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Angiotensin
ATPase activity analyzed, angiotensin modulation revealed
August 26th, 2005
A study from Brazil has reported on the modulation of the (Na+K+)ATPase activity by angiotensin (Ang)-(1-7) in MDCK cells. "In the present paper the effect of Ang-(1-7) on the distal tubule (Na+K+)ATPase activity was evaluated by using MDCK cells as a model," wrote L.S. Lara and colleagues, Federal University of Rio de Janeiro. "Confluent cell monolayers were incubated with increasing concentrations of Ang-(1-7) for 30 min. Thereafter, the (Na+K+)ATPase activity was evaluated and a dose-dependent (from 10-12 to 10-7 M) inhibition was observed. ...
Source: Drug Week (2005-08-26)
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