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Anaphylaxis
C-kit mutation detected by real-time PCR in patients with anaphylaxis
June 17th, 2005
A c-kit mutation was detected by real-time PCR in patients with anaphylaxis. "A well-characterized gain-of-function point mutation within exon 17 of the c-kit proto-oncogene known as Asp816Val is present in patients with mastocytosis. Activation of mast cells through this receptor primes them for IgE-dependent activation, and patients with mastocytosis are at increased risk of anaphylaxis," scientists in England reported. "We hypothesized that the Asp816Val mutation is associated with a history of anaphylaxis in the general population. A mismatch amplification real-time PCR assay was developed and validated to test for the Asp816Val mutation,"...
Source: Drug Week (2005-06-17)
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