Neurodegeneration
Induced nigral degeneration analyzed, neuroprotection by iron chelator revealed
Published in Drug Week, September 9th, 2005
"The cause of the neurodegenerative process in Parkinson disease (PD) remains unclear, but evidence suggests that failure of the ubiquitin-proteasome system may play a major role in the pathogenesis of the disease. Iron is believed to be a key contributor to PD pathology by inducing aggregation of alpha-synuclein and by generating oxidative stress," wrote X. Zhang and colleagues, Wenzhou Medical College.
"Our present studies have shown that micro-injection of the proteasome...
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Source: Drug Week (2005-09-09)
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