Arthritis
Collagen-induced arthritis studied, effect of inhibitor revealed
Published in Drug Week, April 8th, 2005
"FR255031 (2-[(7S)-7-[5-(4-ethylphenyl)-2-thienyl]-1,1-dioxido-4-(2-pyridinylcarbonyl)hexahydrol,4-thiazepin-7-yl]-N-hydroxyacetamide) is a novel synthetic MMP inhibitor that inhibits human collagenases (MMP-1, MMP-8 and MMP-13), gelatinases (MMP-2 and MMP-9) and membrane type I MMP (MT1-MMP/MMP-14).
"FR255031 also inhibits rat collagenase and gelatinase. We studied the effect of FR255031 and Trocade, an inhibitor of collagenase and MMP-14, on a rat collagen-induced arthritis...
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Source: Drug Week (2005-04-08)
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