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Tumor cells take up tailor-made self-assembled polyelectrolyte shells

Published in Drug Week, July 8th, 2005

Tumor cells take up tailor-made self-assembled polyelectrolyte shells.

"Layer-by-layer self-assembled polyelectrolyte shells are a new class of micro/nanocapsules with unique physicochemical properties for potential applications in drug/gene delivery. The objective of this study was to investigate the interactions of polyelectrolyte shells (approximately 1 mcm in diameter) with MCF-7 breast cancer cells and identify key parameters that affect such interactions," researchers in the United States report.

"Tailoring of surface properties of polyelectrolyte shells was achieved by choosing different outermost layer materials, including cationic polymers,...

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