Drug Week
Susan Hasty, Publisher
Table of Contents . . . April 1st, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Age-Related Macular Degeneration - Positive preliminary data presented for EVIZON
Breast Cancer - Positive Abraxane survival data presented
Cancer Therapy - Mean survival time doubles in patients with pancreatic cancer using RP101
Drug Development - Aczone demonstrates reduction in number, severity of acne lesions
Drug Development - Enrollment of new patients in trials of alagebrium temporarily suspended
Hepatitis C Virus - U.S. FDA approves Pegasys and Copegus as hepatitis C treatment for HIV patients
Acute Lymphoblastic Leukemia - Gene expression profiles can predict molecular treatment response
Acute Lymphoblastic Leukemia - Genomic response to L-asparaginase characterized in ALL cells
Acute Myeloid Leukemia - SU11248 produces short-term partial remissions in leukemia patients
Addiction Medicine - Injection drug use status influences HCV-related referral and treatment
Addiction Medicine - MELD scores forecast mortality in patients with alcoholic hepatitis
Addiction Medicine - Striatal proteins associated with nicotine addiction identified
Atherosclerosis - Researchers' findings advance atherosclerosis research
Adverse Drug Reaction - Endometrial responses to SERMS investigated
Adverse Drug Reaction - Immunosuppression may generate eruptive tufted angiomas
Adverse Drug Reaction - Rituximab-based chemotherapy may reactivate hepatitis B virus infection
Age-Related Macular Degeneration - FDA completes review of age-related macular degeneration trial protocols
Age-Related Macular Degeneration - New treatment for wet age-related macular degeneration
Age-Related Macular Degeneration - Preliminary data released on age-related macular degeneration treatment
Cancer Vaccines - Researchers' findings advance cancer vaccines research
Allergy & Immunology - Allergy relief is a few shots away
Allergy & Immunology - Interferon-gamma helps myeloid dendritic cells respond to CpG DNA
Allergy & Immunology - Ten tips to ease allergy symptoms
Allergy Medicine - Molecular basis of pollen-related food allergy elucidated
Amoebiasis - Key molecules in E. histolytica tissue invasion identified
Androstenedione - No hepatotoxicity of androstenedione found in pregnant rats
Diabetes Pathogenesis - New data illuminates research in diabetes pathogenesis
Angina - Company launches phase IIb trial in patients with severe coronary artery disease
Angiogenesis - Pharma company initiates phase II clinical study of lung cancer treatment
Angiology - Circulating bone marrow-derived cells direct adult vasculogenesis
Angiology - New data illuminates research in angiology
Angiology - RGD-modified liposomes guide therapy to vascular targets
Anthracycline - Study tested cell-growth inhibitory effects of anthracyclines
Diabetes Pathogenesis - Reports add new data to diabetes pathogenesis research
Anthrax Vaccine - HEPA/vaccine plan for indoor anthrax remediation outlined
Anthrax Vaccine - Mucosal administration of rPA protects against inhalational anthrax
Antibiotics - Intent-to-treat and per-protocol results in antibiotic trials compared
Antimicrobial - Umbelliferone aminoalkyl derivatives inhibit microbial pathogens
Antimicrobials - Chitinases from pineapple leaf characterized, antifungal activity revealed
Antimicrobials - Marine bacterium analyzed, new broad-spectrum antibacterial protein described
Diabetes Pathogenesis - Researchers report details of new studies and findings in the area of diabetes pathogenesis
Antipsychotics - Muscarinic receptor blockade underlies antipsychotic-induced ACh release
Antipsychotics - Sulpiride does not inhibit cytochrome P450 activity
Antitumor Drug - Peptidyl derivatives have antitumor activity
Aortic Aneurysm - Pharmaceutical company announces SPA agreement for pivotal trial for INO-1001
Apoptosis - Hepatitis C virus core proteins modulate apoptosis in dendritic cells
Apoptosis - Study investigated apoptosis inhibition by NO
Diabetes Therapy - Researchers publish new studies and findings in the area of diabetes therapy
Arsenic Exposure - Eliminating arsenic in drinking water decreased lung cancer mortality in Taiwan
Arthritis - Circulating CD26 analyzed, influence on arthritic inflammation clarified
Asthma - Sodium bicarbonate can help treat children with life-threatening asthma
Asthma - Study reinforces connection between cockroaches and asthma
Atherosclerosis - Cerebral vascular pathology in diabetes reviewed
Atherosclerosis - Findings describe new data in atherosclerosis research
Diabetes Therapy - Researchers' findings advance diabetes therapy research
Atherosclerosis - High blood pressure linked to atherosclerotic plaques in Finns with diabetes
Attention Deficit Hyperactivity Disorder - Pharmaceutical company issues results on phase 2 trial of ADHD treatment
Awards - Biopharmaceutical company named one of top 10 best employers in North Carolina
Awards - Innovation prize finalists announced in "Science of Better"
Bacteriology - U.S. FDA grants priority review for antibiotic treatment for skin infections
Hypertension - Researchers report details of new studies and findings in the area of hypertension
Basal Cell Cancer - PTCH polymorphism mediates susceptibility to basal cell carcinoma
Bioinformatics - Computer models predict the effects of vessel maturation on tumor dynamics
Biomedical Engineering - Companies announce new agreements to jointly develop soft tissue repair products
Biomedical Engineering - Crosslinked hyaluronan film delivers DNA vector to tissues
Biomedical Engineering - Phenylalanine-modified dendrimers have high transfection capabilities
Bioterrorism - Company submits IND to initiate human studies of anthrax drug
Immunology - Researchers' findings advance immunology research
Biowarfare - Chlorine inactivation of bacterial bioterrorism agents reported
Black Tea - Black tea intake does not modulate mutagen excretion from ingested beef
Bladder Cancer - Relative copy number of bladder cancer genes determined by real-time PCR
Blood Banking - Quality control programs ensures quantity/quality of preserved cord blood
Bloodstream Infection - Burkholderia stabilis outbreak caused nosocomial bloodstream infections
Bone Cancer - Zoledronic acid recommended as treatment for patients with bone metastases
Oncology - Findings advance knowledge in oncology research
Bone Marrow Disorders - Modulation of drug resistance transporters as key strategy for treating MDS
Bone Marrow Transplantation - Competing risks approach estimates primary/secondary relapse following ABMT
Bovine Arbovirus - Culicoides oxystoma potential vector for bovine arbovirus in southern Japan
Brain Cancer - Biopharmaceutical company initiates phase 1 trial in metastatic brain cancer
Breast Cancer - Breast cancer resistance protein gene expression modulated using siRNAs
Breast Cancer - CAT study to examine combination hormonal therapy for advanced breast cancer
Oncology - Findings in oncology provide new insights
Breast Cancer - EGCG functioned as anticarcinogen against ER-negative breast cancer cells
Breast Cancer - ERCC2 genotypes and corresponding haplotype linked with breast cancer risk
Breast Cancer - HER-2/neu overexpression decreases wild-type p53 via activating PI3K pathway
Breast Cancer - Neulasta trial results published in The Journal of Clinical Oncology
Breast Cancer - Racial differences in CYP3A5 polymorphisms don't affect tamoxifen metabolism
Breast Cancer - Study: Chemicals in apples could reduce the risk of breast cancer
Oncology - Recent findings in oncology provide new insights
Breast Cancer - XPD polymorphism increases breast cancer risk from PAH-DNA adducts/cigarettes
Breast Cancer Therapy - Role of PI3-AKT signaling in genomic effects of trastuzumab determined
Business & Finance - ATryn maker reports "significant progress" in 2004
Business & Finance - Anti-infectives-focused biotech company reports Q4, year end 2004 results
Business & Finance - Australian biotech firm releases half half-year results and outlook
Business & Finance - Biopharmaceutical company reports 2004 year-end results
Oncology - Recent studies add new data to oncology research
Business & Finance - Cardiology company receives $6M milestone payment
Business & Finance - Pharmaceutical company reports fourth quarter results, clinical progress
Business & Finance - Pharmaceutical firm reports loss of $1.17 per share
Business & Finance - Stem cell-focused biotech company reports 4th quarter, year end 2004 results
Business & Finance - Technology company reports operational & financial results for fiscal year 2004
Business & Finance - ZYFLO maker updates year, reports losses
Oncology - Research add new data to oncology body of knowledge
Business Development - Technology transfer plays increasing role in biomedical business development
Business Update - 2004 global pharmaceutical sales grow 7% to US$550 billion
Business Update - Australian authorities approve manufacturing facility at Panoli
Business Update - Biotech company moves to Karolinska Institutet
Business Update - Biotechnology company closes sale and leaseback transactions
Oncology - Researchers detail new studies and findings in the area of oncology
Business Update - Biotechnology company signs researchers agreements with Access Business Group
Business Update - Biotechnology incubator organization implements new support for network
Business Update - CepTor announces exclusive license agreement for Myodur in the Pacific Rim
Business Update - Ceratopic expands line of dermatology products
Business Update - Companies enter cross-distribution agreements for pre-blended chemistries
Business Update - Companies launch new benchtop protein crystallization system
Oncology - Researchers report details of new studies and findings in the area of oncology
Business Update - DeltaSoft joins MDL Isentris Alliance
Business Update - Distributor reports strong progress in its specialty drug-distribution strategy
Business Update - Drug company to divest 2 OTC products to Alterna, LLC under exclusive license
Business Update - FDA issues warning letter to insulin pump maker
Business Update - First Horizon to acquire rights to Fortamet and Altoprev
Business Update - GE Healthcare launches product with QPI technology
Physiology - Findings advance knowledge in physiology research
Business Update - GPC Biotech acquires assets of kinase drug-discovery firm
Business Update - GenPath Pharmaceuticals changes name
Business Update - Itochu agrees on capital alliance with Japanese biopharmaceutical company
Business Update - Laboratory service company sign contracts with pharmaceutical company
Business Update - Liquid chromatography-chip/mass spectrometry system launched
Business Update - Manufacturer of sleeping products increases global reach, gains sales increase
Pneumococcal Vaccines - Studies add new findings to pneumococcal vaccines body of knowledge
Business Update - Nanobiotech company launched to focus on delivery, therapeutic use of RNAi
Business Update - New mass spectrometer workstation software for LC/MS released
Business Update - Number of retail outlets selling Sucanon increased
Business Update - Pfizer Inc. expands licensing of pathways analysis software
Business Update - Pharmaceutical company receives first order for commercial wound gel for Ecuador
Business Update - Pharmaceutical company receives payment from Serono
Proteomics - Recent findings in proteomics described
Business Update - Pharmaceutical firm expects goodwill impairment charge on U.S. generics
Business Update - Pharmaceutical firm reports $27.6M expansion
Business Update - Pharmaceutical firm reports informal inquiry by U.S. SEC
Business Update - Pharmaceutical marketing firm launched
Business Update - Pharmaceuticals producer signs supply agreement with FragChem Corporation
Business Update - Pharmacy benefit manager announces work-at-home program in North Carolina
Proteomics - Reports describe recent advances in proteomics research
Cancer Diagnostics - FDA does not recommend approval of the proposed indication for Combidex
Cancer Immunotherapy - Lymphocyte contamination makes genetically altered dendritic cells disappear
Cancer Prevention - Designing the selenium and vitamin E cancer prevention trial (SELECT)
Cancer Research - 'Promising' in vivo data on kinase anti-cancer small molecule program presented
Cancer Research - Biopharmaceutical company discovers role of Ero-1L alpha gene
Cancer Research - Pharmaceutical company begins clinical development of OSI-930
Virology - Researchers' data advance virology research
Cancer Research - Pharmaceutical company reports transfer of orphan drug status for oncology drugs
Cancer Risk - Opium smoking associated with elevated carcinoembryonic antigen levels
Cancer Therapy - Alliance established for trial of non-small cell lung cancer vaccine
Cancer Therapy - BRD-glucan appears to be a promising immunochemotherapeutic antitumor agent
Cancer Therapy - Brain tumor can be cured in older kids using radiation, chemotherapy
Cancer Therapy - Combining external radiotherapy and anemia treatment endorsed
Virology - Researchers' work adds to virology body of knowledge
Cancer Therapy - Company announces strategic alliance to develop new cancer therapies
Cancer Therapy - Efficacy of irinotecan and capecitabine as second-line treatment revealed
Cancer Therapy - Efficacy of warfarin in cancer patients inferior to LMW heparin
Cancer Therapy - Eligard now available for treatment of prostate cancer
Cancer Therapy - Experimental cancer treatments help
Cancer Therapy - First patient treated in phase I trial of ThermoDox with heat for liver cancer
Cancer Therapy - From discovery to clinical development of thymidylate synthase inhibitor ZD9331
Cancer Therapy - Genes and pathways associated with oxaliplatin resistance identified
Cancer Therapy - H-Ras oncogene counteracted growth-inhibitory effect of genistein in T24 cells
Cancer Therapy - Histone deacetylase inhibitors showed promise as novel cancer therapeutic agents
Cancer Therapy - Inherited traits, tumor mutations affect response to Treatment of ALL
Cancer Therapy - Intravenous administration of the SMA-THP enhanced effect of pirarubicin
Cancer Therapy - NAC blocks cisplatin-induced apoptosis through caspase signaling pathway
Cancer Therapy - New treatments for difficult cancers improve survival, quality of life
Cancer Therapy - Peptides targeting VEGF limit its autocrine and paracrine functions
Cancer Therapy - Phase I/II study of Amplimexon plus gemcitabine initiated
Cancer Therapy - Polymeric micelle drug carriers showed promise in cancer therapy
Cancer Therapy - Positive trial data presented on anticancer compound, Quinamed
Cancer Therapy - Research add new data to cancer therapy body of knowledge
Cancer Therapy - Taxol- and dEpoB-induced signaling activities compared
Cancer Therapy - Telomerase promoter enhances the efficacy of lung cancer suicide gene therapy
Cancer Therapy - Thioredoxin inhibitor AW464 hammers tumor growth under hypoxic conditions
Cancer Therapy - Vaccine adjuvant shows enhanced immune response in prostate cancer patients
Cancer Therapy - Vinorelbine showed no clinical influence on patients with metastatic melanoma
Cancer Vaccines - Branched lysine peptide has antitumor effect in rat glioma model
Cancer Vaccines - Dendritic cell vaccine elicits long-lasting protective tumor immunity
Cancer Vaccines - Dendritic cells have limited potential in immunotherapy
Cancer Vaccines - Dendritic cells modulate antitumor responses
Cancer Vaccines - HLA-DR beta1*0101- and 1*0401-restricted epitopes identified
Cancer Vaccines - Highly specific overexpression of SOX11 occurs in malignant gliomas
Cancer Vaccines - Human tumor antigens recognized by T cells listed
Cancer Vaccines - New findings in cancer vaccines described
Cancer Vaccines - Peptide with native disulfide bonds enhances antitumor activity
Cancer Vaccines - Peptides from taxol resistance-related protein elicit T-cell responses
Cancer Vaccines - Virosomes for antigen and DNA delivery reviewed
Cardiology - Chief angiogenic growth factors have differential roles in the myocardium
Cardiology - Cypher stent featured at cardiology meeting
Cardiomyocytes - Study explored mechanisms by which T3 mediates decrease in TRalpha1
Cardioprotection - Study evaluated role of DL-alpha-lipoic acid in cardiac damage induced by CP
Cardiovascular Disease - Advanced glycation and endothelial functions link to vascular complications
Cardiovascular Research - Enrollment completed in trial for paclitaxel-eluting coronary stent system
Cell Biology - Immortalized cells foster the study of liver diseases
Cell Development - Caulobacter crescentus studied, role of RodA and MreB clarified
Cell Development - Rhodobacter sphaeroides MreB examined, localization clarified
Central Nervous System - Biopharmaceutical company commences phase I study of CNS trial
Chlamydia Vaccine - Vaccine candidates against Chlamydia pneumoniae identified
Chronic Obstructive Pulmonary Disease - Classes of b-blockers differ in pulmonary effects on patients with COPD
Clinical Trials - Company completes enrollment of immune recovery drug in phase I clinical trial
Clinical Trials - Company to meet with FDA before unblinding of phase III E2F Decoy trial
Clinical Trials - Flamel Technologies announces termination of licensing agreement for Genvir
Clinical Trials - Hemoglobin-based oxygen carrier trial patient enrollment completed
Clinical Trials - Pharma company announces phase II clinical trial with antianxiety agent
Clostridium Infection - Patients with C. difficile-related diarrhea have higher mortality
Cognition - Nef neurotoxicity associated with cognitive deficits in HIV infection
Collaborations - Agreement to provide Kogenate FS for Australians with hemophilia
Collaborations - Agreements transferred to Brookwood Pharmaceuticals, Inc.
Collaborations - Alliance focuses on therapy for cervical high-risk HPV infection, dysplasia
Collaborations - Alliance to deliver biospecimen management solution
Collaborations - Alliance to provide informatics solutions to life science marketplace
Collaborations - Companies enter collaboration to develop therapeutic hepatitis B vaccine
Collaborations - Companies enter strategic collaboration for biopharmaceutical products, services
Collaborations - Deal signed to divest Altoprev, Fortamet to First Horizon Pharmaceutical
Collaborations - Deal signed to manufacture monoclonal antibody
Collaborations - Deal signed to provide protein crystallography to Serenex
Collaborations - Development, marketing agreement for Oxygent is modified
Collaborations - Discovery chemistry companies enter into drug research collaboration
Collaborations - Drug discovery collaboration extended
Collaborations - Genomics company achieves key milestone in joint kinase discovery program
Collaborations - Licensing agreement signed for cystic fibrosis drug
Collaborations - Milestone achieved in collaboration with Dynavax
Collaborations - NIH funds development of T-cell based therapy for AIDS
Collaborations - Pharmaceutical firm signs development, manufacturing deal with Orchid
Collaborations - Red Cross affirms continued support of joint projects with drug research company
Collaborations - Research collaboration to analyze diabetes, breast cancer genetic markers
Collagens - Fibroblast-populated dense collagen matrices studied, cellular aspects shown
Colon Cancer - Avastin proven effective in advanced colorectal cancer patients
Colon Cancer - Serum cathepsin H potential prognostic marker in patients with colorectal cancer
Colorectal Cancer - Culturelle may prevent lesions that can lead to some forms of colon cancer
Colorectal Cancer - MTHFR 677 TT and MTR 2756 GG genotypes confer reduced colorectal cancer risk
Colorectal Cancer - Pharma company engages WorldCare Clinical diagnostics services
Complementary & Alternative Medicine - Effects of Yukmijihwang-tang derivatives on hippocampal genes determined
Complementary & Alternative Medicine - How effective are herbal supplements in reducing illnesses in children?
Complementary & Alternative Medicine - Onion and garlic exert hypoglycemic effects in alloxan-induced diabetic rats
Complementary & Alternative Medicine - St. John's wort amplifies effect of blood thinner Plavix
Congestive Heart Failure - Cardiac recovery system for congestive heart failure presented at conference
Cryptosporidium Outbreaks - Cryptosporidium outbreaks occur from microbiology standard-compliant water
Cysticercosis Vaccine - Method for monitoring vaccines against cysticercosis developed
DNA Damage - TDP1 overexpression counteracts DNA damage mediated by topoisomerases I and II
DPT Vaccine - Pertussis toxoid reduces immunogenicity of diphtheria and tetanus
Dengue Virus - Selection for virulent dengue viruses occurs in humans and mosquitoes
Depression - No significant differences between sexes found in SSRI treatment
Dermatology - Acanthosis nigricans found in plaque of scleredema on diabetic patient
Dermatology - Gene patterns distinguish desmoplastic melanoma from non-desmoplastic melanoma
Dermatology - Light-based cosmetic treatments company introduces new products
Dermatology - New findings in the area of dermatology detailed
Dermatology - Therapies that regulate heparanase can control malignant melanoma
Diabetes Complications - EMEA recommends approval of Cymbalta
Diabetes Complications - N-carboxymethyl-lysine blood levels denote microangiopathy in type 2 diabetes
Diabetes Complications - Role of AGE in pathology of diabetic complications reviewed
Diabetes Genomics and Genetics - Adenovirus transgenes expressed in beta cells prevent type 1 diabetes
Diabetes Genomics and Genetics - PAX4 gene variations predispose to ketosis-prone diabetes
Diabetes Pathogenesis - Beta-cell function from normal glucose tolerance to diabetes analyzed
Diabetes Pathogenesis - Findings advance knowledge in diabetes pathogenesis research
Diabetes Pathogenesis - Insulin deficiency downregulates heat shock protein 60 in diabetic myocardium
Diabetes Pathogenesis - Type 2 diabetes - A matter of beta-cell life and death?
Diabetes Therapy - Accommodating type 2 diabetes in the Chinese American family
Diabetes Therapy - Antigen-specific transduced T cells reverse type 1 diabetes in mice
Diabetes Therapy - Future diabetes drugs may target new protein interaction
Diabetes Therapy - Metformin/glibenclamide combination tablets used to treat type 2 diabetes
Diabetes Therapy - New findings in the area of diabetes therapy detailed
Diabetes Therapy - New orally active antidiabetic vanadyl complex developed
Diabetes Therapy - Oral antihyperglycemic therapy for type 2 diabetes reviewed
Diabetes Therapy - Parameters predictive of rosiglitazone efficacy type 2 diabetes reported
Diabetes Therapy - Synthesis of cholesterol increased in patients with type 2 diabetes
Diabetic Nephropathy - 12/15-Lipoxygenase inhibitors improve albuminuria in diabetic nephropathy
Diabetic Nephropathy - Data on oral endothelin A receptor treatment for diabetic nephropathy complete
Diabetic Nephropathy - Researchers report details of new studies and findings in the area of diabetic nephropathy
Diabetic Neuropathy - Diabetic neuropathy associated with changes in vanilloid receptor expression
Diabetic Neuropathy - Novel neurotrophic peptide developed
Diabetic Retinopathy - Aldose reductase inhibition counteracts oxidative stress in diabetes
Diagnostics - Ac-LDL uptake and CD16 segregate tumor macrophages from endothelial cells
Diagnostics - ELISA developed for detection of bromoxynil in water
Diagnostics - FDA grants clearance to market drug screens with acetaminophen
Diagnostics - Glycoproteomic analysis discovers markers for early HBV-related liver cancer
Diagnostics - Prognostic factor for newly diagnosed metastatic breast cancer published
Dialysis - Lowering dialysis bath temperature improves dialysis outcome in diabetes
Diet & Nutrition - Clinical weight loss programs placed in regional chain drug stores
Diet & Nutrition - Company contracts manufacture, production of nutraceutical products to Bactolac
Diet & Nutrition - Laboratory introduces dietary supplement for men to promote prostate health
Diet & Nutrition - New mixture inhibits DNA damage of ischemia-reperfusion F
Diet & Nutrition - Nutrition company reformulates line of acidophilus products
Disease Associations - ABCA2 polymorphism heralds a genetic risk for early-onset Alzheimer disease
Disease Associations - Amyloid precursor protein cleaving enzyme studied, up-regulation clarified
Disease Associations - Beta cell endoplasmic reticulum stress studied, role of cytokines documented
Disease Associations - Epigenetic regulation of gene expression studied, critical roles established
Disease Associations - Pancreatic stellate cell physiology studied, role of receptor revealed
Disease Associations - Schwann cell ATP secretion studied, response to uridine triphosphate revealed
Disease Associations - Therapy recommendations made for hypercalcemia and childhood cancer
Drug Delivery - DeltaG improves the oral bioavailability of some drugs in rats
Drug Delivery - HepDirect prodrugs guide therapy to liver cells
Drug Delivery - Positive results reported from study of disposable Vibex mini-needle
Drug Development - Active compstatin analogues with altered amino acids synthesized
Drug Development - Additional approvals for Aphthasol granted in Europe
Drug Development - Amevive appears to improve patients' psoriatic arthritis in phase II study
Drug Development - Amgen's osteoporosis treatment will become a blockbuster by 2013
Drug Development - Anti-FAPP monoclonal antibody inhibits pancreatic tumor growth in mice
Drug Development - Aplidin commences phase II clinical trials in prostate and bladder cancers
Drug Development - Asp f16 allergen shows promise for immunotherapy of Aspergillus infection
Drug Development - Average pharmaceutical sales force budget reaches $875M
Drug Development - Biologic advances reported in the treatment of psoriasis
Drug Development - Bone graft trial expanded to include New York hospital
Drug Development - CD33 expression influences gemtuzumab ozogamicin-based toxicity
Drug Development - Compound to treat exposure to terror weapons moves into preclinical development
Drug Development - Cubist Pharmaceuticals to purchase 2% reduction in Cubicin royalty rate
Drug Development - Data on cellular progression of chronic lymphocytic leukemia published
Drug Development - Drugs used to suspend tumor angiogenesis may treat proliferative synovitis
Drug Development - European approval granted for Omnex surgical sealant
Drug Development - FDA grants Fast Track designation for aerosolized Amikacin
Drug Development - FDA grants approvable letter for extended-release Glumetza for diabetes
Drug Development - FDA grants approval for protocol amendment to ARISE phase III trial
Drug Development - Further investment made in smallpox vaccine production
Drug Development - Ginkgolide structural features influencing anti-PAF activity identified
Drug Development - Hepatitis C trials to be initiated
Drug Development - In silico model of drug permeability and CYP inhibition developed
Drug Development - Initiatives in advancement of cell therapy product development announced
Drug Development - Multifunctional bactericidal injectable antibiotic discussed in publication
Drug Development - Partner pharma companies announce compound development nomination
Drug Development - Pharmaceutical company announces agreements with Tris Pharma
Drug Development - Promising results reported in depression research study
Drug Development - Pseudoephedrine controlled delivery technology trial initiated
Drug Development - Report assesses cardiovascular drug marketing
Drug Development - Report: Molecular-diagnostics a driving factor in theranostics
Drug Development - Results to be reported from STELLAR 3 trial of Xyotax
Drug Development - Study sought to lengthen action potential to increase activator calcium
Drug Development - Successful results reported in phase II trial of Teverelix in prostate cancer
Drug Development - Tentative FDA approval for conepezil hydrochloride to Ranbaxy Lab announced
Drug Development - Thiocolchicine dimers active against cisplatin-resistant ovarian tumor cells
Drug Development - Trileucine methyl vinyl sulfones with high trypanocidal activity synthesized
Drug Discovery - First simultaneous multimode ion source for mass spectrometry introduced
Drug Discovery - Interaction profiles improves identification of protein inhibitors
Drug Discovery - Scientists solve 3-D structures of PCNA complexes
Drug Discovery - Utility of hit-directed nearest-neighbor searching evaluated
Drug Importation - International drug sales rose 7% last year but pace of growth slowed
Drug Metabolism - Utility of hepatocyte cultures in prediction of intrinsic clearance evaluated
Drug Resistance - Drug resistance in Streptococcus pneumoniae isolates reported
Drug Resistance - Genotypic monitoring helps manage patients with drug-resistant hepatitis B
Drug Resistance - Medicinal honey used to treat wounds with antibiotic-resistant superbugs
Drug Resistance - Research may provide ways to inhibit cancer's ability to resist treatments
Drug Resistance - Some HIV patients at risk of exhausting treatment options
Drug Safety - Companies voluntarily suspend Tysabri for multiple sclerosis
Drug Safety - FDA advisory panel discussion points to Aleve
Drug Therapy - Spinal cord washout of volatile anesthetics compared to withdrawal from ethanol
Ebola Virus - Ebola glycoprotein toxicity mediated by dynamin-dependent pathway
Embryonic Stem Cell Research - Frozen-thawed embryos superior to fresh for embryonic stem cell establishment
Embryonic Stem Cell Research - Nine-day-old cultured human embryo yields clue to embryonic stem cell origins
Embryonic Stem Cell Research - Pluripotent stem cells generated from neonatal testis
Endocarditis - Treatment phase complete in the Cubicin endocarditis/bacteremia study
Endocrinology - Interleukin-12B gene polymorphisms are not linked to autoimmune thyroid disease
Endocrinology - NDA for human insulin-like hormone to treat IGF-1-caused short stature submitted
Endocrinology - New findings in endocrinology described
Endocrinology - Tamoxifen exerts agonistic effects on clusterin in cancer tumors and metastases
Endocrinology - XIAP gene transfer corrects the adverse effects of immunosuppressive therapy
Endometrial Hyperplasia - Anastrozole assessed as therapy in obese postmenopausal women
Endometriosis - Biopharmaceutical company announces positive endometriosis trial results
Environmental Pollution - Carcinogens in house dust can pose potential health risks
Enzymology - A key product of cytochrome p450 4A may regulate angiogenesis
Enzymology - Macrophage enzyme stimulates remodeling after thymic apoptosis
Epidemics - Outbreak frequency selection explains frequent infection via pathogen evolution
Epidemics Dynamics - Actual reproduction number adds to understanding of epidemic dynamics
Epidermolysis Bullosa - Next stage of clinical trial for treatment of epidermolysis bullosa underway
Epilepsy - Lamotrigine doesn't appear to impact bone turnover in young women with epilepsy
Epstein-Barr Virus - Real-time Q-PCR distinguishes disease-associated EBV from incidental virus
Erectile Dysfunction - Apomorphine has limited use for erectile dysfunction therapy in diabetic men
Erectile Dysfunction - online men's sexual health referral network launched by pharma company
Erosive Gastroesophageal Reflux Disease - Pharmaceutical companies team up to promote XIFAXAN
Estradiol - Multidrug resistance protein studied, role in transport revealed
Extracorporeal Circulation - If perfusion is not maintained in CPB, heparin circuit gives no added benefit
Finance - Aeterna Zentaris subsidiary files preliminary prospectus for IPO
Finance - Biopharma announces 2004 fourth quarter, year-end financial results
Finance - Biopharmaceutical company reports fourth quarter, year-end financial results
Finance - Biopharmaceutical firm reports loss of $1.28 per share
Finance - Biopharmaceutical firm secures $2.5M financing
Finance - Biotech company announces payment, additional put right for notes
Finance - Biotech company reports $50M financing
Finance - Biotech company reports fourth quarter net loss of $14.3M
Finance - Biotech company reports loss of $0.38 per share
Finance - Biotech company reports loss of $0.48 per share
Finance - Biotech company reports on repurchase of notes due 2032
Finance - Biotech firm announces $4.1M financing
Finance - Biotech firm reports 42% increase in revenue
Finance - Cancer-focused biopharmaceutical company reports Q4, year end financial results
Finance - Development-stage company adds to private placement of shares
Finance - Drug delivery company reports 14% decrease in sales
Finance - Drug discovery company reports 2004 financial results
Finance - Drug discovery firm reports 11% decrease in fourth quarter revenue
Finance - Drug discovery firm reports second interim results
Finance - Drug-delivery company reports full-year 2004 sales growth of 50%
Finance - Drug-discovery firm reports record profit from operations
Finance - ECO-4601 developer enters into bought-deal private placment to raise $9M
Finance - Genetic personalization company closes third round of financing for $8.2 million
Finance - Genetics-focused biopharmaceutical company announces full-year 2004 results
Finance - Gliadel maker reports net loss of $87.9 million for 2004
Finance - Healthcare products provider reports Q4 net sales up 26% to $1.2B
Finance - Imaging systems maker reports 4th quarter and full year 2004 financial results
Finance - Lab chip maker reports 13% increase in revenue
Finance - Lab research animal breeder, supplier reports strong fourth quarter
Finance - Laser developer reports record revenues and earnings for Q4 and full year 2004
Finance - Maker of drug eluting stent systems announces $25 million C round financing
Finance - Medical company announces fourth-quarter and year-end financial results
Finance - Medical device company closes $7 million financing
Finance - Medical market intelligence company announces series C funding
Finance - Medical waste firm completes $4.5M equity financing
Finance - Multiple sclerosis drug maker reports loss of $0.24 per share
Finance - Neuroscience firm completes $1.5M private placement
Finance - Newborn health company reports 10% increase in fourth quarter revenue
Finance - Online drug company annnounces private equity financing
Finance - PBM company reports strong fourth-quarter earnings
Finance - Pharmaceutical company announces 2004 financial results
Finance - Pharmaceutical company announces filing of ninth ANDA with U.S.FDA
Finance - Pharmaceutical company announces fourth quarter, year-end 2004 financial results
Finance - Pharmaceutical company completes $25M financing
Finance - Pharmaceutical company reports 2004 4th quarter and year end financial results
Finance - Pharmaceutical company reports 4th quarter and year end 2004 financial results
Finance - Pharmaceutical company reports fourth quarter results
Finance - Pharmaceutical company reports loss of $7.3M
Finance - Pharmaceutical firm completes $1M financing
Finance - Pharmaceutical firm completes $23.9M registered direct offering of stock
Finance - Pharmaceutical firm donates $3M for facility at University of Manitoba
Finance - Pharmaceutical firm reports loss of $0.05 per share
Finance - Pharmaceutical firm reports loss of $0.34 per share
Finance - Pharmaceutical firm reports loss of $0.62 per share
Finance - Pharmaceutical firm reports loss of $1.67 per share for FY2004
Finance - Pharmaceutical firm reports loss of $3.11 per share
Finance - Pharmaceutical firm reports net sales of $12.6M
Finance - Prolieve maker reports revenue of $1.4 million for fourth quarter
Finance - Specialty pharmaceutical company announces reverse stock split
Finance - Specialty pharmaceutical company reports third quarter financial results
Financing - Research organization receives grant to research cancer cell lines
Food Safety - Antimicrobial solution effective against 'Campylobacter jejuni,' company says
Food-Borne Pathogen - Street vended food poses risk of Salmonella and E. coli infection
Fungi Toxin - Molecular aspects determined for fungi toxin
Gastric Cancer - CDX2 methylation correlates with less intake of green tea/cruciferous vegetables
Gastroenterology - Gene therapy enables radioiodine therapy to target colon cancer
Gastroenterology - Researchers report details of new studies and findings in the area of gastroenterology
Gastropathy - Current approaches to prevent NSAID-induced gastropathy outlined
Gene Delivery - Biomaterial-based gene delivery multiplies bioengineering possibilities
Gene Delivery - Chitosan chain length governs the efficacy of polyplex-based gene transfer
Gene Expression - Steroidogenic factor-1 analyzed, role in stimulation of CYP1B1 revealed
Gene Research - Provider of tools for genomics research places 4 molecule analyzers at U.S. labs
Gene Silencing - Electrically mediated short interfering RNA delivery transduces murine muscles
Gene Transfer - pDNA loaded calcium phosphate nanoparticles have high transfection efficiencies
Generic Drugs - FDA gives tentative approval to market donepezil hydrochloride tablets
Generic Drugs - Medical company aligns with major health plans to promote generic medications
Genetic Disorders - Company receives nonapprovable letter for panic disorder indication for Lexapro
Genotoxicity - Genotoxicity of ambient outdoor air due to hundreds of identified compounds
Green Tea Extract - Catechin extracts from green tea promotes tumor cell survival pathways
HIV Prevention - Company announces 50% enrollment in phase III HIV prevention trial in Ghana
HIV Research - Data on investigational HIV compounds presented at CROI
HIV/AIDS - Antibody that neutralizes most HIV strains described
HIV/AIDS - Data comparing Viread vs. Abacavir presented at meeting
HIV/AIDS - Data presented on HIV drug candidate indicates no development of resistance
HIV/AIDS Coinfection - HIV coinfection facilitates the natural history of sexually transmitted diseases
HIV/AIDS Diagnostics - Dermatological symptoms can be first sign of asymptomatic HIV infection
HIV/AIDS Drug Adherence - Good HAART adherence associated with better rates of viral suppression
HIV/AIDS Drug Development - Computational approach predicts drug anti-HIV activity
HIV/AIDS Pathogenesis - Mathematical models study interaction between immune system and HIV
HIV/AIDS Pathogenesis - Studies advance knowledge in HIV/AIDS pathogenesis research
HIV/AIDS Prevention - Studies of the social context of microbicide use to prevent STDs inadequate
HIV/AIDS Research - Cyclo-oxygenase-2 inhibitors restore immune function in retroviral infections
HIV/AIDS Research - HIV-HCV coinfection should be treated with pegylated interferon combination
HIV/AIDS Research - PRO 2000 shown to inhibit HIV and herpes simplex virus
HIV/AIDS Research - Pharma company announces HIV drug candidate trial results
HIV/AIDS Research - Phase 1 trial results for HIV treatment announced
HIV/AIDS Research - Reports advance knowledge in HIV/AIDS research
HIV/AIDS Research - Study of AIDS-blocking pill progressing
HIV/AIDS Testing - Utility of virologic assays in HIV management discussed iat conference
HIV/AIDS Therapy - Antifungal peptide inhibits leukemia proliferation and HIV-1-RT activity
HIV/AIDS Therapy - BioScience company announces data from HIV treatment program
HIV/AIDS Therapy - Study examines lessons learned at Africa's first public antiretroviral clinic
HIV/AIDS Therapy - Variable molecular structures contribute to protease inhibitor resistance
HIV/AIDS Vaccine - DermaVir is a new topical vaccine for HIV/AIDS
HIV/AIDS Vaccine - E-communications company teams with U2's Bono to combat AIDS, poverty in Africa
HIV/AIDS Vaccine - Experiences of men who have sex with men with risk counseling reported
HIV/AIDS Vaccine - HIV genomic RNA sequences in female genital tract and blood reported
HIV/AIDS Vaccine - Innate immunity in experimental SIV infection and vaccination explored
HIV/AIDS Vaccines - Researchers' data advance HIV/AIDS vaccines research
HIV/AIDS-Associated Disorder - Acquired rectal fistula may be sign of HIV infection in children
HIV/AIDS-Associated Virus - CNS DNA/RNA virus types depend on whether immunocompetent or immunocompromised
Haemophilus Vaccine - Method to predict interference in combined Hib/DTaP vaccines developed
Hantavirus - Trafficking of Andes and Sin Nombre hantavirus glycoproteins outlined
Hantavirus Vaccine - Viremia delayed in immunized macaques challenged with hantavirus
Head & Neck Cancer - Antisense oligonucleotides stop osteopontin activity in oral cancer cells
Head & Neck Cancer - Immunoenhanced enteral nutrition improved IL-6 and CRP levels
Head & Neck Cancer - Raltitrexed showed potential as alternative to cisplatin-containing chemotherapy
Head & Neck Cancer - Successful treatment of unresectable CPC in a patient with Li-Fraumeni syndrome
Health Promotion - Added calcium winds up in the trash, not the glass
Healthcare Costs - American Kidney Fund teams with biotech firm for Renagel assistance plan
Healthcare Coverage - Disney World's largest union group asks for free pharmacy
Healthcare Coverage - Drug store chain launches senior card program
Healthcare Coverage - Marketing company to give away million dollars in pharmacy discount memberships
Heart Disease - Diagnostics company provides update on ARISE clinical trial
Heart Failure - Company announces selection of heart failure drug-development candidate
Heart Failure - Program urges action in the fight against heart failure
Heart Failure - Studies have raised apoptosis to a clinical target
Helicobacter Pylori - H. pylori polymorphism differs between African and Caucasian Americans
Hematology - Angiogenesis is a major element of myelodysplastic syndrome progression
Hematology - New research in the area of hematology detailed
Hematology - Strong momentum reported for Advate in Europe
Hematopoiesis - M-CSF essential for proliferation/differentiation of BM-derived stromal cells
Hepatitis B Therapy - Short hairpin RNA clears hepatitis B virus from murine livers
Hepatitis C Therapy - FDA approves drug combination as first hepatitis C treatment for HIV patients
Hepatitis C Virus - Obtaining maximum information about hepatitis C quasispecies discussed
Hepatitis C Virus Therapy - Peginterferon alfa-2a may aid HCV-positive liver transplant recipients
Hippocalcin - Neuronal degeneration studied, hippocalcin protection shown
Hormone Replacement Therapy - Progesterone in combined HRT increases sensitivity to a neurosteroid
Human Herpesvirus-8 Infection - Sociological risk factors determined for HHV8 infection in cancer patients
Human Papillomavirus - Subsequent HPV risk in HIV+ women not lowered by natural infection
Human Papillomavirus Vaccines - Findings in human papillomavirus vaccines provide new insights
Hypercholesterolemia - High doses of statins help heart patients
Hypertension - Monitoring of albuminuria should be part of management of hypertension
Hypertension - Researchers publish new studies and findings in the area of hypertension
Hypertension - Selective COX-2 inhibitors studied, role in renal injury clarified
Hypertension - U.S. FDA extends PDUFA action date for Nebivolol tablets
IMPAX Laboratories - Pharmaceutical company launches oxycodone hydrochloride 80 mg tablets
Imaging - Dobutamine CMR is safe, feasible in patients with suspected myocardial ischemia
Imaging - New imaging technique for diagnosis and treatment of heart failure demonstrated
Immunology - Macrophage chemotaxis studied, immunoregulatory role evident
Immunology - TBT's immunotoxic effects on natural killer cells reversed by interleukin 2
Immunotherapy - Cobra inks deal to supply trial material for TNFa Kinoid
Immunotherapy - Technology yields novel immunotherapeutic protein platform
Infections - Bartonella henselae secretion studied, role of bipartite signal shown
Infectious Disease - New drugs for bad bugs: new approach could bolster antibiotic arsenal
Infectious Diseases - Data demonstrate therapeutic benefit of expanded myeloid progenitors
Infertility - Most couples who have problems getting pregnant do not get treatment
Inflammation - Endothelial nitric oxide synthase activation studied, inflammation role shown
Inflammation - Ozone-induced lung inflammation studied, role of Cat's claw extract revealed
Inflammatory Bowel Disease - New treatment offers hope for Crohn, ulcerative colitis
Influenza - World poorly prepared for next influenza pandemic, scientists warn
Influenza Vaccine - Economic analysis of annual influenza vaccination of children reported
Influenza Vaccine - Epitope analysis for influenza vaccine design reported
Influenza Vaccine - Fluvirin vaccine license reinstated by U.K. regulatory agency
Information Technology - Company awarded NIH grant to develop antimicrobial database
Information Technology - Improvements due to implementing automation system shown in pharmacy study
Information Technology - New cardiotoxicity-related database launched
Information Technology - Online healthcare network launches pay per click subsidiary
Information Technology - Partnership formed to expand global data management capabilities
Information Technology - Pharmaceutical firm selects Medicaid claims processing software
Information Technology - Practice development tool provider introduces Spanish language articles
Injury Response - Mitochondrial Ca2+ is modulator of myocardial dysfunction in injury
Insomnia - Insomnia efficacy study for OX 22 completed
Insulin - Long-acting insulin analog developed using albumin fusion technology
Insulin Delivery - Insulin-chitosan complex nanoparticles developed for oral administration
Insulin Resistance - Acid-base balance influence risk for insulin resistance syndrome
Insulin Resistance - Diacylglycerol may mediate association between PAI-1 and insulin resistance
Ischemia - Ultrasonic tissue characterization provides sensitive detection of ischemia
Kidney Disease - Company issued U.S. patent covering methods for treating chronic kidney disease
Kidney Disease - Published report shows BMP-7 prevents disorders associated with kidney disease
Lab Productivity - Service launched for labs to improve productivity, reduce costs
Lead Poisoning - Lead isotopic measurements in feces match levels in household dust
Legal Issues - Doctor appeals conviction in drugs-for-sex case
Legal Issues - Federal court orders dismissal of shareholder lawsuit against drugmaker
Legal Issues - Methamphetamine bill would set 3-pack monthly max for certain cold remedies
Leishmaniasis Vaccine - Leishmania membrane proteins are prophylactic against leishmaniasis
Leishmaniasis Vaccine - Drug-sensitive Leishmania vaccine developed
Leptin Studies - Clinical features linked to soluble leptin receptor in diabetes reported
Leptospirosis Outbreaks - Morbidity/mortality decreased among children pre-exposed to leptospires
Leukemia - Cytarabine-induced fever complicated the clinical course of leukemia
Leukemia - Expression of CXCR5 enhanced resistance to apoptosis in CD8+CD34+ T cells
Limb Ischemia - Angioplasty safe and effective for treating limb ischemia in diabetes
Lipoxygenase - Fungal manganese lipoxygenase studied, role of putative metal ligands clarified
Listeria Monocytogenes - Low prevalence of Listeria monocytogenes in humans
Liver Cancer - Chemoembolization of large hepatocellular carcinoma was ineffectual
Liver Cancer - Id protein levels rise in differentiated human hepatocellular carcinoma
Liver Cancer - Researchers detail new studies and findings in the area of liver cancer
Lung Cancer - CP + VNR doublet shown as favored treatment in advanced lung cancer
Lung Cancer - Physical activity may reduce lung cancer risk among those with high exposure
Lung Cancer - The future of rexinoids in non-small cell lung cancer emerges
Lung Cancer - Trials of paclitaxel and carboplatin therapy matched results from prior reports
Lupus - Monoclonal anti-idiotype to anti-ribosomal P antibodies developed
Lymphedema - Lower limb lymphedema linked to radiation-induced constrictive pericarditis
Lymphoma - Company initiates pivotal trial with FK228 in cutaneous t-cell lymphoma
MMR Vaccine - Policies on MMR vaccinations must balance freedoms and responsibilities
MMR Vaccine - Respiratory delivery of MMR vaccine more immunogenic than injection
Malaria - Biotechnology corporation to sponsor antimalarial study
Malaria - Researchers publish new studies and findings in the area of malaria
Malaria Diagnosis - Nucleic acid sequence amplification better than PCR to quantify malaria
Malaria Infection - Plasmodium protein proteolytically processed during cell invasion
Malaria Vaccine - Plasmodium merozoite surface protein protects against malaria
Malaria Vaccine - Allele specificity of antibody responses against P. falciparum outlined
Malaria Vaccine - Parasite growth rates measured in volunteers challenged with malaria
Malaria Vaccine - Vaccines with DNA and viral vectors possess differential immunogenicity
Malaria Vaccines - Researchers report details of new studies and findings in the area of malaria vaccines
Malignant Gliomas - FDA clears phase I/II recurrent malignant gliomas clinical trial
Marketing - DTC spend soars, as consumers find ads increasingly believable and likeable
Marketing - Early stage pharmaceutical marketing budgets exceed $20 million
Marketing - Report: Communicate trial results to better manage customer expectations
Measles Epidemiology - Measles virus isolated in Croatia during outbreak characterized
Medicare - Ovations informs Medicare agency it will participate in Part D
Melanoma - Decreased Apaf-1 expression with melanoma progression may up chemo resistance
Melanoma Vaccine - Mimotope immunization elicits specific antibody response to Mel-CAM
Meningitis Vaccine - Antibodies to polysaccharide of Neisseria meningitidis analyzed
Meningococcal Vaccine - Meningococcal polysaccharide-protein conjugate vaccines reviewed
Mental Health - California university seeks volunteers for study of drug for mild depression
Mental Health - Minnesota researchers find promising results for VNS therapy in bulimia patients
Mergers & Acquisitions - Biotech company provides update on sale of subsidiary
Mergers & Acquisitions - Biotech firm sells Milton Pharmaceuticals
Mergers & Acquisitions - Companies discuss proposed acquisition of IMPAC
Mergers & Acquisitions - Cytyc Corp. acquisition clears antitrust review
Mergers & Acquisitions - Definitive agreement signed for CyVera Corporation acquisition
Mergers & Acquisitions - Discovery Partners inks binding letter of intent to acquire German company
Mergers & Acquisitions - Majority control of TherapyEdge acquired
Mergers & Acquisitions - Pharmaceutical companies terminate merger agreement
Mergers & Acquisitions - Pharmaceutical company completes acquisition of Xcel Pharmaceuticals
Mergers & Acquisitions - Sales and marketing services company announces pharma company agreement details
Mesothelioma Vaccine - Fowlpox vector expressing proteins is active against mesothelioma
Metabolic Syndrome - Metabolic syndrome examined in Chinese, Malays, and Asian Indians
Metabolic Syndrome - Short-term very-low-carbohydrate diets improve metabolic abnormalities
Multidrug Resistance Gene - Linkage disequilibrium/haplotype architecture determined for ABCC1 & ABCG2 genes
Multiple Sclerosis - Multiple sclerosis microarray studies with RPI-78M analysis completed
Multiple Sclerosis Vaccine - Phase 2 study on safety, dosing of vaccine for multiple sclerosis announced
Myeloid Leukemia Vaccine - Chronic myeloid leukemia vaccine improves molecular remission rate, data show
Myocardial Infarction - Emergency clopidogrel could save thousands of lives
Myocardial Infarction - Studies report big advance in heart attack care
Myocardial Infarction - VEGF165 and angiopoietin-1 protect the ischemic heart
Natural Products - Company acquires license for edible sponges
Neisseria meningitides - Repetitive-PCR distinguishes N. meningitidis outbreak-related strains
Neural Stem Cell Research - SDF-1alpha/CXC4 pathway directs neural stem cell migration to CNS injury sites
Neurogenesis - Several factors influence the physiological neurogenesis process
Neurology - Neuronal development examined, concomitant protein translocation revealed
Neurology - Redox regulation of neuronal differentiation studied, role of TrkA revealed
Neuropharmacology - Effects of PCP on benzodiazepine binding determined in rat brain
Neuroscience - G protein regulation studied, effects on adenylyl cyclase tolerance clarified
Neuroscience - Grants awarded for neurodegenerative disease program
Neuroscience - Intramedullary contact generates angiogenesis in rabbit tibia
Neuroscience - Research in neuroscience provides new insights
Newcastle Disease Vaccine - Immunogenicity of Newcastle disease vaccines in chickens compared
Non-Hodgkin Lymphoma - Patient enrollment completed for HGS-ETR1 phase II trial in non-Hodgkin lymphoma
Obesity - High-fat diet alters homeostatic regulation of energy balance
Obesity - Obesity increases risk for metabolic and cardiovascular disease
Obesity - Therapeutic targets for obesity-associated diabetes based on inflammation link
Obesity and Diabetes - Associations among diabetes, obesity, and the brain reviewed
Obesity and Diabetes - Growth hormone overexpression results in obesity plus insulin resistance
Obesity and Diabetes - Insulin delivery to muscles delayed after oral glucose load in obese subjects
Obesity and Diabetes - Studies add new findings to obesity and diabetes body of knowledge
Obesity and Diabetes - Subsarcolemmal mitochondria deficiency found in obesity and type 2 diabetes
Obstetrics - Estrogen-dependent factors rule placental angiogenesis throughout gestation
Obstetrics - Fetal monitoring device predicts labor 1-2 weeks in advance in healthy women
Obstetrics - Poor prenatal nutrition permanently damages cells in the pancreas
Oncogenesis - Cancer, type 2 diabetes, and aging reviewed
Oncogenesis - The deleted in esophageal cancer 1 gene may be involved in cancer suppression
Oncology - Activin A amplification improves survival odds for neuroblastoma patients
Oncology - Adenovirus-mediated caspase-8 gene transfer sensitizes cancer to TRAIL
Oncology - Combined use of EGFR and mTOR inhibitors diminishes glioblastoma growth
Oncology - Data advance knowledge in oncology research
Oncology - Enzyme inhibitors augment sulindac sulfide in colon cancer cells
Oncology - Ep-CAM-specific monoclonal antibody MT201 slashes breast cancer cell growth
Oncology - European cancer centers form European Consortium for Research in IORT Studies
Oncology - Hepatitis B virus X protein may play a role in liver cancer formation
Oncology - Melanoma cells require interleukin-18 to produce stem cell factor
Oncology - Promoter-driven apoptin expression impedes small-cell lung cancer growth
Oncology - Tamoxifen-resistant breast cancer cells harbor distinct genetic changes
Orthopedic Surgery - Study shows surgical treatment of hip or knee arthritis does not reduce obesity
Osteoarthritis - Combination gene therapy heals cartilage
Osteoporosis - Effective doses of ibandronate don't alter vascular calcification
Osteoporosis - Strontium ranelate optimizes bone formation and resorption
Osteoporosis - Strontium ranelate reduces vertebral fracture incidence in postmenopausal women
Osteoporosis - Survey shows women fear losing independence from osteoporosis, doctors disagree
Ovarian Cancer - Drug that hinders blood vessel growth under study in ovarian cancer
Pain Management - Florida coalition to advocate for better pain management
Pain Medicine - Assay facilitates primary hyperalgesia assessment in rat deep somatic tissue
Pain Medicine - D3 receptor stimulation promotes proliferation of post-natal SVZ-derived cells
Pain Medicine - N-methyl-D-aspartate receptor regulates morphine tolerance and nociception
Pancreatic Beta Cells - Proliferation of pancreatic duct cells mediated by MEK/ERK cascade
Pancreatic Cancer - Pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis
Pancreatic Cancer - Trial of 2 drugs in chemotherapy-naive pancreatic cancer patients initiated
Pancreatic Cancer Therapy - Molecular mechanisms of 5-aza-2'-deoxycytidine determined
Pancreatic Cancer Vaccine - MUC1 vaccine with SB-AS2 adjuvant is safe in pancreatic cancer patients
Panic Disorder - Cognitive behavioral therapy, medication effective treatments for panic
Patents - Stem cell company, foundation report U.S. patent office rejected all claims
Pediatric Glioma - Oncoscience AG reports response rate of 35.3% in pediatric glioma trials
Pediatric Oncology - Neuroblastoma xenografts reproduce human tumor characteristics
Pediatric Vaccines - Cost of child immunization services in urban Bangladesh reported
Peptide Receptor - Anchor profiles of HLA-specific peptides presented
Personnel - Anticancer drug development company appoints scientific advisory board
Personnel - August J. Moretti joins biotech company as senior VP and CFO
Personnel - Bert Chenard appointed senior VP at pharmaceutical firm
Personnel - Biopharmaceutical company appoints senior VP, medical affairs
Personnel - Biopharmaceutical company appoints vice president
Personnel - Biopharmaceutical firm appoints new members to its scientific advisory board
Personnel - Biopharmaceutical firm creates corporate advisory board
Personnel - Biopharmaceutical firm expands drug discovery, development teams
Personnel - Biotech company appoints Patrick Mooney as chairman of the board
Personnel - Biotech company appoints new executives for European operations
Personnel - Clinical trial adds member to scientific board
Personnel - Corgentech appoints Dorian Rinella vice president of human resources
Personnel - Donald N. Halbert, PhD, named executive VP of research and development
Personnel - Dr. Steven St. Peter joins supervisory board of siRNA company
Personnel - Drug delivery company CEO appointed to board of directors
Personnel - Drug delivery firm reports changes to the board
Personnel - Drug development company appoints nonexecutive director
Personnel - Drug discovery firm names new chief scientific officer
Personnel - Former U.S. FDA chief counsel Peter Barton Hutt nominated to company board
Personnel - International biotechnology company appoints new CEO
Personnel - John Televantos, PhD, joins chemical company's board of directors
Personnel - Joseph A. Schlitz named VP of sales at pharmaceutical company
Personnel - Joseph L. Farmer named general counsel at pharmaceutical calls
Personnel - Med-eMonitor System developer announces new board of directors members
Personnel - Medical IT company appoints vice president & chief scientific officer
Personnel - Medical food and nutraceuticals company adds to board of directors
Personnel - Pharma company appoints new vice president
Personnel - Pharmaceutical company announces 4 promotions, 4 additions to management team
Personnel - Pharmaceutical company announces new member of board of directors
Personnel - Pharmaceutical company appoints VP of Finance
Personnel - Pharmaceutical company appoints chief financial officer
Personnel - Pharmaceutical company appoints director of research & development
Personnel - Pharmaceutical company appoints new CEO
Personnel - Pharmaceutical company expands management team
Personnel - Pharmaceutical company names David Poorvin, PhD, to board; announces new hires
Personnel - Pharmaceutical company names chief medical officer
Personnel - Pharmaceutical company names new members of board of directors, appoints chair
Personnel - Pharmaceutical executive elected to California Healthcare Institute board
Personnel - Stem cell company names chief medical officer and VP of clinical research
Personnel - Technology company appoints new president and chief executive officer
Personnel - West Coast drug store company announces changes at executive level
Pharmaceutical Research - American drug companies out of sync with public opinion
Pharmaceutical Research - Biopharmaceutical contract manufacturing examined in report
Pharmaceutical Research - CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
Pharmaceutical Research - Scientists' findings show regulation of immune cell memory
Pharmaceutical Research - Serum-free Hybri-CYTE added to firm's portfolio of cell culture products
Pharmaceuticals - GlaxoSmithKline says financial impact of drug seizures still uncertain
Pharmaceuticals - High doses of cholesterol drugs can help people with heart disease
Pharmaceuticals - Letter cites lack of medications at territorial hospital
Pharmaceuticals - U.K. group supports plans to allow nurses, pharmacists to prescribe medicines
Pharmacology - Photolysis of caged drug enables control of NO output in cell culture
Pharmacology - Prolonged exposure to allosteric modulators heightens M2 mAChR expression
Physiology - Corticotropin-releasing factor receptor studied, effects of cocaine revealed
Physiology - Data advance knowledge in physiology research
Pneumococcal Vaccine - Pneumococcal polysaccharide mimotope induces protective response
Pneumococcal Vaccines - Research add new data to pneumococcal vaccines body of knowledge
Polio Vaccine - Immunization schedules affect excretion of polio vaccine strains
Polio Vaccine - Seroprevalence of poliovirus antibody in northern Greece reported
Polycystic Ovary Syndrome - Rosiglitazone improves insulin resistance in obese women with PCOS
Porcine Epidemic Diarrhea Virus - Competitive blocking ELISA detects porcine epidemic diarrhea virus in feces
Premenstrual Syndrome - OCs containing drospirenone more effective on PMS symptoms than levonorgestrel
Prion Disease - Trapping prion protein in endoplasmic reticulum impairs maturation
Probiotics - Guidelines are important in developing and using probiotics
Product Labeling - Labeling revision for cholesterol-reducing statin approved by U.S. FDA
Product Licensing - Companies announce peptide license agreement for new line of skin care products
Product Licensing - Licensing agreement signed for Miyarisan's oral therapeutic drug product
Product Licensing - Marketing agreement for non-antibiotic generic formulations forged
Product Licensing - Serono licenses the Rosetta Resolver system for gene expression analysis
Prostate Cancer - Epigenetic changes in prostate cancer reviewed
Prostate Cancer - HPV DNA found in prostate tissue suggests role in prostate cancer
Prostate Cancer - Paclitaxel and epirubicin treatment showed potential as prostate cancer therapy
Prostate Cancer - Phase 3 data on satraplatin as chemotherapy for prostate cancer published
Prostate Cancer - Some rights to implant to treat prostate cancer in Asia-Pacific out licensed
Prostate Cancer - Sosei files Japan marketing authorization application for prostate cancer drug
Prostate Cancer - Three-dimensional TRUS gave better results than 2-D imaging for prostate cancer
Prostate Cancer - Transcriptional response to bicalutamide treatment characterized
Protein Conformation - Estrogen receptor studied, pesticide-induced conformational state revealed
Protein Signals - Chronic hyperalgesic priming examined, role of two pathways revealed
Proteomics - Angiostatin staunches inflammation by suppressing leukocyte recruitment
Proteomics - Brain amyloid beta protein level analyzed, antibody effect revealed
Proteomics - Chinese hamster ovary cells produce recombinant human angiopoietin-2
Proteomics - Endostatin does not require heparan to bind to vascular targets
Proteomics - Endostatin obstructs angiogenesis on several levels
Proteomics - New findings in the area of proteomics detailed
Proteomics - New laser technology launched for proteomics research
Proteomics - Trace fear conditioning studied, role of events in dorsal hippocampus clarified
Pseudomonas Aeruginosa - Multilocus sequence typing used for genetic analysis of P. aeruginosa
Pulmonary Medicine - CXCL11 hinders bleomycin-induced lung fibrosis by altering vessel remodeling
Pulmonary Medicine - Electroporation enables therapeutic genes to clear lung fluid
Quality Assurance - Hospital association recommends policy changes to ensure patient safety
RNA Research - Data presented on RNAi therapeutics for age-related macular degeneration
RNA Research - Data published on short-interfering RNAs
Rabies Vaccine - Rabies prophylaxis in malnourished children provides protection
Receptor Kinase - Adrenergic receptor down-regulation studied, role of receptor kinase revealed
Reperfusion - Na+-dependent chloride transporter examined, role in cerebral ischemia shown
Research Equipment - Analytical instrument company displays solutions at conference
Respiratory Medicine - Asthma affects major cities in California
Respiratory Syncytial Virus - Research company expands distribution for monoclonal antibodies against RSV
Restenosis - Perivascular gene transfer staunches angioplasty-induced neointima formation
Retinoic Acid - Enhancer polymorphism decreases binding and responsiveness to retinoic acid
Retinopathy - Tumor necrosis factor-alpha inhibition mitigates retinal pathology
Rheumatoid Arthritis - Biotech company announces phase 2 study of rheumatoid arthritis treatment
Rheumatology - The COX-2 inhibitor DFU regulates VEGF expression in rheumatoid synovial cells
Rotavirus Vaccine - Distribution of rotavirus serotypes has implications for vaccines
SARS - Multiple factors increase risk of developing SARS in health care workers
SARS - Researchers publish new studies and findings in the area of SARS
SARS Coronavirus - SARS coronavirus detected in lungs by RT-PCR following death from SARS
SARS Coronavirus - SARS coronavirus more stable than human coronavirus HcoV-229E in lab conditions
Salmonella Vaccine - Overexpression of Salmonella proteins induces CD4 and CD8 T cells
Salmonellosis Outbreak - Salmonellosis outbreak associated with rare phage type of S. enteritidis
Sexually Transmitted Infection - Exploring sexual networks yields insights into sexually transmitted infections
Sexually Transmitted Infection - Presumptive periodic treatment an ineffective anti-HIV strategy in sex workers
Smallpox Vaccine - Neutralizing anti-vaccinia antibodies titration method standardized
Smallpox Vaccine - Poxvirus CD8+ T cell determinants aid smallpox vaccine design
Smoking Cessation - New drugs may help you quit smoking
Smooth Muscles - Endothelin-1 analyzed, effect on channels in arterial smooth muscle cells found
Stem Cell Banking - Company applies for cryogenic stem cell bank certification in California
Stem Cell Research - Biology of stem cells not fully understood
Stem Cell Research - Embryonic cells retain pluripotent potential after Sendai virus transfection
Stem Cell Research - High affinity leptin receptors found in MSCs from control & osteoporotic donors
Stem Cell Research - Intermediate-type stem cells may be instrumental in tumor genesis and growth
Stem Cell Research - Molecular pathways regulating HSC self-renewal not fully understood
Stem Cell Transplantation - Amniotic-membrane and limbic stem cell transplantation treats ocular burns
Stomach Cancer - Allelic distribution of STRs correlates with different gastrointestinal tumors
Streptococcal Meningitis - Protein synthesis-inhibiting antimicrobial agents are neuroprotective
Streptococcus Vaccine - C-polysaccharide in Streptococcus pneumoniae vaccines characterized
Streptococcus Vaccine - Immunity to Streptococcus pneumoniae mediated by MyD88
Streptococcus Vaccines - Studies add new findings to streptococcus vaccines body of knowledge
Stroke - Aspirin prevents strokes in women
Stroke - CREST trial for carotid artery disease therapy is expanded
Stroke - Journal publishes results of acute intracerebral hemorrhage trial
Stroke - Women's Health Study: Low-dose aspirin lowers stroke risk among older women
Syphilis - Syphilis rates increasing around the world
Syphilis Epidemic - Syphilis epidemics in U.S. have unforced oscillations every 8-11 years
Systemic Sclerosis - Vitamin E treatment not effective in clinical trial
Tapasin - Tapasin examined, role of charged amino acid in MHC function shown
Tendonitis - Plasma-based treatment for tendonitis shows promise, Standford researcher says
Theileriosis Vaccine - Timing of live theileriosis vaccine is critical for efficacy
Thermal Hyperalgesia - Activation of p38 MAPK studied, thermal hyperalgesia activity
Thrombosis - Danaparoid is safe for pregnant women with heparin intolerance
Thyroid Cancer - Company gets European marketing approval of Thyrogen for thyroid tissue ablation
Tissue Engineering - Cardiac cells self organize into contractile 3-dimensional cardiac tissue
Tissue Engineering - Extracellular matrix component distribution of engineered cartilage determined
Tissue Engineering - Surgisis collagen mesh useful alternative for tissue replacement in pediatrics
Tissue Engineering - Synchronous contractions induced in cardiac tissue engineered constructs
Toxicology - Researchers' data advance toxicology research
Toxoplasma Gondii - Anti-Toxoplasma gondii antibodies detected in patients with neoplasia
Transdermal Drug Delivery - Efficacy of topical emedastine formulations evaluated
Transfusions - Prior transfusions in cancer patients increased risk of subsequent transfusions
Transplant Medicine - Researchers' findings advance transplant medicine research
Transplant Vascular Disease - Review describes aspects of transplant vascular disease and myogenic tone
Tuberculosis - Structure of M. tuberculosis thymidylate kinase complex determined
Tuberculosis Vaccine - Early BCG vaccination elicits adult-like immune response in calves
Tuberculosis Vaccines - New research in the area of tuberculosis vaccines detailed
Tumors - RGS-5 is activated in pericytes during active vessel remodeling
Type 1 Diabetes - New drug application filed for inhaled human insulin powder
Type 2 Diabetes - Aspirin prevents platelet activation resulting from acute hyperglycemia
Type 2 Diabetes - Phase 1 clinical trial for type 2 diabetes treatment results announced
Umbilical Cord Blood - Cord blood banking regulated in the EU to assure safety/efficacy
Umbilical Cord Blood - Cord stem cells may replace embryonic stem cells for tissue therapy in future
Vaccinations - Study says a worrisome number of U.S. children get their shots late
Vaccine Adjuvant - Natural endogenous adjuvants reviewed
Vaccine Adjuvant - Subcutaneous injection of IL-12 induces systemic inflammatory responses
Vaccine Development - IL-15-independent antiviral function of CD8+ T cells outlined
Vaccine Development - In vivo induced antigen technology reviewed
Vaccine Development - Oral vaccination with biodegradable particulates reviewed
Vaccine Development - Vaccination practices in U.S. emergency departments reviewed
Vaccine Safety - Pediatric vaccines exert divergent effects on female and male mortality
Vaccine Safety - Thimerosal neurotoxicity associated with glutathione depletion
Vaccines Development - Researchers provide details of new studies and findings in the area of vaccines development
Varicella-Zoster Virus - Polymorphisms to distinguish varicella-zoster virus strains evaluated
Vector Development - A number of factors sway the success of adenovirus-mediated transduction
Vector Development - Headgroup interactions determine the extent of liposome-based transfection
Vector Development - PEI-based core-shell nanoparticles may be good gene carriers
Vector Development - Polymeric conjugates conduct in vitro gene delivery
Vector Development - Recombinant Newcastle disease virus transfers genes to tumor cells
Virology - Efavirenz-related K103N mutation may not be detected by standard genotyping
Virology - Hepatitis B virus mutants induce apoptosis in tree shrew liver cells
Virology - Hepatitis C can persist in patients deemed sustained virological responders
Virology - Hepatitis C virus genotypes share similar cell entry properties
Virology - Hepatitis C virus type 4 strains deviate across populations
Virology - Human cytomegalovirus upregulates functionally active VEGF expression
Virology - Immunogenic peptides in retroviral vectors may confound gene therapy
Virology - La Crosse virus protein counteracts effects of short interfering RNA
Virology - Pathologist experience improves histological scoring of chronic viral hepatitis
Virology - Peginterferon and high dose ribavirin eradicate hepatitis C infection
Virology - Proline 306 substitutions regulate hepatitis B virus replication
Virology - Recombinant adenoviral vectors alter major drug metabolizing enzymes
Virology - Researchers describe findings in virology studies
Virology - The adenovirus type 5 fiber uses a unique cell entry pathway for gene transfer
Virology - The subtyping capabilities of TRUGENE and INNO-LiPA hepatitis C assays differ
Virology Vaccine - Mucosal immunization induces IgG/IgA responses in CD4+-deficient mice
Virus Contamination - PCR is an alternative to MAP tests for the detection of viral contaminants
West Nile Encephalitis Vaccine - Live measles vaccine expressing protects against West Nile encephalitis
Xenograft - Molecular images of oncogene mRNA expose the genetics of breast cancer
Zoonosis - Hepatitis E virus chimeras portray replication in cultured cells
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