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Alzheimer Disease
Chronic melatonin therapy not effective in murine model
June 17th, 2005
Chronic melatonin therapy failed to produce significant benefits in a murine model of Alzheimer disease. "Melatonin has been proposed as a treatment for Alzheimer disease based on the demonstration of antioxidant and 'anti-amyloid' effects in vitro and in vivo," neurologists in the United States explained. In a study conducted by J. Quinn and coauthors at the Portland VA Medical Center, the efficacy of "chronic melatonin therapy in old, amyloid plaque-bearing transgenic mice" was evaluated. "Tg2576 mice started melatonin treatment at 14 months of age," according to the report. "After 4 months of treatment, there were no...
Source: Drug Week (2005-06-17)
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