Hemophilus ducreyi

H. ducreyi dsrA mutant killed by normal human serum initiated by IgM binding

Published in Drug Week, August 12th, 2005

Hemophilus ducreyi dsrA mutant killing by normal human serum is initiated by immunoglobulin M binding.

"Previously, we showed that serum resistance in Hemophilus ducreyi type strain 35000HP required expression of the outer membrane protein DsrA because the isogenic dsrA mutant FX517 is highly serum susceptible.

"In this study, we confirmed this finding by construction of additional serum-susceptible dsrA mutants in more recently isolated serum-resistant strains," wrote investigators in the United States.

"We also demonstrated that killing of dsrA mutants required an intact classical complement cascade but not the...

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Source: Drug Week (2005-08-12)

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