Addiction Medicine
Beta-carbolines block opiate withdrawal
Published in Drug Week, November 11th, 2005
Scientists in Spain performed a study to "determine the affinity and binding profile of beta-carbolines for imidazoline I2 receptors and catalytic sites of monoamine oxidase (MAO)-A/B in rat brain and liver, and "assess the in vivo effects of norharman (beta-carboline) and LSL 60101 (I2 ligand) on brain 3,4-dihydroxyphenylalanine (DOPA) synthesis in morphine-dependent rats."
"Competition experiments against [3H]2-BFI revealed that beta-carbolines recognize the high- and low-affinity...
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Source: Drug Week (2005-11-11)
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