Acute Myeloid Leukemia
Wnt/beta-catenin pathway involved in acute myeloid leukemia pathogenesis
Published in Drug Week, June 24th, 2005
According to a study from England, "The beta-catenin protein is at the core of the canonical Wnt signaling pathway. Wnt stimulation leads to beta-catenin accumulation, nuclear translocation and interaction with T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors to regulate genes important for embryonic development and proliferation.
"Wnt/beta-catenin can promote stem cell self-renewal and is dysregulated in colon carcinoma. We have examined the role of the Wnt pathway in the development of acute myeloid leukemia (AML) and find that the...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Drug Week
Source: Drug Week (2005-06-24)
More Articles from Drug Week
- Chemotherapy-Induced Anemia
Data: Aranesp dosed every 2 weeks is comparable to Epoetin alfa dosed weekly - Drug Development
Positive data reported from phase II trial of GVAX vaccine for leukemia - HIV/AIDS Therapy
U.S. FDA approval granted for once-daily Kaletra (lopinavir/ritonavir) - Paclitaxel
Phase I study of paclitaxel and doxifluridine therapy in gastric cancer patients - Premature Ejaculation
Men with PE show improvement with dapoxetine hydrochloride - Addiction Medicine
Forebrain A2A receptors key to pyschostimulant sensitization - More from this issue of Drug Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
