Poxvirus Vaccine
Murine interferon lambdas exhibit antiviral activity against poxvirus
Published in Drug Week, August 12th, 2005
According to a study from England, "Human interferon lambdas (IFN-lambdas) (type III IFNs) exhibit antiviral activity in vitro by binding to a receptor complex distinct from that used by type I and type II IFNs, and subsequent signaling through the Janus kinase signal transducers and activators of transcription (STAT) pathway. However, evidence for a function of type III IFNs during virus infection in vivo is lacking. Here, the expression of murine IFN-lambdas by recombinant vaccinia virus (VACV) is described and these proteins are shown to have...
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Source: Drug Week (2005-08-12)
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