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Allergy & Immunology
Immune escape may offer hepatitis C virus variants a survival advantage
November 18th, 2005
Immune escape may offer hepatitis C virus (HCV) variants a survival advantage. According to recent research from Italy, "cellular immune responses are induced during HCV infection and acute-phase CD8+ T cells are supposed to play an important role in controlling viral replication. In chimpanzees, failure of CD8+ T cells to control HCV replication has been associated with acquisition of mutations in MHC class I-restricted epitopes." "In humans, although selection of escape mutations in an immunodominant CTL epitope has been recently described, the overall impact of immune escape during acute HCV infection is unclear," wrote S. Guglietta and...
Source: Drug Week (2005-11-18)
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