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Antioxidants
Red blood cell model optimized for the study of antioxidant drugs
November 18th, 2005
A red blood cell model was optimized, according to the concentrations of oxidant and phosphate buffer, for the study of antioxidant drugs. According to recent research from France, "The aggression of erythrocytes by an oxidative stress induces hemolysis. This paper aims to valid a model of erythrocytes in terms of composition of the phosphate buffer solution and of concentration of a well-known oxidant, AAPH." "Three compositions of phosphate buffer solution are mixed with three concentrations of oxidant. The influence of these two parameters on hemolysis is independently studied by a variance analysis and a Kruskal-Wallis test when ANOVA is not...
Source: Drug Week (2005-11-18)
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