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Angiology
Heparin detection limit obtained with new stripping voltammetry method
November 18th, 2005
A detection limit of 0.13 unit/mL for heparin was obtained using a stripping voltammetry method. "Heparin, a highly negatively charged polysaccharide, which has been used widely as an anticoagulant and antithrombotic, was detected by ion-transfer voltammetry at the interface between 1,2-dichloroethane and an aqueous buffer solution or undiluted blood plasma," researchers in Pennsylvania report. "Quaternary ammoniums with different numbers of methyl and long alkyl groups were examined as positively charged heparin ionophores using pipet electrodes filled with the organic electrolyte solutions of their tetrakis(4-chlorophenyl)borate salts." "It was...
Source: Drug Week (2005-11-18)
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