Cancer Immunotherapy
Antigen-encoded viruses offer protection against prostate cancer
Published in Drug Week, July 8th, 2005
"Gene therapy for prostate cancer may be realized through transduction of whole genes, such as prostate specific antigen (PSA) or prostate specific membrane antigen (PSMA), into immunotherapeutic dendritic cells (DCs). An oncoretroviral vector encoding human PSMA and a bicistronic oncoretroviral vector encoding human PSA and cell surface CD25 cDNAs were constructed," researchers in Canada report.
"Remarkably, transfer of PSA/CD25 or PSMA cDNA during murine hematopoietic cell differentiation into DCs occurred with approximately 80% efficiency. In vitro, transduced DCs retained...
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Source: Drug Week (2005-07-08)
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