Published in Drug Week, May 13th, 2005
In a recent study, the "antinociceptive effect of nicotine administered intracereboventricularly (i.c.v.) or intrathecally (i.t) in several pain models was examined" by researchers in South Korea.
"We found that i.t. treatment with nicotine (from 5 to 20 g) dose-dependently blocked pain behavior revealed during the second phase, but not during the first phase in the formalin test," reported K.J. Han and coauthors at Hallym University. "In addition, i.c.v. treatment with nicotine (from 0.1 to 10 microg) dose-dependently attenuated pain...
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