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Analgesia
Ultralow-dose naltrexone enhances oxycodone analgesia
August 26th, 2005
Ultralow-dose naltrexone augments the analgesic effects of oxycodone. "Oxytrex is a novel drug that combines oxycodone with ultralow-dose naltrexone, an opioid antagonist," scientists in the United States explained. "Ultralow-dose opioid antagonists have been demonstrated to enhance and prolong opiate analgesia and alleviate opioid tolerance and withdrawal in rodents." In a "3-week, Phase II clinical trial," V.L. Chindalore and colleagues working at Anniston Medical Clinic in Anniston, Alabama assessed the "safety and analgesic efficacy of Oxytrex in patients with moderate to severe pain from osteoarthritis." "Patients with a pain...
Source: Drug Week (2005-08-26)
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