Cancer Therapy

Median survival improved by more than half in phase III metastatic melanoma trial of Oncophage

Published in Drug Week, November 11th, 2005

Antigenics, Inc., (AGEN) announced findings from its preliminary analysis of a randomized phase III study of Oncophage (vitespen; formerly HSPPC-96) in patients with metastatic melanoma.

The study, which is not intended for registration, showed that in all randomized (intent-to-treat) stage IV M1a patients, median survival improved by more than 50% in the Oncophage-treated arm compared with those in the physician's choice treatment arm (20.9 months versus 12.8 months), which included the current array of therapies such as chemotherapeutics, biological agents and/or surgery.

This is the first phase III randomized trial of a cancer vaccine to show a...

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Source: Drug Week (2005-11-11)

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