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Adipose Tissue
Rosiglitazone upregulates lipases in brown adipocytes
August 26th, 2005
Rosiglitazone upregulates lipoprotein lipase, hormone-sensitive lipase, and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats. "Although thiazolidinediones are now widely used to treat type 2 diabetes, their mechanism of action remains largely unknown. They are agonists for the transcription factor PPAR-gamma, and in addition to their insulin-sensitizing effects, they can promote adipogenesis and control gene expression in adipose tissues. We have explored the effect of rosiglitazone on insulin-mediated induction of pivotal genes involved in lipid metabolism and thermogenesis in brown fat,"...
Source: Drug Week (2005-08-26)
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