Published in Drug Week, September 9th, 2005
"Carcinoembryonic antigen (CEA) is a tumor-associated antigen targeted for the development of colorectal tumor vaccines. In this study, we developed papillomavirus pseudoviruses encoding the truncated CEA without NH2 -terminal signal peptide (PV-CEA) as an oral vaccine to induce CEA-specific CTL responses. In CEA transgenic (CEA-Tg) mice orally immunized with PV-CEA, the immunologic tolerance to CEA as a 'self-antigen' was overcome and both mucosal and systemic CEA-specific cytolytic activities were detected by in vitro 51Cr release assays,"...
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