Drug Week
Susan Hasty, Publisher
Table of Contents . . . April 8th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Cancer Drugs - RLIP76 transported vinorelbine and mediated drug resistance in NSCLC
Menopause - Growth hormone improves symptoms of metabolic disorder in postmenopausal women
Mental Health - Abilify (aripiprazole) granted approval for new indication
Myocardial Infarction - Data support clinical benefits of GP IIb-IIIa inhibitors, Integrilin Injection
Neuroscience - Long-term effects seen with use of Agilect in Parkinson disease patients
Acinetobacter Infection - Risk factors identified for multidrug-resistant A. baumannii infection
Acute Coronary Syndrome - AGGRASTAT injection clinical data presented at cardiology meeting
Acute Leukemia - Liposomal amphotericin B safe and effective for fungal infection treatment
Acute Myeloid Leukemia - Ceplene receives orphan drug designation in Europe for AML
Acute Myeloid Leukemia - Gemtuzumab ozogamicin suitable for first-line therapy in elderly patients
Addiction Medicine - A key mu-opioid receptor gene polymorphism correlates with alcohol dependence
Atherosclerosis - Researchers' work adds to atherosclerosis body of knowledge
Adriamycin - Eliminating afferent nerves promotes adriamycin-induced myocardial dysfunction
Adverse Drug Reaction - Data: Trospium chloride does not affect sleep patterns in older adults
Adverse Drug Reaction - Fluoxetine-induced changes in sexual arousal not mediated by tactile sensation
Age-Related Macular Degeneration - Eye care company reports clinical study data on macular degeneration
Age-Related Macular Degeneration - Gene believed responsible for age-related macular degeneration discovered
Age-Related Macular Degeneration - Study shows hypoxia inducible gene may serve role in chordial neovascularization
Cancer Therapy - Researchers describe findings in cancer therapy studies
Air Monitoring - PCR method quantifies A. fumigatus conidia from environmental air samples
Allergy Medicine - New findings in the area of allergy medicine detailed
Allergy and Immunology - Asthma relapse in children is common, possible risk factors identified
Allergy and Immunology - Eosinophils in human blood stimulate angiogenesis
Allergy and Immunology - FDA approves CLARINEX-D 24 hour
Allergy and Immunology - Genetic make-up determines immune-inflammatory response after burn injury
Cancer Therapy - Studies advance knowledge in cancer therapy research
Allergy and Immunology - Immunomodulatory therapy for chronic hepatitis B prevents liver complications
Allergy and Immunology - RNA transcripts are targets for asthma therapy
Alzheimer Disease - Cerebral hemorrhage dependent on antibody recognition of amyloid beta
Alzheimer Disease - Long-term statin treatment alters gene expression in mouse cerebral cortex
Alzheimer Disease - Researchers link insulin abnormalities with Alzheimer disease
Anemia - Positive data for phase I study of anemia treatment announced
Cancer Vaccines - Studies describe new findings in cancer vaccines research
Angina - Positive gene therapy trial results for angina published
Angiology - Biodegradable implants containing factor XIII stimulate vessel growth in rats
Angiotensin - Angiotensin inhibition may uncover vasodilator effects of UK-357,903
Anthrax Vaccines - Reports advance knowledge in anthrax vaccines research
Antimicrobial Resistance - Carbapenem resistance is emerging in strains worldwide
Dermatology - Recent findings in dermatology described
Antimicrobial Resistance - Tn1546 elements in vancomycin-resistant Staphylococcus compared
Antimicrobial Resistance - Vancomycin resistance increases mortality in patients with neutropenia
Antioxidant Activity - Antioxidant activities correlated with phenolic of mushroom extracts
Antipsychotic Drug - Caution must be paid with the use of prochlorperazine
Antipsychotic Drug - Disposition of quetiapine in determined specimens from postmortem cases
Antipsychotic Therapy - Effects of neuroleptics on ethanol-induced striatal AA output characterized
Diabetes Pathogenesis - Reports advance knowledge in diabetes pathogenesis research
Antiviral Therapy - Acylated peptides battle hepatitis B virus infection
Arthritis - Collagen-induced arthritis studied, effect of inhibitor revealed
Asthma - Company signs second asthma feasibility study deal in 3 months
Asthma - Interleukin-5 controls UGRP-1 during allergic airway inflammation
Asthma Vaccine - Vaccine protects against B. pertussis exacerbation of allergic asthma
Atherosclerosis - Management of atheromatous disease in diabetic renal failure outlined
Diabetes Pathogenesis - Researchers describe findings in diabetes pathogenesis studies
Atherosclerosis - Mouse gene turned on by fatty food linked to human heart-disease gene
Atherosclerosis - Physiopathology of atherosclerosis in diabetic patients reviewed
Atherosclerosis - Researchers' data advance atherosclerosis research
Atrial Fibrillation - Article reviews options for drug therapy of atrial fibrillation
Atrial Fibrillation - It is premature to abandon rhythm control in atrial fibrillation
Diabetes Pathogenesis - Studies add new findings to diabetes pathogenesis body of knowledge
Attention Deficit Hyperactivity Disorder - Survey shows parents and teens agree ADHD treatment works
Avian Influenza - Cross-impact analysis predicts mutation trends in influenza A
Awards - GlaxoSmithKline CEO Jean-Pierre Garnier gets Global Business Leadership award
Bacteriology - Listeria monocytogenes cell entry studied, role of host proteins revealed
Bacteriology - Carbohydrate microarrays facilitate detection and study of pathogens
Bioartificial Liver - Bioreactor developed that supports bioartificial liver
Enzymology - Recent findings in enzymology described
Bioartificial Liver - Collagen/chitosan/heparin improves hepatic tissue engineering biocompatibility
Biochemistry - Relatively common mutation affects heparin affinity
Biomedical Engineering - Chitosan improves cationic emulsion-mediated gene transfer
Biomedical Engineering - Collagen films support osteoblast activity and bone formation
Biomedical Engineering - Company dedicates expanded kinase screening facility in Dundee, Scotland
Biotechnology - Jonathan Pockson named SVP and CFO
Immunology - Studies describe new findings in immunology research
Biotechnology - Molecular mechanisms of Ezetimibe elucidated
Bioterrorism - U.S. NIAID $15 million contract awarded to develop three monoclonal antibodies
Blood Pressure - Trials have provided much evidence regarding treatment with BP-lowering drugs
Bone Marrow - Bone marrow stromal cell osteogenic potential studied, modulation revealed
Bone Marrow Research - Bone marrow cells engraft within epidermis and proliferate without cell fusion
Borna Disease - Orf virus protects against Borna disease virus infection of the brain
Malaria Vaccines - Researchers describe findings in malaria vaccines studies
Botulinum Toxin - Fatal case of Botox-related anaphylaxis reported
Bovine Viral Diarrhea Virus - Genome analysis of live bovine viral diarrhea virus vaccine conducted
Brain Cancer - Therapy against protein kinase C cedes little relief to glioma patients
Breast Cancer - New research in the area of breast cancer detailed
Breast Cancer - New tool can assess side effects of treatment and prevention of breast cancer
Breast Cancer - Positherapy with F-18-FDG improves survival, reduces tumor growth in mice
Metabolic Syndrome - Studies add new findings to metabolic syndrome body of knowledge
Breast Cancer - Reduced PTEN expression predicts relapse in patients treated with tamoxifen
Breast Cancer - Toxicity of UFT and leucovorin higher in older women with advanced disease
Breast Cancer Metastases - Rare case of bilateral breast metastases from femoral Ewing sarcoma reported
Breast Cancer Therapy - Arg-482 not essential for transporting antibiotics, bile acids, and sterols
Breast Cancer Vaccine - DNA vaccine inhibits breast cancer in mice through induction of autoimmunity
Business & Finance - Anti-infectives-focused drug company reports fourth quarter 2004 results
Oncology - Reports add new data to oncology research
Business & Finance - Biopharma company announces financial results
Business & Finance - Biotechnology company approved to trade on OTC Bulletin Board
Business & Finance - Company focused on histone deacetylases enzymes raises $27 million financing
Business & Finance - DNA testing services company announces financial results
Business & Finance - Generics company reports increased income, discusses Novartis merger
Business & Finance - ITX International Holdings announces $700K financing and licensing partnership
Oncology - Research in oncology provides new insights
Business & Finance - Organic, natural products company reports record sales in 2004, plant relocation
Business & Finance - Pharma company reports year-end operating results, product candidates progress
Business & Finance - Pharmaceutical firm provides 2005 guidance, strategy update
Business & Finance - Pharmaceutical firm reports 11% increase in revenues, provides clinical update
Business & Finance - Therapeutics company reports financial results, provides clinical update
Business & Finance - Woman's health company updates quarter and year; revenues dip
Oncology - Researchers' work adds to oncology body of knowledge
Business Update - Australian company receives ethics approval for phase II endpoint study
Business Update - Biopharmaceutical company achieves milestone in Sanofi-Aventis collaboration
Business Update - Biopharmaceutical company to present abstracts at 2005 EASL
Business Update - Biotech company submits response for inclusion in Universal Protectants Proposal
Business Update - Biotherapeutics company announces strategic updates at investment meeting
Business Update - Cancer biology company announces cancer biomarker discovery collaboration
Oncology - Studies add new findings to oncology body of knowledge
Business Update - Company announces disruption of supply for Paxil CR and Avandamet
Business Update - Company announces official name change to Winsted Holdings, Inc.
Business Update - Company changes name to Biothera
Business Update - Company launches microarray data generation and analysis services
Business Update - Contract signed for leukocyte reduction filters
Business Update - Dowpharma inks agreement to develop a cell line
Oncology - Studies advance knowledge in oncology research
Business Update - Drug development company announces achievement of business milestone
Business Update - Drug development firm participates in FDA task force
Business Update - Enzon announces termination of agreements
Business Update - Fairmount Park Commission approves Fox Chase Cancer Center expansion plan
Business Update - Feminine hygiene maker receives $1M purchase order from Jin Ming Shi Pharma
Business Update - Herbal extracts producer and nutraceutical ingredient company announce alliance
Osteoporosis - Recent findings illuminate research in osteoporosis
Business Update - Marketing budgets on the rise as pharmaceutical brands face key challenges
Business Update - One million SNP Genotyping BeadChips planned for release by June 2006
Business Update - Partnership to offer technology interoperability for discovery applications
Business Update - Pharma companies enter agreement for deorphanization of a series of proteases
Business Update - Pharma company appoints CRO to manage phenoxodiol trial
Business Update - Pharma company names CPA to board, granted European patent
Tuberculosis Vaccines - Recent findings in tuberculosis vaccines described
Business Update - Pharma company releases annual general meeting statement
Business Update - Pharmaceutical company updates Novartis peptide deformylase inhibitor program
Business Update - Pharmaceutical firm receives GMP approval of Swiss facility
Business Update - Public relations firm wins nutraceuticals account
Business Update - excelleRx expansion projected to create 462 jobs in Philadelphia
Cancer Drugs - Adult T-cell leukemia lymphoma cells displayed sensitivity to TRAIL
Virology - Recent findings illuminate research in virology
Cancer Drugs - Carbohydrate-geldanamycin conjugates synthesized into potent anticancer drug
Cancer Drugs - Etodolac enhanced carboplatin-induced apoptosis of human tongue carcinoma
Cancer Drugs - Korean medicine, Gagam-whanglyun-haedoktang, induced apoptosis in HL-60 cells
Cancer Drugs - Mithramycin inactivated ADH enzyme by inducing structural change
Cancer Drugs - Phase III trial failed to show benefits of tamoxifen in LSSCLC patients
Cancer Drugs - Retinoic acid induced sulfotransferases at the transcriptional level
Virology - Researchers' findings advance virology research
Cancer Drugs - Tumor growth controlled by prescribing SOD mimics along with cytotoxic drugs
Cancer Drugs - Two protein phosphatase inhibitors, cantharidin and nor-cantharidin, assessed
Cancer Genetics - Inhibiting angiotensin II may prevent or treat breast cancer
Cancer Immunotherapy - CpG oligodeoxynucleotides activate tumor-specific immune responses
Cancer Metastasis - Genetically engineered mice capture the essence of invasive prostate cancer
Cancer Research - Pharma company announces milestones in production of human antibodies
Virology - Studies advance knowledge in virology research
Cancer Therapy - Adenovirus-delivered anti-Tie-2 intrabody shuts down tumor angiogenesis
Cancer Therapy - Company initiates phase I trial for anticancer compound XL880
Cancer Therapy - DHMEQ targets the nuclear factor kappaB pathway to fight cancer
Cancer Therapy - Data advance knowledge in cancer therapy research
Cancer Therapy - Data reported from phase III trial of BAY 43-9006
Cancer Therapy - Dose optimization enables rapamycin to suppress tumor angiogenesis
Virology - Studies describe new findings in virology research
Cancer Therapy - Doxazosin halts vascular endothelial cell adhesion, migration, and invasion
Cancer Therapy - Liposomal encapsulation augments systemic efficacy of aphidicolin
Cancer Therapy - Newly discovered pathway might help in design of cancer drugs
Cancer Therapy - Patient enrollment almost complete in study of vaccine for prostate cancer
Cancer Therapy - Phase III trials of Bema fentanyl to be initiated
Cancer Therapy - Primary endpoint met in CoFactor phase II metastatic colorectal cancer trial
Cancer Therapy - Rituximab effective for radiation-relapsing primary cutaneous B-cell lymphoma
Cancer Therapy - Tarvacin equivalent inhibits tumor growth by up to 90%
Cancer Therapy - Ultraviolet-B radiation caused upregulation of Survivin in human keratinocytes
Cancer Treatment - Simulator for radiation therapy treatment installed at Tennessee medical center
Cancer Vaccine - Blockade of B7-H1 and PD-1 by antibodies potentiates cancer immunity
Cancer Vaccine - DNA vaccination against tumors reviewed
Cancer Vaccine - DNA vaccine encoding genetic fusion of CEA and GM-CSF developed
Cancer Vaccine - Imatinib mesylate overcomes tumor-induced CD4+ T-cell tolerance
Cancer Vaccine - Impact of p53-based immunization on chemically-induced tumors investigated
Cancer Vaccine - Role of exosomes in cancer-associated T-cell signaling defects investigated
Cancer Vaccines - Reports describe recent advances in cancer vaccines research
Candidiasis - Discovery may lead to better antifungal drug
Cardiac Transplantation - Withdrawing CNIs after heart transplantation improved renal function
Cardiology - Calcyclin is a global negative controller of cardiac gene expression
Cardiology - Companies expand collaboration agreement to target cardiovascular disorders
Cardiology - Enrollment begins for large drug-eluting stent registry
Cardiology - Recent findings in cardiology described
Cardioprotection - L-carnitine is cardioprotective against antimony-induced cardiomyopathy
Cardiovascular Disease - Drug-induced reduction of heart rate may be beneficial in clinical conditions
Cardiovascular Research - Platelet inhibitor demonstrates consistent inhibition of platelet aggregation
Cell Biology - Carboxyl terminus of p21 activates novel apoptosis pathway
Cell Biology - Cooperation between POT1 and TRF2 maintains telomeric integrity
Cell Biology - Select signaling pathways could be targeted for breast cancer inhibition
Chagas Disease Vaccine - Oral immunization with Phytomonas serpens protects against Trypanosoma
Chemoprevention - Retinoid cancer model used for developing chemoprevention strategies
Chlamydia Vaccine - Immunology of Chlamydia infection aids Chlamydia vaccine design
Cholera Monitoring - Monitoring environment and cholera presence predicts diarrhea epidemics
Chronic Liver Disease - Hepatitis C virus and oxidative stress constitutively activate STAT-3
Chronic Lymphocytic Leukemia - FCGR3A/2A polymorphisms may not affect response to alemtuzumab
Clinical Trials - Clinical trials for injected multiple myeloma retreatment initiated
Clinical Trials - Encouraging results from study of investigational drug for myloma welcomed
Clinical Trials - Enrollment in phase 1 clinical trial of atherosclerosis treatment begun
Clinical Trials - Enrollment of phase 2 clinical trial of antibody for treatment of HIV complete
Clinical Trials - Report: Drug companies lose millions due to clinical trial inefficiencies
Coagulation Therapy - Protein C anticoagulant activity examined, role of cholesterol revealed
Coagulation Therapy - Study finds self-testing a reliable alternative to laboratory INR monitoring
Collaborations - Agreement signed for CRO for clinical trials
Collaborations - Alliance formed to develop predictive models for preclinical drug development
Collaborations - Alliance to investigate diabetes drug toxicity
Collaborations - Alliance with Wyeth continues for development of RNA for vaccine production
Collaborations - Biotech companies collaborate to develop range of nerve repair compounds
Collaborations - Endo Pharmaceuticals and IWHL team up on new health initiative
Collaborations - Flu drug development agreement signed
Collaborations - Long-term contract signed for plasma products
Collaborations - Testing, research initiative signed for drug delivery device
Colon Cancer - Avastin set to rollout in Europe for patients with advanced colorectal cancer
Colon Cancer - Gene replacement therapy suppresses colorectal tumors in animal models
Community-Acquired Pneumonia - Pharma company completes enrollment in phase III FACTIVE trial for pneumonia
Complementary & Alternative Medicine - Scientists seek to brew up anticancer drugs from green tea
Complementary and Alternative Medicine - New herbal eye wash introduced
Complementary and Alternative Medicine - Wine and tea polyphenols treat human ailments by diminishing new vessel growth
Constipation - Phase 3 trial for opioid-induced constipation top-line results announced
Coronary Artery Disease - Noninvasive fingertip test may identify patients with coronary disease
Coronary Artery Disease - Positives results reported for ENDEAVOR drug-eluting stent
Corynebacterium - Iron transport in Corynebacterium diphtheriae investigated
Cowpox - Cowpox virus infection associated with streptococcal septicemia
Crimean-Congo Hemorrhagic Fever - ELISA method used to diagnose Crimean-Congo hemorrhagic fever
Cystic Fibrosis - I.V. aminoglycosides should be used cautiously in CF patients
Cystic Fibrosis - Persistent environmental reservoirs of P. aeruginosa not found in CF center
Cytomegalovirus Vaccine - Cytomegalovirus DNA vaccine protects against murine cytomegalovirus challenge
DNA Fingerprinting - Cancer cell line identification by short-tandem-repeat profiling assessed
DNA Research - Safety of Strattera for treating ADHD clarified by DNA testing
DNA Research - TAT/DNA polyplexes analyzed, influence of TAT-peptide polymerization detailed
Deep Vein Thrombosis - First patient recruited in ThromboView phase II North American clinical trials
Dendritic Cell Vaccine - CD70 induction on dendritic cells promotes CD8+ T cell responses
Dengue Hemorrhagic Fever - Dengue hemorrhagic fever increasing among children in northern Brazil
Depression - Costs of antidepressants could have funded effective alternatives
Depression - Differences in cortisol response to reboxetin found between sexes
Depression - Successful feasibility study in depression treatment reprted
Dermatology - New research in the area of dermatology detailed
Diabetes Diagnosis - IA-2A and GADA measurement aids diagnosis and prognosis of type 1 diabetes
Diabetes Genomics and Genetics - Findings in diabetes genomics and genetics provide new insights
Diabetes Pathogenesis - Adiposity increased in first-degree relatives of type 2 diabetic patients
Diabetes Pathogenesis - Dendritic cell maturation impaired in children at risk of type 1 diabetes
Diabetes Pathogenesis - Integrin peptide antagonist inhibits T-cell adhesion to pancreatic islets
Diabetes Pathogenesis - Recent findings illuminate research in diabetes pathogenesis
Diabetes Risk Factors - Lifestyle westernization increases diabetes risk in Japanese-Americans
Diabetes Risk Factors - Renin-angiotensin system inhibition prevents type 2 diabetes
Diabetes Risk Factors - T-cell receptor function normal in newborns of type 1 diabetic mothers
Diabetes Surgery - Researchers' data advance diabetes surgery research
Diabetes Therapy - Early metformin treatment reduces late-developing diabetes complications
Diabetes Therapy - Ertiprotafib improves glycemic control and lowers lipids
Diabetes Therapy - Future therapy of diabetes reviewed
Diabetes Therapy - Jambolan tree fruit from Brazil does not improve diabetes
Diabetes Therapy - Lisofylline is potential lead for treatment of diabetes
Diabetes Therapy - Psychosocial factors linked to poor diabetes self-care management outlined
Diabetes Therapy - Recent findings in diabetes therapy described
Diabetes Therapy - Thiazolidinediones possess pleiotropic activity
Diabetes Therapy - Vanadium compounds with insulino-mimetic and anti-diabetic effects developed
Diabetes Treatment - New affiliate of Ohio diabetes research, treatment center opens in Dayton
Diabetes Type 1 - Diabetes type 1 outbreak earlier in immigrants' children born in Italy
Diabetic Foot - Economic burden of diabetic foot and ankle disorders reviewed
Diabetic Foot - Foot ulcers negatively impact quality of life of patients with diabetes
Diabetic Nephropathy - Cicletanine protects renal function in diabetic hypertensive rats
Diabetic Nephropathy - Ethnic differences in microalbuminuria prevalence in diabetes reported
Diabetic Nephropathy - Microalbuminuria for screening in cystic fibrosis-related diabetes examined
Diabetic Nephropathy - Mouse models of diabetic nephropathy reviewed
Diabetic Nephropathy - Stobadine improves sodium handling of renal Na,K-ATPase in diabetes
Diabetic Nephropathy - Two combination regimens to reduce albuminuria in diabetic patients compared
Diabetic Neuropathy - Bradykinin B-1 receptor antagonist enhances vascular permeability in diabetes
Diagnostic Imaging - Contrast-enhanced ultrasonography discerns the vascularity of liver tumors
Diagnostics - Studies add new findings to diagnostics body of knowledge
Diarrheal Illness - Hygiene interventions identified to reduce diarrhea in less developed countries
Diet & Nutrition - Avoid calcium crisis with milk for healthy bones, dairy association says
Diet & Nutrition - Mortality risk from CHD higher for older women on long-term high-protein diet
Diet & Nutrition - Nutritional supplement company launches natural weight management emulsion
Dilated Cardiomyopathy - Dilated cardiomyopathy requires immunohistochemical and molecular investigation
Disease Associations - Epstein-Barr LMP2A and LMP2B studied, effect on epithelial cells noted
Disease Associations - Erythropoietin receptor agonists prevented activation of NF-kappaB pathway
Disease Prevention - Women urged to learn latest on aspirin therapy and heart disease prevention
Drug Delivery - Copolymer-conjugates localize to tumor vessels
Drug Delivery - New oral dispenser packaging launched for ward, bedside applications
Drug Delivery - New ways to design safer, more effective topical drugs announced
Drug Delivery - Polymerization conditions affect network properties of dex-HEMA microspheres
Drug Delivery - Positive results reported for EuroSTAR drug-eluting stent trial
Drug Delivery - Study shows prescription drug patches gaining ground
Drug Development - 87% of market research groups collect competitive intelligence
Drug Development - Advances have improved R&D success rates in drug development
Drug Development - Antibiotic for acne, rosacea moves into preclinical trials
Drug Development - Compound for MS, Crohn disease included in U.S. FDA clinical hold
Drug Development - Dermatologists comment on FDA decision regarding eczema medications
Drug Development - Encapsulated cells release soluble factors after brain implantation
Drug Development - Generic Salagen 5mg tablets launched
Drug Development - Glaucoma compounds show potential to treat eye disease
Drug Development - Hematide demonstrates ability to stimulate production of red blood cells
Drug Development - Hepatitis C replicons enhance our ability to develop new antivirals
Drug Development - New data demonstrate Crestor reduced C-reactive protein levels
Drug Development - Phase II trials commence for hydromorphone transdermal patch for pain
Drug Development - Phase III study of rhASB in MPS VI demonstrates improvements in endurance
Drug Development - Platelet-derived growth factor-CC initiates post-ischemia neovascularization
Drug Development - Sharing and Workgroups in Ingenuity Pathways Analysis now available
Drug Development - Study shows cisplatan treatment unhindered by drug for drug-induced hearing loss
Drug Development - Update provided on Tysabri for multiple sclerosis
Drug Discovery - Text mining research and development program targets life sciences applications
Drug Metabolism - CYP2C8 polymorphism alters disposition of (R)-ibuprofen
Drug Metabolism - Ginseng extracts do not induce hepatic CYP gene expression in rats
Drug Metabolism - Interactions between UGT isoforms and CYP3A4 characterized
Drug Metabolism - UGT isoforms involved in mycophenolic acid glucuronidation identified
Drug Resistance - New blood testing system evaluates response to antiplatelet drugs
Drug Resistance - Scientists track antimicrobial-resistant organisms
Drug Safety - Arthritis patients remain confused about safety of pain medications
Drug Safety - Pain reliever remains safe, effective when taken as directed
Drug Safety - Pharmaceutical company issues clarification on Paxil CR for depression, anxiety
Embryonic Stem Cell Research - Cell-surface marker found on embryonic hepatoblasts
Embryonic Stem Cell Research - Embryonic stem cell differentiation evaluated in different culture conditions
Embryonic Stem Cell Research - Enforced PU.1 expression rescues osteoclastogenesis from ESCs lacking Tal-1
Embryonic Stem Cell Research - Repository stores embryonic stem cell lines with genetic disorders
Embryonic Stem Cell Research - Stably transfected ESC clones maintain self-renewal and pluripotency
Endocrinology - High ACTH levels make a familial glucocorticoid deficiency patient taller
Endocrinology - Inhibited glycoprotein processing studied, effect on osteoblast-like cells shown
Endocrinology - Single-chain tetradomain glycoprotein hormone analog demonstrates bioactivity
Environmental Health - Propiconazole generates cytochrome P450 gene variations in animal livers
Environmental Health - Reverse transcription-PCR detects hepatitis A in spring water
Environmental Health - The fungicide fenarimol exhibits antiandrogenic effects in in vivo studies
Enzymology - Angiogenesis and phospholipase A2 alpha correlate in human colorectal cancer
Enzymology - Dictyostelium chemotaxis studied, soluble guanylyl cyclase activation revealed
Enzymology - Findings in enzymology provide new insights
Epilepsy - Antiepileptic drugs alter reproductive endocrine hormones in men
Equine Infectious Anemia Virus - Specificity of antibodies induced by equine infectious anemia virus reported
Esophageal Cancer - Full-dose chemoradiotherapy found effective as esophagectomy
Estradiol - Impaired coronary artery vascular contraction studied, dependences revealed
Ethics - Report explores ethical issues associated with patient refusal of VAD
Exercise and Nutrition - Exercise and diet have roles in prevention of chronic disease
Facilities - All-digital heart hospital and research institute to open in Florida
Feto-Maternal Tolerance - Heme oxygenase could be therapeutic target in immunological pregnancy problems
Finance - Anti-infectives-focused biotech company announces $5.5 million rights offering
Finance - Biopharma sales and marketing company announces improved financial results
Finance - Biopharmaceutical company announces completion of $35 million financing
Finance - Biopharmaceutical company announces underwriters' purchase of common stock
Finance - Biopharmaceutical company completes $7 million financing
Finance - Biopharmaceutical company raises $20M in private placement
Finance - Biopharmaceutical company records net loss of $1.62 per share
Finance - Biopharmaceutical firm reports loss of $1.12 per share
Finance - Biosciences corporation announces strong first quarter financial results
Finance - Biotech company receives going concern qualification in FY2004 audit report
Finance - Biotech firm reports loss of $0.14 per share
Finance - Biotechnology company announces 2004 year-end financial results
Finance - Cancer therapeutics development co. announces $4.1 million private placement
Finance - Cardiac drug maker files prospectus for an offering of common shares
Finance - Cardiology devices company reports preliminary third quarter fiscal 2005 results
Finance - Clinical lab company records 27% increase in first quarter net revenues
Finance - Drug company announces sale of common stock
Finance - Drug developer announces OTC revenues up 18%
Finance - Drug discovery and development company announces loss of $.09 per share
Finance - FUZEON sales growth contributes to improved 2004 earnings results
Finance - Fish oils producer reports 2004 financial results
Finance - Glycobiology company to close on $6,500,000 of funding from institutions
Finance - HIV-focused company reports fourth quarter and full year 2004 financial results
Finance - Hair testing drug abuse company announces record net income
Finance - Health and wellness products company increases earnings estimates
Finance - Health services company announces annual net revenue of $1.78B
Finance - Life sciences company reports 9% increase in sales
Finance - Lifesciences organization reports 44% increase in fourth quarter revenues
Finance - MyVax maker reports 2004 net loss of $27 million
Finance - Nutritionals company announced results of tender offer
Finance - OTC migraine remedy maker engages Wall Street Consultants Corp.
Finance - Pharma company announces 16% increase in year over year fourth quarter revenue
Finance - Pharma company announces net loss of $.40 per share
Finance - Pharma company reports improved 2004 financial results
Finance - Pharmaceutical company announces IPO pricing
Finance - Pharmaceutical company reports fourth quarter full year 2004 financial results
Finance - Pharmaceutical company reports loss of $0.72 per share
Finance - Pharmaceutical firm announces successful completion of IPO
Finance - Pharmaceutical firm closes first tranche of private placement
Finance - Pharmaceutical firm reports 54.7% increase in gross profits
Finance - Pharmaceutical firm reports 73% increase in revenue
Finance - Pharmaceutical firm reports loss of $0.01 per share
Finance - Stem cell-focused biotech company announces Q4, year end 2004 financial results
Finance - Thelin maker to offer $100 million of convertible senior notes
Finances - Biopharmaceuticals company restates its 2003 and 2002 financial statements
Fluconazole - Bioequivalence of fluconazole capsules evaluated
Gastric Cancer - Heparanase expression aligns with gastric carcinoma invasion and metastasis
Gastroenterology - Barium sulfate suspension provides improved distension, studies shows
Gastroenterology - Hepatocyte phosphoinositide breakdown studied, diacylglycerol buildup shown
Gene Research - Families with Milroy disease possess VEGFR-3 mutations
Gene Research - Footprinting experiments outline retinoblastoma gene promoter regulation
Gene Research - Genetic therapy reverses nervous system damage in animal model
Gene Research - Genetics-based company's technology enables personalized drug therapy
Gene Research - Interleukin-1 gene polymorphisms render susceptibility to Behcet disease
Gene Research - Many variables limit autogene-based cytoplasmic expression systems
Gene Silencing - Small interfering RNA downregulates protein expression in rodent grafts
Generalized Anxiety Disorder - Generalized anxiety disorder phase II trial of serotonin 1A initiated
Genetics & Genomics - Chromosomal imbalances linked to drug- and thermoresistance in pancreatic cancer
Genetics & Genomics - Company launches new tools for analyzing gene transcription and regulation
Genetics & Genomics - Full genome sequence of virus with cluster-SBS technology completed
Genetics & Genomics - IS1- or IS10- activated AcrEF efflux pump may relay AcrAB in serovar Typhimurium
Genomic Expression - Cytokine allele frequencies differ between racial and ethnic groups
Geriatrics - Use of inappropriate medications among elderly common in some European countries
Gingivitis - Bioactive glass ameliorates gingivitis-related inflammation
Glioblastoma Multiforme Tumors - Enrollment commences in INO-1001 trial in glioblastoma multiforme
Glucose Uptake - Aminoimidazole riboside analyzed, role in jejunal glucose transport revealed
Glycemic Control - More emphasis needed on postprandial glycemic control
Growth Hormone Insensitivity Syndrome - FDA accepts for review SomatoKine NDA for GHIS
Gynecology - Recent studies add new data to gynecology research
Gynecology - Sentinel cells expand upon CpG oligodeoxynucleotide transfer in the vagina
HIV/AIDS - Styrylquinolines are synergistic with other antiretroviral agents
HIV/AIDS Drug Development - Anti-HIV-1 compounds separated via capillary zone electrophoresis
HIV/AIDS Drug Development - PNA-transportan conjugate targeted to HIV-1 TAR is antiviral and virucidal
HIV/AIDS Drug Development - Plant extracts have anti-HIV activity
HIV/AIDS Drug Discovery - HIV-1 integrase inhibitors identified using 3D pharmacophore-guided database
HIV/AIDS Drug Resistance - Drug-resistant HIV-1 genotypes detected only in subjects infected after 2000
HIV/AIDS Drug Resistance - HIV-1 Vif changes associated with development of protease inhibitor resistance
HIV/AIDS Infection - Amphotericin-B reactivates latent HIV-1 infection
HIV/AIDS Lipodystrophy - VLDL elevation in early HAART therapy caused by impaired VLDL clearance
HIV/AIDS MALT Lymphoma - HIV+ MALT lymphoma remission induced by HAART alone
HIV/AIDS Pathogenesis - APOBEC3G polymorphisms not associated with HIV disease progression
HIV/AIDS Pathogenesis - C-terminal domain of HIV-1 integrase is a DNA-binding domain
HIV/AIDS Pathogenesis - Cytoplasmic tail slows HIV-1 Env folding from late prebundle into 6-helix bundle
HIV/AIDS Pathogenesis - Late stage R5 HIV-1 infection induces cytokine and CCR5 expression
HIV/AIDS Pathogenesis - M-tropic HIV-1 activation increases virus load in intestinal mucosa
HIV/AIDS Pathogenesis - Separate HIV Nef domains are required to affect MHC-1 and CD4 cells
HIV/AIDS Pathogenesis - Vpr enhances RANKL production via glucocorticoid receptor activity potentiation
HIV/AIDS Prevention - Appropriate HIV education maximizes acceptance of antenatal HIV antibody test
HIV/AIDS Prognosis - Survival prognostic factors differ by CD4 count among IVDU pre/post HAART era
HIV/AIDS Research - CD4+ cell response differs between HIV-exposed seronegative and HIV+ women
HIV/AIDS Research - MLV RNase H primer grip is an important determinant of fidelity of DNA synthesis
HIV/AIDS Research - Tat methylation by PRMT6 regulates HIV-1 gene expression
HIV/AIDS Screening - Molecular diagnostics company reports detection of HIV-DNA AIDS patients' urine
HIV/AIDS Screening - Urgent care center-based routine HIV screening programs are effective
HIV/AIDS Therapy - 20 mg/kg of amprenavir twice daily is safe for HIV-infected children
HIV/AIDS Therapy - C/EBP alpha reverses anti-adipogenic effects of nelfinavir
HIV/AIDS Therapy - Encouraging results reported from phase 2 trial of HIV immune-based therapy
HIV/AIDS Therapy - Expansion of AIDS centers needed to prevent spread of HIV in Russia
HIV/AIDS Therapy - Fixed conformation nucleoside analogs inhibit excision-proficient HIV-1 RT
HIV/AIDS Therapy - HAART leads to normalization of anti-Hsp70 and anti-cholesterol Ab levels
HIV/AIDS Therapy - IL-16 levels increase after structured intermittent HAART interruption
HIV/AIDS Therapy - Legal order allows challenge to AIDS drug pricing in South African to go forward
HIV/AIDS Therapy - Researchers' work adds to HIV/AIDS therapy body of knowledge
HIV/AIDS Therapy - Ritonavir does not inhibit calpain
HIV/AIDS Vaccine - Anti-CXCR4 antibodies differ significantly in ability to inhibit HIV entry
HIV/AIDS Vaccine - C-terminal tail of HIV transmembrane glycoprotein involved in cell fusion
HIV/AIDS Vaccine - HIV preclinical interventions in nonhuman primates investigated
HIV/AIDS Vaccine - HIV preventive vaccine trials in developing countries examined
HIV/AIDS Vaccine - Peptide immunogens enhance immune response against HIV mutant strains
HIV/AIDS Vaccine - Poxvirus SIV vaccine partially protects juvenile macaques against SIV
HIV/AIDS Vaccine - Predictive value of primate models for AIDS therapies reviewed
HIV/AIDS Vaccine - Rhabdoviral prime-boost induces strong anti-HIV immune responses
HIV/AIDS Vaccine - Role of IL-7 in pathogenesis and treatment of HIV infection reviewed
HIV/AIDS Vaccine - Targeting CD4i epitope in HIV vaccine design explored
HIV/AIDS Vaccines - Researchers' findings advance HIV/AIDS vaccines research
HIV/AIDS-Associated Lipodystrophy - Subcutaneous fat loss not due to accelerated apoptosis in HIV lipodystrophy
Head & Neck Cancer - Assay for quantification of viability in spheroids of malignant glioma reviewed
Head & Neck Cancer - Metastatic glioblastoma in cervical lymph node found after repeated craniotomies
Head & Neck Cancer - Successful treatment of head and neck cancer with radiation and chemotherapy
Head and Neck Cancer - Dendritic cells mature in presence of tumor cells from head and neck cancer
Head and Neck Cancer - Interleukin-8 levels rise in patients with progressive squamous cell cancer
Healthcare Coverage - Healthcare information company reports market gains of pulmonary disease therapy
Healthcare Coverage - Pharmacy benefit manager chosen to administer RX program for ISG VEBA Trust
Healthcare Coverage - Program to help Indiana residents find prescription drug assistance
Heart Attack - Relation between genetics and heart attacks in patients investigated
Heart Disease - Norvasc-based treatment reduces cardiovascular mortality in study patients
Heart Failure - Study investigated effects of SCH00013 on Ca2+-induced force generation
Hematology - Angiogenic cytokines predict multiple myeloma progression
Hematology - Estrogen receptor gene expression deviates in human blood mononuclear cells
Hematology - Heat shock factor-1 may be a negative regulator of heme oxygenase-1
Hematology - Hemophilia A patients carry newly discovered missense FVIII gene mutations
Hematopoiesis - Recent findings in hematopoiesis provide new insights
Hemodialysis - L-carnitine supplementation improves several conditions seen in uremic patients
Hepatitis - Osteopontin marks liver damage in patients with fulminant hepatitis
Hepatitis B Therapy - Hepatitis B virus genotypes direct therapeutic response
Hepatitis C Therapy - Chronic hepatitis C resolves following antiviral treatment and relapse
Hereditary Angioedema - Protein therapeutic company recombinant human C1 inhibitor trial approved
Herpes Simplex Virus Type 1 - Differences between sexes in HSV-1 infection and disease studied
Hormones - Adrenocorticotropin response studied, nature of desensitization clarified
Human Papillomavirus - Epitope specificity of vaccine-induced T cell response against HPV18 reported
Human Papillomavirus - HPV-13 polymorphisms determined for HIV+ and women at risk for HIV infection
Human Papillomavirus - New research targets men to study virus that causes cancer in women
Hypertension - Articles support ICG use in hypertension management
Hypertension Therapy - Prostacyclin does not inhibit Rho-kinase
Hypertrophy - CV events in HT patients is related to LV mass achieved during treatment
Immunology - Data advance knowledge in immunology research
Immunology - TIM-3 gene polymorphism associated with atopic disease susceptibility
Immunosuppression - Mycophenolate mofetil delays hepatitis C recurrence after liver transplantation
Immunotherapy - Addition of GS doesn't enhance proapoptotic properties of MTX
Immunotherapy - Study shows utility of small-molecule telomerase activators for HIV/AIDS therapy
Infection Control - Emerging Infections Program reduces response time to foodborne disease
Infections - Inflammatory and antiviral responses in liver studied, requirements clarified
Infectious Disease - Corporation reports initial success of specific antibody development
Infertility - Award helps establish international consortium for fertility research
Influenza - Biotech company to pursue accelerated approval process for influenza vaccine
Influenza Vaccine - Acidic polymerase epitope of influenza elicits potent antiviral response
Influenza Vaccine - Approaches to influenza prevention and treatment in travelers reviewed
Influenza Vaccine - Growth of attenuated influenza vaccine strains in cell lines achieved
Influenza Vaccine - Safety and immunogenicity of adenovirus-vectored influenza vaccines reviewed
Influenza Vaccines - Findings describe new data in influenza vaccines research
Information Technology - Company introduces eCaseLink version 6.0 technology to suite of EDC products
Information Technology - Contract services company customizes products for training
Information Technology - Disease management system linking physicians, payers, patients introduced
Information Technology - Information technology companies announce strategic alliance
Information Technology - Information technology company ready to support Medicare Part C and D
Information Technology - Pharma strategy co. complies with controlled substance reporting requirements
Information Technology - University and healthcare technology company enter academic partnership
Insulin Resistance - Estradiol represses insulin receptor gene causing insulin resistance
Ischemic Heart Disease - Cardioselective nitrates may replace classical nitrates ischemic HD therapy
Kaposi Sarcoma-Associated Herpesvirus - New findings in the area of kaposi sarcoma-associated herpesvirus described
Kidney Cancer - Renal cysts might be possible precursors for renal clear cell carcinomas
Kidney Cancer Vaccine - Vaccine elicits diverse CD8+ T-cell responses to renal cell cancer antigens
Kidney Transplantation - Immunosuppressives reduce production of TNF alpha in NHBD kidneys
Kidney Transplantation - Rituximab may prevent acute rejection of B-cell-replete kidney grafts
Kinase - Human Aurora-A analyzed, requirements for destruction elucidated
Knee Replacement - Antibiotic-loaded articulating spacer effective against TKA infection
Legal Issues - SAppeals court rules healthcare company did not violate patent antitrust laws
Leptin Studies - Recent findings in leptin studies described
Leukemia Vaccine - Leukemia vaccines may benefit from immune responses against Wilms tumor WT1
Leukemia Vaccine - Natural killer cell receptor-expressing cells play role in leukemia therapy
Liposomal Delivery - Liposome-encapsulated prolidase studied, role as delivery system assessed
Liposomal Drug Delivery - Cardanol may be superior to cholesterol for liposome stabilization
Liposomal Drug Delivery - Effect of PEG level on permeability of PEG-grafted liposomes determined
Listeria Therapy - CpG oligodeoxynucleotides enhance neonatal resistance to Listeria
Liver Cancer - Liver tumor ablation gains increasingly clinical importance
Liver Cancer - MAGE-A10- and SSX-2-specific CD8+ responses in liver cancer characterized
Liver Cancer - Researchers report survival and tumor results from liver cancer therapy trial
Lymphoma Therapy - CEOP-E regimen for patients with aggressive non-Hodgkin lymphoma reviewed
Lymphoma Vaccine - Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody
Macular Degeneration - Pharma company begins phase III clinical trial in macular degeneration therapy
Malaria Epidemiology - Researchers offer new estimates on extent of malaria
Malaria Vaccine - CD28 in T and B cell responses required for protection against malaria
Malaria Vaccine - Genetic approach to identify immunity targets in malaria parasites developed
Malaria Vaccine - Polymerized d-peptides used for immunizing animals against malaria
Malaria Vaccines - Recent findings illuminate research in malaria vaccines
Mantle Cell Lymphoma - Utility of MCL cell lines as in vitro models evaluated
Market Analysis - Bonuses account for a third of pharmaceutical company director's earnings
Measles Vaccine - Impact of population decline on dynamics of measles in Italy explored
Medical Devices - Study shows CYPHER stent associated with fewer blood clots at stent site
Medical Errors - Hospital executives have concerns about error reporting systems
Melanoma Vaccine - Gene expression in melanoma metastases and daughter cell lines investigated
Melanoma Vaccine - Hypothesis to explain ability of BCG and vaccinia to treat melanoma presented
Melanoma Vaccine - Melanoma-associated antigen mimotope inhibits melanoma cell growth
Melonoma - Pharma companies announce results of phase I/II study of melonoma treatment
Mental Health - Alcohol dehydrogenase examined, nature of enhanced stress clarified
Mental Health - Genotype - social environment interactions guide stress vulnerability
Mental Health - S-COMT promoter methylation is not a major cause of schizophrenia
Mental Health - Therapy for dementia in elderly, risk of cerebrovascular adverse event studied
Mergers & Acquisitions - Acquisition of nutritional drink producer announced
Mergers & Acquisitions - Allergy control company to acquire Allergy Control Products
Mergers & Acquisitions - BP Amoco BDO operations acquired by specialty chemicals supplier
Mergers & Acquisitions - Bioanalytical tools company acquires Transfluor imaging technology
Mergers & Acquisitions - Biotech and laboratory automation equipment company acquired by Rigaku/MSC
Mergers & Acquisitions - Biotechnology company completes purchase of Protexia operations and assets
Mergers & Acquisitions - Cheminformatics, structural informatics products companies complete merger
Mergers & Acquisitions - Cytyc closes acquisition
Mergers & Acquisitions - Pharmacy benefit manager acquires California pharmaceutical network
Mergers & Acquisitions - Shareholders of pharmaceuticals companies approve merger
Metabolic Syndrome - Research add new data to metabolic syndrome body of knowledge
Metastatic Spinal Disease - Surgery versus radiotherapy for treatment of metastatic spinal epidural disease
Mucosal Immunization - Studies describe new findings in mucosal immunization research
Multiple Myeloma - External analyses of multiple myeloma trial announced
Multiple Sclerosis - IFN beta-1a dose regimens compared in relapsing-remitting MS
Muscular Dystrophy - Cyclosporine A treatment ameliorates symptoms in mice
Myelodysplastic Syndrome - Immunobiologic therapies for myelodysplastic syndrome reviewed
Myeloma Vaccine - Anti-alpha 4 integrin monoclonal antibody inhibits multiple myeloma growth
Myocardial Infarction - Common medication to prevent MI, stroke cost-effective when given long-term
Myocardial Infarction - Double dose of anticlotting drug before angioplasty drops heart attack risk
Myocardial Infarction - Drug therapy may be comparable to invasive cardiac procedures
Myocardial Ischemia - Nitrate therapy may be safely switched to trimetazidine therapy
Nanotechnology - Report released on the nanoenabled drug discovery solutions market
Natural Products - Company completes safety studies of Canadian Willowherb
Neural Embryonic Stem Cell Research - Neuronal differentiation achieved from cultured embryonic germ cells
Neural Stem Cell Research - Antibody microarray correlates cell phenotype with surface marker
Neural Stem Cell Research - Ginsenoside-Rd from Panax notoginseng enhances NSC astrocyte differentiation
Neural Stem Cell Research - NSCs from ESCs relieve symptomatic motor behavior in Parkinson disease model
Neural Stem Cell Research - RB & RB2/p130 genes have overlapping functions during early NSC differentiation
Neural Stem Cell Research - Repeated cytokine administration improves generation of dendritic cells
Neurodegeneration - Apolipoprotein E gene transfer alters Abeta in Alzheimer disease models
Neurology - NMDA receptor interacting proteins studied, developmental expression revealed
Neuromuscular Disease - Spastin gene deletion causes mild hereditary spastic paraplegia
Neuropeptides - Neuropeptide receptor activation studied, gender-modulated behavior revealed
Neuropeptides - Receptor internalization and endosomal processing inhibited by lithium
Neuroscience - Angiogenic cytokines influence brain injury after radiation therapy
Neuroscience - Cathepsin B and angiogenesis foster glioma progression
Neuroscience - EEG values change with age in patients receiving interferon for hepatitis C
Neuroscience - Glial cell line-derived neurotrophic factor ameliorates neurodegeneration
Neuroscience - Marrow stromal cells aid axonal regeneration after spinal cord injury
Neuroscience - Recent findings in neuroscience provide new insights
Nicotine Patch - Effects of transdermal nicotine on prose memory and attention clarified
Norovirus - New data illuminates research in norovirus
Nutrition - Health Sciences Group acquires Open Cell Biotechnologies
Obesity Pathogenesis - Extracellular signal-regulated kinase isoform needed for adipogenesis
Obesity Therapy - Administration of immunomodulators induces anorexia in Zucker rats
Obesity and Diabetes - CCK-A receptor-deficient OLETF rats have increased sucrose sensitivity
Obstetrics - Researchers' work adds to obstetrics body of knowledge
Occupational Health - Gas chromatographic test to quantify bromopropane in urine developed
Oncogenesis - Orthodenticle homologue 2 is linked to the formation of medulloblastoma
Oncogenesis - Smad4 changes are involved in the formation of cervical cancer
Oncology - Angiogenesis denotes a risk for second primary tumors in oral cancer patients
Oncology - Angiotensin type 1a receptor signals trigger tumor-associated angiogenesis
Oncology - Daniel Von Hoff, MD, honored at cancer conference for advancing drug therapy
Oncology - Folate pathway genes influence the pharmacodynamics of leukemia therapy
Oncology - Gene networks reverse breast cancer tumorigenesis after chromosome 8 delivery
Oncology - Gleason score did not appear to impact survival in metastatic prostate cancer
Oncology - Granulocyte chemotactic protein-2 bolsters tumor formation
Oncology - Methylation changes in prostate genes may encourage oncogenesis
Oncology - Network of cancer treatment centers adds northwestern Connecticut center
Oncology - New data illuminates research in oncology
Oncology - Progression-elevated gene-3 promoter selects cancer cells for gene delivery
Oncology - The isoflavone genistein uses select molecules to harness angiogenesis
Oncology - The origins of testicular germ cell tumors are poorly understood
Oncology - Tumor location guides the approach of rapamycin against glioma
Oncology - VEGF receptor inhibition impairs mammary tumor growth in mice
Ophthalmology - Pirenoxine prevents excimer laser-induced corneal haze in rabbits
Opioid-Induced Bowel Dysfunction - Companies report initial results from phase II studies of Entereg (alvimopan)
Opportunistic Infection - Neutrophil depletion method affects outcome of murine pulmonary aspergillosis
Osteoporosis - HRT guidelines for prevention of postmenopausal bone loss are problematic
Osteoporosis - New findings in osteoporosis described
Osteoporosis - Vitamins K2 and D2 plus calcium supplements increase BMD in women with AD
Ovarian Cancer - Neutral endopeptidase 24.11 stops disease progression
Ovarian Cancer - Peptides from HER-2/neu-overexpressing tumors induce antitumor responses
Pain Management - Journal article suggests opioids are an alternative for COX-2 pain medications
Pain Medicine - Doctor suggested cannabis for pain relief, say one in six medicinal users
Pain Medicine - Matrix metalloproteinases mediate acetaminophen-induced hepatotoxicity
Pain Medicine - TYR-MIF-1 peptides studied, antiopioid properties observed
Pancreatic Cancer - Mayo Clinic discovers 'new pathway' against pancreatic cancer
Pancreatic Cancer - Pancreatic cancer clinical trial begins using MedPulser tumor ablation system
Pancreatic Cancer - Pancreatic tumors should be profiled before COX-2 inhibitors are initiated
Parkinson Disease - AGILECT demonstrated improvement in levodopa-treated Parkinson patients
Parkinson Disease - Foundation commits funds to research treatments for Parkinson disease
Patents - Company announces new compound patents pending for Neurodur in MS
Patents - EPO rules Symbicort combination patent still valid
Patents - Patent issued for Alzheimer blood test technology
Patents - RNA interference-based therapeutics company granted patent
Patents - Re-examination of two more PharmaStem cord blood stem cell patents requested
Patents - Stem cell instruments patent filed with U.S. patent office
Patents - U.S. patent office says it will confirm claims of reexamined Periostat patent
Pathogenic Escherichia coli - E. coli O157:H7 survival on vegetables dependent on soil compost type
Patient Information - Web-based information about herbal medicines for cancer treatment was inaccurate
Pediatric Cancer - Costs for childhood rhabdomyosarcoma minimized by selective treatment omission
Personnel - Behavioral health company CEO appointed to mental health organization board
Personnel - Biomed company announces R&D appointments
Personnel - Biopharm company announces resignation of president and CEO; elects interim
Personnel - Biopharmaceutical company announces appointment of board of directors member
Personnel - Biopharmaceutical company appoints member of board of directors
Personnel - Biopharmaceutical firm names Susan Watson as chief scientific officer
Personnel - Biotech company appoints CEO
Personnel - Biotech company names senior advisor to Bioterrorism Preparedness Advisory Board
Personnel - Biotech firm appoints new business development, R&D employees
Personnel - Biotech firm names Donald R. Joseph as senior VP, general counsel
Personnel - British Columbia recruits top cancer researcher from U.K.
Personnel - Buccal drug delivery company announces prospective new director
Personnel - Cephalon announces executive appointment
Personnel - David Erinakes becomes vice president, sales and marketing
Personnel - Drug development company names president and CEO
Personnel - Drug discovery company appoints new director of clinical development
Personnel - Elpidio Villarreal named VP, associate general counsel by healthcare company
Personnel - Finance director named at drug delivery firm
Personnel - Frank Douglas elected to pharmaceutical company's supervisory board
Personnel - Gene therapy company adds member to board
Personnel - GeneMaps-focused company adds scientific team
Personnel - James P. Merryweather, PhD, named EVP, pharmaceutical corporate development
Personnel - James W. Sutton, MD, appointed VP, clinical development by HIV-focused company
Personnel - Juha-Matti Savola appointed to science, technology council in Finland
Personnel - Margaret A. Liu, MD, appointed to board of DNA-focused biosciences company
Personnel - Nanolytical tools developer appoints marketing director
Personnel - New senior VP, general counsel named at pharmaceutical firm
Personnel - Nicholas Vrolijk, PhD, named VP of manufacturing operations
Personnel - Ophthalmic pharmaceutical firm names Phil Tracy chairman of the board
Personnel - Pain-management company names Peter A. Lankau CEO
Personnel - Pharma company appoints board member
Personnel - Pharma company names vice president of government relations
Personnel - Pharmaceutical company announces promotions of senior managers
Personnel - Pharmaceutical company names Alzheimer association president to management team
Personnel - Pharmaceutical firm appoints chief medical officer
Personnel - Pharmaceutical firm appoints new CEO
Personnel - Research, technology development organization names VP of biosciences division
Personnel - Ruedi E. Waeger appointed to board of directors at pharmaceutical firm
Personnel - Synthetic blood-focused biopharm company convenes medical advisory board
Personnel - Thomas E. Hodapp resigns as director of clinical trials management company
Personnel - Tissue service company appoints new president, chief operating officer
Personnel - William Claypool, MD, appointed to board of morphogenics-focused biotech company
Pertussis Genomics and Genetics - Differential gene promoter activation in B. pertussis demonstrated
Pharmaceutical Research - Early study data show average of $70 million is spent on cancer drug launches
Pharmaceutical Research - Healthcare, biotech ompanies join forces to conduct cancer biomarker study
Pharmaceutical Research - Study examining Asia's drug consumption released
Pharmacokinetics - Insulin kinetics in type 1 diabetes described
Pharmacology - In vivo disintegration of encapsulated sumatriptan characterized
Philanthropy - Foundation awards $2 million for uninsured health care programs
Pneumocystis Infection - Neonatal lungs lack maturation factors for efficient cellular functioning
Policy - Drug companies and governments must act on fake drug problem
Polio Vaccines - Researchers' work adds to polio vaccines body of knowledge
Polycystic Ovary Syndrome - Insulin-sensitizing drugs boost endogenous dopaminergic tone in obese patients
Post-Herpetic Neuralgia - Biopharma company announces results of post-herpetic neuralgia phase II study
Pre-eclampsia Risk Factors - Smoking does not increase severity of pre-eclampsia
Product Licensing - BN ImmunoTherapeutics inlicenses technology for breast cancer vaccine
Product Licensing - Biopharmaceutical co. achieves milestone payments for successful collaborations
Product Licensing - Biopharmaceutical company licenses Opioid Growth Factor from Penn State
Product Licensing - Cancer signal inhibitor therapies company licenses CNS drug discovery property
Product Licensing - Chemicon licenses Quantum Dot antibody reagent line
Product Licensing - Endo licenses topical ketoprofen patch
Product Licensing - Rights to Neurodex technology acquired
Professional Education - Second Upstate Young Cell Signaller Award winners to be announced in Dundee, UK
Prostate Cancer - Biopharmaceutical company enters exclusive option agreement with UCSF
Prostate Cancer - Data from satraplatin trial for hormone-refractory prostate cancer published
Prostate Cancer - Earlier use of prostate cancer vaccines urged by Hopkins scientists
Prostate Cancer - Silencing of polo-like kinase 1 induced apoptosis of prostate cancer cells
Prostate Cancer Vaccine - Dendritic cell vaccine rescues peripheral T cell tolerance in prostate cancer
Protein Interactions - Protein-protein c-Myc interactions studied, specific inhibition described
Protein Kinase - Calcium/calmodulin-dependent protein kinase II in phosphorylation clarified
Proteomics - Low molecular weight cyclin E isoforms augment melanoma metastasis
Proteomics - New findings in the area of proteomics described
Proteomics - Transient transfection technology scales up protein production
Psoriasis - Survey shows psoriasis foundation members more aware, satisfied with treatments
Pulmonary Arterial Hypertension - Company reports positive clinical data from STEP study
Pulmonary Disease - First AERO stent implanted in the United Kingdom
RNA Research - Gene silencing technique looks promising for potential ALS therapy
Renal Cancer - Antisense oligonucleotide to Ki-67 limits tumor growth but not vessel density
Respiratory Pathogen - Respiratory infection spread during air travel rarely occurs
Restenosis - Promising results reported for Cypher stent
Retroviruses - Env disulfide bond isornerase examined, nature of triggering clarified
Rotavirus Vaccine - Immunization with rotavirus virus-like particles elicits immune responses
Rotavirus Vaccines - Researchers detail new studies and findings in the area of rotavirus vaccines
SARS - Convalescent plasma therapy shortens hospitalization stays of SARS patients
SARS - Events reconstructed during SARS outbreak in February 2003 in Singapore
SARS - Novel monoclonal antibodies neutralize SARS coronavirus in vitro
SARS - Nursing students more stressed than medical students during SARS outbreak
SARS - SARS seroprevalence rate is low in apparently healthy healthcare workers
SARS - SARS spike membrane glycoprotein studied, membrane active regions revealed
SARS Coronavirus - Recombinant nucleocapsid protein-based assay detects anti-SARS-CoV IgG
SARS Prevention - Residents of Taiwan have increased "willingness to pay" to reduce SARS risk
SARS Vaccine - Two neutralizing regions on SARS spike glycoprotein identified
SARS Virus - Hamster is better model than mouse for therapy against SARS virus replication
SARS Virus - SARS clinical features in the United States described
Salmonellosis Vaccine - Salmonella pathogenicity island trigger colitis
Salmonellosis Vaccine - Extracts from Salmonella Enteritidis protect against salmonellosis
Schistosomiasis - Impact of 10-year project on schistosomiasis control in China reported
Schistosomiasis - Results of small study show praziquantel treatment is safe during pregnancy
Schistosomiasis Vaccine - Calpain found in penetration glands of Schistosoma japonicum cercariae
Sepsis - Study identified sepsis-induced changes in signal transduction pathways
Sexual & Reproductive Health - Australian group makes inroads to male infertility
Smallpox Vaccine - Severe headaches common after smallpox vaccination
Sporotrichosis - Sporotrichosis diagnosis may be confounded by Leishmania coinfection
Squamous Cell Cancer - DPD expression predicted survival outcome and chemosensitivity of OSCC patients
Statins - Statin therapy was associated with lower risk of death in transplant patients
Stem Cell Research - 4-Hydroxynonenal inhibits cell proliferation in fetal liver HSCs
Stem Cell Research - Bcl-2 reduced/Fas activated by SCF/KIT inhibition signaling in melanocyte SCs
Stem Cell Research - Cytokines reverse gamma-globin gene silencing in erythroid stem cells
Stem Cell Research - HSC homing is optimal when CXCR4 is incorporated in membrane lipid rafts
Stem Cell Research - Negative feedback loop controls SCF-KIT signaling pathway
Stem Cell Research - PBMCs and BM-derived HPC populations affected by acute soman poisoning
Stem Cell Research - Prominin-1/CD133 is expressed certain types of kidney cancer
Stem Cell Research - United Nations votes to ban human cloning
Stem Cell Transplantation - Chronic GVHD risk increased in patients with HLA class I mismatched donors
Stem Cell Transplantation - High plasmacytoid dendritic cell recovery improves overall survival after ASCT
Stem Cell Transplantation - Selected cytokine elimination does not alter allogeneic hematopoietic resistance
Stroke Therapy - Antibodies specific for myelin-associated glycoprotein are neuroprotective
Surgical Technology - Companies provide equipment for revolutionary surgery at Walter Reed
Systemic Lupus Erythematosus - Rituximab induced remission from hypercoagulable state associated with LA
Tissue Engineering - Articular chondrocytes express phenotype in a collagen-containing sponge
Tissue Engineering - Hyaluronan gels useful for tissue engineering of aortic heart valves
Tissue Engineering - Mechanical load promotes osteoblastic stem cell proliferation in Col I matrix
Tissue Engineering - tHA ceramics support cell attachment/proliferation/differentiation
Tobacco Use - Smoking cessation market presents opportunity for NicAlert product
Toxicology - Rapid screening test for drug-induced phospholipidosis developed
Transplant Medicine - Autoimmune hepatitis forms following orthotopic liver transplantation
Transplant Medicine - Cyclosporine A-based combo therapy ineffective in preventing bone rejection
Transplant Medicine - Cyclosporine is rescue therapy for living donor adult liver transplant patients
Transplant Medicine - Findings describe new data in transplant medicine research
Transplant Medicine - Islet transplant completed in a patient with type 1 diabetes
Transplant Medicine - Livers from older donors may harm transplant recipients with hepatitis C
Transplant Medicine - Unexplained hepatitis in renal graft recipients may be caused by hepatitis E
Trypanosomiasis - Positive results announced from clinical trial of DB289 in trypanosomiasis
Tuberculosis - M. tuberculosis SigD sigma factor required for full virulence
Tuberculosis - String test as sensitive as sputum induction for TB detection in HIV infection
Tuberculosis Therapy - Mortality high among HIV-infected tuberculosis patients
Tuberculosis Vaccine - Fragmented M. tuberculosis cells increase efficacy of therapy against TB
Tuberculosis Vaccine - Plasmid DNA encoding mycobacterial hsp65 is effective treatment for TB
Tuberculosis Vaccine - Secretory protein ESAT-6 of Mycobacterium tuberculosis cloned
Tuberculosis Vaccine - Vaccination of possums with BCG reduces Mycobacterium bovis replication
Tuberculosis Vaccines - New findings in the area of tuberculosis vaccines detailed
Tuberculosis and Candida Coinfection - Candida coinfection higher in tuberculosis patients with complications
Type 1 Diabetes - First insulin-producing islet cell transplantation completed in diabetes patient
Type 1 Diabetes Therapy - Clinical approach to type 1 diabetes reviewed
Type 2 Diabetes - Hypoglycemia in type 2 diabetes reviewed
Type 2 Diabetes - Phase 2a clinical study with GLP-1 agonist for type 2 diabetes finalized
Umbilical Cord Blood Research - TGF-beta1 suppresses CTL differentiation of cord blood naive CD8+ cells
Urinary Incontinence - Market research firm forecasts trends for stress urinary incontinence treatment
Urology - Hypoxia-inducible factor predicts the risk for bladder cancer progression
Vaccine Development - Accomplishments noted in smallpox vaccine program
Vaccine Development - Company expands work load in support of vaccine development
Vaccine Development - Nanoparticle-based immunization challenges hepatitis B virus infection
Vaccine Development - Proteome microarrays used to profile humoral immune response to infection
Vaccine Development - Vaccinia or BCG immunization of melanoma patients linked to better survival
Vaccine Vector - Vector with mutant neo gene selects stable clones expressing fusion protein
Variant Creutzfeldt-Jakob Disease - Model choices for variant Creutzfeldt-Jakob disease projections are problematic
Vascular Prostheses - Endothelial cell attachment to prosthesis materials characterized
Vector Development - Inorganic phosphate nanoparticles support efficient pDNA transfection
Vector Development - Non-viral gene vectors composed of copolymers stabilize gene transfer
Vector Development - Small peptides provide controlled release of DNA from fibrin matrices
Venous Thromboembolism - VTE incidence calculated among Factor V Leiden carriers
Virology - 'Shooting galleries' spawn the transmission of infectious diseases
Virology - Apoptosis markers trace histological activity in viral hepatitis patients
Virology - Assembly polymerase chain reaction builds near full-length HCV cDNA clones
Virology - Clonal expansion accompanies woodchuck hepatitis virus infection
Virology - Findings describe new data in virology research
Virology - Herpes simplex virus infection studied, endoplasmic reticulum effects clarified
West Nile Virus - Interferon can cure cells of West Nile virus replicons
Wounds - Specialty pharmaceutical company granted patents for wound-healing products
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