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Anthrax
Critical step traced in anthrax infection
August 26th, 2005
Scientists at Harvard Medical School (HMS) have revealed details of a key step in the entry of anthrax toxin into human cells. The work, which grew out of an ongoing effort to produce a better anthrax therapeutic, shows that the protective antigen component of the bacterial toxin plays an active role in transferring the other two components of the toxin through the cell membrane. The research, led by R. John Collier, professor of microbiology and molecular genetics at HMS, provides insight into the broader question of how proteins cross cell membranes. The findings appeared in Science. An anthrax bacterium secretes three nontoxic proteins that...
Source: Drug Week (2005-08-26)
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