Hepatitis B Therapy

Alamifovir and its metabolites have positive pharmacokinetics in healthy men

Published in Drug Week, July 22nd, 2005

Alamifovir and its metabolites have positive pharmacokinetics in healthy men.

"Alamifovir, a purine nucleotide analogue prodrug, and its hydrolyzed derivatives have shown preclincal efficacy activity against wild-type and lamivudine-resistant hepatitis B virus. Two studies were conducted to examine the single-and multiple-dose alamifovir pharmacokinetics after oral administration in healthy males," investigators in Singapore report.

"In study 1, subjects were given single doses (0.2 to 80 mg), with a subset receiving 20 mg in a fed state. Study 2 subjects were dosed with 2.5 to 15 mg twice daily for 15 days. Plasma samples were collected over 72 h in...

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Source: Drug Week (2005-07-22)

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