Phosphorylation
Na+/H+ exchanger studied, phosphorylation process clarified
Published in Drug Week, September 9th, 2005
"Transfection studies using mutant constructs have implicated one or both PKA consensus phosphorylation sites [Ser-552 and -605 in rat NHE3] as critical for mediating inhibition of NHE3 in response to several stimuli including dopamine. However, whether one or both of these sites is actually phosphorylated in endogenous NHE3 in proximal tubule cells is unknown," wrote H.S. Kocinsky and colleagues, Yale University.
"The...
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Source: Drug Week (2005-09-09)
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