Published in Drug Week, April 8th, 2005
"In the context of bone development and regeneration, the intimate association of the vascular endothelium with osteogenic cells suggests that ECs may directly regulate the differentiation of osteoprogenitor cells," wrote D. Kaigler and colleagues, Harvard University.
"To investigate this question, BMSCs were cultured in the presence of EC-conditioned medium, on EC extracellular matrix, and in EC cocultures with and without cell contact. RNA and protein were isolated from ECs and analyzed by reverse...
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