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Apoptosis
Alpha-tocopheryl succinate selectively induced apoptosis in neuroblastoma cells
November 18th, 2005
Alpha-tocopherol succinate (alpha-TOS) selectively induced apoptosis in neuroblastoma (Nb) cells. "Vitamin E (VE) analogues, epitomized by alpha-TOS, are potent inducers of apoptosis and anti-cancer agents. Here, we tested their effect on the highly malignant N-type Nb cells and their differentiated, neuron-like counterparts," investigators in Australia reported. "Nb cells were highly susceptible to several VE analogues, while differentiated Nb cells were relatively resistant to alpha-TOS. The importance of caspase-9 rather than caspase-8, as judged by specific siRNAs studies, together with the loss of the inner mitochondrial potential, suggests that...
Source: Drug Week (2005-11-18)
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