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Allergy & Immunology
Mnks role in cytokine regulation indicates value as new anti-inflammatory target
November 18th, 2005
The Mnks are novel components in cytokine regulation, and potential new targets for anti-inflammatory therapy. "Post-transcriptional regulatory mechanisms control TNF alpha expression through Au-rich elements in the 3'UTR of its mRNA. This is mediated through Erk and p38 MAP kinase signaling, although the mechanisms involved remain poorly understood," scientists in Canada report. "Here," proposed M. Buxade and colleagues, University of British Columbia, "we show that the MAP kinase signal-integrating kinases (Mnks), which are activated by both these pathways, regulate TNFa expression in T cells via the 3'UTR. A selective Mnk inhibitor or...
Source: Drug Week (2005-11-18)
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