Drug Development
Novel furocoumarin derivative shows promise as antiarrhythmic agent
Published in Drug Week, June 24th, 2005
In a recent study from South Korea, a "furocoumarin derivative, oxypeucedanin, was purified from Angelica dahurica, and its effects on the human Kv1.5 (hKv1.5) channel and on the cardiac action potential duration (APD) were examined using the patch-clamp technique and the conventional microelectrode technique."
"Oxypeucedanin inhibited the hKv1.5 current in a concentration-dependent manner, with an IC50 value of 76 nm, while it had no effect on human eag-related gene (HERG) current," J.S. Eun and coauthors at Chonbuk National University found....
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Source: Drug Week (2005-06-24)
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