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Drug Week

Susan Hasty, Publisher
Table of Contents . . . November 18th, 2005
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Drug Week | Other Publications

Contraception - First scientific data for Lybrel presented at ASRM meeting

Drug Development - ACT 4 study initiated in acute treatment of atrial fibrillation

Drug Development - Acetohydroxyacid synthase inhibitor active against Mycobacterium tuberculosis

Addiction Medicine - Many substance abuse treatment counselors unaware of buprenorphine

Adverse Drug Reaction - Male SARS patients have reduced bone mineral density due to prolonged steroid therapy

Adverse Drug Reaction - Tysabri safety evaluation complete; no new confirmed cases of PML

Advocacy - Trade group: BioShield II bill needed, but without patent extensions

Aging - Growth hormone is illegal for off-label anti-aging use

Alcohol Use - Viboliv to enter the hepatoprotectives market

Breast Cancer - Reports add new data to breast cancer research

Alcoholic Liver Disease - Magnesium supplementation has limited effects on muscle function

Alcoholism Therapy - Increasing leptin levels precede relapse in detoxified alcoholics

Allergy & Immunology - Hepatitis C virus therapy alters the efforts of natural killer T cells

Allergy & Immunology - Immune escape may offer hepatitis C virus variants a survival advantage

Allergy & Immunology - Mnks role in cytokine regulation indicates value as new anti-inflammatory target

Allergy Medicine - Recent findings in allergy medicine provide new insights

Breast Cancer - Researchers report details of new studies and findings in the area of breast cancer

Alzheimer Disease - Alzheimer disease rat model offers insights into biomarker identification

Alzheimer Disease - Ebixa approved for the treatment of moderate Alzheimer disease in Europe

Alzheimer Disease - Nicotinic drugs appear to protect against beta-amyloidosis; further development is indicated

Alzheimer Disease - Research reveals promising approach to treatment of Alzheimer disease

Analgesia - Ketamine enhances morphine-and-bupivacaine-induced analgesia at {{>=}}20 ng/mL

Anemia - Levels of a hematopoiesis inhibitor partially explain anemia in heart failure

Breast Cancer - Researchers' findings advance breast cancer research

Anesthesia - Basic science and medical aspects of obesity reviewed for anesthetists

Anesthesia - Magnesium sulfate pretreatment attenuates etomidate-induced myoclonus

Angiology - Flow cytometry of platelet-leukocyte aggregates may permit monitoring of platelet function

Angiology - Heparin detection limit obtained with new stripping voltammetry method

Angiology - Neovascularization prevails in acute venous thrombosis

Angiology - Nitric oxide is critical in maintaining vasodilator tone in the llama fetus

Breast Cancer - Researchers' work adds to breast cancer body of knowledge

Angiology - Phenylephrine increases blood flow in the radial artery used as a coronary bypass conduit

Angiology - Prevention efforts reduce hepatitis B virus-associated polyarteritis nodosa cases

Angiology - Researchers provide details of new studies and findings in the area of angiology

Angiology - Sex difference in vascular injury response related to AT₂ receptor expression

Angiology - Study identifies role for Axl in angiogenesis and tumor growth

Angiotensin - Simvastatin therapy normalizes sympathetic neural control in experimental heart failure

Cancer Therapy - Recent findings illuminate research in cancer therapy

Antibacterial Agents - Availability of preoperative antibacterial skin preparation announced

Antibacterial Agents - New metronidazole vaginal gel, 0.75% for bacterial vaginosis introduced

Antimicrobial Resistance - Campaign to Prevent Antimicrobial Resistance in Healthcare Settings assessed

Antioxidants - Red blood cell model optimized for the study of antioxidant drugs

Antipsychotics - Neuroleptic treatments did not affect energy regulation in male rats

Apoptosis - Alpha-tocopheryl succinate selectively induced apoptosis in neuroblastoma cells

Cancer Therapy - Reports advance knowledge in cancer therapy research

Apoptosis - Arsenic trioxide induces apoptosis in neuroblastoma cell lines

Apoptosis - Ceramide activates a mitochondrial p38 mitogen-activated protein kinase

Apoptosis - Cyclosporine A and its nonimmunosuppressive derivative induce apoptosis of malignant melanoma cells

Apoptosis - Glycolysis linked to apoptosis

Apoptosis - Studies advance knowledge in apoptosis research

Asthma Therapy - Research add new data to asthma therapy body of knowledge

Cancer Vaccines - New findings in cancer vaccines described

Atrial Fibrillatiion - Decision to use anticoagulant therapy must take gender into consideration

Autoimmune Disease - MRCP imaging of the MPD helps diagnose pancreatitis with autoimmune phenomenon, but a negative result does not preclude such diagnosis

Avian Influenza - Broad-spectrum antiviral medicine inhibits bird flu virus by blocking attachment

Avian Influenza - Volunteers sought for avian flu vaccine study

Awards - Myeloma organization honors David B. Agus, MD, for unlocking secrets of cancer

Bacterial Vaginosis - Treatment agents for bacterial vaginosis differ in microbiologic effects

Cancer Vaccines - New findings in the area of cancer vaccines described

Bacteriology - Kinetics of acute and chronic Brucella infection in mice parallels human infection

Bacteriology - Researchers discover Plectasin effective on resistant bacterial infections

Biliary Tract Spasm - Hymecromone has bile acid-independent effect on bile secretion

Biofilms - T. denticola and P. gingivalis require flagella, fimbriae and Arg-gingipain B

Biomedical Engineering - Cd²⁺ effects on sulfur assimilation and GSH metabolism studied in three cell models

Biomedical Engineering - Cryopreserved skin substitutes release cytokines essential for wound healing

Cancer Vaccines - New findings in the area of cancer vaccines detailed

Biomedical Engineering - Photoimmobilized micropatterned Hyal surface induced chondrocytes adhesion and alignment

Biomedical Engineering - Placing nonbiodegradable PMMA beads into bone may create higher drug levels in marrow

Biomedical Engineering - PsN-Toolkit makes it easier to use traditional methods in pharmacometric data analysis

Bioterrorism - Positive data presented from preclinical and clinical studies with Neumune

Bioterrorism - Radilex may safeguard people from formaldehyde gas

Blood Clotting - Coagulation system is activated in Duchenne muscular dystrophy patients with cardiac dysfunction

Cancer Vaccines - Reports describe recent advances in cancer vaccines research

Blood Safety - Blood screening and vaccines lower the risk of transfusion-transmitted infections in Italy

Bone Loss - Alfacalcidol exerts higher bone-protective properties with fewer side effects

Bone Marrow Transplantation - Campath-1H does not alter bone marrow cell regulatory function

Bowel Disease - Analysis shows maintenance therapy with Remicade sustains healing in Crohn patients

Breast Cancer - Breast cancer survivors likely candidates for low BMD and undiagnosed osteoporosis

Breast Cancer - Cholesterol levels, lipid-lowering drugs are not associated with the risk of breast cancer

Cardiology - New findings in the area of cardiology described

Breast Cancer - Data shows Herceptin plus chemotherapy reduces risk of breast cancer recurrence

Breast Cancer - New findings in breast cancer described

Cardiology - Researchers' data advance cardiology research

Breast Cancer Therapy - New aromatase inhibitors for treatment of metastatic breast cancer examined

Business & Finance - Agreement signed with Korean pharmaceutical company for purchase of 1.5M shares of stock

Business & Finance - Avid Bioservices to provide development services for monoclonal antibody

Business & Finance - Biomedical development corporation announces stock exchange transition to OTC market

Business & Finance - Biotech company announces final settlement of 4-year Serostim investigation

Business & Finance - Cancer-focused biopharmaceutical company raises $11.6 million in private funding

Diabetes Therapy - Recent findings in diabetes therapy described

Business & Finance - Cardiovascular drug discovery company completes $31.9 million financing round

Business & Finance - Cardiovascular-focused drug discovery company reports Q1 2006 financial results

Business & Finance - Defibrotid maker completes $10.9 million private placement

Business & Finance - Drug-delivery company receives Nasdaq letter addressing need to add director

Business & Finance - Drug-delivery company returns to profitability in the third quarter

Business & Finance - Drug-development company grows EPS 26%; delivers record orders and margins

Diabetes Therapy - Recent studies add new data to diabetes therapy research

Business & Finance - Gene-based company announces plan to sell myoblast cell therapy program

Business & Finance - Genetics therapy-focused biotech company completes $30 million financing

Business & Finance - PLME drug developer completes $6.9 million private placement; company to seek U.K. AIM listing

Business & Finance - Pharmaceutical company updates program for lupus renal disease drug candidate

Business & Finance - Pharmacy and drug distribution provider regains compliance with Nasdaq listing requirement

Business & Finance - Thyrogen maker delivers strong third-quarter results; revenue increases 24%

Diabetes Therapy - Researchers describe findings in diabetes therapy studies

Cancer Cell Inhibition - D-allose demonstrated inhibitory effect on cancer cell proliferation

Cancer Research - Ependymomas arise from rare CNS stem cells, researchers say

Cancer Research - Stanford study shows dual role of protein menin in cancer growth

Cancer Risk Factors - Ovulation stress might cause ovarian cancer

Cancer Therapy - 5-Fluorouracil catabolic potential measured by oral loading

Cancer Therapy - All adult patients with Burkitt lymphoma should receive CNS-directed therapy

Diagnostics - Research in diagnostics provides new insights

Cancer Therapy - Butyrate regulates sphingomyelin in colon and liver cancer cells

Cancer Therapy - Findings advance knowledge in cancer therapy research

Cancer Therapy - Four diterpenoid inhibitors of Cdc25B phosphatase extracted from marine anemone

Cancer Therapy - Growth inhibition activity of squamostolide evaluated

Cancer Therapy - Interventions needed to reduce decision-making difficulty and emotional distress

Cancer Therapy - LY293111 administered safely to patients with advanced solid tumors

Diagnostics - Researchers describe findings in diagnostics studies

Cancer Therapy - Lymphoma patients with advanced disease and poor prognosis require intensified treatment

Cancer Therapy - New strategies for treatment of lymphoma described

Cancer Therapy - New therapeutic targets for multiple myeloma identified

Cancer Therapy - New trial to investigate combination of HYB2055 with chemotherapy

Cancer Therapy - Nine new cell lines distributed for cancer research

Cancer Therapy - No changes in symptoms recorded in patient self-assessments from vitamin E and pentoxifylline use

Diagnostics - Studies advance knowledge in diagnostics research

Cancer Therapy - Oral verrucous hyperplasia and oral leukoplakia treated with biweekly topical ALA-PDT sessions

Cancer Therapy - Preliminary results reported from randomized phase II trial of Avastin and Tarceva in kidney cancer

Cancer Therapy - Salicylic acid interfered with anticancer action of anthracyclines

Cancer Therapy - Src inhibition may be feasible for treating pancreatic cancer

Endocrinology - Researchers detail new studies and findings in the area of endocrinology

Cancer Therapy - Target suppression and antitumor activity of MEK inhibitor CI-1040 demonstrated

Cancer Therapy - VEGF conjugate guides boronated dendrimers to tumor vessels

Cancer Treatment - Scientists contend reducing chemotherapy due to obesity should be avoided

Cancer Treatments - Combination chemotherapy treatment is the choice for women with rare cancer

Cancer Vaccine Development - Epitopes recognized by antibodies specific for tumor antigen NY-ESO-1 identified

Cancer Vaccine Development - Sensitized CD62L^low lymph node cells possessed anti-tumor activity

Endocrinology - Researchers publish new studies and findings in the area of endocrinology

Cancer Vaccines - Findings describe new data in cancer vaccines research

Cancer Vaccines - Strategy for developing vaccine therapies for pediatric malignancies outlined

Hepatocellular Carcinoma - Research in hepatocellular carcinoma provides new insights

Candidiasis - HAART reduces frequency of candidiasis in AIDS patients

Carcinogens - Human natural killer cell function inhibited by ziram and pentachlorophenol

Cardiac Surgery - Malleable surgical ablation probe receives U.S. FDA 501(k) clearance

Cardiac Surgery - New approach to antiplatelet therapy during coronary interventions under study

Cardiac Transplantation - Researchers detail new studies and findings in the area of cardiac transplantation

Cardiology - Are over-the-counter cold medicines safe for your heart?

Leukemia - Reports describe recent advances in leukemia research

Cardiology - Findings advance knowledge in cardiology research

Cardiology - Hepatocyte growth factor gene therapy blunts vascular remodeling in hypertrophic hearts

Cardiology - Linear ablation lesion strategy is safe for noninducible or nonsustained tachycardia

Cardiology - Non-cardiac QTc-prolonging drugs increases the risk of sudden cardiac death

Cardiology - Rate-control yields better prognosis than rhythm-control in patients with atrial fibrillation

Leukemia - Research add new data to leukemia body of knowledge

Cardiology - Small fiber muscle mechanoreceptors act to inhibit cardiac vagal tone to produce tachycardia

Cardiology - Study shows Hedgehog pathway protects and preserves heart muscle function

Cardiology - Viagra blunts the effects of stress on the human heart

Cardiomyopathy - Combined cell therapy benefits severely ischemic hearts in canine models

Cardiovascular Disease - Analysis suggests Cypher Stent more cost effective than bypass surgery

Neuroscience - Reports add new data to neuroscience research

Cardiovascular Disease - People lower on the socio-economic scale are less likely to get treatment to prevent heart disease

Cardiovascular Disease - Phase 1 study underway of rFXIII for patients undergoing cardiac surgery

Cardiovascular Disease - Radical approach to cardiac resynchronization shows promise

Cardiovascular Research - Prostacyclin protects against elevated blood pressure and cardiac fibrosis

Cardiovascular Risk Factors - Olive and sunflower oil blend decreases estimate of 10-year cardiovascular risk

Cataract Removal - Ketorolac and prednisolone superior for postoperative inflammation control

Neuroscience - Researchers provide details of new studies and findings in the area of neuroscience

Cell Biology - Hepatitis C virus infection modifies THP-1 monocytoid cell behavior

Cervical Cancer - Researchers' data advance cervical cancer research

Chemotherapy - Antitumor effect of cisplatin enhanced with low-voltage electrochemotherapy

Chemotherapy - Bamet-UD2 overcomes resistance to cisplatin

Chemotherapy - Chemotherapy in children may affect teeth growing at time of treatment

Chemotherapy - Combination of oxaliplatin, leucovorin and fluorouracil deemed effective

Neuroscience - Studies add new findings to neuroscience body of knowledge

Chemotherapy - Gemcitabine used in treatment of advanced head and neck cancer

Chemotherapy - Irinotecan plus temozolomide was well tolerated in malignant glioma patients

Chemotherapy - Low-dose GM-CSF used as salvage therapy in breast and genital tract carcinoma

Chemotherapy - Platinum compound inhibits Stat3 signaling and induces cell cycle arrest

Chemotherapy - Temsirolimus used to treat recurrent glioblastoma multiforme

Chemotherapy - Temsirolimus used to treat relapsed mantle cell lymphoma

Oncology - Recent findings in oncology provide new insights

Chromatography - Recent findings in chromatography described

Chronic Daily Headache - High-dose Botox shows promise as prophylactic treatment

Chronic Heart Failure - Flow-mediated vasodilation predicts outcome in patients with chronic heart failure

Chronic Pain - Opioid dosing trends and mortality in Washington State workers' compensation assessed

Clinical Trials - Clevidipine phase 3 program resumes, phase 3 interim data affirms safety profile

Clinical Trials - DNA 'prime-boost' vaccine technology enters phase 2 clinical trial for HIV

Oncology - Research add new data to oncology body of knowledge

Clinical Trials - Phase 2 clinical trial of drug candidate for allergic asthma patients initiated

Clinical Trials - Phase 2 testing of HIV vaccine developed with Vaccine Research Center initiated

Clinical Trials - Prostate cancer trial ended, metastatic breast cancer trial continues, company reports

Clinical Trials - Results of phase 3 trial on immunotherapy Virulizin for pancreatic cancer reported

Clinical Trials - Study shows interferon treatment delays MS onset in patients showing clinical signs

Clinical Trials - Trial of melanin-stimulating topical fomulation EPT1647 begins in London

Oncology - Researchers describe findings in oncology studies

Collaborations - ABC(2) and collaborator announce second brain cancer collaboration

Collaborations - Alliance focuses on protein structures, to prioritize proteins as drug targets

Collaborations - Alliance formed to combat infectious diseases

Collaborations - DirectDesign Discovery collaboration inked with KAI Pharmaceuticals

Collaborations - Drug discovery company inks multiyear deal for nonprescription compounds

Collaborations - Electronic data management partnership signed for managing clinical trial data

Proteomics - Research in proteomics provides new insights

Collaborations - Gene function analysis company enters codevelopment agreement

Collaborations - North American distribution agreement signed for in vitro assay products

Collaborations - Pharmaceuticals company enters collaboration and license agreement with Amgen

Colon Cancer - Genasense Injection increases anticancer activity of radiation

Colon Cancer - Recent findings in colon cancer provide new insights

Colorectal Cancer - Carbohydrate compound company begins phase II trail of Davanat /5-FU

Vaccines Delivery - Findings advance knowledge in vaccines delivery research

Colorectal Cancer - TroVax trial achieves primary endpoints for cancer immunotherapy treatment

Complementary & Alternative Medicine - Cuminum cyminum decreases lipid levels in alcohol and oxidized oil induced toxicity

Complementary & Alternative Medicine - Chef, cancer survivor shares ingredients to help patients find strength to live

Complementary & Alternative Medicine - Justicidin A induces apoptosis in human colorectal cancer cells

Complementary & Alternative Medicine - Viscous injectable pure alginate sol inhibits fibroblast proliferation and migration

Coronary Artery Disease - L-Arginine bolsters angiogenic response in hypercholesterolemia models

Virology - Researchers provide details of new studies and findings in the area of virology

Coxiella Burnetii - Virulent Coxiella burnetii does not activate dendritic cells

Crohn Disease - Phase II Trial results for treatment of Crohn Disease with Cimzia are positive

DNA Research - Oral epithelial cells indicate CYP1B1 may be early biomarker for oral cancer

Depression - Biopharma company discovers gene for major depression

Depression Therapy - Interaction of fluoxetine with phosphatidylcholine liposomes examined

Depression Treatments - Vagus nerve stimulation and SSRI treatment cause similar cerebral blood flow changes

Virology - Researchers publish new studies and findings in the area of virology

Dermatology - Data: Remicade can quickly and significantly improve psoriasis symptoms

Dermatology - Few patients with lichen planus in Iran have underlying hepatitis C infections

Dermatology - Pharma company launches midpotency steroid lotion for children and adults

Developmental Biology - Slit-like 2 regulates zebrafish vascular and nervous system morphogenesis

Diabetes Complications - Postprandial hyperglycemia predicts diabetic microangiopathy in type 2 diabetes

Diabetes Complications - Statins reduce the risk of heart disease in diabetic patients with chronic kidney disease

Diabetes Therapy - Costs of therapy for insulin-treated diabetes in Germany reported

Diabetes Therapy - Findings advance knowledge in diabetes therapy research

Diabetes Therapy - Ginsenosides from Panax ginseng possess antihyperglycemic activity

Diabetes Therapy - Tesaglitazar improves metabolic abnormalities linked to insulin resistance

Diabetic Nephropathy - Irbesartan plus perindopril needed to reduce aldosterone, proteinuria, and TGF-beta₁

Diabetic Nephropathy - Meprin-alpha appears to play a role in chronic diabetic nephropathy

Diabetic Neuropathy - Studies show QR-333 safe for topical use

Diagnostic Imaging - Functional CT discerns vessel perfusion in tumors treated with antiangiogenic therapy

Diagnostics - Contrast-enhanced 1.5 harmonic imaging ultrasonography diagnosed hepatic tumors

Diagnostics - New findings in the area of diagnostics detailed

Diagnostics - Patients fare well after receiving liver biopsies performed with automated devices

Dialysis - Polymyxin B effective in CAPD peritonitis caused by multiresistant K. pneumoniae

Diet & Nutrition - Pharma company named exclusive manufacturer of Nascobal for QOL Medical

Disease Associations - Cardiac troponin I predicts adverse events in stable coronary disease

Disease Associations - Gelatinase T polymorphism relation to ischemic heart disease explored

Disease Associations - Human herpes virus 8 implicated in lymphoproliferative disorders

Disease Associations - Interferon-gamma induces apoptosis in developing mast cells

Disease Associations - Oral phosphate binders in the treatment of pseudoxanthoma elasticum

Disease Associations - Palmoplantar keratoderma associated with esophagus squamous cell cancer

Disease Associations - Prior aspirin use is not a marker of increased mortality in elderly patients with acute MI

Disease Associations - Smoking and disease are predictive of thrombotic events in systemic lupus erythematosus

Dosimetry - Amifostine allows additional delivery of paclitaxel in patients undergoing radiotherapy

Dosimetry - Dose-escalating study of docetaxel, capecitabine, and carboplatin conducted

Dosimetry - Recommended dose of docetaxel in combination with 5-fluorouracil calculated

Drug Abuse - Analysis shows use of prescription sleeping aids increasing and at younger ages

Drug Abuse - Detection of designer 4-MTA in human urine was successful using GC-MS

Drug Abuse - Med school residents more likely to use contracts to control opiod misuse

Drug Delivery - CPP matrices developed for vancomycin delivery in osteomyelitis treatment

Drug Delivery - GMD/PAA hydrogels show promise for colon-specific drug delivery

Drug Delivery - Study: For injectable drug delivery, drug companies must keep both eyes on end user

Drug Development - Alfacalcidol may improve symptoms in patients with rheumatoid arthritis

Drug Development - Application filed with U.S. FDA for combined therapy for cancer treatment

Drug Development - Biofocus expands its supply and services agreement with Serono

Drug Development - Cellular events analyzed using CellCard System in multiplexed assays

Drug Development - Company secures $2.22 million for drug development from Finnish national agency

Drug Development - Data being analyzed in phase II CoFactor trial in patients with metastatic colorectal cancer

Drug Development - Discovery Systems business sold to Nexus Biosystems

Drug Development - Enrollment strong in Phase III trials of treatment for pulmonary fibrosis

Drug Development - First patients enrolled, treated in IRX-2 phase II head and neck cancer study

Drug Development - Hematide is potent erythropoiesis-stimulating agent for anemia due to cancer, kidney disease

Drug Development - High-throughput screening steadily increasing success in drug discovery, according to report

Drug Development - Highly immunogenic hepatitis C virus peptides may produce new therapy

Drug Development - In silico ensemble method for drug discovery developed

Drug Development - Inhibition of matriptase prevents invasive growth of prostate and colon cancers

Drug Development - Intratect approved for nine European countries

Drug Development - Laboratorios Davur acquires right to market pravastatin

Drug Development - Malaria drug positioned for treatment in pregnant, lactating women

Drug Development - Meeting requested with U.S. FDA to seek guidance on neurodegenerative diseases drug

Drug Development - New approaches to drug development in pediatric oncology discussed

Drug Development - Novel antimutagenic factors derived from mushroom Agrocybe cylindracea

Drug Development - Pharma company announces agreement for optimization of drug discovery leads

Drug Development - Phase I trial for CHIR-12.12 initiated in multiple myeloma

Drug Development - Phase I trial of AG-707 therapeutic vaccine for genital herpes initiated

Drug Development - Phase II trial of PPI-0903 initiated in patients with bacterial infections

Drug Development - Progress is reported toward acetate supplementation therapy for Canavan disease

Drug Development - Response submitted to U.S. FDA regarding approvable letter for iPlex

Drug Development - Screen couples Cyt P450 online bioaffinity detection with gradient reversed-phase HPLC

Drug Development - Synthetic glycosaminoglycan mimetic jumpstarts angiogenesis

Drug Development - U.S. FDA accepts Orapred ODT NDA filing

Drug Development - U.S. FDA issues approvable letter for Pargluva, an oral treatment for type 2 diabetes

Drug Development - U.S. FDA maintains clinical hold on IND application for RESUS phase II/III trial of Hemopure

Drug Development - U.S. FDA submission for Zimycan deemed a complete response

Drug Development - United States' exclusivity for Tramadol ER confirmed by U.S. FDA

Drug Development - Workshop proceedings discuss managing risks of therapeutic products

Drug Research - Plasma homocysteine is not increased by the chronic administration of nandrolone

Drug Resistance - AN-238 inhibits growth of experimental, drug resistant endometrial carcinomas

Drug Resistance - Bis-glycosylated diamino alcohol active against multidrug-resistant MTB

Drug Resistance - New findings in the area of drug resistance described

Drug Resistance - Prevalence of multiresistance to antituberculous drugs increases after treatment

Drug Safety - Over-the-counter medicine safety organization aims education program at women

Duchenne Muscular Dystrophy - Development-stage biopharma targets January 2006 to submit IND application for Myodur In DMD

Eczema - Research shows benefits of Elidel in eczema patients as alternative to steroids for eczema patients

Embryonic Stem Cells - Autogeneic feeder cell system efficiently supports undifferentiated ESC growth

Embryonic Stem Cells - Transplanted dopamine neurons derived from primate ESCs survive long-term

Endocrinology - Recent findings in endocrinology provide new insights

Environmental Toxins - Carcinogenic behavior of diethanolamine observed in mice may not apply to humans

Enzymology - Aldehyde oxidase demonstrates stereospecific oxidation of (S)-enantiomer of RS-8359

Epilepsy - Ketogenic diet highly effective after failed pharmacologic therapy

Epilepsy - Review finds ativan best for treating severe epilepsy

Erectile Dysfunction - Tadalafil effective during thiazide diuretic hypertension therapy

Esophageal Cancer - Failure patterns linked to proportion of residual cancer after chemoradiotherapy

Facilities - Construction begins on pharmaceutical packaging plant in China

Facilities - Molecular diagnostics company opens new headquarters in Illinois

Facilities - Nabi completes $20 million Florida vaccine plant

Fiberoptic Bronchoscopy - Ketamine superior to alfentanil in propofol-based patient-controlled sedation

Fibromatosis - Patients with pediatric aggressive fibromatosis retrospectively analyzed

Fibromyalgia - Dehydroepiandrosterone proves ineffective in treatment of fibromyalgia symptoms

Finance - Antibacterial product developer delisted from Nasdaq

Finance - Biologic-based cancer drug maker records 9% increase in revenue

Finance - Biopharma company receives grants from the U.S. National Institutes of Health

Finance - Biopharma outsourcing organization announces 6.1% increase in revenue

Finance - Biotech company receives phase II SBIR contract for liver injury biomarkers

Finance - Bladder cancer drug developer signs agreement for private financing

Finance - California biosciences company announces $14.7 million private placement

Finance - Chronic inflammatory disease drug maker posts loss of $0.61 per share

Finance - Contract research organization reports net revenue of $273.3 million

Finance - Cypher Stent sales fuel stock increase for manufacturer

Finance - Drug delivery developer secures new investors

Finance - Endocrine-focused biopharma company secures $75 million equity financing facility

Finance - Flinn Foundation awards genomics research organization an additional $9 million

Finance - Gene-based drug maker reports loss of $0.42 per share

Finance - Gene-identification company reports 27% increase in revenues in the fourth quarter

Finance - Hyaluronic acid-based therapy developer reports 57% increase in revenues

Finance - Insomnia drug developer receives investment from private placement offering

Finance - Lexapro maker reports second-quarter earnings per share of $0.59

Finance - Macular degeneration drug maker receives $7M for partial royalty rights

Finance - Medical products supplier announces second quarter sales of $112 to $115 million

Finance - Men's health company announces exercise of over-allotment option

Finance - Monoclonal antibodies-focused company files shelf registration statement

Finance - Nanotechnology company participates in NanoforLife program

Finance - Novartis generic drug business records $487 million sales in first 9 months 2005

Finance - Obesity drug developer records loss of $0.46 per share

Finance - Pharma company reports operating income of Rs 239.32 crore

Finance - Pharma company reports third-quarter 2005 net income down from last year

Finance - Pharmaceutical IT firm reports 13% revenue growth

Finance - PhosLo revenues exceed expectations; set stage for StaphVax launch

Finance - Proteomics-focused diagnostics company reports 14% increase in revenue

Finance - Provider of acute hospital care products lowers 2005 guidance, reports on Q3 results

Finance - Systems biology developer receives $13M from Bill & Melinda Gates Foundation and Amgen

Finance - Therapeutic antibodies developer implements a secured issue of shares worth SEK 160 million

Finance - Transient gene expression-focused firm donates $35,000 to breast cancer research

Finance - Vaccine maker listed on OTCBB

Finance - Venture capital firm announces EUR 7 million investment in Kika Medical, SA

Finance - Viral disease-focused pharmaceutical firm prices public offering of common stock

Finance - Virus-focused biopharma company reports Q3 2004 Fuzeon net sales of $48.9 million

Fitness & Wellness - Peripheral forearm vasodilatation in CAD is not improved by mild endurance exercise and pravastatin

Gastric Cancer Vaccine - Ig superfamily 11 (IGSF11) is target for gastrointestinal and liver cancer

Gastroenterology - Angiogenesis is an ambiguous element of inflammatory bowel disease

Gene Delivery - VEGF gene transfer stimulates angiogenesis and muscle regeneration in ischemic muscles

Gene Research - DNA-based diagnostics company to supply ARUP Labs with genetic metabolism tests

Generic Drugs - U.S. FDA approves ANDA for Pilocarpine HCL tablets for dry mouth from radiation

Genetic & Genomic - S. ribosidificus biosynthetic gene cluster shows similar route for Rbm and butirosin

Genetics & Genomics - Genetic detection system used to detect low-level mutation in mast cell leukemia

Genetics & Genomics - Genomics company forms pharmaceutical subsidiary focused on personalized medicine

Genetics & Genomics - Human hepatocytes proposed for assessing genetic polymorphism of CYP2D6 substrates

Genetics Research - U.K. consortium partners with Perlegen, Affymetrix to find genetic origins of diseases

Genotoxicity - Handling of antineoplastic drugs associated with genotoxic risks in oncology nurses

Geriatric Nocturia - Loxoprofen treatment reduces nocturnal urine production

Giardiasis - Metronidazole-treated patients with giardiasis became 100% parasite-free

Glaucoma - Calcineurin blockade prevents retinal ganglion cell death in animal models

Graft versus Host Disease - U.S. FDA approves trial of stem cell drug for acute graft vs. host disease

Grant Funding - Canadian Institutes of Health Research grants $11.6 million for medical research

HIV/AIDS Antiretroviral - UC-781 inhibits HIV-1 infection of cervical tissue and dissemination by migratory cells

HIV/AIDS Diagnostics - Genotypic assay determines all HIV-1 protease and reverse transcriptase subtypes

HIV/AIDS Diagnostics - HIV reverse transcriptase activity correlates with viral load

HIV/AIDS Diagnostics - Ultrasensitive p24 antigen ELISA diagnoses subtype C HIV-1 infection in infants

HIV/AIDS Drug Development - Covalent stabilization of coiled coils of the HIV gp41 N region inhibits viral infection

HIV/AIDS Drug Development - Pleiotrophin inhibits HIV infection by binding the cell surface-expressed nucleolin

HIV/AIDS Drug Development - Two HIV-1 entry inhibitors prevent gp120 binding to CD4

HIV/AIDS Drug Mutations - HIV RT L74V mutation reduces ATP-dependent removal of ZDV-MP from newly synthesized viral DNA

HIV/AIDS Drug Mutations - Mutations that abrogate HIV-1 RT dimerization affect maturation of the RT heterodimer

HIV/AIDS Drug Resistance - Molecular footprint of drug-selective pressure identified in HIV transmission chain

HIV/AIDS Drug Resistance - Reverse transcriptase inhibitors act together to increase HIV-1 mutation frequencies

HIV/AIDS Epidemiology - Monte Carlo model estimates the natural variation in HIV infection

HIV/AIDS Exposure - CD91 expression increased on monocytes of exposed yet HIV-1-seronegative persons

HIV/AIDS Neurology - HIV-1 species barrier does not extend to uptake by the blood-brain barrier

HIV/AIDS Pathogenesis - Cul5-E3 ligase is a common pathway hijacked by HIV-1 Vif to defeat h-A3F and h-A3G

HIV/AIDS Pathogenesis - HIV reactivation by phorbol esters or T-cell receptor ligation requires PKCalpha and PKCtheta

HIV/AIDS Pathogenesis - Morphine inhibits anti-HIV activity of CD8+ cells in HIV latently infected cells

HIV/AIDS Pathogenesis - Type I IFN production is profoundly and transiently impaired in primary HIV-1 infection

HIV/AIDS Prevention - India's HIV/AIDS pandemic threatens economic and social fabric

HIV/AIDS Prevention - Vaginal microbicide phase III trial underway, 10,000 women to be enrolled

HIV/AIDS Prognosis - APOBEC3G/CEM15 mRNA levels inversely associated with HIV viremia

HIV/AIDS Prognosis - HLA-B63 is associated with low HIV RNA

HIV/AIDS Research - Procyon announces positive preclinical results for lead HIV protease inhibitor

HIV/AIDS Therapy - AIDS Support Organization opens AIDS counseling and training center in Uganda

HIV/AIDS Therapy - Abacavir/lamivudine/zidovudine improves HAART adherence in HIV-1-infected patients

HIV/AIDS Therapy - HIV protease inhibitor ritonavir increases endothelial monolayer permeability

HIV/AIDS Therapy - Trials comparing therapies for HIV/AIDS, related Kaposi's sarcoma are urgently needed in sub-Saharan Africa

HIV/AIDS Therapy - Updated HIV guidelines support fusion inhibitor plus protease inhibitor therapy

HIV/AIDS Vaccine Development - HIV trials feasible with fewer animals if subjects repeatedly challenged with low doses

HIV/AIDS Vaccine Development - HIV-1 Env clones developed for standardized assessments of vaccine-elicited neutralizing antibodies

HIV/AIDS Vaccine Development - Research collaboration formed to develop topical delivery of therapeutic DNA vaccines

HIV/AIDS-Related Atherosclerosis - HIV-1 Tat induces VCAM-1 expression in pulmonary artery endothelial cells

HIV/AIDS-Related Infection - Incidence of esophageal candidiasis in AIDS patients in Europe is declining

HIV/AIDS-Related Kaposi Sarcoma - AIDS-Kaposi sarcoma patients treated with HAART have a high clinical response rate

Headache - Research suggests headaches caused by oral contraceptives improve with continued use

Headache & Migraine - Clopidogrel reduces migraine with aura

Health Policy - EU drug harmonization not yet streamlined

Healthcare Coverage - Pharmacy benefits manager to administer Medicaid benefits in Vermont

Healthcare Coverage - Wellpartner, Northwest Human Services team to provide drug savings

Helicobacter Pylori - Probiotic supplementation improves tolerance to H. pylori eradication therapy

Hemodialysis - Intravenous iron gluconate alters plasma beta₂ -microglobulin features and levels

Hepatitis A Vaccine - Havrix now approved for use in children aged 12 months and older

Hepatitis B Therapy - Findings describe new data in hepatitis B therapy research

Hepatitis B Vaccine Development - Agreement signed to produce hepatitis B therapeutic vaccine candidate

Hepatitis B Virus - Membrane heparan sulfate interactions facilitate hepatitis B virus-induced cytokine production

Hepatitis B Virus - Residues modulate hepatitis B virus X protein binding

Hepatitis C Therapy - Cyclic molecule targeting hepatitis C virus IRES RNA domain blocks translation

Hepatitis C Therapy - Lactoferrin has no effect on the response of chronic hepatitis C to standard therapy

Hepatitis C Therapy - New findings in the area of hepatitis C therapy detailed

Hepatitis C Vaccine - Spontaneous responders to hepatitis C viremia have expansive epitope recognition

Hepatitis C Vaccine Development - Epitope characterization paves the way for hepatitis C peptide-based vaccines

Hepatitis C Virus - Company introduces hepatitis C virus in vitro culturing technology in China

Hepatitis C Virus - Human hepatocytes to be evaluated as models for hepatitis C drug development

Hepatocellular Carcinoma - Recent findings in hepatocellular carcinoma provide new insights

High Cholesterol - Children's hospital to participate in study of single nucleotide polymorphisms

Hookworm Vaccine Development - Hookworm heme-binding glutathione transferase has vaccine potential

Hormone Replacement Therapy - Estrogen use associated with increased myocardial fatty acid utilization

Hormone Therapy - Hot flash experienced in men with prostate cancer

Hospice - Guidelines for treating infections in cancer patients receiving hospice care described

Human Papillomavirus - Humoral immune response recognizes a complex set of epitopes on HPV-6 L1 capsomers

Hypertension - Calcitonin gene-related peptide functions in hypertension

Hypertension - High blood pressure is inversely related to the presence and extent of coronary collaterals

Hypertension - Protective role for diastolic blood pressure evident in normal population

Imaging - Early restaging with F-18-FDG PET predicts outcome of nasopharyngeal carcinoma

Imaging - Image-guided radiotherapy offers hope for tumors impeded by respiratory movement

Imaging - Parkinson disease SPET and PET brain imaging help to optimize research strategies

Immunodeficiency - Natural killer cell-mediated cytotoxicity spawns liver failure

Immunotherapy - LCC passaged human nasal epithelial culture model developed for antiallergic drug studies

Immunotherapy - Study confirms synergy of Coramsine and immune-stimulating agent

Infections - Research in infections provides new insights

Influenza - Antivirals and vaccines maker offers pandemic flu plans

Influenza - Majority of Americans with asthma not immunized against flu despite known risks

Influenza - Use of antiviral for treating flu eight times higher than last year, company says

Influenza Vaccines - Dutch company updates progress in scale-up of cell-culture-based influenza vaccine programs

Information Technology - Agreement to distribute Varian's radiation treatment planning software announced

Information Technology - iPlan RT Prostate Automatic Segmentation software aids treatment of patients with prostate cancer

Invasive Aspergillosis - A new analysis supports starting with VFEND for life-threatening fungal infections

Irritable Bowel Syndrome - Study findings show improvement in work attendance after consistent treatment of IBS

Irritable Bowel Syndrome - Tegaserod improves work and daily activity in IBS patients with constipation

Ischemia - CH3-DTPA-GD (NMS60) is superior to GD-DTPA in evaluating acute myocardial ischemia

Ischemic Stroke - Data supports benefit of low energy ultrasound on thrombolytic drugs

Kidney Transplantation - Equine polyclonal antibody induction may heighten PTLD risk

Legal Issues - Biotech group supports Santorum/Hart bill to amend tax law

Legal Issues - Settlement on antidepressant patent infringement litigation announced

Legal Issues - U.K. court rules in key European patent cases on cholesterol drug atorvastatin

Leukemia - Findings advance knowledge in leukemia research

Leukemia - Initial study yields positive results from drug for acute myeloid leukemia

Leukemia - Multicenter study to assess combination treatment for acute myelogenous leukemia

Leukemia - U.S. Food and Drug Administration grants fast track designation for Troxatyl

Leukemia Vaccine Development - Acute promyelocytic leukemia cells cleared by adaptive immune mechanisms

Lipid Research - Raloxifene positively affects lipid profile and body fat distribution

Liver Cancer - New findings in the area of liver cancer detailed

Liver Cancer Vaccine Development - Autoantibodies against tumor-associated antigens in liver cancer identified

Liver Transplantation - Children with extended hepatoblastoma should be referred to transplant surgeon

Lung Cancer - Camptothecin-somatostatin conjugates inhibit growth of lung cancer cells

Lung Cancer - New research shows Onconase inhibits tumor growth in non-small cell lung cancer

Lung Cancer - New test measures epidermal growth factor receptor in lung cancer patients

Lung Transplantation - Glutathione improves the function of porcine pulmonary grafts

Lymphoma - Clinical features of primary cutaneous marginal zone B-cell lymphoma described

Lymphoma - Researchers report details of new studies and findings in the area of lymphoma

Malaria - HRP2 antigen levels remain elevated for at least 7 days after malaria treatment

Malaria Drugs - HIV-1 protease inhibitors have antimalarial activity

Malaria Therapy - Trimethoprim-sulfamethoxazole is efficacious for uncomplicated malaria

Malaria Vaccine - Binding hot spot for invasion inhibitory molecules on P. falciparum antigen identified

Malaria Vaccine - Protective human immunity is a vaccine discovery tool for falciparum malaria

Malaria Vaccine Development - Changes in host cell tropism limits efficacy of malaria vaccine

Market Analysis - Global pharmaceutical market set to grow 6-7% in 2006; U.S. demand increasing

Marketing - PR/IR firm's bioscience practice adds four clients

Medicaid - Pharmacy trade organizations form Coalition for Meaningful Medicaid Reform

Medical Devices - Bifurcation stenting presents an increased risk of stent thrombosis

Medical Devices - Company files application with U.S. FDA for polymer coated surgical mesh product

Medical Devices - Frequency of late incomplete stent apposition after sirolimus-eluting stent implantation determined

Medical Devices - Results find vascular brachytherapy effective treatment for in-stent restenosis

Menopause - Declining estrogen levels can cause dermatologic changes in post-menopausal women

Menopause - Novel class of estrogen receptor-subtype modulators identified

Menopause - Pharmaceutical company gets exclusive North American rights to Estrasorb topical emulsion

Menopause - Study reveals physician understanding of menopause and patient interaction

Menopause Symptoms - Use of tibolone for managing menopausal symptoms contrasted with traditional therapy

Mental Health - Fluvoxamine maleate approved for treatment of social anxiety disorder in Japan

Mental Health - Launch of Alzhemed, Flurizan will drive dementia drug market, reports indicates

Mergers & Acquisitions - Acquisition of Beijing Wanwei Pharmaceutical Co., Ltd., has been approved

Mergers & Acquisitions - Acquisition of BioFocus complete

Mergers & Acquisitions - Cardiology company merges with Aries Ventures

Mergers & Acquisitions - PBM completes the acquisition of Priority Healthcare

Mergers & Acquisitions - Pain management solutions company acquires The Centeno Clinic

Mergers & Acquisitions - Pharmaceutical company to divest its noncore pharmaceutical products

Mergers & Acquisitions - Report: Healthcare merger and acquisition activity surges in third-quarter 2005

Mergers & Acquisitions - U.S., global generics business sold to Actavis for $810M

Migraine - Implant developer receives U.K. approval for migraine intervention study

Molecular Biology - Disease progression accelerates in response to hypoxia

Muscular Dystrophy - Early cardiac screening is necessary for muscular dystrophy patients

Mycobacterium Avium - Antineutrophil cytoplasmic antibody vasculitis associated with M. avium intracellulare infection

Myocardial Infarction - Endothelial nitric oxide synthase polymorphism is important during myocardial infarction

Myocardial Infarction - Hepatocyte growth factor generates therapeutic angiogenesis in ischemic canine hearts

Myocardial Injury - Menadione can restore calcium oscillations and cardiomyocyte contractility

Nanotechnology - New line of high purity zinc oxide nanoparticles offers greater transparency

Natural Products - (S)-(+)-curcuphenol dimers isolated from Didiscus aceratus were investigated

Neurogenesis - HR6B is up-regulated by nerve growth factor and required for neurite outgrowth

Neurology - New findings in the area of neurology detailed

Neuropeptides - Additional class of neuropeptide Y receptor sites exists in rat brain

Neuroscience - Recent findings illuminate research in neuroscience

Non-Small Cell Lung Cancer - Enrollment opens in Phase III study of treatment for non-small cell lung cancer

Nosocomial Infections - Global nosocomial safety campaign with guidelines on hand hygiene launched

Obesity - Drug-development company awarded $2.1 million NIH grant for obesity research

Obesity Therapy - Tungstate decreases weight gain and adiposity in obese rats

Obesity Treatment - A new kind of appetite suppressant may mean hope for the obese

Obstetrics - Angiogenic balance may be essential for evading preeclampsia

Obstructive Cholangitis - Moxifloxacin transported into obstructed bile via active secretion mechanism

Oncology - Cyclin A1 mediates vascular endothelial growth factor signals in prostate cancer

Oncology - Electronics company unveils AcQSim3 to advance image guided radiation therapy

Oncology - Endoglin and vascular endothelial growth factor mark esophageal adenocarcinoma angiogenesis

Oncology - Hepatitis B virus X protein may permit cancer formation by limiting DNA repair

Oncology - Marrow-derived endothelial precursors rarely contribute to tumor vascularization

Oncology - Recent findings illuminate research in oncology

Oncology - Receptor engagement drives tumor neovascularization

Oncology - Study shows AEOL 10150 protects against radiation-induced lung injury

Oncology - Study shows chemotherapy project improving quality of care nationwide

Ophthalmology - Cytochrome P450 antagonists may prevent corneal neovascularization

Ophthalmology - Keratinocyte growth factor prevents oxidative stress damage in RPE cells

Ophthalmology - Researchers' data advance ophthalmology research

Oral Health - Gingival crevicular fluid harbors hepatitis C virus RNA

Oral Mucositis - Pharma company successfully concludes Phase II of oral mucositis drug trial

Organophosphate Poisoning - Several anticonvulsants reduce soman-induced epileptiform activity in vitro

Orthopedics - Angiogenesis is a prerequisite for bone induction during distraction osteogenesis

Osteoporosis - Indices of bone formation increase with teriparatide

Osteoporosis - Tanshinones from Chinese sage root suppress osteoclast differentiation

Ovarian Cancer - Women at high risk of ovarian cancer are ready subjects for chemoprevention trials

Packaging - U.S. FDA approves Flexbumin, an albumin solution, in a flexible container

Pain Management - Acceptance-based coping may be useful tool in controlling pain

Pain Management - European authorities recommend approval for IONSYS

Pain Management - Image-guided percutaneous cryoablation requires less analgesia than RF ablation

Pain Management - Intrathecal neostigmine induces anti-inflammatory activity via spinal M₂ receptor activation

Pain Management - Positive preliminary results announced from phase II study for postoperative-pain-relief depot

Palliation - Opioid switch in palliative care suggested according to clinical need

Pancreatic Cancer - Initial results of phase II trial compare MetXia against gene based therapies

Patents - Biotech company announces patent for reovirus for the treatment of neoplasia

Patents - Japanese Patent Office's ruling on pravastatin favors generic drug company

Patents - Patent coverage granted extending exclusive license of Xyotax in Japan to 2018

Patents - Patent request filed for THC nasal spray to control nausea and vomiting

Patents - Patents for rheumatoid arthritis compound granted by European Patent Office

Patents - U.S. patent granted for single-ingredient extended-release guaifenesin products

Patients - U.S. patent issued for Potelligent technology

Pediatric Cancer - Late effects in childhood cancer survivors analyzed to establish therapy starting point

Pediatric Cancer - Tool to assess therapy for pediatric anorexia and cachexia evaluated

Peptides - Intermedin may function as a cardiovascular active peptide

Personnel - Actos developer reports J. Erik Fyrwald elected to board of directors

Personnel - Biotechnology company appoints Wiltrud Treffenfeldt to supervisory board

Personnel - Biotechnology company elects Doyle to board, Palmin as chief executive officer

Personnel - Cell therapy company names Brooks Boveroux to board of directors

Personnel - Cell-based therapy company appoints Walter C. Ogier as CEO

Personnel - Contract research organization appoints Richardson as senior VP

Personnel - Contract research organization names Fede as senior vice president

Personnel - Donna Z. Bliss, PhD, named director of Clinical Research Nursing Society

Personnel - Dr. Shijie Yang named as chairman and president of Jilin Tian Yao Drug Safety Evaluation Co., Ltd.

Personnel - Eugene A. Bauer steps down as dermatology company director

Personnel - Generic pharmaceuticals maker votes on board of directors nominees

Personnel - Genomics research organization names MaryAnn Guerra chief operating officer

Personnel - Gregg A. Linn appointed chief operating officer of nutritional products company

Personnel - Henry Hsu appointed as chief medical officer at company developing anti-angiogenesis drugs

Personnel - Hygroton maker appoints new director of regulatory affairs

Personnel - Hypogonadism drug maker hires Steven M. Lyons as senior VP of program management

Personnel - Jeffrey H. Sakamoto, CFO of microalgae-focused company, resigns

Personnel - Jill M. Forrest named VP of marketing and sales at immunotherapeutics company

Personnel - John J. Howarth named VP, investor relations, of pharmaceutical company

Personnel - Lakey to direct development of Pher-O2 for organ and islet transplantation

Personnel - Lars Ramneborn appointed to board of directors of European generic drug company

Personnel - Medical device company appoints Williamson president and chief executive officer

Personnel - Medical device company names G. Ray Martin president and CEO

Personnel - Nasally delivered pharmaceuticals developer names two new members to its board of directors

Personnel - Pharma company appoints Jeffrey M. Johnston as vice president and chief medical officer

Personnel - Robert C. Young, MD, named to board of directors

Personnel - Ronald Peterson, MD, named Abbott Northwestern vice president of medical affairs

Personnel - Roy C. Levitt, MD, resigns as CEO; John L. Armstrong, Jr., to take the helm

Personnel - Therapeutic apheresis company appoints Ball as midwest regional medical director

Personnel - Therapeutic vaccine maker appoints management board for further growth

Personnel - Xyotax developer appoints John Bauer to board of directors, chair of audit committee

Pertussis Vaccines - New research in the area of pertussis vaccines detailed

Pharmaceutical Research - Assessment service launched for pharmaceutical industry

Pharmaceutical Research - Diabetes therapy pioglitazone hinders liver disease in rodent models

Pharmaceutical Research - No differences were found in solid-state NMR spectra of bambuterol hydrochloride samples

Pharmaceutical Research - Quantitative NMR is an ideal method for synthetic and combinatorial drug synthesis

Pharmaceutical Research - RiVax maker provides business and clinical update; RiVax phase I trial complete

Philanthropy - Foundation pledges $1 million for Sloan-Kettering cancer survivor programs

Philanthropy - New HIV/AIDS collaboration launched in Kenya

Physiology - Age and physical activity govern angioregulatory mediators in healthy adults

Physiology - C-terminal amino acids of SUR2A and SUR2B function in cardiovascular ATP-sensitive K⁺ channels

Physiology - Carbonyl reductase is involved in pig heart superoxide

Physiology - Spironolactone corrects cardiorenal abnormalities associated with high sodium intake

Physiology - Synergistic interactions between Ca²⁺ entries occur in normal and failing rat heart

Physiology - Zolpidem exhibits sleep-related vagotonic effect

Pneumococcal Vaccines - Recent studies add new data to pneumococcal vaccines research

Product Licensing - Drug development company enters license and supply agreement on Estrasorb

Product Licensing - Full PCR license acquired from Roche Diagnostics

Product Licensing - Global licensing agreement for anticancer product Tocosol Paclitaxel announced

Product Licensing - Holding company acquires patent-pending method for expansion of stem cells

Product Licensing - Hormone replacement drug distribution rights sold to Breckenridge Pharmaceutical

Product Licensing - License agreement inked to commercialize feedback canceller for hearing aids

Product Licensing - Rabbit monoclonal antibody technology licensed for antibody development

Professional Education - Medical education provider launches resource library for pharma industry professionals

Prostate Cancer - Researchers' work adds to prostate cancer body of knowledge

Proteomics - Findings in proteomics provide new insights

Proteomics - GTPase Sar1p initiates membrane curvature and completes fission of COPII vesicle

Proteomics - Genedata comarkets solution for high-throughput protein-gel processing

Proteomics - P-gp expression, but not BCRP, upregulated in early pregnancy to protect fetus

Proteomics - Pregnancy-associated plasma protein-A modulates stem cell matrix mineralization and angiogenesis

Quality Assurance - Results show 2-year collaborative project is improving patient safety in ICUs

RNA Research - Phase 1 trial data on RNA molecule for age-related macular degeneration updated

Radiation Therapy - Proteasome inhibition improved fractionated radiation treatment

Radiofrequency Ablation - Radiofrequency ablation used to treat renal cell carcinomas under MR-guidance

Restless Legs Syndrome - Studies show sustained efficacy in treatment for restless legs syndrome

Retinoblastoma - Investigators demonstrate potential treatment for retinoblastoma

Rett Syndrome - Discovery provides new clues about causes of Rett syndrome

Rheumatoid Arthritis - Patient enrollment complete in study of the safety and efficacy of MM-093

SARS - Reports advance knowledge in SARS research

SARS Coronavirus - Immunodominant epitopes identified on the membrane protein of SARS coronavirus

Scabies - HTLV-1 infection is an important co-factor related to Norwegian scabies in Peru

Seasonal Allergic Rhinitis - Cetirizine more effective than fexofenadine at 5-12 hours posttreatment

Sedation - Adverse cardiovascular events observed during respiratory sedation of pediatric patients

Sepsis Therapy - Drotrecogin alfa not beneficial for severe sepsis with low risk of death

Sexual & Reproductive Health - Interferon-based therapy Alferon treats human papilloma virus

Sexual & Reproductive Health - Pharmaceutical company presents results of in vitro fertilization trial

Sexual & Reproductive Health - Steroid signaling regulates ovarian surface epithelium

Smallpox Vaccines - Reports describe recent advances in smallpox vaccines research

Staphylococcal Infection - Intensive ceftobiprole medocaril therapy effective in murine MRSA model

Stem Cell Research - Biotech company announces agreement with Becton, Dickinson and Company

Stem Cell Research - Government contractor, AntiCancer Inc. collaborate to develop neural diseases therapy

Stem Cell Research - Mesenchymal stem cells are present in the adult lung

Stem Cell Transplantation - MDR1 gene expression enhances long-term engraftibility of cultured bone marrow cells

Stroke - Botox injections are effective for treating stroke spasticity

Stroke - Oral atorvastatin has long-term protective effects in animal model

Surgical Technology - New soft helical finishing coil to improve durability of aneurisym repair

Surgical Technology - Pivotal trial of percutaneous alternative to open-heart mitral valve surgery begins

Surgical Technology - Stent placement is an alternative to complex arterial bypass surgery or reconstruction

Surgical Technology - Study shows stent less prone to target vessel failure than brachytherapy

Thrombosis Therapy - Aprotinin needed to accurately monitor hemostatic system during desmoteplase treatment

Tourette Syndrome - Flip-flopped chromosome reveals a first clue to Tourette syndrome

Toxicity - High blood pressure is a symptom of paraquat-induced toxicity

Toxicology - Tefluthrin provokes cellular Ca²⁺ overload in ventricular myocytes

Transmissible Spongiform Encephalopathy - Technology shown to remove transmissible spongiform encephalopathy infectivity

Transplant Medicine - Infectious tolerance in heart allografts can be adoptively transferred

Transplant Medicine - Kidney foundation recognizes London researcher Anthony Jevnikar for excellence

Transplant Medicine - Kidney transplant patients with GI complaints improve with coated Myfortic

Transplant Medicine - Patients with de novo hepatitis after liver transplantation display overlap syndrome

Transplant Medicine - Recent findings illuminate research in transplant medicine

Transplant Medicine - Stable mixed chimerism is required for the suppression of cellular rejection

Transplant Medicine - Study indicates steroid-free immunosuppression is safe in pediatric renal transplants

Trigeminal Neuralgia - Botulinum toxin can ease intense facial pain

Trypanosoma Cruzi - DHEA enhances reduces level of Trypanosoma cruzi parasites

Tuberculosis - PCR is more cost-effective than Ziehl-Neelsen smear microscopy for TB diagnosis

Tuberculosis - Recurrent tuberculosis in HIV-infected children is common in a high-burden TB setting

Tuberculosis Therapy - Rifampin-pyrazinamide not recommended for treatment of latent TB

Tumor Metastasis - Chondroitin sulfate addition to CD44H negatively regulates hyaluronan binding

Type 1 Diabetes - Development program initiated for intranasal formulation of rapid-acting insulin

Ulcerative Colitis - Trials show Remicade effective for mucosal healing in ulcerative colitis

Urinary Tract Infections - Free soluble globotriose effective in murine model

Uterine Cancer - Improved survivial achieved with Platinum-based chemotherapy

Vaccine Development - Recombinant antibody libraries aid vaccine research

Vaccines Delivery - Data advance knowledge in vaccines delivery research

Vasculogenic Erectile Dysfunction - Novel rat model of VED with generalized atherosclerosis validated

Vasodilation - Circulating elastin peptide levels decrease in humans with sepsis

Vector Development - Findings describe new data in vector development research

Virology - Duck hepatitis B covalently closed circular DNA persists after transient infection

Virology - Findings in virology provide new insights

Virology - HIV and hepatitis C virus infection elicit similarities in natural killer cells

Virology - Hepatitis B virus pseudotypes elucidate early infection activity

Virology - Liver enzyme flares require scrutiny in HIV-HCV coinfected patients beginning therapy

Weight Loss - Pharma company initiates recruitment process for clinical trial of obesity drug

Wound Repair - Pharmacological preconditioning extends the survival of ischemic skin flaps

X-Ray Exposure - Germ cell-transmitted alteration may be initiated by preconceptual maternal X-ray exposure

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