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Angiotensin
Simvastatin therapy normalizes sympathetic neural control in experimental heart failure
November 18th, 2005
According to recently published research from the United States, simvastatin (SIM) therapy normalizes sympathetic neural control in experimental heart failure. "In a previous study, we showed that SIM therapy normalized sympathetic outflow and cardiovascular reflex regulation in chronic heart failure (CHF). However, the precise neural and cellular pathways for these effects are unknown. "We hypothesized that SIM exerts its beneficial effect on autonomic function in CHF by downregulating central angiotensin II (Ang II) and superoxide mechanisms," wrote L. Gao and colleagues, University of Nebraska. "Experiments were carried out on...
Source: Drug Week (2005-11-18)
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