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Trypanosoma

Plant arginine decarboxylase gene expressed in Trypanosoma cruzi

Published in Drug Week, January 28th, 2005

Researchers report the heterologous expression of a plant arginine decarboxylase gene in Trypanosoma cruzi in a recent issue of Biochimica Et Biophysica Acta - General Subjects.

According to a study from Argentina, "Wild-type Trypanosoma cruzi epimastigotes lack arginine decarboxylase (ADC) enzymatic activity. However, the transformation of these parasites with a recombinant plasmid containing the oat ADC cDNA coding region gave rise to the transient heterologous expression of the enzyme, suggesting the absence of endogenous mechanisms that could inhibit the expression of a hypothetical own ADC gene or the assay used to measure its enzymatic...

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