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Anthrax
Complement depletion renders mice sensitive to Bacillus anthracis
August 26th, 2005
Complement depletion renders C57BL/6 mice sensitive to the Bacillus anthracis Sterne strain. According to recent research published in the journal Infection and Immunity, "Concerns regarding safety and control of virulent Bacillus anthracis have created substantial hurdles to the study of anthrax. The Sterne strain is considered relatively safe to study, but this acapsular strain has a defect in normal mice and is often studied in A/J mice." "A/J mice are highly susceptible to the Sterne strain, due to a defect in the Hc locus, which encodes complement factor 5 (C5)," said Eric T. Harvill and collaborators at the U.S. Food and...
Source: Drug Week (2005-08-26)
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