinical cutoffs for TYPE HIV-1 resistance test established
HIV/AIDS Therapy - Deferring HAART initiation until CD4 cells drop below 200mm3 is detrimental
HIV/AIDS Therapy - NNRTI capravirine reduces HIV-1 viral load in phase 1 study
HIV/AIDS Therapy - New therapeutic vaccine for HIV/AIDS eliminates needles and excessive toxicity
HIV/AIDS Therapy - Reports advance knowledge in HIV/AIDS therapy research
HIV/AIDS Therapy - Researchers describe findings in HIV/AIDS therapy studies
HIV/AIDS-Associated Infection - Saquinavir & miconazole synergistic against C. albicans & C. neoformans
HIV/AIDS-Related Disease - Tumid lupus erythematosus uncovered following HAART-related immune restoration
HIV/AIDS-Related Nutrition - Vitamins C and E protect against AZT-induced oxidative stress
Hair Studies - Forkhead gene Foxe1 required for hair follicle morphogenesis
Healthcare Coverage - Pharmacy group offers tips to boost pharmacy drug benefits lingo
Heart Disease Risk Factors - Adiponectin reduced in acromegaly and normalized by growth hormone correction
Heart Disease Risk Factors - Endothelial dysfunction in women with PCOS related to insulin resistance
Heart Failure - Nursing professor wins prize for arteriosclerosis , heart failure report
Heat Shock Proteins - Structure of small heat shock proteins changed in response to pH
Heathcare Costs - Missouri sees $7.7 Million in mental health services savings
Helicobacter pylori - Helicobacter pylori may play role in conjunctival MALT lymphoma
Hematology - Novel ligand display technology transduces hematopoietic cells
Hematology - Prenatal gene therapy corrects hemophilia B in immunocompetent mice
Hematology - Proangiogenic protein protects multiple myeloma from apoptosis
Hematology - Tests detect occult hepatitis B in North American hemodialysis patients
Hematopoiesis - Follistatin and follistatin-related gene have distinct hematopoietic functions
Hematopoietic Malignancy - Blocking constitutive STAT5 activation may treat hematopoietic malignancies
Hemoglobinuria - Clostridium septicum mutants used to diagnose hemoglobinuria
Hepatitis B Therapy - Peg-IF monotherapy effective in over one-third of patients
Hepatitis B Virus - Thymalfasin has the potential to treat patients with chronic hepatitis B
Hepatitis C Therapy - Company reports results from phase Ia/Ib studies of Actilon for hepatitis C
Hepatitis C Virus - A HCV IRES-mediated translation initiation model clarifies domain function
Hepatitis C Virus - Ampligen clinical program initiated in HIV patients with or without HCV
Hepatitis C Virus - CD4+CD25+ regulatory T lymphocytes encourage hepatitis C virus persistence
Hepatitis C Virus - Positive results from study of oral protease inhibitor for hepatitis C reported
Hepatitis C Virus - Testing for hepatitis C should be routine for persons at increased risk
Hepatitis Therapy - DHEA reduces hepatic inflammation in hepatitis models
Hereditary Antithrombin Deficiency - Company provides ATryn program update
Herpes Simplex Virus - Herpes simplex virus studied, activity of alpha-helical peptides revealed
Hormone Replacement Therapy - Review supports link between HRT and stroke
Human Papillomavirus - CDK inhibitor inhibits HPV-16 E7-induced numerical centrosome anomalies
Human T Cell Leukemia Virus - HTLV-1 Tax ubiquitination modulates its activity
Human T-Cell Leukemia Virus - Stable ubiquitination of HTLV-1 tax required for proteasome binding
Hyperglycemia - VEGF and high glucose levels mediate placenta growth factor activity
Hypertension - Calcium channel blockers boost women's risk of CVD death than other treatments
Hypertension - DETA/NO has potent blood pressure lowering effects
Hypertension - Gene mapping supports a relationship between the Add1 gene and blood pressure
Hypertension - New findings in the area of hypertension described
Hypertension - New findings in the area of hypertension detailed
Hypertension - Sodium intake influences vasoconstriction in cold-induced hypertensive rats
Hypertension - TDI analysis could detect precocious LV global diastolic dysfunction
Hypodermoclysis - Vitrase launches in the United States
Hypogonadism - Companies announce approval of Tostrex gel in first European country
Immunology - Beta-casein (1-28) exerts mitogenic effect on T and B lymphocytes
Immunology - Researchers provide details of new studies and findings in the area of immunology
Immunology - Researchers report details of new studies and findings in the area of immunology
Immunology - Studies add new findings to immunology body of knowledge
Immunology - Studies advance knowledge in immunology research
Immunosuppression - Leflunomide protects the liver from T-cell-mediated injury
Infection - Inhibition of human and Leishmania donovani topoisomerases revealed
Infections - Growth of Escherichia coli O157:H7 inhibited in vitro by colicin
Infectious Disease - Poly(ADP-ribose) polymerase-1 inhibition disrupts the chlamydial life cycle
Influenza - Flu activity picking up in Colorado; vaccine restrictions lifted
Influenza Vaccine - Alabama health officials expand list of people who can get flu shots
Influenza Vaccine - Flu vaccine to be more widely available in New Mexico
Influenza Vaccine - Missouri relaxes guidelines for flu vaccine
Influenza Vaccine - More adult flu vaccine available in Florida
Influenza Vaccine - New Jersey eases restrictions on influenza vaccine
Influenza Vaccine - New York relaxes flu shot restrictions
Information Technology - Company awards $4.6 million for studies of cardiac safety monitoring services
Information Technology - Pharma firm adopts MDL Isentris platform to boost R&D
Information Technology - Technology company to install IT infrastructure for Wockhardt Pharmaceuticals
Information Technology - Updated commerce-optimization software released
Irritable Bowel Syndrome - Study of pro-motility agent shows improved work productivity in women with IBS
Ischemia - Neuroprotection analyzed, role of fructose-1,6-bisphosphate revealed
Ischemia - Reports describe recent advances in ischemia research
Kaposi Sarcoma-Associated Herpes Virus - Small GTPase Rac1 links KSHV vGPCR to cytokine secretion and paracrine neoplasia
Kaposi Sarcoma-Associated Herpesvirus - Fetal mesencyhmal stem cells susceptible to KSHV infection
Kaposi Sarcoma-Associated Herpesvirus - Findings describe new data in kaposi sarcoma-associated herpesvirus research
Kearns-Sayre Syndrome - Deleted mitochondrial DNAs reduced by ketogenic treatment
Kidney Disease - Altered podocyte-derived VEGF assembly may precipitate diabetic glomerulopathy
Knee Replacement - Two-stage reimplantation of infected TKA has high long-term success rate
Lactation - Breast milk samples from different donors contain similar oligonucleotides
Lead Poisoning - Low levels of lead affect proliferation and differentiation of embryonic NSCs
Legal Issues - Jury finds for Utah women in diet drug fen-phen verdict with $2.1 million award
Legal Issues - Lilly denies report of missing Prozac documents
Legal Issues - Pfizer sued over painkiller
Legal Issues - U.S. Attorney reports guilty plea in kick-back case
Legal Issues - U.S. court upholds patent infringement suit against generic antibiotic maker
Legionella pneumophila - Legionella pneumophila genomes have high plasticity
Leishmania Diagnostics - Real-time RT-PCR and PCR-ELISA quantifies L. infantum from tissue biopsies
Leishmaniasis - Drug company receives regulatory approval in Germany for leishmaniasis therapy
Leishmaniasis - New findings in the area of leishmaniasis described
Leukemia - Chemotherapy drug combination shows promise for leukemia treatment
Leukemia - Isolated extramedullary relapse appears common after Chemo-DLI
Lipid Studies - Hazelnut oil reduces aortic cholesterol accumulation
Liposomal Delivery - Production of TGF-beta studied, role of a kinase and liposomes revealed
Listeria - Epidemic L. monocytogenes dairy farm strain causes sporadic human illness
Liver Cancer - Quercetin induces selective growth inhibition/apoptosis in hepatic tumor cells
Liver Disease - Action plan released addressing burden of liver disease
Liver Disease - CYP2E1 inhibitors oppose liver injury
Liver Disease - NIH action plan charts future challenges for research
Liver Disease - Nuclear import of proinflammatory transcription factor fuels liver cell death
Liver Fibrosis - A dual reporter gene transgenic mouse aids hepatic fibrogenic investigation
Liver Fibrosis - Antioxidant boosters staunch fibrosis in rodent livers
Lung Research - Technique allows lung-specific delivery of reagents
Lysosomal Storage Disease - Alpha-N-acetylglucosaminidase replacement treats Sanfilippo syndrome models
Lysteria monocytogenes - L. monocytogenes attachment to alfalfa sprouts leads to irrigation changes
Macular Degeneration - Study shows drug effectively treats neovascular age-related macular degeneration
Malaria - Travelers to Dominican Republic should take prophylaxis
Malignant Mesothelioma - MM cells expressing Slug have increased resistance to chemotherapeutic agents
Market Analysis - What is driving the rise in over-the-counter drugs?
Mastitis - Calcium inhibits bap-dependent multicellular behavior in Staphylococcus
Medical Errors - Deadly drug mistakes spike at the start of each month
Medical Errors - New medication management products, consulting services launched
Medical Errors - Robot mixes medications, prepares syringes
Melanoma - Order of treatment critical for avoiding toxicity
Mental Health - Effects of lithium on neuronal growth cone behavior determined
Mental Health - Effects of oral hormone receptor antagonist studied in a primate stress paradigm
Mental Health - New treatment for depression approved in Europe
Mental Health - Quetiapine elevates noradrenaline and dopamine release in rat prefrontal cortex
Mental Health - Rgs2 is a quantitative trait gene for anxiety in mice
Mergers & Acquisitions - Biotech company puts merger plans with Panacos Pharmaceuticals on hold
Mergers & Acquisitions - DTLL, Inc., closes on acquisition
Mergers & Acquisitions - French contract research organization acquired
Mergers & Acquisitions - Institutional pharmacy provider acquires UniScripts, Inc.
Mergers & Acquisitions - Nanotechnology company merges with C Sixty
Mergers & Acquisitions - Oral care product development business acquired for EUR 8M
Mergers & Acquisitions - Pharma company to acquire ProBio International
Mergers & Acquisitions - Pharmaceutical company merger approved
Mergers & Acquisitions - Therapeutics company acquires interest in Alzheimer-focused Ellipsis
Mergers and Acquisitions - Medical closure system company to sell drug delivery business
Metabolic Syndrome - Growth hormone and placental lactogen genes linked to metabolic syndrome
Metabolic Syndrome - Hepatic lipase mRNA, protein, and enzymes increased in insulin resistance
Metabolic Syndrome - Research shows metabolic syndrome drug market to increase by 2013
Metabolic Syndrome - Studies add new findings to metabolic syndrome body of knowledge
Metabolic Syndrome - von Willebrand factor does not predict development of metabolic syndrome
Metalloproteins - Alpha-helical coiled coil peptide that binds Ni(II) and Cu(II) designed
Metastatic Melanoma - Taxanes may be treatment option for metastatic melanoma
Migraine Therapy - Cost of prophylactic migraine treatments outlined
Molecular Diagnostics - Multiplexed RT-PCR valuable for high throughput screening applications
Monoclonal Antibody - Analysis of myeloma cell lines for antibody production conducted
Monoclonal Antibody - System to select cells producing glycosylated single-chain Fv developed
Mucosal Immunization - Research add new data to mucosal immunization body of knowledge
Multiple Myeloma - Cancer drug study results indicate potential for treating multiple myeloma
Multiple Sclerosis - Alpha lipoic acid has implications as a therapy for multiple sclerosis
Multiple Sclerosis - Software selected to support multiple sclerosis research partnership
Mutagenesis - Electrochemiluminescence assay shows point mutations in cancer samples
Mutagenesis - Researchers' data advance mutagenesis research
Mutagenesis - Topoisomerase inhibitors pursue chromatin to alter paternal chromosomes
Myelodysplastic Syndrome - MoDCs in MDS have abnormalities that contribute to defective immune response
Myopathy - Gene mutations associated with congenital myopathies produce varying effects
Nanoparticles - Biomolecular interaction between biotin and streptavidin detected
Natural Medicine - Phyllanthus amarus extract reduces HIV replication
Neoplasia - Bcl-2-related genes important in tumor initiation/progression/therapy response
Neovascularization - Ex vivo murine aorta cultures model angiogenesis
Neovascularization - Mast cell-derived angiopoietin-1 promotes plasmacytoma growth
Neurodegeneration - Beta-synuclein gene transfer protects mice from nervous system degeneration
Neurodegeneration - Geranylgeranylation inhibition mediates HMG-CoA reductase inhibitors
Neurodegeneration - New findings in neurodegeneration described
Neurology - Genetic and epigenetic events highlight the etiology of autism
Neurology - Inositol monophosphatase 2 expression is implicated in bipolar disorder
Neuroscience - Effects of PVN spider venom on blood-brain barrier permeability clarified
Neuroscience - Effects of fluoxetine on locus coeruleus in early protein deprivation assessed
Neuroscience - Estradiol uses a receptor-dependent mechanism to protect hippocampal neurons
Neuroscience - Hepatocyte growth factor revitalizes memory function after cerebral ischemia
Neuroscience - Increasing attention has provided information about social phobia
Neuroscience - Ligation preconditioning protects the rodent brain from hypoxia-induced injury
Neuroscience - New research in the area of neuroscience detailed
Neuroscience - Recent findings in neuroscience described
Neuroscience - Recent findings in neuroscience provide new insights
Neuroscience - The Wilms tumor gene is overexpressed in primary astrocytic tumors
Neutropenic Sepsis - Infusion of G-CSF may reduce duration, severity of neutropenia
Nitric Oxide - Endogenous NO modulates aldosterone synthesis in humans
Non-Hodgkin Lymphoma - Pesticide exposure may be associated with increased risk of NHL among women
Non-Small Cell Lung Cancer - Cancer vaccine trial data updated
Nutritional Supplements - Alliance calls for donation of children's vitamins for Asian tsumani victims
Obesity Genomics and Genetics - Mutation in PPAR-gamma promoter linked to partial lipodystrophy
Obesity Pathogenesis - Adiponectin linked to increased weight gain in small infants
Obesity Pathogenesis - Brain region-specific forms of obesity linked to agouti expression
Obesity Pathogenesis - IL-6 regulates adipose tissue lipid metabolism and leptin production
Obesity Pathogenesis - New data illuminates research in obesity pathogenesis
Obesity Surgery - Studies advance knowledge in obesity surgery research
Obesity Therapy - Findings advance knowledge in obesity therapy research
Obesity and Diabetes - Age has independent effect on insulin sensitivity and beta-cell function
Obesity and Diabetes - Beta-cell function and insulin sensitivity associated with body fatness
Obesity and Diabetes - Ciliary neurotrophic factor decreases weight and improves metabolism
Obesity and Diabetes - Free fatty acid levels modulate microvascular function
Obesity and Diabetes - Intranasal insulin reduces body fat in men but not in women
Obesity and Diabetes - Mitochondrial remodeling in adipose tissue associated with obesity
Obesity and Diabetes - Phosphatidylinositol/AKT/atypical PKC pathway improves insulin sensitivity
Obesity and Diabetes - c-Cb-deficient mice have reduced adiposity and improved insulin action
Obstetrics - Higher dose of clomiphene doesn't appear to increase risk of poor outcome
Obstetrics - Newer antidepressants don't appear to adversely effect pregnancy outcome
Oncogenesis - Hepatitis C virus transfection produces liver cell growth and tumorigenesis
Oncogenesis - Research in oncogenesis provides new insights
Oncology - Chromosome changes are prognostic indicators in multiple myeloma patients
Oncology - Integrin signals link survival elements in recurrent prostate cancer
Oncology - Interleukin-10 may enable liver cancer to evade immune response mechanisms
Oncology - Paclitaxel halts angiogenesis at similar rates despite dissimilar scheduling
Oncology - Researchers provide details of new studies and findings in the area of oncology
Oncology - Studies advance knowledge in oncology research
Oncology - T cell type cancer predominates in Korean primary hepatic lymphoma cases
Osteoporosis - Bone response to PTH and high-dose E2 involves patterned gene regulation
Osteoporosis - Effects of alendronate last longer after discontinuation than estrogen
Osteoporosis - Researchers' findings advance osteoporosis research
Osteoporosis - Wyeth selects drug targets in osteoporosis collaboration with Belgium company
Ovarian Cancer - Assay combination has potential to double response rate to chemotherapy
Ovarian Cancer - Company enrolls, initiates reviews phases of clinical trials for cancer drug
Pain Medicine - Novel encapsulation method improves efficacy of intrathecal chromaffin cells
Patents - Anesthetic delivery system developer announces new patent protection
Patents - Company gets patent for differentiating hESCs into neural cells
Patents - Company secures license to SirT2 and SirT3 patents from University of California
Patents - European patent granted for learning and memory compound
Patents - U.S. patent allowed for stabilized hydroxyvitamin D2 products
Patient Compliance - Compliance is compromised when patients are treated with multiple pills
Pediatrics - Narrow measures govern neurogenetic models of ADHD etiology
Pediatrics - New clinical guidelines advise when to treat flat feet in children
Peripheral Blood - Recombinant IL-2 analog induces proliferation of unstimulated T cells
Personnel - Allergy-focused company appoints Deborah A. Smeltzer as CFO
Personnel - Biopharma company announces vice president, general counsel and secretary
Personnel - Biopharma company names CEO
Personnel - Biopharma company names new board member
Personnel - Biopharmaceutical company names director of pharmaceutical development
Personnel - Biotech company announces promotions, appointments
Personnel - Biotech company names Thomas E. Shenk to board of directors
Personnel - Biotechnology company appoints director of regulatory affairs
Personnel - Biotechnology company names vice president, worldwide sales
Personnel - Byproducts company announces board addition, president and CEO
Personnel - California controller names Philip Pizzo, MD, to stem-cell oversight committee
Personnel - Charles B. O'Keeffe named to board of Florida-based pharmaceutical company
Personnel - Dr. Goran Ando joins board of directors
Personnel - Drug development company names science and technology advisors
Personnel - Leslie J. Williams named president, CEO of pharmaceuticals company
Personnel - Medical device company announces board member addition
Personnel - Pain-management company announces executive appointments
Personnel - Pharmaceutical firm appoints Robert Roe to board of directors
Personnel - Prescription savings company names Mark Chamness VP of pharmacy networks
Personnel - Richard C. Williams named interim CEO of specialty biopharmaceutical company
Personnel - Therapeutics company names member to board
Personnel - Vijay Sondhi appointed chief financial officer by pharmaceutical company
Personnel - William Nuerge named CEO of women's health and urology focused drug company
Philanthropy - Antibiotics valued at $50M donated to AmeriCares
Philanthropy - Florida philanthropist Alexander W. Dreyfoos gives Scripps Institute $1 million
Philanthropy - Pharmaceutical company contributes $300K, products to tsunami relief efforts
Physiology - Caveolin-1 analyzed, functional form necessary for alpha-hemolysin assembly
Physiology - Study evaluated effects of nutritional stress on AMPK activity in vivo
Plague - Virulence factor expression in Yersinia pestis characterized
Plant-based Medicine - Tea tree oil's antimicrobial activity studied in Staph. aureus-infected wounds
Pneumococcal Vaccines - Recent findings in pneumococcal vaccines described
Pompe Disease - Company files for European approval of Myozyme for Pompe disease
Porphyromonas Gingivalis - Oxidative damage repair studied in Porphyromonas gingivalis
Positron Emission Tomography - Application demonstrated new radiotracer to be safe and useful
Preventive Medicine - 20M smokers resolve to quit in 2005 again
Product Licensing - Biopharmaceutical company licenses human protein BPI to Zephyr Sciences, Inc.
Product Licensing - CTI licenses Lisofylline and related portfolio for development in diabetes
Product Licensing - Company inks licensing agreement in Mexico for Decapeptyl Depot, Decapeptyl LA
Product Licensing - HEALTHPOINT enters licensing agreement for two late-stage topical analgesics
Product Licensing - License agreement for glioblastoma multiforme treatment candidate signed
Product Licensing - License rights for gene targeting technologies granted to Johnson & Johnson
Prostate Cancer - Calcitriol induces prostate-derived factor expression in tumor cells
Prostate Cancer - Company reaches milestone in development of prostate cancer classification test
Protein Methylation - Stable HeLa cell protein methylation produced by adenosine dialdehyde treatment
Protein Structure - Predictive models for protein crystallization developed
Proteomics - Application of mass spectrometry data to proteomics research described
Proteomics - Bone morphogenetic proteins are secreted early during embryonic development
Proteomics - Desensitization of activated sphingosine-1-phosphate receptors revealed
Proteomics - Phospholipase C-epsilon studied, activation mechanism revealed
Proteomics - Protection techniques foster the construction of oligonucleotide constructs
Proteomics - Rapid analysis of large protein-protein complexes using NMR developed
Proteomics - Real-time organelle analysis performed using surface plasmon resonance
Proteomics - STA1 expression in yeast studied, role of Swi/Snf complex clarified
Proteomics - Structural basis of cellular redox regulation by human TRP14 described
Proteomics - Zinc-finger protein TIS11b destabilizes angiogenic cytokine
Pseudomonas - MucA-mediated coordination of secretion in Pseudomonas investigated
Psoriatic Arthritis - U.S., European submissions made for Humira
Pulmonary Hypertension - Results from STRIDE-4 released
Pulmonary Hypertension - U.S. FDA approves Ventavis for pulmonary arterial hypertension
Pulmonary Hypertension - Vasoactive mediators from smoke exposure provoke pulmonary artery changes
RNA Research - DNA and RNA surveillance are linked to mRNA export
RNA Research - Fourier transform infrared spectroscopy discerns RNA bulge structures
RNA Research - RNA polymerase II-dependent promoter derivatives expand the potential of siRNA
Receptor Studies - Entrapment of membrane-bound receptors in silica reported
Receptor Studies - Opioid receptor blockade helps mice escape Fas-induced hepatitis
Receptor Studies - Quantitative analysis of drug-protein binding conducted
Receptor Studies - Toll-like receptors may be targets for treating chronic inflammatory diseases
Recombinant Research - Heat shock proteins used to produce recombinant proteins in E. coli
Renal Cancer - Angiogenesis inhibitors help patients with advanced renal cell carcinoma
Renal Cell Carcinoma - Use of retinoids in the treatment of renal cell carcinoma may be a futile effort
Renal Disease - Chloride channel Kb gene mutations direct renal tube cell calcium handling
Renal Disease - Company partners with ADDNET consortium
Renal Disease - Kidney disease in Arima syndrome resembles disease in other disorders
Renal Disease - Renal complications in Fabry disease associate with a unique gene variant
Respiratory Medicine - Bronchoalveolar lavage fluid tests do not reflect pulmonary fibrinolysis
Respiratory Medicine - Interferon benefits patients with recurrent respiratory papillomatosis
Respiratory Medicine - Phase II trial initiated to study aerosolized antibiotic for pneumonia
Retinopathy - Upregulated VEGF in RPE cells does not produce choroidal neovascularization
Rhodopsin - Rhodopsin signaling and organization studied in knockout mice
Ribosomes - Small ribosomal subunit changes shape during translocation
SARS - Assay for studying mutations of SARS virus protease developed
SARS - Geographic information system offered real-time tracking of SARS spread
SARS Coronavirus - Reports describe recent advances in SARS coronavirus research
Salmonella - B12 -adenosyl transferase encoded within Salmonella enterica operon
Salmonella - Lack of YggX results in chronic oxidative stress in Salmonella
Scabies Diagnostics - Asymptomatic S. scabiei infestation revealed by serology of Caprinae hosts
Sexual & Reproductive Health - New drug application submitted for premature ejaculation
Sexual and Reproductive Health - Murine scans identify genes associated with oocyte maturation
Sexual and Reproductive Health - Primary follicles are stockpiled in polycystic ovary syndrome
Smallpox Vaccines - Recent findings in smallpox vaccines provide new insights
Soft Tissue Sarcoma - Licensed oncology drug for soft tissue sarcoma in clinical trials at Wayne State
Spinal Cord Injury - BMTs provide tissue protection/axon guidance after contusive spinal cord injury
Spinal Cord Injury - Federal grant to be used for cell therapy research
Stem Cell Research - CD19+/CD20+ cells efficiently separated via magnetic cell separation technique
Stem Cell Research - CXCR4 important for mediating specific migration of MSCs to bone marrow
Stem Cell Research - Delayed TNF-alpha exposure increases yield of CD83+ dendritic cells
Stem Cell Research - FGF6 role in maintenance of reserve pool of progenitor cells in skeletal muscle
Stem Cell Research - Hematopoietic stem cell expansion is a plausible clinical goal
Stem Cell Research - MMG disrupts collagen I/integrin signaling during osteoblastic differentiation
Stem Cell Research - Mesangioblasts transdifferentiate into satellite cells in myogenic environment
Stem Cell Research - Mesenchymal progenitor cells are present in the umbilical cord
Stem Cell Research - Microfabricated platform studies stem cell fates
Stem Cell Research - Non-muscle stem cells do not regenerate normal muscle tissue
Stem Cell Research - Nucleostemin plays important role in self-renewal of cancer cells
Stem Cell Research - Oct4 required for primordial germ cell survival
Stem Cell Research - Physical defect repair enhanced by implanting MSC cultured with TGF-beta 3
Stem Cell Research - SKPs can be isolated from skin during embryogenesis and persist into adulthood
Stem Cell Research - Trabecular bone fragment alternative source of mesenchymal stem cells
Stem Cell Research - hEBs generated from ESC suspensions within 3D porous alginate scaffolds
Stem Cell Transplantation - GVHD still a major limitation to successful hematopoietic SCT
Stem Cell Transplantation - HD radiochemotherapy followed by ASCT improves survival in follicular lymphoma
Stem Cell Transplantation - Non-myeloablative SCT safer than myeloablation for autoimmune diseases
Stents - Researchers prefer stenting for SA obstructive lesions
Stress Induction - Multiple stress signals induce p73 beta accumulation
Stroke - Specific gene variations may pose a risk for ischemic stroke
Surgical Technology - Imaging center announces noninvasive procedure for uterine fibroids
Systemic Lupus Erythematosus - U.S. FDA grants epratuzumab Fast Track Product designation
Thrombin - Lung barrier function studied, differential thrombin regulation revealed
Tobacco Use - Nicotine increases blood-brain barrier permeability in vivo
Toxicology - Cell sorting techniques are not genotoxic to spermatozoa
Toxicology - Method for in vivo bioluminescent monitoring of toxicity developed
Toxicology - Synthesized compounds immobilize cadmium or lead toxins
Toxicology - Tool to study oxidative stress and inhalation toxicokinetics developed
Transcription Factors - R-dependent transcription factor activity studied, different mechanisms revealed
Transfection - Researchers detail new studies and findings in the area of transfection
Trichomonas vaginalis - T. vaginalis inhibits proinflammatory cytokines via NF-kappa B supression
Trypanosoma - Plant arginine decarboxylase gene expressed in Trypanosoma cruzi
Tumor Suppression - Cdk inhibitor p21 has tumor suppressor function in colon
Type 1 Diabetes - Intracellular stress signaling pathways activated during islet preparation
Type 1 Diabetes Screening - Simple test for autoantibodies to glutamic acid decarboxylase developed
Type 2 Diabetes - 7-Hydroxystaurosporine inhibits Akt Thr308) not Ser473 phosphorylation
Type 2 Diabetes - Hepatic production of VLDL1 but not VLDL2 related to insulin resistance
Type 2 Diabetes - Stage-matched intervention promotes exercise in patients with type 2 diabetes
Ulcerative Colitis - Management of postoperative pouchitis reviewed
Uterine Fibroids - Interim assessment of 1-month data from uterine fibroid therapy released
Vaccine Development - Dendritic cell expansion potentiates the immunogenicity of plasmid DNA vaccine
Viral Genomics - Findings advance knowledge in viral genomics research
Virology - Aromatic cations eradicate viral infection in cells destined for cloning
Virology - DNA aptamer prevents influenza infection
Virology - New research in the area of virology detailed
Wound Care - Hydrogels as wound-dressing materials investigated
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