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Antimicrobial Therapy
Aminoglycoside extended interval dosing safe and effective for neonates
August 26th, 2005
Aminoglycoside extended interval dosing is safe and effective for neonatal patients. In a recent study, pediatricians in Norway examined "evidence from controlled clinical trials of neonates given equal daily aminoglycoside doses as extended interval dosing (dosage interval typically 24 hours in term and 36-48 hours in immature neonates) compared with traditional dosing (dosage interval typically 8-12 hours in term and 12-24 hours in immature neonates)." E. Nestaas and coauthors at the Hospital of Vestfold in Tonsberg conducted a "systematic review and meta-analysis" of controlled trials found in electronic databases, trial registers, and references...
Source: Drug Week (2005-08-26)
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