Drug Resistance

Targeting senescence pathways reversed drug resistance in cancer

Published in Drug Week, May 6th, 2005

Scientists proposed that targeting senescence pathways might reverse drug resistance in cancer.

"Irreversible proliferation arrest (also called senescence) has emerged recently as a drug-responsive program able to influence the outcome of cancer chemotherapy. Since the drug amounts required for induction of proliferation arrest are much lower than those necessitated for induction of cell death, forcing cancer cells to undergo senescence may represent a less aggressive approach to control tumor progression," investigators in the United States reported.

"However, to achieve a long-standing control of proliferation, the ability of cancer cells to escape...

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Source: Drug Week (2005-05-06)

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