Cancer Immunotherapy
Fusion protein fights cervical cancer in murine models
Published in Drug Week, April 29th, 2005
According to a study from the United States, "a major agenda for tumor immunology is the generation of specific immune responses leading to the destruction of incipient and frank neoplasia. In this report, we show that a novel HPV16 E7 fusion protein can produce objective therapeutic responses against incipient cervical cancer in genetically engineered mice that express in the cervix the HPV16 early region genes implicated as causative agents in human cervical cancer."
"Although nonresponsive toward the HPV16 E7 oncoprotein in the CD8+ T-cell compartment by virtue of MHC haplotype, the mice were...
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Source: Drug Week (2005-04-29)
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