Drug Week
Susan Hasty, Publisher
Table of Contents . . . May 6th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Angina - Phase IIb GENASIS clinical trial receives recommendation to proceed
Cancer Therapy - Personalized melanoma vaccine trial commences
Drug Development - New drug application filed for narcolepsy therapy Nuvigil
Drug Resistance - Targeting senescence pathways reversed drug resistance in cancer
Peripheral Arterial Disease - Drug-eluting stent trial to treat PAD enrolls first patient at Stanford
AIDS Research - Initiating ART in primary SIV may lead to mucosal immune system restoration
AIDS Therapies - UN says anti-AIDS gel for women isn't far off
AIDS Therapy - ddI leads to depletion of mtDNA in lymphocytes, functional impairment
Accutane - Isotretinoin levels after single oral dose determined by HPLC
Acinetobacter Outbreaks - Acinetobacter baumannii nosocomial outbreak strain produces PER-1 ESBL
Acute Myeloid Leukemia - Chemosensitivity index enables prediction of individual chemotherapy responses
Cancer Therapy - Reports describe recent advances in cancer therapy research
Acute Myeloid Leukemia - New findings in acute myeloid leukemia described
Addiction Medicine - Hepatitis C-positive injection drug users remain RNA negative after therapy
Addiction Medicine - New drug application submitted to U.S. FDA for Vivitrex
Addiction Medicine - Nicotine patch and lozenge effective in very heavy smokers
Addiction Medicine - Phase 3 study results on drug, therapy in alcohol dependent patients in JAMA
Addiction Medicine - Spending on mental and substance use disorders concentrated in public sector
Cancer Therapy - Researchers' findings advance cancer therapy research
Adenovirus - Interaction of adenovirus protein with packaging sequences examined
Adjuvant Therapy - Combined estrogen/antipsychotic therapy doesn't prevent relapse in females
Adverse Drug Reaction - Bugs in the gut could help doctors develop individualized healthcare
Adverse Drug Reaction - Pre-existing immunity alters host response to systemic adenoviral vector
Adverse Drug Reaction - Study shows Botox may reduce frequency of chronic migraine headaches
African Swine Fever - Invader assay adapted for African swine fever virus DNA detection
Diabetes Therapy - Recent findings in diabetes therapy provide new insights
Allergic Rhinitis - Efficacy and safety clinical data for R112 phase II study published
Allergy & Immunology - Academy advises avoid triggers, use anti-inflammatory medications for asthma
Allergy & Immunology - Inhaled antisense oligonucleotide alleviates murine asthma
Allergy & Immunology - Institute announces effectiveness of nasal filter against hay fever
Allergy & Immunology - Supplemental new drug application submitted to FDA for ZYFLO
Allergy Medicine - New research in the area of allergy medicine detailed
Diagnostics - Studies describe new findings in diagnostics research
Alzheimer Disease - Anti-tau antibodies have research and therapeutic value
Alzheimer Disease - Delay in AD onset seen for first time
Alzheimer Disease - Nicotine exacerbates tau pathology in vivo
Alzheimer Disease - Research in Alzheimer disease provides new insights
Androgen Receptor - Notch signaling mediator Hey1 is an androgen receptor corepressor
Angelman Syndrome - Characteristics of epilepsy in Angelman syndrome patients elucidated
Endocrinology - Researchers report details of new studies and findings in the area of endocrinology
Angiology - Alternate techniques increase the depth of saphenous vein gene transfer
Angiology - Biotechnology company to supply autologous thrombin kits to Biomet, Inc.
Animal Models - Structure of rat behavior in forced swimming test clarified
Anti-Infectives - Metabolic status and viability of S. mutans cells analyzed
Antibiotics - Staphylococcus aureus examined, roles of penicillin-binding protein 2 shown
Antibiotics - Daptomycin used to treat serious Gram-positive infections
HIV/AIDS Vaccines - Reports add new data to HIV/AIDS vaccines research
Anticancer Therapy - Inhibitory effects of anticancer peptide from Mercenaria examined
Antimicrobial Agents - Orthophthalaldehyde surpasses glutaraldehyde for disinfecting medical devices
Antioxidants - Cranberry phenolics-mediated antioxidant enzyme response
Antisense Technology - Morpholino antisense oligomers targeting human midkine fights cancer
Antitumor Activity - Antitumor activity of an ethanol extract of Nigella sativa seeds
Hematology - New findings in hematology described
Antivenom - Equine monovalent and polyvalent snake antivenoms compared
Antiviral Drug Development - Understanding viral life cycles crucial to exploit antiviral strategies
Apoptosis - Annexin A5 analyzed, downregulation of tissue factor expression revealed
Apoptosis - Apoptosis in neutrophils studied, role of protein phosphatase 2A defined
Apoptosis - CIN85 analyzed, association with tumor necrosis factor receptor clarified
Apoptosis - Data advance knowledge in apoptosis research
Malaria Vaccines - Recent studies add new data to malaria vaccines research
Apoptosis - Myeloma cell survival analyzed, critical cell cycle step identified
Apoptosis - p53 has crucial role in signal transduction pathways of silica-induced apoptosis
Arteriovenous Malformations - Liquid embolic agents studied with intracranial arteriovenous malformations
Arthritis - Lyme arthritis synovium studied, diverse antibody repertoire demonstrated
Arthritis - Pharma co receives U.S. FDA clearance for injured tissue stem cell therapy trial
Arthritis - Two drugs combined more cost-effective, safer for high-risk patients
Malaria Vaccines - Researchers describe findings in malaria vaccines studies
Arthritis Therapy - Novel microemulsion enhances transdermal piroxicam delivery
Assisted Reproduction - IVF/breast cancer patients safely use tamoxifen or letrozole plus low-dose FSH
Asthma - Reports describe recent advances in asthma research
Asthma - Treating GERD may not improve asthma control
Atherosclerosis - Recent findings in atherosclerosis provide new insights
Atherosclerosis Risk Factors - Plasma asymmetric dimethylarginine is high in acute coronary syndrome
Malaria Vaccines - Researchers provide details of new studies and findings in the area of malaria vaccines
Atrial Fibrillation - Medical treatment of atrial fibrillation remains controversial
Attention Deficit Hyperactivity Disorder - Effect of methylphenidate on brain activity characterized
Attention Deficit Hyperactivity Disorder - Pharmaceutical companies announce positive data for transdermal ADHD treatment
Autoimmune Disease - Immune disease-focused biopharm company acquires assets for monoclonal antibody
Autoimmune Disease - Toll-like receptor 9 polymorphism is not linked to systemic lupus erythematosus
Avian Influenza - Health officials detail avian influenza cases in Viet Nam, Cambodia
Melanoma Vaccines - Studies advance knowledge in melanoma vaccines research
Bacille Calmette-Guerin Infection - PB/BM findings described in disseminated bacille Calmette-Guerin infection
Bacteriology - M. gastri cause of disseminated infection in children of same family
Bacteriology - Antimicrobial activity of Croton cajucara Benth linalool-rich essential oil
Bacteriology - PCR detects and quantitates benzoyl-CoA reductase genes from bacteria
Bacteriology - Stanford researchers to investigate antibiotic effects on intestinal microbes
Bacteriology - Staphylococcal superantigen-like protein studied, effects clarified
Metabolic Syndrome - Researchers' data advance metabolic syndrome research
Basal Cell Cancer - Candidate for basal cell carcinoma under co-development by Genentech, partner
Biological Therapy - Transfected B cells defeat problems linked to dendritic cell-related therapy
Biomedical Engineering - Scaffolds containing PEI-condensed DNA regenerate bone growth
Biomedical Engineering - Technological advances exploited to engineer cardiac tissue
Biomimetics - Electrochemical activation of titanium investigated
Biotechnology - Enzyme productivity increased by induced oxidative stress
Obesity and Diabetes - Researchers describe findings in obesity and diabetes studies
Biotechnology - ParAllele BioScience inks license and comarketing agreement
Bioterrorism - Phase I clinical study on NEUMUNE begins
Bone Cancer - Tumor volume change after chemotherapy used as a predictive factor of survival
Bone Marrow Transplantation - Early VRE infection post-BMT associated with rapid deteriorating clinical course
Bovine Viral Diarrhea Virus - Cellular insertion in NS2 gene of BVDV is potential pathogenic marker
Brain Cancer - Therapeutic effects of holmium-166 chitosan complex in rat brain tumor model
Oncology - Researchers provide details of new studies and findings in the area of oncology
Breast Cancer - Antibody plus paclitaxel improves survival in patients with metastatic disease
Breast Cancer - Breast cancer risk higher with synthetic progestin than micronized progesterone
Breast Cancer - Conjugated linoleic acid reduced murine mammary tumor cell
Breast Cancer - Enrollment initiated in study of Abraxane as first-line therapy
Breast Cancer - Few at-risk women are willing to take tamoxifen prophylactically
Breast Cancer - Health Canada approves letrozole
Oncology - Studies add new findings to oncology body of knowledge
Breast Cancer - Ki67 breast cancer marker correlates with regulation of apoptosis-related genes
Breast Cancer - Methyl mercury influences growth-related signaling in breast cancer cells
Breast Cancer - PEA3 and AP-1 involved in regulation of breast cancer-linked gene, mammaglobin
Breast Cancer - Real-time PCR measures Epstein-Barr virus DNA in archival breast adenocarcinomas
Breast Cancer - Reimbursement coding expands access of accelerated partial breast irradiation
Breast Cancer - Reports add new data to breast cancer research
Pneumococcal Vaccines - Researchers' work adds to pneumococcal vaccines body of knowledge
Breast Implants - U.S. FDA seeks more information on cohesive gel breast implant PMA application
Bronchitis - Telithromycin safe and effective for treatment of acute exacerbations
Bronchopulmonary Dysplasia - Surfaxin phase III results published in peer-reviewed journal
Brucellosis - Researcher reviews brucellosis at dawn of the 21st century
Business & Finance - Biosciences company updates business, financial results, and ECO-4601 progress
Business & Finance - Drug company concludes credit agreements to refinance Aventis acquisition
Pneumococcal Vaccines - Studies add new findings to pneumococcal vaccines body of knowledge
Business & Finance - Orthopedic devices provider added to Russell Indexes
Business & Finance - Pharmaceutical company announces year-end results
Business Update - Biotech company retains consultant to pursue U.S. SEC reporting status
Business Update - Buccal-drug-delivery company establishes regulatory compliance committee
Business Update - Clinic offering bacteriophage therapy announces expansion
Business Update - Company focused on HIV prevention receives grant for product development
Tissue Engineering - Studies advance knowledge in tissue engineering research
Business Update - Crucell and DSM announce PER.C6 licensing agreement
Business Update - Dalton Chemical Laboratories, Inc. announces name change
Business Update - Developer of small molecule pharmaceuticals signs agreement with Invitrogen
Business Update - Genetronics announces name change
Business Update - High-content screening capabilities expanded at China's NCDS
Business Update - Kinase inhibitor libraries to be exploited via kinase screening services
Virology - Findings in virology provide new insights
Business Update - Maker of cellular therapies for tissue regeneration buys campus in Switzerland
Business Update - Medical device company establishes new x-ray life sciences laboratory
Business Update - Medical device company renames surgical navigation business
Business Update - Microbial identification system meets U.S. FDA good manufacturing practices
Business Update - Nanobiotechnology company changes name and enters new markets
Business Update - New drug screening company opens in Wisconsin
Virology - Recent findings illuminate research in virology
Business Update - PacifiCare extends business process outsourcing contract
Business Update - Pharma company acquires Tarpan Therapeutics; names chief executive officer
Business Update - Pharmaceutical company gives update on progress
Business Update - Pharmaceutical firm discontinues AAV gene therapy funding
Business Update - Pharmaceutical firm opens R&D center in India
Business Update - Pharmaceutical firm participates in Partnership for Prescription Assistance
Virology - Researchers' work adds to virology body of knowledge
Business Update - Phillips Health, LLC, announces name change
COX-2 - Skin tumors studied, role of kinases clarified
Cancer Drug Resistance - GSH inhibits trypsinization of C-terminal MRP1
Cancer Genetics & Genomics - Single-round PCR assay detects BCL2-IGH
Cancer Immunotherapy - Adjuvant can boost the efficacy of natural killer cell-based cancer therapy
Cancer Immunotherapy - Interleukin 12 gene transfer retards fibrosarcoma growth and metastasis
Cancer Inhibitor - Leukemia inhibitory factor receptor characterized in goldfish
Cancer Prevention - Anthocyanidins from fruits and vegetables inhibit tumor cell growth
Cancer Research - FDA clearance received to initiate phase I REOLYSIN trial for solid tumors
Cancer Risk Factors - HBV genotype A raises liver cancer risk in Bantu-speaking sub-Saharan Africans
Cancer Therapy - Amifostine protection from cisplatin toxicity is time-dependent
Cancer Therapy - Animal cancer diagnostics company launches directed chemotherapy assay
Cancer Therapy - Antiemetic drug receives marketing authorization in Europe
Cancer Therapy - Company initiates clinical development of proprietary antibody to PSMA
Cancer Therapy - EMEA issues final advice letter on pancreatic cancer trial protocol
Cancer Therapy - Endogenous angiogenesis inhibitors are endothelium-specific tumor suppressors
Cancer Therapy - Enrollment completed for phase III trial of Trisenox in leukemia patients
Cancer Therapy - Eradication of tumors in various mouse models by company's BiTE drugs reported
Cancer Therapy - Irreversible electroporation ablates cancer without causing thermal injury
Cancer Therapy - Liver-selective thyromimetic KAT-681 prevents liver tumors in rodent models
Cancer Therapy - Microcatheter-arterial port system shows promise for intra-arterial therapy
Cancer Therapy - New findings in cancer therapy described
Cancer Therapy - Spinal cancer treatment development funded by U.S. National Institutes of Health
Cancer Vaccine - Modification of tumor antigen induced divergent T lymphocyte responses
Cancer Vaccine - Monoclonal antibody fused to GM-CSF breaks tolerance to CEA
Cancer Vaccines - MHC epitope presentation by cancer vaccines is transporter-independent
Cancer Vaccines - New findings in the area of cancer vaccines detailed
Carcinogenesis - Carcinogens generate gene-specific changes in murine liver tumors
Carcinogenesis - Classification of carcinogenicity of N-nitroso compounds reviewed
Carcinogenesis - Coal tar mixture activated carcinogenesis
Carcinogenesis - Effects evaluated of arsenic and ultraviolet B on normal cultured keratinocytes
Cardiac Surgery - Autologous blood predonation with erythropoietin avoids homologous transfusion
Cardiac Surgery - Bivalirudin use was associated with fewer bleeding events
Cardiac Surgery - Symptomatic cerebrovascular accidents are rare following the Fontan procedure
Cardiology - Catheter maker reports modifications in cardiac assist strategy
Cardiology - IND filed with U.S. FDA to evaluate AMD3100 for heart attack patients
Cardiology - Periadventitial angiopoietin-1 gene transfer generates neovascular growth
Cardiology - Women with PCOS at increased risk for cardiovascular disease, study shows
Cardiomyopathy - Serial assessment may not be optimal for detecting myocardial damage
Cardioprotection - Antioxidative activity may affect cardioprotection of Ganoderma lucidum
Cardioprotection - Treatment with melatonin and derivatives could reduce oxidative stress
Cardiovascular Disease - Fruit juice, herb extracts can be effective in managing oxidation-linked disease
Cardiovascular Disease - Role of therapies in preventing heart disease in diabetes outlined
Cell Biology - beta-Catenin modulates the fate of avian mesonephric endothelial cells
Cell Development - Trophoblast cells studied, expression of cFABP and PPAR defined
Central Precocious Puberty - Long-term leuprorelin treatment effective for boys and girls
Chemokines - Chemokines examined, binding to sulfatides documented
Chikungunya Virus - RT-PCR without RNA extraction detects/quantifies African Chikungunya viruses
Childhood Immunization - Combination vaccine produces lower immune response
Chlamydia Therapy - Treatment failures for Chlamydia trachomatis evaluated
Cholera Epidemics - Seasonal cholera epidemics inversely correlate with cholera phage prevalence
Chronic Hepatitis C - Immunoregulatory cytokine polymorphisms do not predict hepatitis C clearance
Chronic Liver Disease - Liver steatosis predicts how hepatitis C patients will respond to interferon
Chronic Myeloid Leukemia - Recent approaches to CML interrupt key signaling pathways activated by Bcr-Abl
Chronic Obstructive Pulmonary Disease - Analysis suggests Spiriva may slow decline in FEV1 in COPD patients
Clinical Trials - Cancer/inflammation-focused pharma announces Celgene investment
Clinical Trials - Clinical trials of onercept for psoriasis, Canvaxin for melanoma discontinued
Clinical Trials - Clot buster enters Phase II stroke trial
Clinical Trials - Novel product effective against antibiotic resistance
Clinical Trials - Phase 2 clinical trial for metastatic breast cancer therapy to proceed
Clinical Trials - Phase I study of novel oral cancer compound, INCB7839, begins
Clinical Trials - Positive phase 2a results for post-herpetic neuralgia drug reported
Clinical Trials - Positive preliminary clinical data on transdermal treatment for ADHD announced
Clinical Trials - U.S. National Institutes of Health grant for telemedicine trial approved
Clinical Trials - U.S.FDA grants approval of IND for clinical trial of organic arsenic compound
Colitis - Intestinal homeostasis falters in mice that cannot produce interleukin 10
Collaborations - Cancer discovery collaboration with Dendreon expanded
Collaborations - Curis announces second major collaboration
Collaborations - Cytos expands collaboration for new drug targets
Collaborations - Deal signed for development, marketing of Oxygent in China
Collaborations - License granted to Boehringer Ingelheim for access to technology
Collaborations - Pharma companies announce drug target validation project milestone reached
Collaborations - Pharmaceutical firms sign deal for development of urological disorder therapy
Collaborations - Transfer of plasma business assets to Talecris Biotherapeutics is complete
Colon Cancer - Curcumin inhibits colon cancer via PPARgamma activation
Colon Cancer - Gastrin promotes colon cancer via CCK-2 receptor-mediated COX-2 induction
Colon Cancer - Quercetin inhibits beta-catenin/Tcf signaling in colon cancer cells
Colon Cancer - Researchers report details of new studies and findings in the area of colon cancer
Colorectal Cancer - n596 gene deletion causes hereditary nonpolyposis colorectal cancer
Complementary & Alternative Medicine - About 70% of older adults use alternative medicine
Complementary & Alternative Medicine - Glucotize launched for treatment of diabetes complications
Complementary & Alternative Medicine - Immunoglobulin protein isolate may lower LDL cholesterol, study shows
Complementary & Alternative Medicine - Korean herbal medicine Panax notoginseng prevents rodent liver dysfunction
Complementary & Alternative Medicine - Maker of TCM-based drugs to establish company in New York, eyes global expansion
Complementary & Alternative Medicine - NaoXingQing-derived flavonoids reduce oxidative cell damage
Complementary & Alternative Medicine - Survey assesses medical marijuana use of in U.K.
Complementary & Alternative Medicine - Use of CAM by psychiatric inpatients evaluated
Congestive Heart Failure - Research suggests need to rethink causes of heart failure
Contraception - Formulation completed for new contraceptive transdermal gel
Contraception - Mifepristone's potential as an emergency contraceptive drug is examined
Contraception - Unique reproductive-cell protein in mice could lead to new contraceptives
Contraceptive Microbicide - Contraceptive microbicide nonoxynol-9 has deleterious effects on endometrium
Coronary Bifurcational Lesions - Single- and double-branch sirolimus-eluting stent treatment has similar outcome
Cost-Benefit Analysis - Cost-benefit analysis of kidney and cardiovascular disease treatment program
Crohn Disease - Utility of antibiotic treatment reviewed
Cryptococcus - MAT mating types of Cryptococcus neoformans stimulate B cells
Cushing Disease - Pioglitazone treatment does not attenuate symptoms
Cutaneous Tuberculosis - Tuberculosis verrucosa cutis results in fixed-flexion deformity of arm
Cyclooxygenase - Macrophage prostaglandin production studied, molecular aspects elucidated
Cyclosporin - Podocyte expression examined in nephrosis, cyclosporin impact clarified
Cytomegalovirus - Cytomegalovirus-specific CTLs enhanced by recombinant virus
DNA Research - Researchers develop new method to detect loss, gain of DNA regions across genome
Deep Vein Thrombosis - New nonsurgical techniques effective in deep vein thrombosis treatment
Depression Therapy - Escitalopram superior to citalopram for treatment of severe depression
Dermatology - Interleukin 10 variants correlate with overall survival in advanced melanoma
Dermatology - Lab company releases prescription benzoyl peroxide products for acne vulgaris
Dermatology - Medical company completes enrollment for study of nail fungal treatment
Diabetes Pathogenesis - Activation of rapamycin pathway target inhibits insulin signaling
Diabetes Pathogenesis - Diabetic hyperalgesia absent in bradykinin B1 receptor-knockout mice
Diabetes Pathogenesis - Effects of Stat4/6 deficiency on type 1 diabetes due to T cells
Diabetes Pathogenesis - Loss of glucagon response to hypoglycemia in diabetes explained
Diabetes Pathogenesis - Munc18c heterozygous knockout mice susceptible to glucose intolerance
Diabetes Pathogenesis - Researchers' work adds to diabetes pathogenesis body of knowledge
Diabetes Pathogenesis - Sphingolipids play role in producing common features of type 2 diabetes
Diabetes Therapy - Automated protein-tyrosine phosphatase 1B inhibition assay developed
Diabetes Therapy - Chimeric rice seeds stimulate beta-cell insulin secretion
Diabetes Therapy - Coronary revascularization procedures in diabetic patients compared
Diabetes Therapy - Docosahexaenoic acid metabolites reported as antidiabetic agents
Diabetes Therapy - European Commission extends marketing authorization of diabetes treatments
Diabetes Therapy - Findings in diabetes therapy provide new insights
Diabetes Therapy - Glimepiride enhances intrinsic PPAR-gamma activity in 3T3-L1 adipocytes
Diabetes Therapy - Glutamate inhibits protein phosphatases and promotes insulin exocytosis
Diabetes Therapy - Importance of treating both diabetes and hypertension outlined
Diabetes Therapy - Palmitate-derivitized analogues of GIP have antihyperglycemic activity
Diabetes Therapy - Pioglitazone benefits patients with diabetes and metabolic syndrome
Diabetes Therapy - Private company to produce iron-binding drugs for use in U.S. clinical studies
Diabetes Therapy - Thiazolidinediones upregulate fatty acid uptake in adipose tissue
Diabetic Foot - Pressure dressing and antibiotics for diabetic foot treatment reviewed
Diabetic Nephropathy - Angiotensin blockade attenuates development of renal injury in diabetes
Diabetic Nephropathy - Mechanical stretch induces monocyte chemoattractant activity
Diabetic Nephropathy - Mechanisms of bradykinin promotion of glomerular injury outlined
Diabetic Nephropathy - Myotubes use saturated palmitate and unsaturated oleate differently
Diabetic Nephropathy - Recent studies add new data to diabetic nephropathy research
Diabetic Neuropathy - Damage caused by diabetic neuropathy may be irreparable
Diagnostics - Blood RNA assays detect mutations linked to hereditary kidney disease
Diagnostics - Company enrolls first patient in ATPace phase II trial
Diagnostics - Contrast-enhanced MRI can be used to monitor tumor microvasculature
Diagnostics - Electronic nose capable of sniffing out early traces of lung cancer
Diagnostics - Flow cytometry detects circulating endothelial cells and their progenitors
Diagnostics - Flow cytometry quantifies corneal angiogenesis in murine models
Diagnostics - French in vitro diagnostics company will play role in platelet collection system
Diagnostics - PCR-RFLP discriminates Campylobacter jejuni strains
Diagnostics - Reports describe recent advances in diagnostics research
Diarrhea - Phase III study begins of therapy for C. difficile-associated diarrhea
Diet & Nutrition - Elemental diet improves nutritional recovery from diarrhea/malnutrition
Diet & Nutrition - Nutritional products company inks joint venture agreement with Kikkoman
Diet & Nutrition - Vitamin E supplements may speed up development of cancer, study says
Diet and Nutrition - Study compares absorption rates of different types of nutritional chromium
Diet and Nutrition - Study shows effectiveness of conjugated linoleic acid supplement in weight loss
Disease Associations - Matrix metalloproteinase pattern in celiac duodenal mucosa
Disease Associations - Neuron oxidative toxicity studied, role of reversible phophatase oxidation shown
Dopamine Receptors - Pinealocyte dopamine receptor activation studied, pathway revealed
Drug Abuse - Drug treatment center tackles illegal steroid use
Drug Delivery - Chemical library aids in developing drug system for nerve damage
Drug Delivery - Collagen-chondroitin sulfate-based PLLA-SAIB-coated rhBMP-2 studied
Drug Delivery - Drug services company adopts security system to help combat drug counterfeiting
Drug Delivery - Effects of lyophilization on liposome stability determined
Drug Delivery - FDA approves intravenous formulation for NEXIUM
Drug Delivery - Large-scale production techniques extend lipoplex shelf-life
Drug Delivery - New findings in the area of drug delivery detailed
Drug Delivery - Novel polysaccharidic gel matrix developed and characterized
Drug Delivery - PEG-p(CL-co-TMC) copolymers show promise as oral delivery system
Drug Delivery - Tissue reactions of in situ-formed dextran hydrogels investigated
Drug Development - BG-12 psoriasis study meets primary endpoint
Drug Development - Benchmarks for pharmaceutical market research function outlined in report
Drug Development - Best practices for cold chain management discussed at meeting
Drug Development - Biopharma company confirms scale up of Cascade technology for plasma proteins
Drug Development - Branded drug companies release their own generic versions
Drug Development - CEL-1000 peptide effective against viral encephalitis in mice
Drug Development - Clinical trial initiated for new pain drug candidate
Drug Development - Computer modeling allows vaccine design by computer
Drug Development - Data released in study of Coroxane for restenosis
Drug Development - Glycerophosphoinositols inhibit tumor cells from invading extracellular matrix
Drug Development - Hormone developer comments on U.S. NIH estrogen therapy statement
Drug Development - Hybrid molecule inhibits amyloid beta-induced neurotoxicity
Drug Development - Interim results of Rectogesic hemorrhoid trial released
Drug Development - Launch of eszopiclone drug for treatment of insomnia announced
Drug Development - Medical research co. announces that Elafin will be subject to clinical testing
Drug Development - NDA for investigational compound to treat chronic constipation submitted
Drug Development - Novel apolipoprotein E-derived agent improves outcome after brain trauma
Drug Development - ONYX-015 and MAP chemotherapy may help some patients with advanced sarcomas
Drug Development - Orphan drug designation granted by U.S. FDA for ovarian cancer treatment
Drug Development - Patient enrollment completed in European phase II trial of Hemopure
Drug Development - Pharma company announces proprietary manufacturing process for Mutacin 1140
Drug Development - Pharma company enters new drug development partnership with Kirin for NU206
Drug Development - Pharmaceutical company announces IND filing for topical anti-viral product
Drug Development - Pharmaceutical company expands commercial catalyst portfolio
Drug Development - Pharmaceutical firm to produce phenylephrine hydrochloride
Drug Development - Phase II trial of Hematide initiated for treatment of anemia
Drug Development - Phase III trial for estradiol gel completed
Drug Development - Phase III trial of Phenoptin initiated for PKU
Drug Development - Portugal-based company successful in drug development
Drug Development - Replicon systems are not exact predictors of anti-hepatitis C activity
Drug Development - Rheumatoid arthritis drug completes phase II trial
Drug Development - Scientific review of TransMab technology is published
Drug Development - Zanaflex capsules launched for spasticity management
Drug Importation - Texas, Canada pharmacists, state legislator fight importing of Internet drugs
Drug Resistance - Data shows increase in multi-drug resistant Streptococcus Pneumoniae in U.S.
Drug Resistance - Findings in drug resistance provide new insights
Drug Therapy - Dihydrofolate reductase analyzed, catalytic site configurations explored
Embryonic Stem Cell Research - Embryonic stem cells generate airway epithelial tissue
End-Stage Renal Disease - Several factors influence reported rises in end-stage renal disease.
Endocrinology - Genetic assays of adrenocortical tumors define cancer and recurrence risk
Endocrinology - Insulin's stimulation of VEGF promotes angiogenesis and fat accumulation
Endocrinology - Limited diffusion impedes the transfection of pituitary tumors
Endocrinology - Reports add new data to endocrinology research
Endocytosis - G protein-coupled receptor studied, endocytosis revealed
Enzymology - Crystal structure provides insights into glucocorticoid interconversion
Enzymology - HBV X protein-induced enzyme activity causes cancer
Enzymology - Rubinstein-Taybi syndrome is caused by CBP and EP300 gene mutations
Epidemiology - Multidrug-resistant A. baumannii outbreak confined to ICU and surgical ward
Epidemiology - Nosocomial outbreak investigation database developed
Epilepsy - Zonisamide capsules don't affect pharmacokinetics of OCs containing EE, NOR
Epirubicin - Effects of epirubicin on proliferation of Ehrlich ascites carcinoma cells
Epstein-Barr Virus - Epstein-Barr virus dUTPase upregulates the production of TNF-alpha
Erectile Dysfunction - PDE5 inhibition prevents erectile function in diabetic rats
Esophageal Cancer - CDC2/CDK1 expression in esophageal cancer is potential drug target
Ethics - Execution by lethal injection is not humane or painless, suggests study
Ethics - Researcher sheds light on ghostwriting in medical journals
Fatty Liver Disease - Serum antioxidant levels change in patients with non-alcoholic steatohepatitis
Fibromyalgia - Researchers' work adds to fibromyalgia body of knowledge
Fibromyalgia - Study shows pregabalin improves symptoms
Finance - ATP maker reports net loss of $1,561,000 for 2004
Finance - Atrium Biotechnologies files final prospectus for $75M IPO
Finance - Bioactive products company reports financial results
Finance - Biodefense grant awarded to analyze genomes
Finance - Biopharmaceutical company updates its 2005 revenue guidance
Finance - Biotech company announces agreement for sale of common stock
Finance - Biotech company commences exchange offer for notes due 2032
Finance - Biotech company completes $5.9M financing round
Finance - Biotech company complies with NASDAQ rule regarding 10-K
Finance - Biotech company records loss of $0.28 per share
Finance - Botaniex projects fiscal 2005 revenue of over $2,000,000
Finance - Cancer-focused pharmaceuticals company files shelf registration statement
Finance - Cellular storage company reports 27% increase in revenue
Finance - China-based nutritional supplement company reports Q4, 12-month financials
Finance - Company announces $56M partnership for commercialization of ANDAs
Finance - Drug-delivery company announces closing of $15.74 million stock offering
Finance - FemOne announces 2004 earnings results: Gross profits increased 99%
Finance - Immune system-focused biotech company reports full year Q4 2004 results
Finance - India-based pharmaceutical company offers $40 million foreign currency bonds
Finance - Investors in pharma company exercise option to purchase additional senior notes
Finance - Lexapro maker revises guidance downward
Finance - Molecular-diagnostics company closes follow-on series C funding
Finance - Nutrition products company reports fiscal 2005 third quarter financial results
Finance - Pharma company discloses first quarter results for FACTIVE tablets
Finance - Pharmaceutical company reaches sales of EUR900 million in 2004
Finance - Pharmaceutical company reports 355% increase in revenue
Finance - Pharmaceutical company reports loss of $0.18 per share
Finance - Pharmaceutical firm announces $17.1M common stock offering
Finance - Pharmaceutical firm announces closing of underwriters' option
Finance - Pharmaceutical firm announces results of tender offer
Finance - Pharmaceutical firm files resale registration statement
Finance - Pharmaceutical firm files resale registration statement for notes
Finance - Pharmaceutical services company lowers earnings estimate
Finance - Pharmaceutical services company reaffirms first quarter guidance
Finance - Weight loss company expects to report record first quarter revenues
Food Safety - Use of product to control microbe growth in seafood confirmed by U.S. FDA
Gangrene - Clostridium perfringens alpha-toxin characterized
Gastric Varices - Microcatheter-based retrograde transvenous obliteration effective
Gastroenterology - Mature insulin-like growth factor transfection arrests colon cancer growth
Gene Research - Genetic elements affect susceptibility to hemolytic uremic syndrome
Gene Silencing - PEI powers small interfering RNA into cells
Gene Transfer - Cells internalize biologically active recombinant DNA spontaneously
Gene Transfer - Optimized ligand conjugation degree improves PPA gene carrier ability
Generic Drugs - Generics association praises Israel for providing 5 years of data exclusivity
Generic Drugs - Pharma announces agreement to make, distribute controlled-release generic
Generic Drugs - Pharma company receives FDA approval to market a generic alternative to Macrobid
Genetics & Genomics - Database of human organ gene expression profiles developed
Genetics & Genomics - New application for gene expression profiling of rat and mouse tissues
Genetics & Genomics - New signature genetics test allows physicians to personalize drug therapy
Glioma - Utility of MRI in clinical trials of adult patients reviewed
Gonadotropins - Cushing syndrome studied, screening for illegitimate receptors described
Gynecology - Specific KIR genes and genotypes may be linked to cervical cancer neoplasia
HIV-2 Epidemiology - SIVsm strains isolated from Sierra Leone bush meat highly divergent from HIV-2
HIV/AIDS & Syphilis Coinfection - Seronegative syphilis in HIV patient tests positive by dark field examination
HIV/AIDS Diagnostics - Early response to antiretroviral treatment predicts long-term response
HIV/AIDS Diagnostics - NucliSens EasyQ correlates with Roche Amplicor in monitoring HIV-1 RNA in Africa
HIV/AIDS Diagnostics - Sensitive PCR estimates HIV-1 in CD4+ cells in patients responding to HAART
HIV/AIDS Drug Development - CCR5 antagonist suppresses replication/CPE in HIV-infected mouse model
HIV/AIDS Drug Interactions - Antiretrovirals often interact with medications for OIs and primary care
HIV/AIDS Drug Resistance - Recent findings in HIV/AIDS drug resistance described
HIV/AIDS Epidemic - Assay screens HIV-1 in epidemics characterized by mono/dual clade predominance
HIV/AIDS HAART - High blood lipids observed with PIs increase 10-year coronary risk
HIV/AIDS Healthcare - Treatment-seeking behavior same in HIV/AIDS orphans/nonorphans in Kampala
HIV/AIDS Pathogenesis - APOBEC3G antiviral function can dissociate from cytidine deaminase activity
HIV/AIDS Pathogenesis - HIV-1 catalytic core domain residues important for HIV-1 replication/integration
HIV/AIDS Pathogenesis - HIV-1 clade promoters strongly influence replication spatial/temporal dynamics
HIV/AIDS Pathogenesis - HIV-1-specific CD4+ cell turnover and activation increase upon viral rebound
HIV/AIDS Pathogenesis - POSH is essential for HIV-1 production
HIV/AIDS Pathogenesis - Unintegrated HIV-1 reservoir in recently infected resting CD4+ cells very labile
HIV/AIDS Pediatrics - Infants are increasingly exposed antiretrovirals even from conception
HIV/AIDS Research - "Preloaded" natural killer cells efficiently lyse HIV-infected target cells
HIV/AIDS Research - Quantitation of RT-PCR defective/ecotropic viruses in murine AIDS
HIV/AIDS Risk Behavior - Puerto Rican crack users in Puerto Rico have riskier sex than those in New York
HIV/AIDS Therapy - Chronic viral hepatitis alters the pharmacokinetics of antiretroviral therapy
HIV/AIDS Therapy - Lethal mutagenesis may be used to extinguish HIV infection
HIV/AIDS Therapy - NNRTIs and RNase H inhibitors given in same HAART regimen may be beneficial
HIV/AIDS Therapy - Older antiretroviral strategies show renewed interest
HIV/AIDS Therapy - UK government lauded for microbicide development support
HIV/AIDS Vaccine - Data on DNA-binding protein to correct human genes published online in 'Nature'
HIV/AIDS Vaccine - HLA peptide processing by dendritic cells from HIV+ patients examined
HIV/AIDS Vaccine - Immune-based biopharmaceutical company auditors note going-concern qualification
HIV/AIDS Vaccine - Segments of consecutive AA residues of HIV gp120 proposed as vaccine candidates
HIV/AIDS Vaccine - Vaccine-elicited antibodies reduce viremia in SIV-challenged macaques
HIV/AIDS Vaccines - Findings advance knowledge in HIV/AIDS vaccines research
HIV/AIDS-Associated Emphysema - AIDS-associated emphysema due in part to HIV-1 infection of alveolar macrophages
HIV/AIDS-Epidemiology - High HSV-2/HHV-8 in remote area belies behavior that may facilitate HIV spread
HIV/AIDS-Related Hodgkin Lymphoma - LMP-1 deletion mutants highly associated with HIV-related Hodgkin's lymphoma
Head & Neck Cancer - Full-dose chemotherapy combined with radiotherapy to treat head and neck cancer
Healthcare Costs - Employers concerned with increasing use of high-cost injectable medications
Healthcare Coverage - Crawford & Co. partners with e-Triage
Healthcare Coverage - Pennsylvania urges consumers to sign up for free prescription drugs benefit
Healthcare Coverage - Pharma company joins Partnership for Prescription Assistance
Hearing Disorders - Aminoglycoside controls hearing loss in those with A1555G mutations
Heart Devices - Clinical site for phase 2 oxycyte trial at Virginia Commonwealth center opened
Heart Failure - Final oxypurinol clinical results released
Heart Failure - Intermittent levosimendan infusions prolonged survival of heart failure patients
Helicobacter Pylori - H. pylori infection correlates with DNA damage in gastric mucosa cells
Hematology - Findings describe new data in hematology research
Hematology - Major functional genes become deregulated in acute myeloid leukemia subtypes
Hematology - Platelet count can predict development of heparin-dependent antibodies
Hepatitis A Virus - Hepatitis A virus grown in mouse liver cell line
Hepatitis B Therapy - Long-term lamivudine improves outcomes for chronic hepatitis B patients
Hepatitis B Vaccine - Immune response to hepatitis B DNA vaccine improves upon protein boosting
Hepatitis C Therapy - Pharmacological inhibition of viral protease restores antiviral function
Hepatitis C Virus - Hepatitis C virus constructs model viral behavior in vitro
Hepatitis E Virus - Interactions involved in assembly of hepatitis E virus capsid analyzed
Hepatitis Treatment - What researchers learn about NK cells could yield hepatitis treatment
Hereditary Antithrombin Deficiency - Company to begin ATryn U.S. clinical study
Herpesvirus Vaccine - Genital herpes protection linked to vagina-associated lymphoid tissue
Herpesvirus Vaccines - Recent findings in herpesvirus vaccines provide new insights
Hip Replacement - Vancomycin-loaded bone allografts effective in infected hip arthroplasty
Hormones - Researchers detail new studies and findings in the area of hormones
Human Papillomavirus - Down-regulation of p21 contributes to apoptosis induced by HPV E6
Human Papillomavirus - Papillomavirus virus-like particles activate Langerhans cells
Human Papillomavirus Vaccines - Researchers publish new studies and findings in the area of human papillomavirus vaccines
Human Papillomavirus-Associated Cancer - HPV strongly associated with several cancers independent of HIV infection
Huntington Disease - Biomarkers milestone for monitoring progression of Huntington disease achieved
Hyperhidrosis - Survey raises awareness of impact of excessive sweating on quality of life
Hypertension - Article reviews hemodynamic factors in hypertension and role of ICG technology
Hypertension - Emphasis should be on optimal BP control rather on the drug used to achieve it
Hypertension - Rare promoter and coding region variants sway angiotensinogen levels
Hypertension - Single risk factor intervention for HT is being challenged
Hypertension - Treatment effective in lowering blood pressure for patients with kidney disease
Hypoglycemia - Fructose normalizes responses to hypoglycemia in type 1 diabetes
Idiopathic Muscular Torticollis - Botulinum toxin safe and effective for refractory neonatal IMT
Imaging - Reports advance knowledge in imaging research
Immune Regulating Hormones - IRHs efficacious in lung inflammation, septic shock and multiple sclerosis
Immunology - Natural killer cells examined, control of adaptive immune responses defined
Immunology - Study investigated dendritic cell distribution after heart transplantation
Immunotherapy - Pre-emptive immunotherapy prevents relapse in children with MDS after ASCT
Inflammation - Lupus erythematosus inflammation studied, role of type I interferon clarified
Inflammation - Metalloproteinase examined, role in airway inflammatory response defined
Inflammatory Bowel Disease - N-acetylcysteine attenuates toxic colon damage in rats
Inflammatory Diseases - Common factor is behind myocardial infarction, rheumatism and MS
Influenza Vaccine - Company's cell-culture technology to be part of U.S. flu vaccine program
Influenza Vaccine - Double-stranded RNA poly(I:C) enhances influenza vaccine protection
Influenza Vaccine - U.S. HHS awards $97M contract to develop cell-culture-based influenza vaccine
Influenza Virus - Avian influenza strain causes lethal systemic infections in ferrets
Information Technology - Data manager improves laboratory workflow
Information Technology - Three developers award $5 million for cardiac monitoring of phase 3 programs
Insulin Resistance - Endoplasmic reticulum chaperone improves insulin resistance in diabetes
Insulin Secretion - Insulin signaling plays multiple roles in gene expression and secretion
Intermittent Claudication - Novel treatment can remedy common cause of disabling leg pain
Irritable Bowel Syndrome - New Donnatal Elixir grape flavored introduced for IBS
Juvenile Myelomonocytic Leukemia - Trend towards graft-versus-leukemia in juvenile myelomonocytic leukemia in ABMT
Kidney Cancer - Rhabdoid tumor from Wilms' tumor and mesoblastic nephroma showed differentiation
Kidney Cancer - von Hippel-Lindau (VHL) tumor suppressor protein sensitized cancer to bortezomib
Kidney Disease - Human kidney protein that regulates heart contraction and blood pressure found
Laboratory Methods - Scientists engineer microscopes at microscopic size
Lassa Fever - Conference presentation shows Tarvacin has significant antiviral activity
Legal Issues - Court rules in favor of defendant company in Tiazac class action
Legal Issues - Dialysis products company announces receipt of subpoena
Leishmaniasis Vaccine - Leishmania chagasi proteinase developed to diagnosis leishmaniasis
Leishmaniasis Vaccine - IL-9 is a susceptibility factor in Leishmania major infection
Leptin Studies - High-dose leptin treatment results in leptin resistance
Leukemia - AS132 targeted specific proteins for destruction by the proteasome in leukemia
Leukemia - New aspects of chronic lymphocytic leukemia reviewed
Leukemia - Pomolic acid triggered mitochondria-dependent apoptotic cell death in leukemia
Leukemia Therapy - Recent findings in leukemia therapy provide new insights
Lip Cancer - Meyer's surgical procedure for the treatment of lip carcinoma outlined
Listeria Monocytogenes - Black seed oil inhibits Listeria monocytogenes
Lithium - Lithium treatment inhibits renal GSK-3 activity
Liver Cancer - Molecular signatures characterize hepatocellular carcinoma
Liver Regeneration - Follistatin encourages retroviral-mediated gene transfer in liver cells
Liver Regeneration - Multidrug resistance-associated protein studied, role in hepatic repair shown
Lung Cancer - Glucocorticoids induce 15-PGDH in lung adenocarcinoma cells
Lung Cancer - Lung cancer trial shows heat directly kills tumors in 93% of cases
Lung Cancer - Sulindac enhances adenoviral vector-mediated apoptosis in lung cancer
Lung Injury Biomarker - Elevated sTNF receptors associated with morbidity/mortality in acute lung injury
Lupus Vulgaris - Misdiagnosis can result in severe skin lesions in lupus vulgaris
Malaria - Mutations in pfmdr1 incur fitness cost in Plasmodium falciparum
Malaria Vaccine - Antibody response to Plasmodium vivax apical membrane antigen reported
Malaria Vaccine - Spleen important in malaria
Malaria Vaccines - Recent findings illuminate research in malaria vaccines
Market Analysis - Biotech's momentum stalls during first quarter
Matrix Metalloproteinase - Matrix metalloproteinases studied, nature of expression modulation clarified
Measles Vaccine - Measles-specific cytokine response after measles vaccinations reported
Measles Virus - Measles virus rescued from cloned cDNA using SLAM-expressing cells
Medical Devices - New compact flow cytometry system for drug discovery launched
Medical Devices - Radiology study shows connection of varicose veins to chronic pelvic pain
Medical Devices - Reference site established to use patch clamp system for cardio drug discovery
Medicare - Study shows pharma and biotech revenues at risk due to focus on Medicare Part B
Melanoma - DSMB recommends discontinuation of Canvaxin phase III trial for melanoma
Melanoma - Eugenol caused melanoma growth suppression through inhibition of E2F1
Melanoma Vaccine - Anti-vaccine T cells increased after vaccination with MAGE-3 protein
Melanoma Vaccines - Findings advance knowledge in melanoma vaccines research
Memory - Eyelid conditioning responses analyzed, need for protein synthesis revealed
Meningitis Vaccines - Research add new data to meningitis vaccines body of knowledge
Menopause - Bone fracture rates reduced in patients on bisphosphonate therapy
Mental Health - New approach to treatment of depression presented at congress of psychiatrists
Mental Health - Schizophrenics on atypical antipsychotic treated longer than with typical drugs
Mergers & Acquisitions - Acquisition to help ESA Biosciences extend HPLC detection business
Mergers & Acquisitions - Age-related dermatology products company ends merger talks with IGI, Inc.
Mergers & Acquisitions - Companies unite to form new pharma company located in Chicago, Illinois
Mergers & Acquisitions - Diagnostics firm announces proposal to acquire BioSource International
Mergers & Acquisitions - Elekta, oncology company announce expiration of Hart-Scott-Rodino waiting period
Mergers & Acquisitions - EpiPharma receives notice to extinguish letter of intent
Mergers & Acquisitions - Gentiva Health Services to acquire Utah-based Heritage Home Care Services
Mergers & Acquisitions - Health products company executes definitive agreement to merge with RiceX
Mergers & Acquisitions - Johnson & Johnson Completes Acquisition of TransForm Pharmaceuticals, Inc.
Mergers & Acquisitions - Medical grade makeover treatment company acquires EnVogue International
Mergers & Acquisitions - Medical service group, clinical trials recruiting company complete merger
Mergers & Acquisitions - Radiation therapy company acquires five centers in Nevada
Mergers & Acquisitions - Sleep and respiratory company acquires Mini-Mitter
Mergers & Acquisitions - Therapeutic antibody companies merge to combine operations
Metabolic Syndrome - Reports describe recent advances in metabolic syndrome research
Methadone-Related Rash Outbreaks - Syndromic rash outbreaks affected methadone clinic patients in New South Wales
Microencapsulation - 5-Fluorouracil-loaded poly(epsilon-caprolactone) microspheres developed
Monoclonal Antibodies - Life sciences company extends monoclonal antibodies license through July 2011
Multiple Myeloma - FDA grants full approval for VELCADE (bortezomib) for injection
Multiple Myeloma - Phase I/II clinical trial of GCS-100LE in multiple myeloma begins
Mumps Virus - Rat-based neurovirulence test for mumps virus assessed
Myocardial Infarction - Which patients are likely to have adverse outcomes from clot dissolving therapy?
Natural Killer Cells - Natural killer T cell development studied, nature of regulation clarified
Natural Products - Tridax procumbens extract defends rat livers against oxidative stress
Neonatal Diabetes - Bisulfite sequencing diagnoses transient neonatal diabetes
Nephrotic Syndrome - Mycophenolate mofetil safe as CyA replacement in pediatric NS
Nerve Regeneration - Nerve guidance system developed for nerve regeneration/functional recovery
Neurodegeneration - Oxidative stress upreglates genes associated with Alzheimer disease
Neurodegenerative Disease - Asian herbal extract reverses memory impairment in mice
Neurology - Hypothalamic neural activity examined, influence of protein kinase C shown
Neuroscience - Dopamine induces C/EBPP and GADD153 expression in neural cells
Neuroscience - Genetic interactions may establish susceptibility to anorexia nervosa
Neuroscience - Genetically modified fibroblasts treat Parkinson disease models
Neuroscience - Prostate innervation does not increase in postnatal rodents
Neuroscience - R208H mutations influence vulnerability to Creutzfeldt-Jakob disease
Neurotoxicity - Cytosolic phospholipase studied, oxygen-mediated decreased mRNA levels revealed
Nipah Virus - Extra-cellular domain of Nipah virus glycoprotein purified
Nitric Oxide - Nitric oxide analyzed, effect on methylmalonate-induced changes documented
Non-Small Cell Lung Cancer - Effects of cryo- and chemotherapy characterized in xenografted mice
Obesity - Drug can reduce body weight and cardiovascular risk factors in obese people
Obesity - Increased cancer risk noted for overweight and obese patients
Obesity Pathogenesis - Adaptive responses to hypercaloric fat load in humans examined
Obesity Surgery - Consensus panel calls surgery most effective treatment for morbid obesity
Obesity Therapy - Amines derived from fluoxetine act as potent appetite suppressants
Obesity Therapy - Potent human beta3 -adrenergic receptor agonist discovered
Obesity and Diabetes - Reports add new data to obesity and diabetes research
Oncology - Clinical pharmacogenomics in oncology clinical trials reviewed
Oncology - Researchers detail new studies and findings in the area of oncology
Oncology - The genetics of bladder tumor progression in humans and mice are not the same.
Oncology - Thymidine phosphorylase is a critical target for cancer therapy
Ophthalmology - Matrix metalloproteinase-2 promotes inflammation-related corneal vessel growth
Osteocarcoma - PAF receptor antagonist potent/cytotoxic Ca2+ mobilizer in osteosarcoma cells
Osteopetrosis - High peripheral blood SCs enable autologous backup before SCT for osteopetrosis
Osteoporosis - Researchers report details of new studies and findings in the area of osteoporosis
Osteoporosis - Study shows effects of parathyroid hormone treatment on osteoporosis
Otorhinolaryngology - P. gingivalis outer membrane protein studied, immune response clarified
Ovarian Cancer - Orphan drug status granted for 2-methoxyestradiol
Ovarian Cancer - Phase III trial of YONDELIS initiated in ovarian cancer patients
Ovarian Cancer - Reservoir ports superior to standard vascular access in advanced disease
Pain Management - Abstract on lidocaine vaginal gel published
Pain Medicine - "Pain pen" shows promise for treatment of breakthrough cancer pain
Pancreatic Cancer - Clinical trial testing Rexin-G opens in New York
Pancreatic Islets - Glucagon-like peptide-1 (7-37)/polymer conjugate synthesized
Paracoccidioidomycosis - Active formamidase of Paracoccidioides brasiliensis characterized
Parasitology - Actin-based motility of intracellular pathogens reviewed
Parkinson Disease - Continuous dopaminergic stimulation lowers dyskinesia risk in primates
Parkinson Disease - Ibuprofen may lower risk of PD
Parkinson Disease - Low neurotrophic factor levels lead to the loss of dopaminergic neurons
Parkinson Disease - Parkin examined, role in ubiquitination of synphilin-1 revealed
Patents - Pharmaceutical firm granted U.S. patent related to surgical adhesion therapy
Patents - U.S. patent issued for peptide-biomarker discovery, identification technology
Patient Safety - Smart-pumps need to interface with other technology better
Pediatric Cardiology - DHA may improve cholesterol particle size in at-risk children, study shows
Pediatric Care - Treatment of bronchiolitis in children varies widely, study shows
Penicillium - Ras and Rho GTPases genetically interact to regulate cell polarity
Peptide Mapping - Human serum albumin studied, physiologically critical site identified
Peripheral Arterial Disease - Study shows peripheral arterial disease should be treated nonsurgically
Peritoneal Dialysis - Rapamycin guides the epithelial-to-mesenchymal transition of peritoneal cells
Personnel - Biopharma company names chief commercial officer
Personnel - Biopharmaceutical company announces new leadership
Personnel - Biopharmaceutical company appoints new VP, therapeutic applications
Personnel - Biotech company reports change in supervisory board
Personnel - David H. MacCallum joins board; Dr. Bruce L.A. Carter named chairman
Personnel - Formation of scientific advisory board to provide guidance on PT-141 announced
Personnel - Former Fleishman-Hillard executive joins vaccine company
Personnel - G. John Mohr named chief business officer by biopharmaceutical company
Personnel - Heart surgeon appointed chair of cardiothoracic surgery at Montefiore Medical
Personnel - Jonathan Rothberg to step down as CEO of genomics-focused pharmaceutical company
Personnel - Maker of MRI pharmaceuticals names Sheila DeWitt VP
Personnel - Michael C. Venuti, PhD, named of chief scientific officer
Personnel - Molecular biology company appoints Gary C. Carter as VP
Personnel - Personalized medicine company adds two to scientific advisory board
Personnel - Pharmaceutical company appoints new vice presidents
Personnel - Pharmaceutical company names Fred M. Powell as CFO
Personnel - Pharmacy benefit management company appoints pharmacy medical director
Personnel - Philip Jochelson, MD, named senior VP and chief medical officer by drug company
Personnel - Specialty pharmaceutical company names chairman of the board
Personnel - Stem cell therapy company appoints Robert Shorr to board of directors
Personnel - Tendonapothies treatment company appoints advisory board
Personnel - Two directors appointed to board of dermatology products company
Personnel - Vaccines company announces addition to board of directors
Personnel - Woman-focused pharma elects William J. Robinson to board of directors
Pharmaceutical Research - Maine research lab presents Gairdner Award to emeritus scientist Douglas Coleman
Pharmaceutical Research - Report examines pharma investment between late-stage trials
Pharmaceutical Research - Sales coaching and incentives effective to create sales-oriented culture
Pharmaceutical Research - SonoLysis shows promise as a declotting agent for dialysis patients
Pharmaceutical Research - Study shows corporate information centers employ cost avoidance programs
Pharmaceutical Research - Survey examines sales growth in rheumatoid arthritis markets
Pharmaceutical Research - Survey on pharma companies' drug launches released
Philanthropy - Pharmaceutical company joins program to assure patient access to certain drugs
Phosphorylation - Myosin chain phosphorylation studied, role in aqueous humour outflow shown
Photodynamics - Melatonin generates singlet oxygen on laser irradiation
Physiology - Decapping reaction of mRNA studied, requirement for Dcp1 observed
Pneumococcal Vaccine - Pneumococcal antibodies require CD1 molecules and CD8+ cells
Pneumococcal Vaccines - Research add new data to pneumococcal vaccines body of knowledge
Polio Vaccine - Childhood mortality after oral polio immunization campaign reported
Portopulmonary Hypertension - Bosentan therapy shows promise
Product Licensing - Genomics company obtains exclusive license to develop new anemia drug
Product Licensing - Pharma company licenses feed-through fly control product to Pfizer
Professional Education - Health information company announces pharmacy student-focused initiatives
Prostate Cancer - Case-control pilot study of prostate cancer data compared
Prostate Cancer - Inhibition of IkappaB kinase activity promoted apoptosis in prostate cancer
Prostate Cancer - Phase I/II clinical trial begins in patients with recurrent prostate cancer
Prostate Cancer - Radiotherapy and sKDR gene delivery demolish malignant prostate tumors
Prostate Cancer - Smad7 protein levels may predict therapy response
Prostate Cancer - Study shows prostate cancer patients live longer when given goserelin
Prostate Cancer - Synthetic hormone injectable suspension therapy for prostate cancer available
Protein Expression - Enzymatic function studied, effects of Hg2+ and Cu2+ revealed
Protein Expression - Link between protein structure and solubility on expression discussed
Protein Kinase - Ilimaquinone studied, role on gap junctional communication defined
Protein Synthesis - eIF2 alpha phosphorylation and stress perception in CHO cells examined
Proteomics - Chitosan derivatives block tumor-related angiogenesis
Proteomics - Endogenous variants of angiogenesis inhibitors foster protein exploration
Proteomics - Endostatin relies on heparan sulfate for angiostatic activity
Proteomics - Endostatin works with membranes bearing phosphatidylserine to cause cell death
Proteomics - Exercise changes renal atrial natriuretic peptide receptor gene expression
Proteomics - Mechanism of guanine nucleotide exchange of Ras GTPase outlined
Proteomics - New data illuminates research in proteomics
Psychosis - U.S. FDA issues public health advisory for antipsychotic drugs in elderly
Pulmonary Medicine - Hypoxia-induced mitogenic factor stimulates post-pneumonectomy lung growth
Pulmonary Medicine - Repair-related gene expression is time-dependent following diaphragm injury
Pulmonary Medicine - Researchers describe findings in pulmonary medicine studies
Pulmonary Medicine - Researchers identify new clinical syndrome caused by hemolysis
Pulmonary Medicine - Shortened viral expression cassettes transfer genes to lung epithelia
Receptor Studies - 5-HT1A receptor expression low in brain during pancreatic regeneration
Receptor-Mediated Signaling - G protein-coupled receptor studied, agonists and antagonists localized
Recombinant Technology - Company receives FDA priority review for Enhanze SC NDA
Renal Cancer - Anti-Ki-67 peptide nucleic acid terminates renal carcinoma cell growth
Renal Cancer - p53 is an independent biomarker for renal cell carcinoma progression
Renal Physiology - Lithium promotes cell survival in the absence of soluble survival factors
Renal Transplantation - Mycophenolate mofetil decreases rejection in renal transplants
Reproductive Medicine - Cetrorelix doesn't protect macaques from radiation-induced testicular injury
Respiratory Medicine - Canada-based asthma-focused biopharmaceutical company wins 2 industry awards
Respiratory Medicine - Cyclophosphamide and low-dose prednisolone compared in study
Rheumatic Fever - Myocardial tissue damage occurs in rabbits injected with streptococci
Rheumatoid Arthritis - LymphoStat-B efficacious in patients with rheumatoid arthritis
Rheumatoid Arthritis - Pharma company announces rheumatoid arthritis clinical study collaboration
Rheumatoid Arthritis - Rheumatoid arthritis Rituxan trial meets primary endpoint
Rheumatology - Non-transforming herpesvirus saimiri vectors regulate inflammatory cytokines
Rheumatology - Therapy and dosing for pediatric rheumatic disorders reviewed
SARS Coronavirus - Reports describe recent advances in SARS coronavirus research
SARS Virus - Recent findings in SARS virus described
Salmonella Vaccines - Research in salmonella vaccines provides new insights
Sensorineural Hearing Loss - Intratympanic dexamethasone/hyaluronic acid effective for refractory SHL
Sepsis - Low-dose propofol may attenuate inflammation
Septicemia - Postmortem markers of sepsis studied, serial monitoring reported
Shigellosis - Tyrosine kinase signaling and effectors of Shigella invasion reviewed
Sickle Cell Disease - Long-term outcome determined for children with elevated velocities on TCD
Simian T-Cell Lymphotropic Virus Type 1 - Africa is origin of Tulane primate center STLV-1 sooty mangabey strain
Sjogren Syndrome - 5-Aza-CdR treatment induces aquaporin-5 expression in ductal cells
Skin Cancer - 1,25-Dihydroxyvitamin D-3 and analogues protect against UVB-induced DNA damage
Smallpox Vaccines - Researchers publish new studies and findings in the area of smallpox vaccines
Snow Mountain Virus - Immunity following Snow Mountain virus challenge examined
Spinal Cord - Polypeptide expression defined in bladder pathways after spinal cord injury
Spinal Cord Injury - Melatonin treatment reduces inflammation and tissue damage in rats
Statins - Achieving low levels of LDL-cholesterol often requires high doses of a statin
Stem Cell Research - A new embryonic stem cell line encodes a key cystic fibrosis mutation
Stem Cell Research - Bone marrow-derived stem cells contribute little to human tumor vessel growth
Stem Cell Research - Hes1 has inhibitory role in Paneth cell differentiation in small intestine
Stem Cell Research - LIF induces kidney stem-like cell multilineage differentiation via cadherin 16
Stem Cell Research - Prolonged-survival neonatal PMNs have enhanced inflammatory/cytotoxic response
Stem Cell Research - Research needed to determine efficient delivery of SCs to appropriate sites
Stem Cell Research - SVP modifies self-renewal SC program to allow chronological change of cell fates
Stem Cell Research - Sonic hedgehog controls stem cell behavior in postnatal and adult brain
Stem Cell Research - VEGF helps embryonic stem cells survive hypoxic stress
Stem Cell Research - alpha1LG4-5 provides vital signals for SC conversion to polarized epithelium
Stem Cell Research - c-Myb and p300 regulate stem cell proliferation and hematopoiesis
Stem Cell Transplantation - ABO incompatibility does not affect clinical outcome after APBSCT
Stem Cell Transplantation - Back-up donor identification saves time in unrelated stem cell transplantation
Stem Cell Transplantation - Circulating DC subsets post-ASCT correlate with acute GVHD severity in children
Stem Cell Transplantation - PBSC graft composition affects outcomes after nonmyeloablative conditioning
Stem Cell Transplantation - Relaxation breathing does not improve leukocyte numbers in AHSCT
Stem-Cell Transplantation - Retinoic acid may heighten risk of bone marrow transplant nephropathy
Stents - Successful drug-eluting stents are under investigation in all types of lesions
Streptococcus Vaccines - Reports add new data to streptococcus vaccines research
Stress - Osmolytes examined, opposing effects on thermal enzyme inactivation revealed
Stroke - Statin use before or after stroke improves recovery
Stroke Therapy - Olanzapine may be useful in treatment of hemiballismus
Suicidal Behavior Gene - Serotonin synthesis genes involved in predisposition to suicidal behavior
Surgical Technology - New radiology technique allows longer lasting option of access for dialysis
Surgical Technology - Providence Medical Center treats patients with image-guided radiosurgery
Systemic Lupus Erythematosus - Company announces preliminary results of Genovate's clinical trial of prasterone
Testicular Cancer - Transcriptional repression domain in N-terminal region of p53 identified
Theileriosis Vaccines - Recent studies add new data to theileriosis vaccines research
Thrombocytopenia - Knowing etiology of low platelet count is important in managing thrombocytopenia
Thyroiditis - Class II MHC expression on thyrocytes does not cause thyroiditis
Tissue Engineering - Bovine collagen constructs used to reconstruct full-thickness scalp defects
Tissue Engineering - Researchers describe findings in tissue engineering studies
Tobacco Use - NicAlert successfully used as clinical tool for expectant mothers in Nevada
Toxicology - Naked DNA protects murine models against the deadly neurotoxin soman
Toxin - Milleporin-1 examined, phospholipase activity described
Transdermal Drug Delivery - AOT water-in-oil microemulsion shows promise as penetration enhancer
Transplant Medicine - Combined gene therapies support allograft healing mechanisms
Transplant Medicine - Cyclosporine inhalation solution improves survival in lung transplant patients
Transplant Medicine - Heart and Lung Transplant Society marks 25 years
Transplant Medicine - ISHLT seeks to update guidelines for heart and lung transplants
Transplant Medicine - Noninvasive test to determines risk of rejection in heart transplant patients
Transplant Medicine - Studies add new findings to transplant medicine body of knowledge
Transplant Medicine - VEGF expansion elicits poor long-term outcomes in renal graft recipients
Tuberculosis - Two sputum specimens adequate for pulmonary tuberculosis diagnosis
Tuberculosis Vaccine - Challenges in tuberculosis vaccine development reviewed
Tuberculosis Vaccine - Control of human host immunity to mycobacteria reviewed
Tuberculosis Vaccine - Expanding BCG antigenic repertoire improves protection against TB
Tuberculosis Vaccine - Nasal boost improves primary BCG-induced protection against TB
Tuberculosis Vaccine - TB vaccines for the world reviewed
Tuberculosis Vaccines - Researchers' data advance tuberculosis vaccines research
Type 1 Diabetes - Health insurance coverage for type 1 diabetes reviewed
Type 2 Diabetes - Diachrome initiative for Native Americans living with type 2 diabetes announced
Type 2 Diabetes - ID 1101 enters Phase Ib clinical trial
Umbilical Cord Blood - CB chromosomal aberrations associated with prenatal exposure to carcinogenic PAH
Uveal Melanoma - Efficacy of human melanocytic cell lines examined in rabbit choroidal melanoma
Vaccine Development - Antibodies adsorbed to aluminum adjuvants characterized
Vaccine Development - Hepatitis B virus capsid protein is a potent antigen carrier for vaccines
Vaccine Development - Single-stranded RNA that stimulates CD14+CD11c+ monocytes identified
Vaccines Adjuvant - New findings in the area of vaccines adjuvant described
Vaccinia Virus Vaccine - Poxvirus-specific CD8+ CTL epitopes with distinct profiles identified
Varicose Veins - Study: Endovenous laser ablation is effective at treating varicose veins
Vascular Graft - Procedure developed to extract RNA from cells seeded onto cylindrical conduits
Vector Development - Coated polymeric double-layered micelles transfect cells with low toxicity
Vector Development - Modified vector improves CAR-deficient lung cancer cell transfection
Vector Development - Monoclonal antibody-PEI constructs conduct cell-specific nonviral gene delivery
Vector Development - Toxicity limits the use of Semliki Forest virus vectors in the nervous system
Ventricular Extrasystoles - Report stresses importance of distinguishing benign ventricular extrasystoles
Vibrio Parahaemolyticus - Vibrio multidrug antiporter studied, essential amino acids identified
Virology - DNA flap position does not influence lentiviral vector transduction
Virology - Data advance knowledge in virology research
Virology - Hepatitis C virus NS5B mutations affect viral load and interferon response
Virology - Hepatitis C virus isolates exhibit NS3 protease heterogeneity
Virology - MyD88 expression required for cross-presentation of viral antigens
Virology - Pseudotyped lentiviral vector steers therapy to metastatic melanoma
Virology - Sendai virus nucleocapsid-like particles generated in yeast
Virology - Viruses rely on different factors for capsid protein assembly
Wound Care - Pretreatment with retinoic acid improves healing of diabetic wounds
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