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Drug Week

Susan Hasty, Publisher
Table of Contents . . . August 26th, 2005
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Drug Week | Other Publications

Clinical Trials - Recombinant protein HIV vaccine candidate to be tested in clinical trials

Drug Development - Results reported from pediatric Amoxicillin PULSYS phase III trial

Drug Development - U.S. FDA issues approvable letter for Entereg (alvimopan)

Obsessive Compulsive Disorder - Medication eases obsessive-compulsive symptoms

Prostate Cancer - Phase III Trial: Provenge extends survival in advanced prostate cancer patients

Acetylcholine Receptors - Muscarinic acetylcholine receptor studied, basolateral sorting signal defined

Acne - TAZORAC compliance program launched for teens

Addiction Medicine - Brief access to sweets prevents cocaine-seeking relapse in rats

Addiction Medicine - Daily marijuana use exacerbates chronic hepatitis C-related liver fibrosis

Adipose Tissue - Rosiglitazone upregulates lipases in brown adipocytes

Adverse Drug Reaction - Advance liver disease hampers tolerance to hepatitis C combination therapy

Cancer Vaccines - Researchers publish new studies and findings in the area of cancer vaccines

Adverse Drug Reaction - Automated dispensing system improves ADR reporting

Adverse Drug Reaction - Importance of reporting suspected drug reactions emphasized

Age Related Macular Degeneration - Choroidal neovascularization therapies render similar outcomes

Alcohol Use - Chronic ethanol consumption may contribute to development of restenosis

Allergy & Immunology - Allegra extended release tablets available for allergy sufferers

Alternative Medicine - Capillary zone electrophoresis assay devised for goldenseal extract analysis

Diagnostics - Recent studies add new data to diagnostics research

Alzheimer Disease - Amyloid-mediated endothelial damage studied, lack of estrogen protection shown

Alzheimer Disease - Anti-inflammatory function of AD drugs revealed

Alzheimer Disease - ELISA developed for amino-terminally truncated beta-amyloid peptide quantitation

Alzheimer Disease - Enrollment begins in additional phase IIa studies with AMPAKINE CX717

Alzheimer Disease - Hope for brain disease blossoms

Alzheimer Disease - Novel assays facilitate characterization of BACE-1 inhibitors

Gastroenterology - Recent studies add new data to gastroenterology research

Alzheimer Disease - Study suggesting procaine as exerting neuroprotective properties published

Amyotrophic Lateral Sclerosis - Gene therapy company awarded grant for evaluation of ALS treatment

Amyotrophic Lateral Sclerosis - Intrathecal BDNF doesn't improve autonomic function

Anal Pain - Nicorandil implicated in idiopathic anal ulceration

Analgesia - Ultralow-dose naltrexone enhances oxycodone analgesia

Anemia - Outcome of clinical analysis of chronic benzene poisoning revealed

Gastroenterology - Reports add new data to gastroenterology research

Anesthesia - Study shows effect of multiple opoids on open-heart surgery patients

Angina - Palpation of spine and thorax were used to screen chest pain patients

Angiology - Coronary retrograde perfusion may be technique for myocardial ischemia

Angiology - Laser perforation mobilizes matrix graft adaptation in treated arteries

Angiology - Needle-guided ultrasound enhances cannulation success

Angiology - Researchers publish new studies and findings in the area of angiology

Malaria - Researchers detail new studies and findings in the area of malaria

Angiotensin - ATPase activity analyzed, angiotensin modulation revealed

Angiotensin Converting Enzyme - Assay determines plasma and tissue ACE activity

Anorexia - Megestrol phase II proof-of-concept study results reported

Anthrax - Complement depletion renders mice sensitive to Bacillus anthracis

Anthrax - Critical step traced in anthrax infection

Anti-Platelet Therapy - Point-of-care monitoring system developed

Neuroscience - Recent findings in neuroscience described

Antiarrhythmic Drugs - AF-induced remodeling did not alter flecainide action on conduction

Antibacterial Agents - Data on healthy subjects provide patient target attainment for antibacterials

Antibacterial Agents - Phage therapy examined as treatment option for diarrheal disease

Antibacterial Agents - Pharma company reports results of aminomethylcyclines trial

Antibiotic Resistant Bacteria - Metallo-beta-lactamase-resistant bacteria is an emerging epidemic

Antibiotics - Bacillus subtilis protein inhibition raises antibiotic susceptibility

Neuroscience - Research in neuroscience provides new insights

Antibiotics - Cytotoxic constituents of the fruit body of Daedalea dickisii studied

Antibiotics - Link between antibiotic exposure and breast cancer in New Zealand evaluated

Anticancer Agents - Anticancer agent for hypoxic cells discovered

Anticancer Drug - Deguelin enhances leukemia cell chemosensitivity with active PI3K/AKT pathway

Antimicrobial Resistance - Survivability of vancomycin-resistant enterococci examined

Antimicrobial Therapy - Aminoglycoside extended interval dosing safe and effective for neonates

Oncology - Researchers describe findings in oncology studies

Antimicrobials - Antimicrobial peptides analyzed, polysaccharide interaction clarified

Antimicrobials - Peptides may attenuate lung damage associated with cystic fibrosis

Antioxidants - Bioactivity and protective effects of natural carotenoids identified

Antioxidants - Findings advance knowledge in antioxidants research

Antioxidants - Phycocyanin antioxidant activity studied, affecting factors clarified

Antiplatelet Drugs - Alterations of receptor gene may be a mechanism for clopidogrel failure

Oncology - Researchers' work adds to oncology body of knowledge

Antiplatelet Drugs - Review discusses clopidogrel guidelines based on clinical trial data

Antiproliferative Activity - Hopane and oleanane glycosides exhibited antiproliferative activity

Antituberculosis Therapy - Some antituberculous drugs alone or in combination enhance PMN functions

Aphthous Ulceration - Aphtheal effective at onset on prodromal RAU symptoms

Apoptosis - Apoptosis induced by Eurycoma longifolia Jack extracts

Apoptosis - Apoptosis signal-regulating kinase examined, regulation defined

Oncology - Studies add new findings to oncology body of knowledge

Apoptosis - Cas II-gly induced apoptosis in glioma C6 cells in vitro and in vivo

Apoptosis - Enterolactone induced apoptosis and inhibited growth of colon cancer cells

Apoptosis - Grifolin inhibited tumor cell growth by inducing apoptosis in vitro

Apoptosis - Role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2

Arteriosclerosis - Long-term treatment with nicorandil may prevent cardiovascular events

Arthritis - Early trial results of tgAAC94 in patients with inflammatory arthritis reported

Proteomics - Researchers report details of new studies and findings in the area of proteomics

Arthritis - Inflammation and tissue destruction studied, interferon homeostatic role shown

Arthritis Therapy - Yeast glucan derivative has antioxidant activity in rat model

Asthma - New school policy guide issued to help manage children's asthma

Asthma - Omalizumab add-on therapy reduced severe allergic asthma attacks in 7 studies

Astrocytoma - Magnetic resonance spectroscopy of oligodendroglial tumors aided cancer staging

Atherosclerosis - Phosphatidylethanol boosts smooth muscle cell production of VEGF

Transplant Medicine - Reports add new data to transplant medicine research

Atherosclerosis Risk Factors - Cholesterol efflux to plasma from diabetic patients is enhanced

Attention Deficit Hyperactivity Disorder - Amended NDA for treatment of pediatric ADHD patients resubmitted to FDA

Attention Deficit Hyperactivity Disorder - FDA expands indication for ADDERALL XR to include adolescents aged 13-17

Autoimmune Diseases - Cirrhosis forecasts a poor prognosis for patients with autoimmune hepatitis

Autoimmune Diseases - Human monoclonal autoantibody creates murine autoimmune hepatitis models

Awards - $1.5 million pledged to Runyon foundation accelerate clinical cancer research

Virology - Findings advance knowledge in virology research

Awards - Stephen C. Harrison wins Bristol-Myers Squibb infectious diseases research award

Bacterial Meningitis - Awareness of disease mechanisms leads to better therapies

Barrett Adenocarcinoma - MAPK and PI3K inhibition reduced proliferation of Barrett adenocarcinoma

Bartonella - Bartonella causes a broad number of infectious diseases

Biomedical Engineering - Hollow fiber assays assess anti-neovascular therapy

Biomedical Engineering - Scientists confirm relationship between inflammatory response and glucose levels

Virology - Researchers' findings advance virology research

Biotechnology - Pharma announces senior management changes

Bioterrorism - Agreement inked with Dow for BT-VACC for botulinum toxin poisoning

Blood Banking - Controlled-rate freezing used to cryopreserve embryonic stem cells

Brain Cancer - Findings describe new data in brain cancer research

Brain Cancer - VEGF helps transplanted neural stem cells seek brain tumors

Breast Cancer - Gene found in 90% of breast cancers may be cancer vaccine target

Breast Cancer - Lymph-node micrometastases worsens outcomes for breast cancer patients

Breast Cancer - Mechanisms of omega-3 fatty acid-induced growth inhibition analyzed

Breast Cancer - New treatment for breast cancer and choroidal metastasis described

Breast Cancer - Patterns of toxicity evaluated in older patients receiving adjuvant chemotherapy

Breast Cancer - RALT gene loss impedes the efficacy of HER-2 inhibitor

Breast Cancer - Researchers report details of new studies and findings in the area of breast cancer

Breast Cancer - Traumatic stress, perceived global stress, and life predicted quality of life

Business & Finance - Biotechnologies research company reports second quarter 2005 financial results

Business & Finance - Company announces adoption of share repurchase program

Business & Finance - Cord blood banking company reports strong growth

Business & Finance - Diagnostic testing company reports second quarter 2005 results

Business & Finance - Diagnostic tests company projects first quarter profit

Business & Finance - Drug development company reports second quarter 2005 results

Business & Finance - Drug discovery and development company reports financial results

Business & Finance - Pharma company announces second quarter 2005 results

Business & Finance - Pharma company reports second quarter and 6 month 2005 financial results

Business & Finance - Pharmaceutical company reports second quarter operational and financial results

Business & Finance - Pharmaceutical firm files for Chapter 11 reorganization

Business & Finance - Respiratory market distributor announced financial results

Business Update - Antiviral drug discovery and development company relocates to New Jersey

Business Update - Biopharma company announces new executive share ownership guidelines

Business Update - Biotech company opens laboratory facility

Business Update - Biotech firm retains Financial Dynamics as communications advisor

Business Update - Cancer-focused pharmaceutical company included in new NASDAQ Health Care Index

Business Update - Companies complete $525M purchase from Emory of emtricitabine royalty interest

Business Update - Company announces FDA nonapprovable letter on sNDA for Namenda for mild AD

Business Update - Company announces the launch of Exactacain

Business Update - Company to divest capital equipment business; delays reporting Q2 earnings

Business Update - DNA-focused company achieves "important milestones" in second quarter

Business Update - European Union's CHMP adopts positive opinion for NOXAFIL

Business Update - HealthTronics announces strong second quarter results

Business Update - Human Genome Sciences announces financial results for second quarter of 2005

Business Update - I-Flow second quarter loss narrowed to $0.03 per share

Business Update - Introgen Therapeutics announces strategic investment in UK-Based SR Pharma

Business Update - Pharma company enters distribution and supply agreement for leflunomide tablets

Business Update - Pharmaceutical firm announces new lab, office space

Business Update - Procter & Gamble enters agreement with pharma discovery provider

Business Update - Programs launched for emergency biorepository storage, transition

Business Update - Research shows economic incentives can drive hospital quality improvement

Business Update - Therapeutic apheresis company enters agreement with Advanced Cell & Gene Therapy

Business Update - U.S. marketing rights to eptifibatide injection acquired by healthcare company

Cancer Research - Monoclonal antibody D2-40 helps distinguish HB from CRCC

Cancer Risk Factors - Higher cancer risk found in progeny of mice exposed to X-rays before conception

Cancer Risk Factors - KLF6 gene mutations may encourage gastric cancer progression

Cancer Therapy - Antibody to junctional adhesion molecule-C blocks angiogenesis and tumor growth

Cancer Therapy - Cetuximab arrests hypoxia-inducible factor-1 alpha expression to block VEGF

Cancer Therapy - Chemokine CXCL11 targets tumors but leaves angiogenesis intact

Cancer Therapy - Company initiates phase I clinical trial for anticancer compound XL820

Cancer Therapy - Deltec and Groshong central venous access port systems compared

Cancer Therapy - Drug candidates that counter resistance to Gleevec, Iressa, Tarceva identified

Cancer Therapy - Hydrocortisone may play a key role in cancer immunotherapy

Cancer Therapy - Novel boron-containing carbonic anhydrase inhibitors synthesized

Cancer Therapy - Partnership formed to develop and commercialize new oral chemotherapy

Cancer Therapy - Patient enrollment completed in REOLYSIN clinical trial for cancer treatment

Cancer Treatments - Abducens nerve palsy and Horner syndrome caused by metastatic tumor in sinus

Cancer Treatments - Changes of thymidine kinase helped monitor effects of chemotherapy

Cancer Treatments - IL-15 serum levels elevated in workers exposed to chemotherapeutic agents

Cancer Treatments - Imaging of soft tissue sarcomas advised

Cancer Treatments - Neoadjuvant and adjuvant therapy for extremity soft tissue sarcomas discussed

Cancer Treatments - Olanzapine prevented chemotherapy-induced nausea and vomiting

Cancer Treatments - Possible antitumor ribonucleoside developed

Cancer Treatments - Quality of life during palliative chemotherapy for solid cancer kept intact

Cancer Treatments - Radical radiotherapy with or without chemotherapy compared in NSCLC patients

Cancer Vaccine - Chemosensitization of carcinoma cells enhances vaccine cytotoxicity

Cancer Vaccines - Researchers provide details of new studies and findings in the area of cancer vaccines

Cardiac Drug Therapy - Insufficient data exist to allow selection of specific inotropic agents

Cardiac Drug Therapy - Study examined cerivastatin/nifedipine in injured coronary arteries

Cardiac Therapy - COPD and reversibility should be ascertained before withholding beta-blockers

Cardiography - Magnetocardiography can be useful to improve diagnostic accuracy

Cardiology - CRP discriminates poorly between people with/without coronary disease

Cardiology - Cardiology must embrace preventive interventions that forestall future events

Cardiology - Cardiostimulants increase activity of calcineurin in the heart

Cardiology - Drug blocking the actions of aldosterone beneficial in heart failure treatment

Cardiology - ECG is the most important diagnostic test for aortic regurgitation

Cardiology - Human cytomegalovirus activates signals that trigger neointimal proliferation

Cardiology - MI patients with high BMI were less likely to have invasive coronary procedures

Cardiology - Model provides method to assess changes in cardiac electrophysiology

Cardiology - Nitric oxide synthase ameliorates cardiomyopathy in hearts lacking dystrophin

Cardiology - Research add new data to cardiology body of knowledge

Cardiology - Study compares sirolimus-eluting stents with vascular brachytherapy

Cardiology - Study examined cardiac actions of urotensin II

Cardiology - Study examined role of caveolae in protein kinase A activation

Cardioprotection - Study examined effects of adenosine kinase inhibition on infarction

Cardioprotection - Study examined effects of flavonoid treatment on endothelial functions

Cardiopulmonary Bypass - ACT system increased the heparin dose required to exceed target ACT

Cardiovascular Disease - Experimental studies suggest NAD(P)H oxidase activates vascular remodeling

Cardiovascular Disease - Method measures all known plasma forms of vitamins B₆ and B₂

Cardiovascular Drug Therapy - Inhibition was maintained more effectively with tirofiban than eptifibatide

Cardiovascular Research - 2-methoxyestradiol exerts renal and CV protective effects

Cardiovascular Research - Deficiency of eNOS is compensated in coronary circulation, not in aorta

Cardiovascular Research - Detrimental effect of receptor stimulation was induced by dobutamine

Cardiovascular Research - SR-BI KO/ApoeR61^h/h mice may contribute to understanding of CHD

Cardiovascular Research - Study examined mechanisms of mineralocorticoid receptor antagonism

Cardiovascular Research - Study examined the effect of amiodarone on CV reflexes

Cataract Surgery - Novel vancomycin insert shows promise for endophthalmitis prevention

Cataracts - Ophthalmology company's second quarter sales increase 12.8%

Cell Biology - Malaria mechanism revealed

Cell Biology - Stressed environments change the expression of human chloride channel genes

Central Nervous System - Galanin receptor examined, distribution in central nervous system defined

Childhood Cancer - Management strategies for asymptomatic cardiac damage discussed

Cholera - Positive preliminary results from clinical trial of cholera vaccine reported

Chronic Hepatitis B - Liver disease severity beats hepatitis B genotype as a cause of drug resistance

Chronic Hepatitis C - Hepatitis C genotype 4 is highly insensitive to pegylated interferon

Chronic Liver Disease - Apparent diffusion coefficient measurements help stage liver fibrosis

Chronic Liver Disease - Hepatitis B cirrhosis-related complications arise despite low DNA levels

Chronic Liver Disease - Ultrasound biopsy findings correspond with liver histology

Chronic Lymphocytic Leukemia - Trial begins for telomerase inhibitor drug GRN163L in patients with CLL

Cidofovir - Cidofovir treated recurrent respiratory papillomatosis

Cisplatin - Cisplatin, gemcitabine and treosulfan used to treat metastatic uveal melanoma

Clinical Studies - Single-ingredient compared to combination cream in melasma treatment

Clinical Trials - Cancer-focused company to downsize, focus on taxane compound clinical program

Clinical Trials - Eight-week doxycycline course safe/effective for lymphatic filariasis

Clinical Trials - Eye-disease-focused company reports Q2 revenue of $57.1 million

Clinical Trials - InKine announces the acceptance for filing of its new drug application (NDA)

Clinical Trials - Prasugrel and clopidogrel both resulted in low bleeding rates in PCI patients

Coagulation Therapy - Brand-name and generic warfarin have equivalent performance

Collaborations - Agreement signed to create monoclonal antibodies with improved efficacy

Collaborations - Alliance to phenotype E. coli genome expanded

Collaborations - Collaboration, licensing agreement signed to develop anti-inflammatory agents

Collaborations - Companies ink clinical data management solutions agreement

Collaborations - Compound library agreement signed with Evotec

Collaborations - Deal signed with Boehringer Ingelheim for biomarkers

Collaborations - Deal signed with vaccine developer

Collaborations - Development deal signed for cancer biomarkers

Collaborations - Financing secured for development of BEMA Fentanyl

Collaborations - Hurel Corp. and Johnson & Johnson enter into joint scientific collaboration

Collaborations - Igeneon and Celltrion announce commercialization and manufacturing agreement

Collaborations - Joint ophthalmology research project focuses on nitric oxide-donating compounds

Collaborations - License granted to develop RNAi therapeutics against TNF-alpha

Collaborations - Licensing deal signed for oncology drug eniluracil

Colorectal Cancer - CONFIRM 2 trial disclosure data released

Complementary & Alternative Medicine - Many body-conscious teens use supplements to improve physique

Complementary & Alternative Medicine - Monocytic leukemia cells analyzed, G₁ phase arrest reported

Complementary & Alternative Medicine - Orexin A examined, effects on olfactory bulb and odor responsiveness defined

Complementary & Alternative Medicine - ShimodaAtlantic launches new vertigo drug: Verticil

Congenital Heart Disease - Study examined prescription, tolerance, efficacy of prostaglandin E1

Contraception - NDA filed with U.S. FDA for oral contraceptive with uninterrupted dosing regimen

Coronary Artery Bypass - New anti-blood-thinning drug not as safe as protamine

Critical Care Medicine - Test to rule out heart attack could reduce hospital admissions

Crohn Disease - MAP specific IS900 DNA is a predominant feature of Crohn disease

Cryptococcus Neoformans - CD8+ T cell function independent of CD4+ T cells in C. neoformans infection

Cryptosporidiosis - Unique endemicity of cryptosporidiosis in children in Kuwait described

Cyclooxygenase - FC-77 inhibited inflammatory response in RAW 264.7 macrophages

Cytomegalovirus - CMV-specific cytotoxic T cells expanded using recombinant polyepitope

Depression Therapy - Adjunctive bright light effective in non-seasonal major depression

Dermatology - LYVE-1 antibody detects melanoma cells in the lymphatic system

Diabetes Complications - Serum prorenin levels rise as proliferative diabetic retinopathy forms

Diabetes Risk Factors - Atypical antipsychotic drugs and diabetes examined

Diabetes Therapy - Benidipine improves endothelial dysfunction in diabetic patients

Diabetes Therapy - Metformin does not reduce blood pressure in type 2 diabetes

Diabetes Therapy - Researchers detail new studies and findings in the area of diabetes therapy

Diagnostics - Findings advance knowledge in diagnostics research

Diagnostics - Minisequencing and mass spectrometry uncover hepatitis C genotypes

Diagnostics - Xenograft models link genes to breast cancer metastasis

Diagnostics - Young patients with acute leukemia share unique genetic features

Diet & Nutrition - Functional foods may offer stress management benefits

Diet & Nutrition - High-dose vitamin C supplementation heightens kidney stone risk

Diet & Nutrition - Olive oil compounds are antioxidants, anti-inflammatories, and antimicrobials

Diet & Nutrition - Vending machine program offers healthy snacks and drinks

Diffuse Anterior Scleritis - Celecoxib appears to be an effective treatment for diffuse anterior scleritis

Disease Associations - Alpha-synuclein cleavage studied, role of matrix metalloproteinases defined

Disease Associations - Leprosy bacilli examined, nature of Schwann cell proliferation clarified

Disease Associations - Quinolone signal synthesis studied, regulation in Pseudomonas defined

Disease Monitoring - European monitoring of antibiotic-resistant bacterium indicated

Docetaxel - Alternative docetaxel administration schedule evaluated

Drug Abuse - Meth users show symptoms similar to brain injury patients

Drug Delivery - "Smart" bio-nanotubes developed

Drug Delivery - Cargo molecules obstruct arginine-rich cell-penetrating peptide uptake

Drug Delivery - Dextran hydrogels confer controlled release of therapeutic growth factors

Drug Delivery - Electronic micropump nebulizers effective for ventilated neonates

Drug Delivery - Enteric-coated xyloglucan beads show promise as drug transporter

Drug Delivery - Peptide transporters improve targeted drug delivery

Drug Development - Canadian regulatory body grants approval to start cystic fibrosis trial

Drug Development - Company adds two assays to its broad kinase portfolio

Drug Development - Company files for European marketing approval of Thelin

Drug Development - Company launches cell-based assay technology for studying cell signaling events

Drug Development - Electrophoresis-based test detects enantiomeric impurity

Drug Development - Eric J. Leire joins heparin-focused company as CEO

Drug Development - First European patients enrolled in phase III study of cardiogenic shock drug

Drug Development - Grant funding boosts cancer program development

Drug Development - Interim analysis of beta-amyloid trial released

Drug Development - Isis Pharmaceuticals awarded contract for up to $1.1 million

Drug Development - Merck & Co. reaches clinical milestone using homologous recombination technology

Drug Development - Milestone achieved in collaboration with Merck & Co.

Drug Development - NDA submitted to U.S. FDA for Neurodex for pseudobulbar affect indication

Drug Development - Phase I clinical trial initiated for treatment of mild cognitive impairment

Drug Development - Phase I trial of C. difficile vaccine commences

Drug Development - Phase III trials to start for targeted lung cancer treatment

Drug Development - Preclinical data on human papillomavirus, Lassa fever therapy reported

Drug Development - U.K. patient enrollment commences in multiple sclerosis trial

Drug Development - Warning label expanded for Kadian

Drug Discovery - Antibacterial and antiviral peptide isolated from soya beans described

Drug Metabolism - Novel LC-MS/MS assay measures microsomal glucuronide transport

Drug Resistance - Cytomegalovirus drug resistance mutations phenotyped

Drug Safety - Drug safety coalition warns of counterfeit drugs in European supply chain

Drug Safety - InkSure signs contract for protection of ethical pharmaceuticals

Dyslipidemia - Effects of acute coffee ingestion on lipid levels determined

Embryonic Stem Cell Research - Patient-specific ESCs derived from somatic cell nuclear transfer blastocysts

End-Stage Renal Disease - Cortical excitability characterized in different patient populations

Endocrinology - Decoy therapy raises estrogen receptor alpha protein in breast cancer cells

Endocrinology - Glycodelin analyzed, cholesterol efflux and spermatozoa effects revealed

Endocrinology - Growth hormone status affects vascular growth modulators

Endocrinology - New findings in the area of endocrinology described

Endotoxic Shock - PPARgamma ligand 15d-PGJ₂ ameliorates murine endotoxemia

Entamoeba Histolytica - Entamoeba histolytica Gal/GalNAc lectin-associated proteins analyzed

Enterococcal Infection - Antimicrobial resistance of enterococci in Turkey characterized

Enterocolitis - Necrotizing enterocolitis associated with Clostridium perfringens

Enzymology - Ascochlorin inhibits renal carcinoma cell invasion

Enzymology - Endostatin fragments cut off proangiogenic functions

Enzymology - Recent findings in enzymology provide new insights

Enzymology - Tyrosine kinase inhibitors modify the invasive phenotype of prostate cancer

Epidemiology - Combined genetic polymorphisms encourage chronic hepatitis C progression

Episcleritis - Artificial tears superior to topical ketorolac for treatment

Epstein-Barr Virus - SM protein enhances expression of Epstein-Barr virus lytic genes

Escherichia Coli - E. coli 0157:H7 outbreak caused by nonintact blade-tenderized frozen steaks

Estrogen - Estrogen elicits cortical zone-specific effects on fetal adrenal gland growth

Familial Hypercholesterolemia - DNA array provides information about mutations and familial hypercholesterolemia

Fibrin Glue - Intralesional injection of Tisseel fibrin glue used for lymphangioma resection

Finance - Amex to trade options on pharmaceutical firm

Finance - Biopharma company reports first quarter 2006 financial results

Finance - Biopharmaceutical company announces second quarter 2005 results

Finance - Biopharmaceutical company reports Q2 29% revenue growth over prior year

Finance - Biotech company announces approval of NASDAQ SmallCap Market transfer

Finance - Biotech company reports 20% increase in earnings

Finance - Biotechnology research corporation reports Q2 financial results

Finance - Cancer vaccine developer approved by NASD for trading on Bulletin Board

Finance - Clinical research organization announces second quarter results

Finance - Company reports Q2 results, announces trials for ispinesib

Finance - Cosmetic treatment company reports revenues for second quarter 2005

Finance - Diabetes-focused therapeutics developer reports second quarter financial results

Finance - Drug delivery company reports loss of $0.12 per share

Finance - Drug development services provider announces financial results

Finance - Drug-delivery company plans to reduce convertible debt balance by $5 million

Finance - Electronic clinical data capture company announces financial results

Finance - European biotech company raises financing with institutional investors

Finance - Food products company reports increase in yearly revenues

Finance - Genomics-focused pharma reports Q2 loss of $15.7 million

Finance - HCA reports Q2 results of $0.90 per diluted share

Finance - Health behavioral change company raises $2 million of growth capital

Finance - Health benefits company reports results for second quarter 2005

Finance - Health products company reports second quarter results

Finance - Human tissue products company reports record second quarter 2005 results

Finance - Infections-focused biotechnology company reports second quarter 2005 results

Finance - Medical device firm reports record quarterly revenue of $38.7M

Finance - Men's health company reports Q2 net loss of $10 million

Finance - Micropump maker reports Q2 total revenues of $6.1 million

Finance - Molecular medicines company reports second quarter 2005 financial results

Finance - Nanotechnology company included in new Russell Microcap Index

Finance - Neuroscience company reports loss of $0.13 per share

Finance - Oncology drug maker records loss of $0.47 per share

Finance - Oncology-focused biosciences corporation reports Q2, 6-months 2005 results

Finance - PBM reports record second-quarter net income of $102 million

Finance - Panzem maker reports Q2 net loss of $4.3 million

Finance - Pharma company reports second quarter 2005 results

Finance - Pharma firm repurchases part of Eurobond issue, launches new hybrid bonds

Finance - Pharmaceutical company raises $20M in common stock private placement

Finance - Pharmaceutical company raises $30M in series C financing

Finance - Pharmaceutical company reports 320% revenue increase for second quarter 2005

Finance - Pharmaceutical company reports loss of $0.12 per share

Finance - Pharmaceutical company reports profits ahead of plan, revises year forecast up

Finance - Pharmaceutical company reports record sales for second quarter, first half 2005

Finance - Pharmaceutical company reports second quarter 2005 financial results

Finance - Pharmaceutical firm adopts amended, restated stockholder rights agreement

Finance - Pharmaceutical firm announces underwriter exercises option

Finance - Pharmaceutical firm reports $0.10 per share dividend

Finance - Pharmaceutical firm reports 12.1% increase in revenue

Finance - Pharmaceutical firm reports loss of $0.94 per share

Finance - Pharmaceutical firm reports record sales of $124.5M

Finance - Pharmaceutical firm sets price for public offering

Finance - Pharmaceuticals group reports good second quarter results with milestones met

Finance - Tysabri developer reports second-quarter 2005 financial results

Finance - VNS maker announces revised long-term sales outlook and guidance for fiscal 2006

Finance - Viread maker reports Q2 revenues of $495.3 million, up 55%

Finance - Washington genetics-focused company reports Q2 2005 financial results

Fitness & Wellness - Age does not impair key adaptations to exercise tolerance

Fitness & Wellness - U.S. surgeon general issues first call to action to improve health of disabled

Fucoidan - Fucoidan inhibited adhesion of adenocarcinoma cells to fibronectin

Galectin-1 - Galectin-1 induced apoptosis in human breast cancer and trophoblast tumor cells

Gastric Cancer - Paclitaxel and carboplatin combined to treat advanced gastric cancer

Gastroenterology - Recent findings illuminate research in gastroenterology

Gastroenterology - Reduced-dose rabeprazole has high acid-suppressive efficacy

Gastroenterology - VEGF expression and angiogenesis fluctuate shortly after ulcer formation

Gastrointestinal Stromal Tumors - New developments in gastrointestinal stromal tumors reviewed

Gene Expression - Changes in bacterial gene expression over the course of infection examined

Gene Mutations - Antibiotic resistance in Chlamydia spp. linked to gene mutations

Gene Regulation - Osmotic elements mediate paternally expressed gene 3 expression

Gene Research - A small interfering RNA expression vector library defines apoptosis pathways

Gene Silencing - Positional modifications affect short interfering RNA activity

Gene Silencing - RNA interference elicits tumor response despite hypoxia-induced VEGF-A

Gene Therapy - Enhanced CD20 expression in tumor B cells controlled by ERK-dependent mechanisms

Gene Transfer - SART-1 gene transduction causes cellular destruction

Generic Drugs - Approval granted to market Glimepiride; Vogseal launched in Japan

Generic Drugs - Private labels making steady inroads into U.S. nonprescription drug market

Generic Drugs - U.S. FDA grants tentative approval of tramadol and acetaminophen tablets

Genetics & Genomics - Filtering methods for time course microarray data compared

Genetics & Genomics - Technology company to collaborate with hospital in gene analysis

Genital Herpesvirus Infection - Topical microbicides needed for prevention of genital herpes infections

Genomics - Genomics company to provide physicians on patient's genetic profile

Glycemic Control - Three multiple injection regimens for type 1 diabetes compared

Gout - End-of-phase 2 U.S. FDA review on gout therapy complete, phase 3 trial to begin

Grants - Company awarded SBIR grant for cardiac modeling

Grants - Scientists Invited to apply for new Alzheimer drug discovery grant program

HAM/TSP Pathogenesis - Interferon-beta 1a affects immune mechanisms central to HAM/TSP pathogenesis

HIV/AIDS - Pharma firm reaches agreement with Brazilian government for AIDS drug

HIV/AIDS Coinfection - Neisseria gonorrhoeae enhances infection of dendritic cells by HIV-1

HIV/AIDS Disease Progression Risk Factors - Pattern/type of non-injection drug use associated with progression to AIDS

HIV/AIDS Drug Development - Amino acid Asn136 of HIV-1 RT enables rational design of RT inhibitors

HIV/AIDS Drug Development - Mesuol inhibits HIV-1 replication by targeting NF-kappa B pathway

HIV/AIDS Drug Development - Short hairpin RNAs targeting human cyclin T1 suppresses HIV-1 replication

HIV/AIDS Education - Low health literacy associated with HIV test acceptance

HIV/AIDS Education - Peer education or lecture increases HIV/AIDS knowledge among college students

HIV/AIDS Epidemiology - Differential susceptibility important determinant of steady-state HIV prevalence

HIV/AIDS Epidemiology - Majority of HIV-1 cases among Africa-born patients in Minnesota are non-B

HIV/AIDS Needlestick Injury - Postexposure practice inadequate in medical students with needlestick injury

HIV/AIDS Opportunistic Infection - Calciviruses may be important opportunistic pathogen in HIV-infected children

HIV/AIDS Pathogenesis - CD4+ cells have impaired base excision repair/oxidative base lesion accumulation

HIV/AIDS Pathogenesis - Cultured myeloid dendritic cells from HIV patients fail to differentiate

HIV/AIDS Pathogenesis - HIV Tat induction of IL-10 dysregulation associated with PKR activation

HIV/AIDS Pathogenesis - Infectivity of CXCR4-using isolates depends on CD4 expression

HIV/AIDS Pathogenesis - Peripheral S-phase T cells in HIV disease have a central memory phenotype

HIV/AIDS Pathogenesis - Reports describe recent advances in HIV/AIDS pathogenesis research

HIV/AIDS Perinatal Transmission - Nevirapine resistance after single NVP dose higher in women with HIV-1 subtype C

HIV/AIDS Pharmacokinetics - Body weight/female gender affects enfuvirtide clearance but not safety/efficacy

HIV/AIDS Prevention - HIV prevention program increases willingness to reduce adolescent risk behaviors

HIV/AIDS Prognostic Marker - Early HIV-1 PBMC DNA level predicts disease progression independent of RNA/CD4+

HIV/AIDS Research - CHMP offers positive opinion in Europe for Tipranavir

HIV/AIDS Research - Enrollment complete in phase 1 trial of PRO 140

HIV/AIDS Research - Phase 1/2a study results indicate maraviroc is well tolerated

HIV/AIDS Research - Phase IIb sudy shows Reverset trial results reported

HIV/AIDS Research - Single-chain antibody against HIV-1 external glycoprotein gp120 developed

HIV/AIDS Research - Soluble HIV trimeric Env fragment adopting prefusion gp41 structure developed

HIV/AIDS Risk Behavior - Adults with severe mental illness engage in risky sexual behaviors

HIV/AIDS Risk Behavior - Sexual risk behavior is high among youths in psychiatric care

HIV/AIDS Susceptibility - Screening test may be developed to determine susceptibility to HIV/AIDS

HIV/AIDS Therapy - Company begins phase III trials with aplaviroc (873140) for HIV treatment

HIV/AIDS Therapy - Company provides update of HIV/AIDS drug candidate

HIV/AIDS Therapy - Findings describe new data in HIV/AIDS therapy research

HIV/AIDS Therapy - HIV therapy success rates similar in developing and developed world

HIV/AIDS Therapy - Highly active antiretrovirals for HIV can substantially reduce AIDS rates

HIV/AIDS Therapy - Long-term safety data of antiretroviral in HIV patients with hepatitis reported

HIV/AIDS Therapy - Pharmacokinetics study results presented on once-daily HIV combination therapy

HIV/AIDS Therapy - Phorbol derivative shows promise as anti-HIV agent

HIV/AIDS Therapy - Study shows effectiveness of protease inhibitor in AIDS treatment

HIV/AIDS Therapy - Trial data on HIV antiviral therapy presented at international AIDS meeting

HIV/AIDS Transmission - Incorporation of ABO antigens by HIV-1 may affect viral transmission

HIV/AIDS Treatment - Data on PA-457 drug activity after oral dose in HIV-infected patients presented

HIV/AIDS Treatment - Invirase boosted with ritonavir not associated with development of resistance

HIV/AIDS Treatment - Patients more satisfied with once-daily dosing of EPZICOM

HIV/AIDS Treatment Failure - Prevalence of virologic response disappears after 96 weeks on HAART

HIV/AIDS Vaccines - Researchers provide details of new studies and findings in the area of HIV/AIDS vaccines

HIV/AIDS-Associated Eye Disease - HAART decreases morbidity related to HIV/AIDS-associated eye diseases

HIV/AIDS-Related Drug Use - Methadone treatment decreases heroin overdose-related mortality in HIV patients

HIV/AIDS-Related Kaposi Sarcoma - HAART plus liposomal doxorubicin induces tumor remission in HIV-related KS

Head & Neck Cancer - Paclitaxel, cisplatin, 5-fluorouracil and radiotherapy managed SCC

Heart Failure - Data supports advancement of cardiac myosin activator

Heart Failure - Spironolactone prescriptions increased after study publication

Heartburn - U.S. FDA accepts filing of NDA for ZEGERID Chewable Tablets

Hematology - Genetically modified natural killer cells overcome HLA-mediated resistance

Hematology - Researchers describe findings in hematology studies

Hematology - Suicide genes quell graft-versus-host disease after stem cell transplantation

Hematopoietic - ESCs grown without embryonic fibroblasts/conditioned media undergo hematopoiesis

Hemolytic Uremia - Streptococcus pneumoniae plus hemolytic uremia is rare in Canada

Henoch-Schonlein Nephritis - Azathioprine improves efficacy of steroid treatment in children

Heparin - Homer-1a studied, roles in pyramidal cell homeostatic regulation revealed

Hepatitis B Prevention - School-based factors predict the success of hepatitis B immunization programs

Hepatitis B Therapy - HIV therapy tenofovir battles hepatitis B infection

Hepatitis B Therapy - Oral tenofovir stops woodchuck hepatitis virus infection in woodchucks

Hepatitis B Therapy - Peginterferon is superior therapy for hepatitis B e antigen-positive infection

Hepatitis C Therapy - Findings advance knowledge in hepatitis c therapy research

Hepatitis C Therapy - First demonstration of systemic siRNA efficacy at therapeutic doses published

Hepatitis C Therapy - Ursodeoxycholic acid normalizes lipid peroxides in patients with hepatitis C

Hepatitis C Treatment - Development of nucleoside analog for treating hepatitis C initiated in Japan

Hepatitis C Virus - Antivirals defeat hepatitis C in cirrhotic patients after liver transplants

Hepatitis C Virus - CD8+ T cell response to hepatitis C infection wanes over time

Hepatitis C Virus - Company initiates phase Ib study of GI-5005 for chronic hepatitis C infection

Hepatocellular Cancer - Sirolimus improves the survival of patients transplanted for liver cancer

Hepatocellular Carcinoma - Interferon prevents liver cancer in chronic hepatitis C non-responders

Hepatocellular Carcinoma - Risk factors associated with bile leakage after hepatic resection

Hepatoma - Transforming growth factor beta mediated apoptosis in human hepatoma cells

Herpesvirus - Cathelicidin analyzed, expression and antimicrobial activity defined

Herpesvirus - Varicella-zoster virus prevalence in day-care workers in Lyon reported

Hip Replacement - Aprotinin and EACA treatment reduces post-THA blood loss

Hormone Replacement Therapy - Research add new data to hormone replacement therapy body of knowledge

Hyperlipidemia - Clinicians must be aggressive about hyperlipidemia in transplant patients

Hypertension - ACE I/D polymorphism is not useful to predict anti-HT treatment response

Hypoglycemia - CYP2C9 slow metabolizer genotypes increase severe hypoglycemia risk

Imaging - Electronics company and RaySearch Laboratories expand strategic relationship

Imidazole - Iodinated nitroimidazoles used as radiosensitizers

Immunity - Chemerin examined, neutrophil-mediated maturation demonstrated

Immunogenetics - Immunoglobulin KV genes isolated by PCR from macaque genomic DNA

Immunotherapy - GCAN 101 trial underway

Infection - Gonococci studied, effect on carcinoembryonic antigen-expressing B cells shown

Infection Control - Data: Pathogen inactivation process improves ACL reconstructive surgery results

Infectious Diseases - Galectin-1 examined, effect on Nipah virus and dendritic cells defined

Infectious Diseases - Risk to community of exposure to bacteria from previously hospitalized patients

Inflammatory Bowel Disease - Cannabis-based drugs could offer new hope for IBD patients

Information Technology - Beta-blocker therapy trial included in journal used information from database

Information Technology - OPTIMIZE-HF registry selected for heart failure program

Insomnia - FDA approves ROZEREM (ramelteon), sleep medication

Insomnia - New drug application accepted for insomnia treatment

Insomnia - U.S. FDA grants approval for ramelteon therapeutic for treatment of insomnia

Insulin Resistance - High fat diets modulate genes required for mitochondrial function

Insulin Resistance - PPAR-gamma-activating angiotensin receptor blockers induce adiponectin

Ischemia - Glomerular epithelial cell injury studied, role of ER protein shown

Ischemia - Reports add new data to ischemia research

Kidney Cancer - Gene therapy designed to seek VHL mutations may benefit renal cancer patients

Kidney Disease - Company reports positive results from DCOR trial favoring use of Renagel

Knee Replacement - Epidural analgesia improves early post-TKA rehabilitation

Knee Replacement - Epinephrine-augmented hypotensive epidural anesthesia lowers blood loss

Leukemia - Amino acid concentrations in cerebrospinal fluid measured in ALL children

Leukemia - Children do not show increased susceptibility for developing secondary AML

Leukemia - Glycated fibrinogen-methotrexate conjugates showed antileukemic activity

Leukemia - Intrathecal chemotherapy evaluated in children with acute leukemia

Liver Cancer - Dynamin 2 interactions let radiation send adenoviruses into liver cells

Liver Cancer - Microwave tissue coagulation yields acceptable results in resected livers

Liver Cancer - New findings in liver cancer described

Liver Cancer - Researchers discover link between viral infection and liver cancer

Liver Transplantation - Artificial neural network and genotyping predict liver cancer recurrence

Lung Cancer - Acute esophageal toxicity detected in NSCLC cancer patients after radiotherapy

Lung Cancer - Current approaches in chemotherapy of advanced and metastatic NSCLC detailed

Lung Cancer - Lung cancer incidence increasing in Sardinia

Lung Transplant - BLT1-mediated T-cell trafficking plays key role in rejection

Lymphoma - MTAP gene silenced by promoter hypermethylation in lymphoma cells

MALT Lymphoma - Clinical features of Helicobacter heilmannii infection studied

Malaria - P. falciparum malaria occurred in visitors to E. Coast of Dominican Republic

Malaria - Plasmodium falciparum STEVOR peptides studied, RBC binding defined

Malaria - Parasite-specific IgM plays role in immune response to malaria

Malaria - Research in malaria provides new insights

Malaria Vaccine - A. nancymaae is an animal model for malaria subunit vaccine development

Market Analysis - Biological and silver dressings lead growth in $1.5B burn market

Market Analysis - Pharma companies rate life cycle management functions as adequate

Marketing - Genomics company launches new corporate marketing and product branding campaign

Marketing - Market report indicates makers of lung cancer drugs spend $38 million on launch

Measles Vaccines - Researchers describe findings in measles vaccines studies

Medical Devices - Immunicon announces quality system certification

Medical Imaging - Novel system enables automated micro PET-CT-SPECT image fusion

Medicare - Grocery chain, CMS launch program to help give seniors access to drug benefits

Melasma - FRAXEL laser technology for melasama treatment cleared by U.S. FDA

Meningitis Vaccine - Antibiotic exposure impedes pneumococcal meningitis vaccine protection

Mental Health - Dr. Ed Knight receives psychiatric rehab association Chairperson's Award

Mergers & Acquisitions - Agreement signed to purchase Kirk Pharmaceuticals

Mergers & Acquisitions - Healthcare Technologies signs agreement for the acquisition of Immvarx, Inc.

Mergers & Acquisitions - Invitrogen signs definitive agreement to acquire BioSource International

Mergers & Acquisitions - Pharmaceutical provider for the elderly expands by acquisition

Mergers & Acquisitions - Protein therapeutics firm acquires LemnaGene S.A.

Mergers & Acquisitions - Specialty pharmacy and distribution company to be acquired by Express Scripts

Microbiology - Lactobacillus acidophilus by-products stimulate embryo cell proliferation

Mucin - Gastric mucin secretion analyzed, growth factor receptor mediation clarified

Multidrug Resistant - Carbapenem use {{>=}}7 days risks multidrug resistant to P. aeruginosa

Multiple Myeloma - COX-2 is an independent predictor of poor outcome in multiple myeloma

Muscular Dystrophy - Muscle side population cells reveal myogenic potential

Muscular Dystrophy - Safety and efficacy of creatine and glutamine evaluated

Mycobacterium Avium - High-temperature/short-time pasteurization inactivates M. avium in milk

Mycobacterium Kansasii - High phenotypic variability of M. kansassi may complicate identification

Mycobacterium Tuberculosis - Early treatment improves MTB-induced disseminated intravascular coagulation

Mycobacterium Tuberculosis - Inducible promoter generates conditional Mycobacerium tuberculosis auxotroph

Mycobacterium Tuberculosis - Pyrosequencing assay rapidly detects rifampin-resistant M. tuberculosis

Mycobacterium Tuberculosis - Virulence of MTB isolates dependent on phenolic glycolipid produced by bacilli

Mycoplasma Bovis - Mycoplasma bovis analyzed, new adhesin in low-passaged strain identified

Mycosis Fungoides - Therapeutic approach to mycosis fungoides and Sezary syndrome addressed

Myocardial Infarction - Early EPS/ICD treatment doesn't improve outcome for high-risk patients

Myocardial Infarction - Research links poor aspirin response to increased risk of heart attack or stroke

Myocardial Infarction - Seeded scaffolds intervene to aid the infarcted heart

Myocardial Infarction - Treatment with captopril and valsartan produced similar cardiac changes

Natriuretic Peptides - Natriuretic peptides analyzed, effect on gallbladder muscle defined

Neurology - New findings in neurology described

Neurology - Prostaglandin effect analyzed, role of EP2 and EP4 receptors defined

Neurology - Serotonin receptor expression analyzed, hippocampal ontogeny clarified

Neuropathic Pain - Lacosamide data positive in Phase III trial

Neuropathy - ND6 gene mutations cause Leber hereditary optic neuropathy

Neuroscience - A single molecule - Nova - helps control proteins that control synapses

Neuroscience - Calpain inhibitors may play a therapeutic role in NMDA-related disease

Neuroscience - Cochlear Ca²⁺ signaling analyzed, role of nitric oxide clarified

Neuroscience - Modified embryonic stem cells produce tumors after spinal cord implantation

Neuroscience - Mouse retinal nuclear elements favor endogenous gene repair activity

Neuroscience - New findings in the area of neuroscience described

Neurosteroids - Neurosteroid receptor studied, sensitivity to endocrine disruption reported

Neurotoxins - Neonatal MSG treatment has deleterious effects on rat behavior

Neurotransmitters - Blood-retinal barrier studied, nature of Leu transport defined

Non-Hodgkin Lymphoma - Data safety monitoring board recommends continuation of MyVax phase III trial

Non-Hodgkin Lymphoma - Risk of non-Hodgkin lymphoma associated with occupational exposure

Norovirus - Multiplex real time RT-PCR assay quantitates norovirus genogroups I and II

Nosocomial Infections - Healthcare system starts MRSA screening program

Obesity Surgery - Inpatient pain medication after laparoscopic gastric bypass examined

Obesity Therapy - New medically supervised weight-loss program introduced

Obesity Therapy - Reports add new data to obesity therapy research

Obstetrics - Study reveals effective way for women to breathe easier during labor

Obstructive Sleep Apnea - Alternative therapy proposed for mild sleep-disordered breathing in children

Oncogenesis - New findings in oncogenesis described

Oncology - Heparanase helps establish cancer metastasis to the bone

Oncology - Low VEGF levels may indicate lung cancer's response to gefitinib

Oncology - Mathematical model predicts effect of acidity on tumor growth

Oncology - Microvascular density predicts the survival of bladder cancer patients

Oncology - Oblimersen enhances the antitumor effects of gimatecan in melanoma xenografts

Oncology - Recent findings illuminate research in oncology

Oncology - Securin is a biomarker for breast cancer invasion

Ophthalmic Contact Dermatitis - Sodium lauryl sulfate improves patch test sensitivity

Ophthalmology - Choroidal neovascularization resolves after laser beam injury to the eye

Ophthalmology - Endostatin might inactivate choroidal neovascularization-dependent disorders

Ophthalmology - High-grade myopia is linked to regions of chromosome 2

Ophthalmology - Plasmid DNA encoding interleukin-18 attacks herpetic stromal keratitis

Opiates - Novel chromatography system efficiently separates opiate alkaloids

Oral Health - Salivary pleomorphic adenomas produce a number of VEGF splicing forms

Orthopedics - A new SOST gene mutation associates with skeletal hyperostosis in siblings

Osteomyelitis - Novel goat model facilitates research

Osteoporosis - Bone mineral density test helps determine osteoporosis treatment strategy

Osteoporosis - New findings in the area of osteoporosis detailed

Ovarian Cancer - Chemotherapy affected mutation frequency of ovarian cancer cells

Pain Management - Colorectal distension-induced visceral pain studied, role of sauvagine defined

Pain Management - Role of NMDA receptors in neuropathic pain clarified

Pain Medicine - Novel approach prevents baclofen pump catheter migration

Pamidronate - Pamidronate and 1,24(S)-dihydroxyvitamin D-2 inhibited growth of cancer cells

Pancreatic Cancer - New treatment modalities for pancreatic adenocarcinoma needed

Pancreatic Ductal Carcinoma - Factors predicting recurrence after pancreatic ductal carcinoma resection listed

Panduratin A - Panduratin A induced apoptosis in human colon cancer HT-29 cells

Parkinson Disease - Amphetamine-related drugs effective in treating a mouse model of Parkinson

Patents - Biopharmaceutical firm awarded U.S. patent for AVR118

Patents - Company files U.S. patent application for family of DNA antimicrobial agents

Patents - Company receives notice of allowance for key U.S. EVLT patent

Patient Education - Many discharged patients do not know diagnoses, medications, side effects

Patient Follow-Up - Telephone follow-up experiences at Rapid Response Radiotherapy Program shared

Pediatric Asthma Therapy - Inhaled corticosteroids don't stunt growth in prepubertal patients

Pediatric Cardiac Surgery - Surgery for aortic coarctation has excellent results in children under 1 yr. old

Pediatric Epilepsy Therapy - Vitamin D supplement doesn't prevent treatment-induced osteopenia

Percutaneous Coronary Intervention - PCI with drug-eluting stents highly cost-effective in Germany

Personnel - Alan M. Solinger, MD, named clinical immunology VP by biopharmaceutical company

Personnel - Arun Chockalingam, PhD, named secretary general of World Hypertension League

Personnel - Benefit management company's executive elected to professional association

Personnel - Cancer therapeutics developer names Rotherham, Myers to executive positions

Personnel - Clinical trial company appoints new CFO: John Hallinan

Personnel - Company focusing on osteoporosis adds member to board

Personnel - Contract research organization appoints global clinical trial management

Personnel - Daniel L. Hartman, MD, named senior VP, product development by genetics company

Personnel - David Gury appointed to board of directors at cardiology firm

Personnel - Dean Blechman, Twinlab founding family member, named to nutrition company board

Personnel - Genomics-based drug-discovery company names Ian D. Malcolm VP

Personnel - Icoria adds Anna Mae Diehl, MD, to its scientific advisory board

Personnel - Information technology company adds member to advisory board

Personnel - IntraPace announces Chuck Brynelsen as new CEO

Personnel - John F. Cogan joins Gilead Sciences board of directors

Personnel - John O'Mullane named group VP, R&D, consumer health care, by healthcare company

Personnel - Leo Albert named VP of finance by acute care hospitals, medical centers company

Personnel - Pharma company adds member to scientific advisory board

Personnel - Pharmaceutical developer names Dan McKay VP, intellectual property

Personnel - Physical therapy management services company elects member to board of directors

Personnel - Santa Jeremy Ono, PhD, named chief scientific officer by therapeutics developer

Personnel - Thomas A. Davis, MD named chief medical officer; to lead clinical development

Personnel - Vaccine organization appoints M. M. Sharma to board of directors

Pertussis - G protein signaling analyzed, nature of functional selectivity defined

Pharmaceutical Research - Improved RNA amplification garners more cells for cancer vaccines

Pharmaceutical Research - Report focuses on outsourcing trends released

Pharmaceutical Research - Research examines pharma competitive intelligence strategies

Pharmaceutical Research - Research examines role of medical affairs in pharma companies

Pharmacology - Effects of bisphosphonates on ion channels characterized

Philanthropy - Companies partner to send medical supplies to needy hospitals in Latin America

Photomedicine - Hypericin enacts a multifocal attack on angiogenesis when kept in the dark

Physiology - Candida albicans examined, histatin-induced effects described

Pituitary Gland - Pituitary secretory granule proteins examined, retrieval and reuse clarified

Pneumococcal Vaccines - Data advance knowledge in pneumococcal vaccines research

Pneumonia - C. pneumoniae kills cells by a caspase-independent pathway

Pneumonia - Pneumococcal pneumonia examined, nature of innate immune defense clarified

Product Licensing - California university expands licenses of data mining systems biology software

Product Licensing - Florida medical school signs license agreement for coenzyme with holding company

Product Licensing - Genentech has licensed rights to use ImmunoGen's TAP technology

Product Licensing - Hythiam adds HANDS licensee in San Francisco Bay area

Product Licensing - Pharma company enters license agreement with Lavipharm Laboratories

Product Licensing - Roche Diagnostics grants rights to commercialize NT-proBNP

Progenitor Cells - Epithelial lung cell differentiation studied, protein interactions revealed

Prostate Cancer - AMACR expression altered in prostatic adenocarcinoma following hormone therapy

Prostate Cancer - Adenocarcinoma of the prostate discussed

Prostate Cancer - Concept of hormone therapy in metastatic prostate cancer reappraised

Prostate Cancer - External beam radiotherapy used as curative treatment of prostate cancer

Prostate Cancer - Findings describe new data in prostate cancer research

Prostate Cancer - Trial of ozarelix in patients with hormone-dependent prostate cancer initiated

Protease Inhibitors - Cytotoxic T lymphocytes analyzed, regulatory aspects clarified

Protein Expression - Vascular smooth muscle cells studied, p27 expression clarified

Proteomics - CD105 erases the effects of transforming growth factor on vessel growth

Proteomics - Hepatitis C N-linked glycans are instrumental to cell entry and protein folding

Proteomics - Pigpen protein intensifies oligonucleotide distribution

Proteomics - Protein-protein interactions in cancer detailed

Proteomics - Research in proteomics provides new insights

Proteomics - Researchers determine protein structure of electrical signals in the brain

Proteomics - Six new phosphorylation-site profiling services announced

Pseudomyxoma Peritonei - New surgical strategy examined for treatment of pseudomyxoma peritonei

Radiation Therapy - DNA repair genes make lung cancer cells resist radiotherapy

Radiation Therapy - Data: Electronic brachytherapy accurately delivers nonradioactive radiation

Radiation Therapy - Risk of CV mortality after irradiation for childhood cancer is increased

Receptors - Adenosine receptor studied, functional importance of surfactant revealed

Receptors - Galanin receptor analyzed, important pharmacophores for binding identified

Receptors - Muscarinic acetylcholine receptor studied, conformational changes clarified

Receptors - Myocyte oscillatory currents studied, sodium nitroprusside inhibition revealed

Reconstructive Surgery - Researchers describe findings in reconstructive surgery studies

Rectal Cancer - Role of CEA and CA 19-9 in adjuvant radiochemotherapy assessed

Renal Cell Cancer - Renal cell carcinoma reported secondary to tuberculous nephritis

Renal Cell Carcinoma - Platelet-derived growth factor blockade stops kidney cancer progression

Reproductive Medicine - Progesterone is a major mediator of endometrial angiogenesis

Respiratory Distress Syndrome - Nitric oxide added to CPAP treatment improves oxygenation

Respiratory Medicine - Expanded development agreement for asthma, other respiratory therapies signed

Respiratory Medicine - Inhaled corticosteroid delivery devices reviewed

Respiratory Medicine - Positive final results of in vitro antiviral efficacy studies released

Restorative Dentistry - Antibiotic-loaded membranes enhance guided tissue regeneration

Retinoblastoma - Neurokinin-1-receptor antagonist acted as antitumoral agent on retinoblastoma

Retinopathy - Adeno-associated viral vectors transport therapeutic genes into the retina

Rosacea - Phase 3 trial examinig Oracea for rosacea presented at conference

SARS - Anti-SARS-coronavirus drugs are crucial for control of future outbreaks

SARS - Novel macaque model developed

SARS - Protective mask usefulness during SARS outbreak varies among healthcare workers

SARS - Quarantine is cost saving and effective in containing emerging infections

Sexual & Reproductive Health - Newly researched infertility treatment comes to western U.S.

Sexual & Reproductive Health - Survey reveals personal sacrifices take a toll on infertile women

Smallpox Vaccine - Stable/effective smallpox vaccine constructed from highly attenuated vaccinia

Staphylococcus Aureus - Common food preservative may have antibiotic properties

Statins - Rosuvastatin may be an option for patients requiring 50% LDL reduction

Stem Cell Research - BMSCs have limited plasticity to transdifferentiate into cardiac cells in vitro

Stem Cell Research - Bone graft clinical trial expanded to include Nebraska Medical Center

Stem Cell Research - Collaboration to isolate stem cell-specific differentiation markers

Stem Cell Research - Dopamine specifically inhibits forebrain neural stem cell proliferation

Stem Cell Research - Postnatal muscle-derived stem cells have extra capacity for self-renewal

Stem Cell Research - TGF-beta 1 tightly regulates intestinal mast cell growth/phenotype/function

Stem Cell Research - TGF-beta-1-2-3 & IFN-beta induce hepatocyte growth factor secretion by microglia

Stem Cell Transplantation - CD133+ SCs used for haploidentically mismatched peripheral blood SCT

Stem Cell Transplantation - Fibrinolytic test findings may facilitate early VOD diagnosis in pediatric HSCT

Stem Cell Transplantation - HLH patients with NK-cell deficiency type 3 will probably require SCT to survive

Stem Cell Transplantation - High-dose cyclophosphamide effective for refractory MM after SCT relapse

Stem Cell Transplantation - Most HLH patients using matched related or unrelated donor survive SCT

Stem Cell Transplantation - New research in the area of stem cell transplantation detailed

Stem Cell Transplantation - Nonmyeloablative SCT corrects disease phenotype in leukocyte adhesion deficiency

Stem Cell Transplantation - Reduced-intensity SCT successful in malignant lymphoma/ileostomy patient

Stroke - Angiopoietin-2 supports VEGF-induced brain angiogenesis

Stroke - Atherosclerosis and cervical artery dissection are not well examined

Stroke - Expansion of SAINT II phase III trial with CEROVIVE announced

Stroke - Study examined predictors of reocclusion in stroke patients treated with tPA

Stroke - Transthoracic ECG should be performed for all stroke patients in sinus rhythm

Systemic Lupus Erythematosus - First patient treated in pivotal phase III lupus nephritis study

TIssue Injury - Tissue and nerve injury studied, analgesic effects clarified

Tetanus - ADACEL vaccine begins shipping in the U.S.

Tissue Engineering - Autologous blood vessels engineered from human cells

Tissue Engineering - BMP-2 induces chondrocyte-specific gene expression in synovium-derived SCs

Tissue Engineering - Cultured porcine cartilage pellets used to study rheumatoid arthritis

Tissue Engineering - Keratocan examined, regulation by lumican revealed

Tissue Engineering - Tissue engineering for airway reconstruction avoids tracheotomy

Tissue Engineering - Tissue-engineered vascular autografts seeded with autologous bone marrow cells

Toxoplasma Gondii - Stage-specificity of SRS Ags determines immunogenicity in T. gondi infection

Transplant Medicine - Contrast agent allows better MRI screening of living liver donors

Transplant Medicine - Recent findings illuminate research in transplant medicine

Tuberculosis - Beijing genotype is a major cause of drug-resistant tuberculosis in Kazakhstan

Tuberculosis - Differential regulation of local immune response crucial for containment of MTB

Tuberculosis - ELISA more sensitive than immunoblotting for detection of tuberculosis antibody

Tuberculosis - High prevalence of tuberculosis among health care workers in Kampala

Tuberculosis - Low sunlight/vegetarian diet cause of vitamin D deficiency in foreigners with TB

Tuberculosis - Pharma company joins consortium to develop tuberculosis drugs

Tuberculosis - Short-course chemotherapy safe/effective in pediatric respiratory tuberculosis

Tuberculosis - Targeted screening strategies for pulmonary tuberculosis in prisons unreliable

Tuberculosis - Tuberculosis drugs not handled properly in lower southern Thailand

Tuberculosis - Tuberculosis risk patterns determined for recent immigrants to Ontario

Tuberculous Meningitis - Isoniazid + rifampicin resistance strongly predictive of death in TB meningitis

Tularemia Vaccines - Studies describe new findings in tularemia vaccines research

Tumor Suppression - Interleukin-12 immunotherapy hastens the demise of solid tumors

Type 1 Diabetes - Pancreatic islet transplantation stabilizes diabetes-related pathologies

Umbilical Cord Blood - Mannose-binding lectin and surfactant protein D lower in preterm neonates

Urology - Preoperative chlormadinone reduces blood loss during prostate surgery

Vaccine Development - Development progress of particulate vaccines for biowarfare reviewed

Virology - Data advance knowledge in virology research

Virology - GB virus C protects patients coinfected with HIV

Virology - NESI protein is essential for the assembly of hepatitis delta virus

Virology - Positive results reported on five projects using Neugene antisense drugs

Visceral Leishmaniasis - Novel triphenyl tin complex active against Leishmania donovani

Vitamin B6 - Pyridoxal 5'-phosphate measurements in serum compared

West Nile Fever - WNF encephalitis may present with functional/intellectual impairment in elderly

Yersinia - MAPK/NF-kappa B inhibition needed for rapid apoptosis in infected cells

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