Published in Drug Week, January 28th, 2005
Study 1: Scientists have developed a method to detect low-frequency human antigen-specific CD4+ T cells using MHC class II multimer bead sorting and immunoscope analysis.
"MHC class II tetramers are attractive tools to study antigen-specific CD4+ T cell responses in various clinical situations in humans. HLA-DRA1*0101/DRB1*0401 MHC class II heterodimers were produced as empty molecules using the Drosophila melanogaster expression system. Peptide binding experiments revealed that these molecules could be loaded efficiently with appropriate MHC class II tumor...
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