Metalloproteins

Alpha-helical coiled coil peptide that binds Ni(II) and Cu(II) designed

Published in Drug Week, January 28th, 2005

Recent research from Japan described the design of an alpha-helical coiled coil peptide that is capable of binding two metal ions.

"Metalloproteins are an attractive target for de novo design. Usually, natural proteins incorporate two or more (hetero- or homo-) metal ions into their frameworks to perform their functions, but the design of multiple metal-binding sites is usually difficult to achieve.

"Here," wrote T. Tanaka and colleagues, "we undertook the de novo engineering of heterometal-binding sites, Ni(II) and Cu(II), into a designed coiled coil structure based on an isoleucine zipper (IZ) peptide.

"Previously, we described...

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Source: Drug Week (2005-01-28)

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