Drug Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Drug Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Acetylcholine Receptors
Muscarinic acetylcholine receptor studied, basolateral sorting signal defined
August 26th, 2005
A study from the United States has reported on the identification and structural determination of the M-3 muscarinic acetylcholine receptor basolateral sorting signal. "Muscarinic acetylcholine receptors comprise a family of G-protein-coupled receptors that display differential localization in polarized epithelial cells. We identify a seven-residue sequence, Ala-275-Val-281, in the third intracellular loop of the M-3 muscarinic receptor that mediates dominant, position-independent basolateral targeting in Madin-Darby canine kidney cells," wrote H.A. Iverson and colleagues, University of Washington. "Mutational analyses identify Glu-276, Phe-280, and...
Source: Drug Week (2005-08-26)
|
